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    ANALYSIS OF OVA OR EMBRYOS WITH DIGITAL HOLOGRAPHIC IMAGING
    3.
    发明申请
    ANALYSIS OF OVA OR EMBRYOS WITH DIGITAL HOLOGRAPHIC IMAGING 审中-公开
    用数字全息成像分析OVA或EMBRYOS

    公开(公告)号：US20120196316A1

    公开(公告)日：2012-08-02

    申请号：US13380220

    申请日：2010-06-24

    申请人： Mikael Sebesta ,  Johan Persson ,  Lennart Gisselsson ,  Anna Mölder ,  Anders Längberg

    发明人： Mikael Sebesta ,  Johan Persson ,  Lennart Gisselsson ,  Anna Mölder ,  Anders Längberg

    IPC分类号： G01N21/17 ,  C12M1/34

    CPC分类号： G03H1/0005 ,  C12M21/06 ,  C12M41/14 ,  C12M41/34 ,  C12M41/46 ,  G01N21/453 ,  G03H1/0443 ,  G03H1/0866 ,  G03H2001/0471 ,  G03H2222/13 ,  G03H2222/34 ,  G06K9/00147 ,  G06K9/2018

    摘要： Method for analyzing a sample comprising at least one ovum or embryo, the method being based on digital holographic imaging, the method comprising the following steps: creating at least one object beam and at least one reference beam of light, where said at least one object beam and said at least one reference beam are mutually coherent; exposing said sample to said at least one object beam; superimposing said at least one object beam that has passed through said sample with said at least one reference beam and thereby creating an interference pattern; detecting said interference pattern, called hologram; reconstructing phase and/or amplitude information of object wavefront from said interference pattern; and constructing at least one ovum or embryo analysis image and determining at least one ovum or embryo quality showing parameter from said phase and/or amplitude information.

    摘要翻译： 用于分析包含至少一个卵子或胚胎的样品的方法，所述方法基于数​​字全息成像，所述方法包括以下步骤：产生至少一个物体束和至少一个参考光束，其中所述至少一个物体 并且所述至少一个参考光束是相互相干的; 将所述样品暴露于所述至少一个物体束; 将已经通过所述样本的所述至少一个物体光束与所述至少一个参考光束叠加，从而产生干涉图案; 检测所述干涉图案，称为全息图; 从所述干涉图案重建物体波前的相位和/或幅度信息; 以及构建至少一个卵子或胚胎分析图像，并从所述相位和/或幅度信息确定显示参数的至少一个卵子或胚胎质量。

    Determination of physical parameters associated with erythrocytes
    4.
    发明授权
    Determination of physical parameters associated with erythrocytes 有权
    确定与红细胞相关的物理参数

    公开(公告)号：US09423342B2

    公开(公告)日：2016-08-23

    申请号：US13982951

    申请日：2012-02-15

    申请人： Peter Egelberg ,  Mikael Sebesta ,  Anders Isaksson

    发明人： Peter Egelberg ,  Mikael Sebesta ,  Anders Isaksson

    IPC分类号： G01B9/021 ,  G01N21/41 ,  G03H1/08 ,  G01N21/45 ,  G03H1/04

    CPC分类号： G01N21/41 ,  G01N15/1429 ,  G01N15/1468 ,  G01N21/453 ,  G01N2015/1006 ,  G01N2015/1454 ,  G03H1/0866 ,  G03H2001/0447

    摘要： A method based on digital holography for determining parameters of at least one erythrocyte is provided, said method comprising the steps of: constructing an interference pattern comprising a wave front representative of said at least one erythrocyte arised from the interaction of said at least one erythrocyte and electromagnetic radiation, reconstructing amplitude-and phase information representative of said at least one erythrocyte wave front from said interference pattern and determining the mean corpuscular volume and/or mean corpuscular hemoglobin concentration and/or oxygen saturation and/or mean corpuscular hemoglobin of at least one erythrocyte by combining phase information and amplitude information representative of said at least one erythrocyte.

    摘要翻译： 提供了一种基于用于确定至少一种红细胞参数的数字全息术的方法，所述方法包括以下步骤：构建干涉图案，该干涉图案包括代表所述至少一种红细胞的所述至少一种红细胞的波前，所述至少一种红细胞与所述至少一种红细胞的相互作用和 电磁辐射，从所述干涉图案重建表示所述至少一个红细胞波前的幅度和相位信息，并确定至少一个的平均红细胞体积和/或平均红细胞血红蛋白浓度和/或平均红细胞血红蛋白 通过组合表示所述至少一种红细胞的相位信息和幅度信息来组合红细胞。

    DETERMINATION OF PHYSICAL PARAMETERS ASSOCIATED WITH ERYTHROCYTES
    6.
    发明申请
    DETERMINATION OF PHYSICAL PARAMETERS ASSOCIATED WITH ERYTHROCYTES 有权
    确定与红细胞生成相关的物理参数

    公开(公告)号：US20140113323A1

    公开(公告)日：2014-04-24

    申请号：US13982951

    申请日：2012-02-15

    申请人： Peter Egelberg ,  Mikael Sebesta ,  Anders Isaksson

    发明人： Peter Egelberg ,  Mikael Sebesta ,  Anders Isaksson

    IPC分类号： G01N21/41

    CPC分类号： G01N21/41 ,  G01N15/1429 ,  G01N15/1468 ,  G01N21/453 ,  G01N2015/1006 ,  G01N2015/1454 ,  G03H1/0866 ,  G03H2001/0447

    摘要： A method based on digital holography for determining parameters of at least one erythrocyte is provided, said method comprising the steps of: constructing an interference pattern comprising a wave front representative of said at least one erythrocyte arised from the interaction of said at least one erythrocyte and electromagnetic radiation, reconstructing amplitude- and phase information representative of said at least one erythrocyte wave front from said interference pattern and determining the mean corpuscular volume and/or mean corpuscular hemoglobin concentration and/or oxygen saturation and/or mean corpuscular hemoglobin of at least one erythrocyte by combining phase information and amplitude information representative of said at least one erythrocyte.

    摘要翻译： 提供了一种基于用于确定至少一种红细胞参数的数字全息术的方法，所述方法包括以下步骤：构建干涉图案，其包括代表所述至少一种红细胞的所述至少一种红细胞的波前，所述至少一种红细胞与所述至少一种红细胞的相互作用和 电磁辐射，从所述干涉图案重建代表所述至少一个红细胞波前的幅度和相位信息，并确定平均红细胞体积和/或平均红细胞血红蛋白浓度和/或氧饱和度和/或平均红细胞血红蛋白至少一种 通过组合表示所述至少一种红细胞的相位信息和幅度信息来组合红细胞。

    Method and apparatus for analysis of a sample of cells
    7.
    发明授权
    Method and apparatus for analysis of a sample of cells 有权
    用于分析细胞样品的方法和装置

    公开(公告)号：US07948632B2

    公开(公告)日：2011-05-24

    申请号：US12158156

    申请日：2006-12-22

    申请人： Mats Gustafsson ,  Mikael Sebesta

    发明人： Mats Gustafsson ,  Mikael Sebesta

    IPC分类号： G01B9/021

    CPC分类号： G02B21/14 ,  G02B21/36 ,  G03H1/0005 ,  G03H1/0443 ,  G03H1/0866 ,  G03H2001/005 ,  G03H2001/0428 ,  G03H2001/0447 ,  G03H2001/045 ,  G03H2210/12 ,  G03H2210/62

    摘要： A non-destructive method and device for analyzing a sample comprising transparent living and/or dead cells, by 5 means of a digital holographic microscope, where the sample (8) is exposed to light from a laser (2). The light that travels through the cells in the sample will experience a difference in the optical path length compared to the surrounding media and the wave front that emerges from the 10 cells will thus be phase shifted. This distortion can be detected in the digital hologram, which is reconstructed from the interference pattern detected by a digital sensor (17), such as a CCD or a CMOS, as phase differences or phase shifts and thereby creating a digital hologram. The 15 phase shift of each element of the hologram is then used for analyzing the characteristics of the cells in the sample.

    摘要翻译： 用于通过数字全息显微镜的5种方式分析包含透明活体和/或死细胞的样品的非破坏性方法和装置，其中样品（8）暴露于来自激光器（2）的光。 穿过样品中的细胞的光将与周围的介质相比将经历光路长度的差异，并且从10个单元出现的波前将相移。 可以在数字全息图中检测到这种失真，该数字全息图是由诸如CCD或CMOS的数字传感器（17）检测的干涉图案重建的，作为相位差或相移，从而产生数字全息图。 然后将全息图的每个元素的15相移用于分析样品中的细胞的特征。