公开(公告)号：US20080021275A1

公开(公告)日：2008-01-24

申请号：US11625135

申请日：2007-01-19

申请人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc ,  Norman Nishioka

发明人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc ,  Norman Nishioka

IPC分类号： A61B1/00

CPC分类号： A61B5/0084 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/6852 ,  A61B5/7271 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10101

摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

摘要翻译： 提供了布置，装置，系统和系统以获得至少一个管腔或中空样品中的至少一个部分的数据。 该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见） 第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是 被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置 其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

公开(公告)号：US20070282403A1

公开(公告)日：2007-12-06

申请号：US11670043

申请日：2007-02-01

申请人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

发明人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

IPC分类号： A61N5/06 ,  A61B18/18

CPC分类号： A61B18/24 ,  A61B5/0066 ,  A61B2017/00066 ,  A61B2017/22051 ,  A61B2018/2272

摘要： According one exemplary embodiment of the present invention, method and system can be provided for applying a laser radiation to at least one portion of a biological structure. For example, a beam of the laser radiation can be provided to the portion, whereas a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion. The beam can be applied to the portion (a) based on a predetermined pattern, (b) while modulating a wavelength of the laser radiation, and/or (c) while monitoring a depth of the application of the laser radiation.

摘要翻译： 根据本发明的一个示例性实施例，可以提供用于将激光辐射施加到生物结构的至少一部分的方法和系统。 例如，可以向该部分提供激光辐射束，而光束的横截面积至多为至少一部分的整个区域的大约1/10。 可以基于预定图案将光束施加到部分（a），（b）同时调制激光辐射的波长，和/或（c）同时监视激光辐射的施加深度。

公开(公告)号：US20070274650A1

公开(公告)日：2007-11-29

申请号：US11670069

申请日：2007-02-01

申请人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

发明人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

IPC分类号： G02B6/04

CPC分类号： A61B18/24 ,  A61B1/00082 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/00183 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/2211 ,  A61B2018/2272 ,  G02B23/2423

摘要： An apparatus for controlling at least one of at least two sections of at least one fiber can be provided. The apparatus can include an arrangement which may be provided between the first and second sections of a particular continuous fiber of the fibers. A particular one of the first and second sections may be provided in a particular orientation that is perpendicular to an extension of the particular fiber. The arrangement is capable of controlling the particular fiber such that the particular one of the sections is capable of being rotated for at least 360° with respect to the particular orientation. The arrangement can include a further arrangement that is capable of at least partially wrapping the particular fiber around the second arrangement, and controlling the particular fiber such that the particular one of the sections is capable of being rotated with respect to the particular orientation during a transmission of the electro-magnetic radiation.

摘要翻译： 可以提供一种用于控制至少一个光纤的至少两个部分中的至少一个的装置。 该装置可以包括可以设置在纤维的特定连续纤维的第一和第二部分之间的装置。 第一和第二部分中的特定一个可以以垂直于特定纤维的延伸部的特定方向设置。 该装置能够控制特定光纤，使得特定的一个部分能够相对于特定取向旋转至少360°。 该布置可以包括能够至少部分地围绕第二布置包围特定纤维并且控制特定光纤的另外的布置，使得特定的一个部分能够在传输期间相对于特定取向旋转 的电磁辐射。

公开(公告)号：US20070179487A1

公开(公告)日：2007-08-02

申请号：US11670027

申请日：2007-02-01

申请人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

发明人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

IPC分类号： A61B18/18

CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/6852 ,  A61B18/24 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/207 ,  A61B2090/306 ,  A61B2090/3614

摘要： An apparatus for applying a plurality of electromagnetic radiations to a sample is provided. In one exemplary embodiment, the apparatus can include an arrangement which has a specific portion with a plurality of channels. One of channels can facilitate a first radiation of the radiations to be forwarded to the sample that is within an anatomical structure, and another one of the channels can facilitate a second radiation of the radiations to be forwarded to the sample. The first radiation may have a first wavelength band, and the second radiation may have a second wavelength band. The first wavelength band may be substantially different from the second wavelength band. According to another exemplary embodiment, the first radiation can be adapted to be delivered to a first area of the sample, and the second radiation may be capable of being delivered to a second area of the sample. The first area may be substantially enclosed by the second area. According to yet another exemplary embodiment of the present invention, each of the channels can facilitate at least one particular radiation of the radiations to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample. Centers of every one of the areas may be provided substantially along a line.

摘要翻译： 提供了一种向样品施加多个电磁辐射的装置。 在一个示例性实施例中，装置可以包括具有多个通道的特定部分的装置。 通道中的一个可以促进要转发到解剖结构内的样品的辐射的第一辐射，并且另一个通道可以促进辐射的第二次辐射以被转发到样品。 第一辐射可以具有第一波长带，并且第二辐射可以具有第二波长带。 第一波长带可能与第二波长带显着不同。 根据另一示例性实施例，第一辐射可以适于被传送到样品的第一区域，并且第二辐射可以能够被传送到样品的第二区域。 第一区域可以基本上被第二区域包围。 根据本发明的另一个示例性实施例，每个通道可以促进辐射的至少一个特定辐射被转发到样品的解剖结构内的样品，辐射被递送到样品的解剖结构中 样品。 可以基本沿着一条线提供每个区域的中心。

公开(公告)号：US20060245087A1

公开(公告)日：2006-11-02

申请号：US10542966

申请日：2004-01-21

申请人： Guillermo Tearney ,  Constantinos Pitris ,  Milen Shishkov ,  Brett Bouma

发明人： Guillermo Tearney ,  Constantinos Pitris ,  Milen Shishkov ,  Brett Bouma

IPC分类号： G02B7/02

CPC分类号： G02B21/0072 ,  G02B21/006 ,  G02B21/02 ,  G02B21/33

摘要： A confocal microscope lens arrangement is provided. The confocal microscope lens arrangement includes a lens assembly housing which has a lens assembly, and an exterior housing including a distal end and a proximal end. The exterior housing is configured to allow the lens assembly housing to be placed therein, and translated between the proximal end and the distal end of the exterior housing to focus the lens assembly. The exterior housing has an aperture formed through a distal end thereof. The arrangement also includes an immersion media filling the volume of area between the exterior housing and the lens assembly housing.

摘要翻译： 提供共焦显微镜透镜装置。 共焦显微镜透镜装置包括具有透镜组件的透镜组件壳体和包括远端和近端的外壳。 外部壳体被配置为允许透镜组件壳体放置在其中并且在外部壳体的近端和远端之间平移以聚焦透镜组件。 外壳具有通过其远端形成的孔。 该布置还包括填充外壳和透镜组件壳体之间的面积的浸没介质。

公开(公告)号：US20070177152A1

公开(公告)日：2007-08-02

申请号：US11670058

申请日：2007-02-01

申请人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

发明人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

IPC分类号： G01B9/02

CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/6852 ,  A61B18/24 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/207 ,  A61B2090/306 ,  A61B2090/3614

摘要： In one exemplary embodiment of the present invention, method and system can be provided for obtaining information associated with at least one portion of a sample. For example, a temperature change can be caused in the portion of the sample. At least one first electro-magnetic radiation can be forwarded to a section near or in the portion of the sample. A deformation of the section can be identified at a plurality of depths as a function of (i) a phase of at least one second electro-magnetic radiation provided from the section, and/or (ii) a rate of change of the phase and/or an amplitude of the second electro-magnetic radiation. In another exemplary embodiment of the present invention, method and system can be provided for controlling a temperature distribution in a sample. For example, an electro-magnetic radiation can be provided to the section in the sample at a particular wavelength. The temperature distribution can be controlled by modifying the particular wavelength of the electro-magnetic radiation when the electro-magnetic radiation is provided to the section.

摘要翻译： 在本发明的一个示例性实施例中，可以提供方法和系统来获得与样本的至少一部分相关联的信息。 例如，可以在样品的部分中引起温度变化。 至少一个第一电磁辐射可以转发到样品附近或部分的部分。 可以在多个深度处识别该部分的变形作为（i）从该部分提供的至少一个第二电磁辐射的相位和/或（ii）相的变化率和 /或第二电磁辐射的振幅。 在本发明的另一示例性实施例中，可以提供方法和系统来控制样品中的温度分布。 例如，可以以特定波长向样品中的部分提供电磁辐射。 当电磁辐射提供给该部分时，可以通过修改电磁辐射的特定波长来控制温度分布。

公开(公告)号：US20060093276A1

公开(公告)日：2006-05-04

申请号：US11266779

申请日：2005-11-02

申请人： Brett Bouma ,  Guillermo Tearney ,  Milen Shishkov

发明人： Brett Bouma ,  Guillermo Tearney ,  Milen Shishkov

IPC分类号： G02B6/38 ,  G02B6/42 ,  G02B6/26

CPC分类号： A61B1/3137 ,  A61B1/00183 ,  A61B1/042 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B18/22 ,  A61B2017/00477 ,  G02B6/32 ,  G02B6/3604

摘要： A device, system and method for transmitting electro-magnetic radiation between at least two separate fibers (as well as for imaging a sample) are provided. For example, a first optical fiber and a second optical fiber may be provided, such that the first and/or second fibers is/are rotatable. At least one first optical arrangement may also be included which communicates with at least one end of the first optical fiber and/or the second optical fiber. Further, at least one second arrangement may be included which is configured to control a position of the optical arrangement to align longitudinal axes of the first and the second optical fibers at least at the ends thereof. In addition, at least one third arrangement can be provided which is adapted to rotate the first and/or second optical fibers at a rate that is greater than 40 revolutions per second. It is also possible to include at least one fourth arrangement which can be adapted for connecting the first optical fiber and/or the second optical fiber to a catheter arrangement, such that the fourth arrangement includes a protector provided at least at one end thereof, and wherein the protector is automatically removed upon a connection of the first and/or second optical fiber to the catheter arrangement via the fourth arrangement.

摘要翻译： 提供了用于在至少两个分离的光纤之间传送电磁辐射的装置，系统和方法（以及用于成像样品）。 例如，可以提供第一光纤和第二光纤，使得第一和/或第二光纤是可旋转的。 还可以包括与第一光纤和/或第二光纤的至少一端通信的至少一个第一光学布置。 此外，可以包括至少一个第二布置，其被配置成至少在其端部处控制光学装置的位置以对准第一和第二光纤的纵向轴线。 另外，可以提供至少一个第三布置，其适于以大于40转/秒的速率旋转第一和/或第二光纤。 还可以包括至少一个第四布置，其可以适于将第一光纤和/或第二光纤连接到导管装置，使得第四布置包括至少在其一端提供的保护器，以及 其中所述保护器在经由所述第四布置将所述第一和/或第二光纤连接到所述导管装置时自动移除。

公开(公告)号：US20060067620A1

公开(公告)日：2006-03-30

申请号：US11241907

申请日：2005-09-29

申请人： Milen Shishkov ,  Brett Bouma ,  Guillermo Tearney

发明人： Milen Shishkov ,  Brett Bouma ,  Guillermo Tearney

IPC分类号： G02B6/42 ,  G02B6/00 ,  G02B6/26

CPC分类号： H04J14/0267 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  G02B6/2552 ,  G02B6/262 ,  G02B6/2856

摘要： Apparatus and method are provided for transmitting at least one electromagnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.

摘要翻译： 提供了用于发送至少一个电磁辐射的装置和方法。 特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。 此外，可以与光纤光学协作地提供透光的光学装置。 光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。 第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

公开(公告)号：US20080013960A1

公开(公告)日：2008-01-17

申请号：US11781722

申请日：2007-07-23

申请人： Guillermo Tearney ,  Brett Bouma ,  Milen Shishkov ,  Jonathan Rosen

发明人： Guillermo Tearney ,  Brett Bouma ,  Milen Shishkov ,  Jonathan Rosen

IPC分类号： H04B10/02

CPC分类号： A61B5/0059 ,  A61B1/00096 ,  A61B1/0017 ,  A61B1/043 ,  A61B1/07 ,  A61B5/0062 ,  A61B5/0071 ,  A61B5/0084 ,  G02B21/0036 ,  G02B21/0048 ,  G02B21/0064

摘要： A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means for detecting the received reflected energy. The probe grating and lens delivers a beam of multi-spectral light having spectral components extending in one dimension across a target region and which is moved to scan in another direction. The reflected spectrum is measured to provide two dimensional imaging of the region.

摘要翻译： 一种具有高分辨率和小直径的光谱编码内窥镜探针，包括至少一个柔性光纤; 能源; 所述能量通过所述光栅传播，使得能谱被分散; 用于将分散的能谱聚焦到样品上的透镜，使得每个波长的冲击点是样品上的分离位置，所述波长谱定义波长编码轴; 用于在垂直于波长编码轴的方向上以聚焦能量机械扫描样品的装置; 用于接收样品反射的能量的方法; 以及用于检测所接收的反射能量的装置。 探测光栅和透镜提供具有在一个维度上延伸穿过目标区域并且被移动以沿另一个方向扫描的光谱分量的多光谱光束。 测量反射光谱以提供该区域的二维成像。

公开(公告)号：US20070188855A1

公开(公告)日：2007-08-16

申请号：US11623852

申请日：2007-01-17

申请人： Milen Shishkov ,  Guillermo Tearney ,  Brett Bouma ,  Dvir Yelin ,  Nicusor Iftimia

发明人： Milen Shishkov ,  Guillermo Tearney ,  Brett Bouma ,  Dvir Yelin ,  Nicusor Iftimia

IPC分类号： G02B23/24 ,  A61B1/06

CPC分类号： G02B23/2453 ,  A61B1/00167 ,  A61B1/00188 ,  A61B1/002 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/0086 ,  B24B9/14 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G02B5/18 ,  G02B23/2469 ,  G02B23/26

摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electromagnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can be configured to focus and provide there through the first electromagnetic radiation. Further, the exemplary apparatus can include at least one third dispersive arrangement which is configured to receive a particular radiation which is the first electromagnetic radiation and/or the focused electromagnetic radiation, and forward a dispersed radiation thereof to at least one section of the structure. At least one end of the fiber can be directly connected to the second focusing arrangement and/or the third dispersive arrangement. In addition, an exemplary embodiment of a method for producing an optical arrangement can be provided. For example, a first set of optical elements having a first size in a first configuration and a second set of optical elements in cooperation with the second set and having a second size in a second configuration can be provided. The first and second sets can be clamped into a third set of optical elements. The third set can be polished, and a further set of optical elements may be deposited on the polished set.

摘要翻译： 可以提供用于获得结构信息的示例性装置。 例如，示例性设备可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。 示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。 第二布置可以被配置成通过第一电磁辐射聚焦并提供在那里。 此外，示例性装置可以包括至少一个第三分散装置，其被配置为接收作为第一电磁辐射和/或聚焦电磁辐射的特定辐射，并将其分散的辐射转发到该结构的至少一个部分。 光纤的至少一端可以直接连接到第二聚焦装置和/或第三色散装置。 此外，可以提供用于制造光学装置的方法的示例性实施例。 例如，可以提供具有第一配置的第一尺寸的第一组光学元件和与第二组配合并具有第二配置的第二尺寸的第二组光学元件。 第一组和第二组可以夹紧到第三组光学元件中。 可以抛光第三组，并且可以在抛光组上沉积另外的一组光学元件。