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公开(公告)号：US06403656B1
公开(公告)日：2002-06-11
申请号：US09582614
申请日：2000-09-07
申请人： Michel Rivier , Irina Safonova , Serge Michel
发明人： Michel Rivier , Irina Safonova , Serge Michel
IPC分类号： A61P1702
CPC分类号： A61K31/5575 , A61K31/00 , A61K31/423 , A61K31/4439 , Y10S514/859 , Y10S514/863 , Y10S514/864 , Y10S514/887
摘要： The invention concerns the use of at least one activator of receptors of the PPAR-&ggr; type for preparing a pharmaceutical composition for treating skin disorders related to an anomaly of the differentiation of epidermic cells.
摘要翻译： 本发明涉及至少一种PPAR-γ型受体活化剂在制备用于治疗与表皮细胞分化异常相关的皮肤病的药物组合物中的应用。
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2.发明授权Compositions based on a synergistic mixture of at least one VDR ligand and a retinoid 失效基于至少一种VDR配体和类视色素的协同混合物的组合物公开(公告)号：US06759396B1
公开(公告)日：2004-07-06
申请号：US08836695
申请日：1997-07-11
IPC分类号： A61K3107
CPC分类号： A61K31/593 , A61K31/59 , A61K31/592 , Y10S514/828 , A61K31/19 , A61K2300/00
摘要： A novel combination of one or more ligands with VDR receptor selective activity and one or more retinoids selective for RAR&ggr; receptors as opposed to RAR&agr; receptors is described, as well as the use thereof in cosmetic and skin-care applications for treating disorders related to a hyperproliferation of cells, in particular skin cells, such as psoriasis.
摘要翻译： 描述了一种或多种具有VDR受体选择性活性的配体与对RARγ受体相对于RARα受体选择性的一种或多种类视黄醇的新型组合，以及其用于治疗与过度增生相关的疾病的化妆品和皮肤护理应用中的用途 的细胞，特别是皮肤细胞，如牛皮癣。
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3.发明授权(poly)thiaalkynoic compounds and pharmaceutical/cosmetic compositions comprised thereof 失效（聚）硫炔炔化合物及其组成的药物/化妆品组合物公开(公告)号：US06511670B1
公开(公告)日：2003-01-28
申请号：US09548932
申请日：2000-04-13
申请人： Jean Maignan , Sylvie Genard , Serge Michel
发明人： Jean Maignan , Sylvie Genard , Serge Michel
IPC分类号： A61K600
CPC分类号： A61Q19/007 , A61K8/46 , A61Q5/008 , A61Q19/00 , A61Q19/008 , C07C323/12 , C07C323/52 , Y10S514/858 , Y10S514/865 , Y10S514/886 , Y10S514/887
摘要： Novel pharmaceutically/cosmetically-active (poly)thiaalkynoic compounds have the structural formula (I): R1—Y—CH2—C≡C—CH2—S—CH2—R2 (I) and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example inflammation disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
摘要翻译： 新的药物/美容活性（聚）硫代炔酸化合物具有结构式（I）：并且可用于治疗各种各样的疾病状态，无论是人类或兽医，例如炎症疾病，以及治疗 哺乳动物皮肤和头发状况/病症。
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公开(公告)号：US6001885A
公开(公告)日：1999-12-14
申请号：US921511
申请日：1997-09-02
申请人： Barbara Vega , Serge Michel , Annie Ladoux , Christian Frelin
发明人： Barbara Vega , Serge Michel , Annie Ladoux , Christian Frelin
IPC分类号： A61K31/34 , A61K31/07 , A61K31/11 , A61K31/12 , A61K31/16 , A61K31/166 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/20 , A61K31/203 , A61K31/216 , A61K31/235 , A61K31/24 , A61K31/27 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/445 , A61K31/45 , A61K31/455 , A61K31/465 , A61K31/60 , A61K31/603 , A61K31/63 , A61P3/02 , A61P17/00 , A61P17/06 , A61P27/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , A61K31/075 , A61K31/165
CPC分类号： A61K31/60 , A61K31/12 , A61K31/166 , A61K31/192 , A61K31/195 , A61K31/203 , A61K31/216 , A61K31/235 , A61K31/24 , A61K31/343 , A61K31/381 , A61K31/382 , A61K31/45 , A61K31/455 , A61K31/63
摘要： The retinoids, in particular the anti-AP-1 retinoids, effectively inhibit the expression of VEGF, and thus are useful for the therapeutic treatment of disease states manifesting an overexpression of VEGF.
摘要翻译： 类视黄醇，特别是抗AP-1类维生素A有效地抑制VEGF的表达，因此可用于治疗治疗表现出VEGF过度表达的疾病状态。
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5.发明申请PPAR receptor activator compounds for treating cutaneous disorders/afflictions 审中-公开用于治疗皮肤疾病/病症的PPAR受体激活剂化合物公开(公告)号：US20050208001A1
公开(公告)日：2005-09-22
申请号：US11121124
申请日：2005-05-04
申请人： Jean Maignan , Serge Michel
发明人： Jean Maignan , Serge Michel
IPC分类号： C07D311/04 , A61K8/00 , A61K8/30 , A61K8/36 , A61K8/368 , A61K8/49 , A61K8/92 , A61K31/192 , A61K31/195 , A61K31/353 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/00 , A61P17/02 , A61P25/00 , A61P37/02 , A61P37/04 , A61P43/00 , A61Q17/00 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08 , A61K7/42
CPC分类号： A61K31/195 , A61K8/368 , A61K31/192 , A61K2800/70 , A61Q17/00 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： Compounds of formula (I): characteristically activators of receptors of PPAR type, are well suited for treating cutaneous disorders/afflictions, notably rosacea, intrinsic (or chronological) aging, pigmentation disorders, seborrhoeic function disorders, barrier function disorders and more particularly epidermal lipid secretion disorders, wound healing disorders, corticosteroid-induced cutaneous atrophies, or ulcers, immune system disorders, cardiovascular system conditions, and/or lipid metabolism disorders.
摘要翻译： 式（I）化合物：特征为PPAR受体的激活剂，非常适合于治疗皮肤疾病/病症，特别是红斑痤疮，内在（或时间顺序）衰老，色素沉着病，脂溢性功能障碍，屏障功能障碍，更特别是表皮脂质 分泌障碍，伤口愈合障碍，皮质类固醇诱发的皮肤萎缩或溃疡，免疫系统疾病，心血管系统疾病和/或脂质代谢紊乱。
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公开(公告)号：US06688665B2
公开(公告)日：2004-02-10
申请号：US10181921
申请日：2002-07-26
申请人： Serge Michel
发明人： Serge Michel
IPC分类号： B60N202
摘要： The invention concerns a seat, in particular for a motor vehicle, comprising a seat back, a cushion, a pivoting handle mounted on one of the lateral sides of the seat back and adapted to cause the seat back to tilt onto the cushion from a raised position, a rotary plate fixed under the cushion, and a pivoting lever affixed to the rotary plate and adapted to cause the cushion to rotate on itself with the seat back in the raised position. According to the invention, the seat comprises means for pivoting the pivoting lever immediately after the handle has pivoted so as to cause the cushion to rotate about the rotation axis of the rotary plate immediately after the back has been tilted on the cushion.
摘要翻译： 本发明涉及一种座椅，特别是用于机动车辆的座椅，其包括座椅靠背，坐垫，安装在座椅靠背的侧面之一上的枢转手柄，并且适于使座椅靠背从升高的 位置，固定在所述衬垫下方的旋转板以及固定到所述旋转板的枢转杆，并且适于使所述衬垫在所述座椅靠背处于升高位置时自身旋转。 根据本发明，座椅包括用于在手柄枢转之后立即枢转枢转杆的装置，以便在背部已经在衬垫上倾斜之后立即使衬垫围绕旋转板的旋转轴线旋转。
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7.发明授权Synergistic therapeutic compositions comprising at least one ligand specific for RXRs at least one ligand specific for RAR-.alpha. 失效协同治疗组合物包含至少一种对RXR具有特异性的配体，至少一种对RAR-α特异的配体
公开(公告)号：US5767148A
公开(公告)日：1998-06-16
申请号：US507913
申请日：1995-07-27
IPC分类号： C07D333/38 , A61K31/19 , A61K31/195 , A61K31/235 , A61K31/38 , A61K31/381 , A61K45/06 , A61P35/02 , A61P43/00 , A61K31/335
CPC分类号： A61K31/19 , A61K31/195 , A61K31/38
摘要： Pharmaceutical/dermatological compositions comprising (a) at least one first ligand displaying selective activity for the RXR receptors and (b) at least one second ligand displaying selective activity for the RAR-.alpha. receptor, are useful for modulating the proliferation and/or differentiation of HL-60 type cells, in particular for the systemic treatment of acute promyelocytic leukemia.
摘要翻译： 药物/皮肤病学组合物，其包含（a）至少一个显示对RXR受体的选择性活性的第一配体和（b）至少一个显示针对RAR-α受体的选择性活性的第二配体，可用于调节增殖和/或分化 HL-60型细胞，特别是用于全身治疗急性早幼粒细胞白血病。
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8.发明授权
公开(公告)号：US5541073A
公开(公告)日：1996-07-30
申请号：US231145
申请日：1994-04-22
申请人： Serge Michel , Jacques Bailly , Gaelle Saintigny , Uwe Reichert
发明人： Serge Michel , Jacques Bailly , Gaelle Saintigny , Uwe Reichert
IPC分类号： A61K8/96 , A61K8/00 , A61K8/64 , A61K8/98 , A61K38/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61P17/00 , A61Q19/00 , A61Q19/08 , C07K16/18 , C12N5/18 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/53 , C09K16/18
CPC分类号： C07K16/18 , A61K47/48546 , A61K38/00
摘要： The subject invention relates to a method of diagnosing epidermis differentiation disorders in a patient by obtaining an epidermis sample from the patient, adding to the sample, antibodies that specifically bind to an antigen of the stratum corneum, the said antigen being specifically recognized by BC 21 monoclonal antibody and detecting the presence or absence of the antibodies that are specifically bound to the epidermis sample.
摘要翻译： 本发明涉及一种通过从患者获得表皮样品来诊断患者表皮分化障碍的方法，向样品中加入特异性结合角质层抗原的抗体，所述抗原被BC 21特异性识别 检测特异性结合于表皮样品的抗体的存在或不存在。
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9.发明授权Hybridoma producing a monoclonal antibody specific for an antigen of the stratum corneum of human epidermis 失效产生对人表皮角质层抗原特异性的单克隆抗体的杂交瘤
公开(公告)号：US5312751A
公开(公告)日：1994-05-17
申请号：US652073
申请日：1991-02-07
申请人： Serge Michel , Jacques Bailly , Gaelle Saintigny , Uwe Reichert
发明人： Serge Michel , Jacques Bailly , Gaelle Saintigny , Uwe Reichert
IPC分类号： A61K8/96 , A61K8/00 , A61K8/64 , A61K8/98 , A61K38/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61P17/00 , A61Q19/00 , A61Q19/08 , C07K16/18 , C12N5/18 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/53 , C07K15/28 , C12N15/02
CPC分类号： C07K16/18 , A61K47/48546 , A61K38/00
摘要： The subject invention relates to monoclonal antibodies which react with antigenic determinants which are present of the stratus corneum of human epidermis. Furthermore, the invention also relates to methods of using such monoclonal antibodies in immunoassays. One monoclonal antibody of the present invention which is particularly useful is BC 21.
摘要翻译： 本发明涉及与人表皮层状角质层存在的抗原决定簇反应的单克隆抗体。 此外，本发明还涉及在免疫测定中使用这种单克隆抗体的方法。 特别有用的本发明的一种单克隆抗体是BC21。
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