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25 条记录 (耗时 0.02 秒)

    Peptide compounds containing a cyclic amide structure
    2.
    发明授权
    Peptide compounds containing a cyclic amide structure 失效
    含有环状结构的肽类化合物

    公开(公告)号：US5190923A

    公开(公告)日：1993-03-02

    申请号：US710283

    申请日：1991-06-04

    申请人： Michel Vincent ,  Georges Remond ,  Bernard Portevin ,  Yolande Herve ,  Jean Lepagnol

    发明人： Michel Vincent ,  Georges Remond ,  Bernard Portevin ,  Yolande Herve ,  Jean Lepagnol

    IPC分类号： A61K38/00 ,  A61P25/28 ,  C07K5/08 ,  C07K5/097

    CPC分类号： C07K5/0821 ,  A61K38/00 ,  Y10S514/824 ,  Y10S514/878 ,  Y10S514/879

    摘要： The invention relates to compounds of formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is linked, cyclic amide as defined in the description,B represents, with the nitrogen and carbon atoms to which it is linked, saturated polycyclic structure as defined in the description,R represents hydrogen, optionally substituted lower alkyl, optionally substituted (4-imidazolyl)methyl, (3-pyrazolyl)methyl or optionally substituted (2-pyridyl)methyl,their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid.Medicinal products.

    摘要翻译： 本发明涉及式（I）化合物：其中：A表示与其连接的碳原子和氮原子，描述中定义的环酰胺，B表示与氮和 与其连接的碳原子，如描述中所定义的饱和多环结构，R表示氢，任选取代的低级烷基，任选取代的（4-咪唑基）甲基，（3-吡唑基）甲基或任选取代的（2-吡啶基）甲基 ，它们的对映异构体，非对映异构体和差向异构体以及它们与药学上可接受的酸的加成盐。 药用产品。

    Substituted amino acid compounds
    5.
    发明授权
    Substituted amino acid compounds 失效
    取代的氨基酸化合物

    公开(公告)号：US5151432A

    公开(公告)日：1992-09-29

    申请号：US629823

    申请日：1990-12-19

    申请人： Michel Vincent ,  Georges Remond ,  Bernard Portevin ,  Yolande Herve ,  Jean Lepagnol

    发明人： Michel Vincent ,  Georges Remond ,  Bernard Portevin ,  Yolande Herve ,  Jean Lepagnol

    IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/435 ,  A61K38/00 ,  A61P9/12 ,  A61P25/28 ,  C07D209/94 ,  C07D221/22 ,  C07D453/06 ,  C07K5/02 ,  C07K5/06

    CPC分类号： C07K5/0222 ,  A61K38/00

    摘要： The invention relates to the compounds of formula (I): ##STR1## in which: R.sub.1 represents a linear or branched, lower or higher alkoxy group or a substituted or unsubstituted amino group,R.sub.2 represents a lower alkyl group unsubstituted or substituted with an amino group,R.sub.3 represents an amino, lower or higher alkoxy or a hydroxyl group, with the proviso, however, that at least one amino group is present in R.sub.1 or R.sub.3,R.sub.4 represents a hydrogen atom or an aryl group,m is equal to 1 or 2,n is between 1 and 6, andRa and Rb, which may be identical or different, represent a hydrogen atom when m=1, or a hydrogen atom or an alkyl group when m=2 andmedicinal products.

    摘要翻译： 本发明涉及式（I）的化合物：其中：R1表示直链或支链，低级或高级烷氧基或取代或未取代的氨基，R2表示未取代或取代的低级烷基 氨基，R3表示氨基，低级或高级烷氧基或羟基，但条件是R1或R3中至少有一个氨基，R4表示氢原子或芳基，m为 等于1或2，n为1至6，当m = 1时，Ra和Rb可相同或不同，表示氢原子，当m = 2时为氢原子或烷基，药物。

    2-(1H) quinolinone compounds
    9.
    发明授权
    2-(1H) quinolinone compounds 失效
    2-（1H）喹啉酮化合物

    公开(公告)号：US5776949A

    公开(公告)日：1998-07-07

    申请号：US889920

    申请日：1997-07-10

    申请人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol ,  Philippe Morain ,  Pierre Lestage

    发明人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol ,  Philippe Morain ,  Pierre Lestage

    IPC分类号： A61K31/47 ,  A61P9/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07D215/36 ,  C07D401/04 ,  C07D471/04 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D215/36 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D471/04

    摘要： A compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, which are identical or different, represent hydrogen, halogen, alkyl, nitro, cyano, aminosulfonyl, imidazolyl, or pyrrolyl, or alternatively, when two of them are situated on adjacent carbons, may form with the carbon atoms to which they are attached a benzene ring on C.sub.3 -C.sub.7 cyloalkyl R.sub.4 represents hydroxyl, alkoxy, phenoxy, or amino, their isomers as well as their addition salts with a pharmaceutically-acceptable base, and medicinal products containing the same which are useful as inhibitors of the the pathological phenomena linked to hyperactivation of the neurotransmission pathways by the excitatory amino acids.

    摘要翻译： 式（I）化合物：其中：R 1，R 2，R 3相同或不同，表示氢，卤素，烷基，硝基，氰基，氨基磺酰基，咪唑基或吡咯基，或者， 当它们中的两个位于相邻的碳上时，可以与它们所连接的碳原子一起形成C3-C7环烷基上的苯环R4表示羟基，烷氧基，苯氧基或氨基，它们的异构体以及它们与 药学上可接受的碱和含有它们的药物，其可用作与兴奋性氨基酸对神经传递途径的过度活化有关的病理现象的抑制剂。