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    APPARATUS AND METHOD FOR RANGINGS AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS
    2.
    发明申请
    APPARATUS AND METHOD FOR RANGINGS AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS 有权
    通过并行检测光谱仪的低相干干涉LCI和光学相干TOMOGRAPHY OCT信号的范围和噪声降低的装置和方法

    公开(公告)号：US20080097709A1

    公开(公告)日：2008-04-24

    申请号：US11956129

    申请日：2007-12-13

    申请人： Johannes de Boer ,  Guillermo Tearney ,  Brett Bouma

    发明人： Johannes de Boer ,  Guillermo Tearney ,  Brett Bouma

    IPC分类号： G01R25/04

    CPC分类号： G01B9/02007 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02008 ,  G01B9/0201 ,  G01B9/02032 ,  G01B9/02044 ,  G01B9/02045 ,  G01B9/02079 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01N21/4795

    摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

    摘要翻译： 通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。 对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。 结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。 信号保持不变。 喷射噪声的降低增加了系统的动态范围和灵敏度。

    METHODS AND SYSTEMS FOR OPTICAL IMAGING OR EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF
    3.
    发明申请
    METHODS AND SYSTEMS FOR OPTICAL IMAGING OR EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF 有权
    通过光束扫描对光学成像或上传光学仪器的方法和系统

    公开(公告)号：US20080021275A1

    公开(公告)日：2008-01-24

    申请号：US11625135

    申请日：2007-01-19

    申请人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc ,  Norman Nishioka

    发明人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc ,  Norman Nishioka

    IPC分类号： A61B1/00

    CPC分类号： A61B5/0084 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/6852 ,  A61B5/7271 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10101

    摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

    摘要翻译： 提供了布置，装置，系统和系统以获得至少一个管腔或中空样品中的至少一个部分的数据。 该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见） 第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是 被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置 其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

    APPARATUS FOR CONTROLLING AT LEAST ONE OF AT LEAST TWO SECTIONS OF AT LEAST ONE FIBER
    5.
    发明申请
    APPARATUS FOR CONTROLLING AT LEAST ONE OF AT LEAST TWO SECTIONS OF AT LEAST ONE FIBER 有权
    用于至少控制至少一个光纤的至少两个部分的装置

    公开(公告)号：US20070274650A1

    公开(公告)日：2007-11-29

    申请号：US11670069

    申请日：2007-02-01

    申请人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

    发明人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

    IPC分类号： G02B6/04

    CPC分类号： A61B18/24 ,  A61B1/00082 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/00183 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/2211 ,  A61B2018/2272 ,  G02B23/2423

    摘要： An apparatus for controlling at least one of at least two sections of at least one fiber can be provided. The apparatus can include an arrangement which may be provided between the first and second sections of a particular continuous fiber of the fibers. A particular one of the first and second sections may be provided in a particular orientation that is perpendicular to an extension of the particular fiber. The arrangement is capable of controlling the particular fiber such that the particular one of the sections is capable of being rotated for at least 360° with respect to the particular orientation. The arrangement can include a further arrangement that is capable of at least partially wrapping the particular fiber around the second arrangement, and controlling the particular fiber such that the particular one of the sections is capable of being rotated with respect to the particular orientation during a transmission of the electro-magnetic radiation.

    摘要翻译： 可以提供一种用于控制至少一个光纤的至少两个部分中的至少一个的装置。 该装置可以包括可以设置在纤维的特定连续纤维的第一和第二部分之间的装置。 第一和第二部分中的特定一个可以以垂直于特定纤维的延伸部的特定方向设置。 该装置能够控制特定光纤，使得特定的一个部分能够相对于特定取向旋转至少360°。 该布置可以包括能够至少部分地围绕第二布置包围特定纤维并且控制特定光纤的另外的布置，使得特定的一个部分能够在传输期间相对于特定取向旋转 的电磁辐射。

    APPARATUS FOR APPLYING A PLURALITY OF ELECTRO-MAGNETIC RADIATIONS TO A SAMPLE
    7.
    发明申请
    APPARATUS FOR APPLYING A PLURALITY OF ELECTRO-MAGNETIC RADIATIONS TO A SAMPLE 有权
    将大量电磁辐射应用于样品的装置

    公开(公告)号：US20070179487A1

    公开(公告)日：2007-08-02

    申请号：US11670027

    申请日：2007-02-01

    申请人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

    发明人： Guillermo Tearney ,  Milen Shishkov ,  Brett Bouma ,  Benjamin Vakoc

    IPC分类号： A61B18/18

    CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/6852 ,  A61B18/24 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/207 ,  A61B2090/306 ,  A61B2090/3614

    摘要： An apparatus for applying a plurality of electromagnetic radiations to a sample is provided. In one exemplary embodiment, the apparatus can include an arrangement which has a specific portion with a plurality of channels. One of channels can facilitate a first radiation of the radiations to be forwarded to the sample that is within an anatomical structure, and another one of the channels can facilitate a second radiation of the radiations to be forwarded to the sample. The first radiation may have a first wavelength band, and the second radiation may have a second wavelength band. The first wavelength band may be substantially different from the second wavelength band. According to another exemplary embodiment, the first radiation can be adapted to be delivered to a first area of the sample, and the second radiation may be capable of being delivered to a second area of the sample. The first area may be substantially enclosed by the second area. According to yet another exemplary embodiment of the present invention, each of the channels can facilitate at least one particular radiation of the radiations to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample. Centers of every one of the areas may be provided substantially along a line.

    摘要翻译： 提供了一种向样品施加多个电磁辐射的装置。 在一个示例性实施例中，装置可以包括具有多个通道的特定部分的装置。 通道中的一个可以促进要转发到解剖结构内的样品的辐射的第一辐射，并且另一个通道可以促进辐射的第二次辐射以被转发到样品。 第一辐射可以具有第一波长带，并且第二辐射可以具有第二波长带。 第一波长带可能与第二波长带显着不同。 根据另一示例性实施例，第一辐射可以适于被传送到样品的第一区域，并且第二辐射可以能够被传送到样品的第二区域。 第一区域可以基本上被第二区域包围。 根据本发明的另一个示例性实施例，每个通道可以促进辐射的至少一个特定辐射被转发到样品的解剖结构内的样品，辐射被递送到样品的解剖结构中 样品。 可以基本沿着一条线提供每个区域的中心。

    System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging
    8.
    发明申请
    System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging 有权
    可以使用频谱编码外差干涉测量技术进行成像的系统，方法和布置

    公开(公告)号：US20060270929A1

    公开(公告)日：2006-11-30

    申请号：US11445131

    申请日：2006-05-31

    申请人： Brett Bouma ,  Guillermo Tearney ,  Dvir Yelin ,  Seok-Hyun Yun

    发明人： Brett Bouma ,  Guillermo Tearney ,  Dvir Yelin ,  Seok-Hyun Yun

    IPC分类号： A61B5/05

    CPC分类号： G01N21/4795 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/7257

    摘要： Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. The spectrally-encoded line may be scanned over the sample in a direction approximately perpendicular to the line. Image data containing three-dimensional information can then be obtained based on the interference. The exemplary imaging methods and systems can be used in a small fiber optic or endoscopic probe.

    摘要翻译： 提供了用于获得三维成像数据的系统，布置和方法。 例如，宽带光源可以提供特定的辐射。 可以将第一电磁辐射聚焦和衍射，然后提供给至少一个样品以产生光谱编码的线。 可以将第二电磁辐射提供给参考，其可以包括双遍快速扫描光学延迟，其中第一和第二电磁辐射可以基于特定辐射。 可以检测第三电磁辐射（与第一电磁辐射相关联）和第四电磁辐射（与第二电磁辐射相关联）之间的干扰。 光谱编码的线可以在大致垂直于线的方向上扫描样品。 然后可以基于干扰获得包含三维信息的图像数据。 示例性的成像方法和系统可以用于小型光纤或内窥镜探针。

    Microscope objectives
    9.
    发明申请
    Microscope objectives 失效
    显微镜目标

    公开(公告)号：US20060245087A1

    公开(公告)日：2006-11-02

    申请号：US10542966

    申请日：2004-01-21

    申请人： Guillermo Tearney ,  Constantinos Pitris ,  Milen Shishkov ,  Brett Bouma

    发明人： Guillermo Tearney ,  Constantinos Pitris ,  Milen Shishkov ,  Brett Bouma

    IPC分类号： G02B7/02

    CPC分类号： G02B21/0072 ,  G02B21/006 ,  G02B21/02 ,  G02B21/33

    摘要： A confocal microscope lens arrangement is provided. The confocal microscope lens arrangement includes a lens assembly housing which has a lens assembly, and an exterior housing including a distal end and a proximal end. The exterior housing is configured to allow the lens assembly housing to be placed therein, and translated between the proximal end and the distal end of the exterior housing to focus the lens assembly. The exterior housing has an aperture formed through a distal end thereof. The arrangement also includes an immersion media filling the volume of area between the exterior housing and the lens assembly housing.

    摘要翻译： 提供共焦显微镜透镜装置。 共焦显微镜透镜装置包括具有透镜组件的透镜组件壳体和包括远端和近端的外壳。 外部壳体被配置为允许透镜组件壳体放置在其中并且在外部壳体的近端和远端之间平移以聚焦透镜组件。 外壳具有通过其远端形成的孔。 该布置还包括填充外壳和透镜组件壳体之间的面积的浸没介质。