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1.发明申请INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS 审中-公开靶向硝酸盐药物治疗放射性辐射感染性嗜酸性粒细胞病毒的药物治疗公开(公告)号：US20140199368A1
公开(公告)日：2014-07-17
申请号：US13885391
申请日：2011-11-15
申请人： Michael W. Epperly , Xiang Gao , Joel S. Greenberger , Song Li , Peter Wipf
发明人： Michael W. Epperly , Xiang Gao , Joel S. Greenberger , Song Li , Peter Wipf
IPC分类号： C07D211/94 , C07K5/087 , C07D207/46 , C07F9/22 , C07D471/08
CPC分类号： C07D211/94 , A61K31/13 , A61K31/445 , C07D207/46 , C07D471/08 , C07F9/22 , C07K5/0812
摘要： Provided herein are compositions and related methods useful for prevention or mitigation of ionizing radiation-induced esophagitis. The compositions comprise compounds comprising a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent or mitigate esophageal damage caused by radiation.
摘要翻译： 本文提供了可用于预防或减轻电离辐射诱发的食管炎的组合物和相关方法。 组合物包含包含连接到线粒体靶向基团的含氮氧化物基团的化合物。 化合物可以交联成二聚体而不损失活性。 该方法包括以有效预防或减轻由辐射引起的食管损伤的量和剂量方案将如本文所述的化合物递送给患者。
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公开(公告)号：US08748369B2
公开(公告)日：2014-06-10
申请号：US13320999
申请日：2010-06-04
申请人： Michael W. Epperly , Abhay Sudhir Gokhale , Joel S. Greenberger , Peter Wipf , Julianne Glowacki
发明人： Michael W. Epperly , Abhay Sudhir Gokhale , Joel S. Greenberger , Peter Wipf , Julianne Glowacki
CPC分类号： A61K31/4468
摘要： Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity.
摘要翻译： 本文提供了可用于加速骨愈合和生长的组合物和相关方法。 化合物包含连接到线粒体靶向基团的含氮氧基的基团。 化合物可以交联成二聚体而不损失活性。
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公开(公告)号：US20120252733A1
公开(公告)日：2012-10-04
申请号：US13320999
申请日：2010-06-04
申请人： Michael W. Epperly , Abhay Sudhir Gokhale , Joel S. Greenberger , Peter Wipf , Julianne Glowacki
发明人： Michael W. Epperly , Abhay Sudhir Gokhale , Joel S. Greenberger , Peter Wipf , Julianne Glowacki
IPC分类号： A61K38/05 , A61P19/10 , A61K31/54 , A61K31/44 , A61K38/08 , A61K31/16 , A61K31/133 , A61K31/131 , A61P19/08 , A61K38/06 , A61P19/02 , A61K31/195
CPC分类号： A61K31/4468
摘要： Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity.
摘要翻译： 本文提供了可用于加速骨愈合和生长的组合物和相关方法。 化合物包含连接到线粒体靶向基团的含氮氧基的基团。 化合物可以交联成二聚体而不损失活性。
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公开(公告)号：US20120207687A1
公开(公告)日：2012-08-16
申请号：US13349526
申请日：2012-01-12
IPC分类号： A61K31/445 , A61P17/00 , A61Q17/04 , A61K8/49
CPC分类号： A61K31/4468 , A61K9/0014 , A61K9/127 , A61K31/16 , A61K31/454 , A61K45/06 , A61K2300/00
摘要： A method for preventing or treating skin damage in a radiotherapy subject, comprising topically administering to the subject a composition that includes a therapeutically effective amount at least one targeted nitroxide agent and at least one additional ingredient.
摘要翻译： 一种用于预防或治疗放射治疗受试者的皮肤损伤的方法，包括向所述受试者局部施用包含治疗有效量的至少一种靶向的氮氧化物试剂和至少一种另外的成分的组合物。
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公开(公告)号：US10308663B2
公开(公告)日：2019-06-04
申请号：US15737062
申请日：2016-06-16
IPC分类号： C07D495/04 , A61K31/4365 , A61P35/00
摘要： The invention provides protein tyrosine phosphatase inhibitor compounds, Their pharmaceutical compositions, uses, and methods of use, such as in the treatment of various cancers, and process for making the compounds. Also disclosed is an improved synthesis of protein tyrosine phosphatase inhibitor and precursor compound thienopyridone (5).
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公开(公告)号：US20180170946A1
公开(公告)日：2018-06-21
申请号：US15737062
申请日：2016-06-16
IPC分类号： C07D495/04 , A61P35/00
CPC分类号： C07D495/04 , A61K31/4365 , A61P35/00
摘要： The invention provides protein tyrosine phosphatase inhibitor compounds, Their pharmaceutical compositions, uses, and methods of use, such as in the treatment of various cancers, and process for making the compounds. Also disclosed is an improved synthesis of protein tyrosine phosphatase inhibitor and precursor compound thienopyridone (5).
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公开(公告)号：US09840515B2
公开(公告)日：2017-12-12
申请号：US13992546
申请日：2011-12-08
申请人： Peter Wipf , Qiming Jane Wang
发明人： Peter Wipf , Qiming Jane Wang
IPC分类号： A61K31/55 , C07D495/04 , C07D487/04 , C07D491/048 , C07D491/147 , C07D498/04 , C07D513/04 , C07D513/14
CPC分类号： C07D495/04 , C07D487/04 , C07D491/048 , C07D491/147 , C07D498/04 , C07D513/04 , C07D513/14
摘要： Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription, and protein trafficking. Accordingly, pharmaceutically acceptable compositions of the inventive compounds are candidate therapeutics for pathological conditions conditioned by changes in PKD activity.
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公开(公告)号：US09216976B2
公开(公告)日：2015-12-22
申请号：US14088233
申请日：2013-11-22
申请人： Peter Wipf , Marie-Celine Frantz
发明人： Peter Wipf , Marie-Celine Frantz
IPC分类号： C07D417/12 , A61K31/454 , A61K47/48 , C07D211/58 , C07D401/12 , C07C237/16 , C07D209/46 , C07D211/94 , C07D221/22
CPC分类号： C07K5/08 , A61K31/454 , A61K47/64 , C07C237/16 , C07D209/44 , C07D209/46 , C07D211/58 , C07D211/94 , C07D221/22 , C07D279/06 , C07D401/12 , C07D417/12 , C07D471/08
摘要： Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.
摘要翻译： 本文提供了可用于自由基清除的组合物和相关方法，对线粒体具有特别的选择性。 化合物包含连接到线粒体靶向基团的含氮氧基的基团。 化合物可以交联成二聚体而不损失活性。 本文还提供了用于防止，减轻和治疗由辐射引起的损伤的方法。 该方法包括以有效预防，减轻或治疗由辐射引起的损伤的量和剂量方案将如本文所述的化合物递送至患者。
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公开(公告)号：US20130331460A1
公开(公告)日：2013-12-12
申请号：US14000761
申请日：2012-02-24
申请人： Carole A. Bewley , Peter Wipf
发明人： Carole A. Bewley , Peter Wipf
IPC分类号： C07C39/373 , A61K45/06 , C07C37/14 , A61K31/055
CPC分类号： C07C37/14 , A61K31/055 , A61K31/085 , A61K45/06 , C07C39/373 , C07C43/23 , C07D321/00 , Y02A50/473
摘要： Embodiments of antimicrobial chrysophaentin compounds, pharmaceutical compositions including the chrysophaentin compounds, methods for using the chrysophaentin compounds, and methods for synthesizing the chrysophaentin compounds are disclosed. Certain embodiments of the chrysophaentin compounds inhibit FtsZ protein, thereby inhibiting the growth of clinically relevant bacteria, including drug-resistant strains.
摘要翻译： 公开了抗微生物菌素化合物的实施方案，包括辣椒素化合物的药物组合物，使用辣椒素化合物的方法，以及合成辣椒素化合物的方法。 辣椒素化合物的某些实施方案抑制FtsZ蛋白，从而抑制临床相关细菌（包括耐药菌株）的生长。
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公开(公告)号：US08288551B2
公开(公告)日：2012-10-16
申请号：US12505294
申请日：2009-07-17
申请人： Peter Wipf , Marie Celine Frantz
发明人： Peter Wipf , Marie Celine Frantz
IPC分类号： C07D211/00 , A61K31/445
CPC分类号： C07K5/08 , A61K31/454 , A61K47/64 , C07C237/16 , C07D209/44 , C07D209/46 , C07D211/58 , C07D211/94 , C07D221/22 , C07D279/06 , C07D401/12 , C07D417/12 , C07D471/08
摘要： Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.
摘要翻译： 本文提供了可用于自由基清除的组合物和相关方法，对线粒体具有特别的选择性。 化合物包含连接到线粒体靶向基团的含氮氧基的基团。 化合物可以交联成二聚体而不损失活性。 本文还提供了用于防止，减轻和治疗由辐射引起的损伤的方法。 该方法包括以有效预防，减轻或治疗由辐射引起的损伤的量和剂量方案将如本文所述的化合物递送至患者。
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