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公开(公告)号：US09150852B2
公开(公告)日：2015-10-06
申请号：US13398677
申请日：2012-02-16
IPC分类号： C40B50/08 , C12N15/10 , G01N33/543 , G01N33/58
CPC分类号： C12N15/1075 , C12Q1/6874 , C40B50/08 , G01N33/5436 , G01N33/58
摘要： The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
摘要翻译： 本发明提供条形码文件库及其制备和使用方法，包括获得多个核酸构建体，其中每个构建体包含独特的N-聚体和功能性N-聚体，并将构建体分离成流体隔室，使得每个隔室含有一个 或更多的独特构造的副本。 本发明还提供数字PCR和数字PCR中条形码库的使用方法。
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公开(公告)号：US20120220494A1
公开(公告)日：2012-08-30
申请号：US13398677
申请日：2012-02-16
CPC分类号： C12N15/1075 , C12Q1/6874 , C40B50/08 , G01N33/5436 , G01N33/58
摘要： The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
摘要翻译： 本发明提供条形码文件库及其制备和使用方法，包括获得多个核酸构建体，其中每个构建体包含独特的N-聚体和功能性N-聚体，并将构建体分离成流体隔室，使得每个隔室含有一个 或更多的独特构造的副本。 本发明还提供数字PCR和数字PCR中条形码库的使用方法。
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公开(公告)号：US20130210659A1
公开(公告)日：2013-08-15
申请号：US13764459
申请日：2013-02-11
CPC分类号： C12N15/1072 , C12Q1/6827 , C12Q1/6844 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , C12Q2525/155 , C12Q2525/161 , C12Q2563/159 , C12Q2563/179 , C12Q2565/629 , C12Q2521/319 , C12Q2521/501 , C12Q2545/101
摘要： The invention generally relates to method for screening for a condition in a subject. In certain embodiments, methods of the invention involve obtaining a pool of nucleic acids from a sample, incubating the nucleic acids with first and second sets of binders, in which the first set binds uniquely to different regions of a target nucleic acid in the pool, the second set binds uniquely to different regions of a reference nucleic acid in the pool, and the first and second sets include different detectable labels, removing unbound binders, detecting the labels, and screening for a condition based upon results of the detecting step.
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公开(公告)号：US09562897B2
公开(公告)日：2017-02-07
申请号：US13250702
申请日：2011-09-30
申请人： Michael Samuels , Darren Roy Link
发明人： Michael Samuels , Darren Roy Link
IPC分类号： G01N33/50 , G01N33/543
CPC分类号： G01N33/54366 , B01F13/0062 , B01F13/0071 , C12Q1/6874
摘要： The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte.
摘要翻译： 本发明一般涉及在液滴中进行夹心测定。 在某些实施方案中，本发明提供了用于检测目标分析物的方法，所述方法涉及形成包含疑似含有目标分析物的样品的一部分和样品标识符的分离部分的流体，具有靶标识的第一粘合剂， 在产生第一和第二结合剂与目标分析物的复合物的条件下对目标分析物特异性的结合剂，分离复合物，并检测复合物，从而检测目标分析物。
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公开(公告)号：US20120122714A1
公开(公告)日：2012-05-17
申请号：US13250702
申请日：2011-09-30
申请人： Michael Samuels , Darren Roy Link
发明人： Michael Samuels , Darren Roy Link
CPC分类号： G01N33/54366 , B01F13/0062 , B01F13/0071 , C12Q1/6874
摘要： The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte.
摘要翻译： 本发明一般涉及在液滴中进行夹心测定。 在某些实施方案中，本发明提供了用于检测目标分析物的方法，所述方法涉及形成包含疑似含有目标分析物的样品的一部分和样品标识符的分离部分的流体，具有靶标识的第一粘合剂， 在产生第一和第二结合剂与目标分析物的复合物的条件下对目标分析物特异性的结合剂，分离复合物，并检测复合物，从而检测目标分析物。
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公开(公告)号：US20070043185A1
公开(公告)日：2007-02-22
申请号：US11448474
申请日：2006-06-07
IPC分类号： C08F4/44
摘要： A process for the production of polymers in which an oligomeric precursor is formed first in a melt phase. A phase transition is then induced in the polymerizing reaction medium under the action of shear in such a way that the simultaneous action of the shear, and the ongoing polymerization through the phase transition produces a product that is in a powdered form.
摘要翻译： 一种生产聚合物的方法，其中首先在熔融相中形成低聚前体。 然后在剪切作用下在聚合反应介质中诱导相变，使得剪切的同时作用和通过相变的持续聚合产生粉末形式的产物。
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公开(公告)号：US20060014461A1
公开(公告)日：2006-01-19
申请号：US11230008
申请日：2005-09-19
申请人： Vishal Bansal , Hyun Lim , Harry Samuelson , Michael Samuels
发明人： Vishal Bansal , Hyun Lim , Harry Samuelson , Michael Samuels
IPC分类号： B32B5/24
CPC分类号： D01F8/16 , D01F8/14 , Y10T428/2929 , Y10T428/2931 , Y10T442/3146 , Y10T442/444 , Y10T442/60 , Y10T442/637 , Y10T442/653
摘要： A flame retardant fabric comprising bicomponent fibers having a sheath and a core wherein the sheath comprises a fully aromatic thermoplastic polymer with a Limited Oxygen Index of at least 26 and the core comprises a thermoplastic polymer.
摘要翻译： 一种包含具有鞘和芯的双组分纤维的阻燃织物，其中所述护套包含具有至少26的有限氧指数的完全芳香族热塑性聚合物，并且芯包含热塑性聚合物。
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公开(公告)号：US20090099029A1
公开(公告)日：2009-04-16
申请号：US11453256
申请日：2006-06-15
申请人： Michael Samuels
发明人： Michael Samuels
IPC分类号： C40B30/04 , G01N33/566
CPC分类号： C12Q1/485 , C07K14/4713
摘要： The present invention relates to methods of conducting kinase assays using a myelin basic protein subtrate and a tyrosine kinase. Also provided herein are compositions that include myelin basic protein and a tyrosine kinase. Illustrative embodiments of these assays are performed on a microarray. In another embodiment, provided herein is a universal substrate that includes myelin basic protein.
摘要翻译： 本发明涉及使用髓磷脂碱性蛋白质缓冲液和酪氨酸激酶进行激酶测定的方法。 本文还提供了包含髓磷脂碱性蛋白和酪氨酸激酶的组合物。 这些测定的说明性实施方案在微阵列上进行。 在另一个实施方案中，本文提供的是包含髓磷脂碱性蛋白质的通用底物。
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公开(公告)号：US20060219713A1
公开(公告)日：2006-10-05
申请号：US11438518
申请日：2006-05-22
申请人： Michael Samuels , Marion Waggoner , Joel Citron , Roger Moons , Charles Molnar
发明人： Michael Samuels , Marion Waggoner , Joel Citron , Roger Moons , Charles Molnar
IPC分类号： H05B6/80
CPC分类号： C08L101/12 , A47J36/027 , Y10T428/2918
摘要： Ovenware for microwave ovens which contain a composition comprising a susceptor and a thermoplastic or thermoset polymer are improved when the composition also has a thermal conductivity of about 0.7 W/m° K. or more. Heat generated by absorption of microwave radiation by the susceptor is more readily conducted to the food being cooked when the thermal conductivity of the composition is high, particularly when the part containing the susceptor is relatively thick. Also described are designs for various pieces of ovenware containing this composition.
摘要翻译： 当组合物还具有约0.7W / m°K.或更高的热导率时，含有包含感受器和热塑性或热固性聚合物的组合物的微波炉的烤箱得到改进。 当组合物的导热性高时，特别是当包含感受体的部分相对较厚时，由感受器吸收微波辐射产生的热量更容易被传导到被烹饪的食物。 还描述了包含该组合物的各种烤箱的设计。
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公开(公告)号：US20100022414A1
公开(公告)日：2010-01-28
申请号：US12504764
申请日：2009-07-17
申请人： Darren Link , Brian Hutchison , Michael Samuels , Michael Weiner
发明人： Darren Link , Brian Hutchison , Michael Samuels , Michael Weiner
CPC分类号： B01F3/0807 , B01F5/0646 , B01F5/0653 , B01F13/0062 , B01F2215/0037 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00418 , B01J2219/00479 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00599 , B01J2219/0065 , B01J2219/00657 , B01J2219/00664 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , C40B40/04 , C40B50/08 , G01N15/1459 , G01N33/5008 , G01N2015/1006 , G01N2500/00 , Y02A90/26
摘要： The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
摘要翻译： 本发明一般涉及液滴库以及用于形成液滴库的系统和方法。 本发明还涉及在各种生物，化学或诊断测定中利用这些液滴文库的方法。
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