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11 条记录 (耗时 0.037 秒)

    Water cooling apparatus for electric circuit elements
    5.
    发明授权
    Water cooling apparatus for electric circuit elements 失效
    电路元件用水冷却装置

    公开(公告)号：US4368448A

    公开(公告)日：1983-01-11

    申请号：US166702

    申请日：1980-07-03

    申请人： Shigeo Kobayashi ,  Kazuo Kobayashi ,  Eiki Takahashi

    发明人： Shigeo Kobayashi ,  Kazuo Kobayashi ,  Eiki Takahashi

    IPC分类号： H01L23/34 ,  H01L23/36 ,  H01L23/473 ,  H01F27/10

    CPC分类号： H01L23/473 ,  H01L2924/0002

    摘要： A water cooling apparatus for an electric circuit element is disclosed in which an internal waterway is connected with an external waterway by a connector with the whole body, the forward end or the inside part of the forward end thereof alone made of an alloy containing iron, nickel and/or chromium as main components. The water cooling apparatus may further comprise a net of an alloy containing iron, nickel and chromium as main components, the net being stretched in said waterway at the inside part of the forward end of the connector.

    摘要翻译： 公开了一种用于电路元件的水冷却装置，其中内部水路通过连接器与外部水路连接，全连接器，其前端的前端或内侧单独由含铁的合金制成， 镍和/或铬为主要成分。 水冷却装置还可以包括以铁，镍和铬为主要成分的合金网，该网在连接器前端内部的所述水路中拉伸。

    Screening method
    6.
    发明申请
    Screening method 审中-公开
    筛选方法

    公开(公告)号：US20100168014A1

    公开(公告)日：2010-07-01

    申请号：US12591105

    申请日：2009-11-09

    申请人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Toru Arai

    发明人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Toru Arai

    IPC分类号： A61K38/22 ,  G01N33/53

    CPC分类号： A61K38/17 ,  G01N33/566 ,  G01N2500/04 ,  Y02A50/406

    摘要： The present inventors have found that relaxin-3 has a feeding-stimulating activity, a body weight increasing activity, and fat weight increasing activity by intracerebroventricularly administering relaxin-3 to rats and observing the amount of feeding, body weight and fat weight, and so on after the administration. According to the present invention, a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing said polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of said polypeptide; a kit for said screening; and an agent which comprises a substance which inhibits expression of said polypeptide, such as a feeding-surpressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.

    摘要翻译： 本发明人已经发现松弛素-3具有喂养刺激活性，体重增加活性和通过脑内给予松弛素-3对大鼠的体重增加活性，观察喂养量，体重和脂肪重量等 在管理之后。 根据本发明，具有刺激进食，增加体重和育肥的有效作用的多肽; 含有所述多肽的治疗剂; 筛选活化或抑制所述多肽受体的化合物，物质或其盐的方法; 用于筛选的试剂盒; 以及包含抑制所述多肽表达的物质的试剂，例如饲料抑制剂，治疗肥胖症的治疗剂和治疗糖尿病的治疗剂。

    Methods of affecting feeding and weight in mammals by administration of relaxin-3
    8.
    发明授权
    Methods of affecting feeding and weight in mammals by administration of relaxin-3 失效
    通过施用松弛素-3影响哺乳动物饲喂和体重的方法

    公开(公告)号：US07638490B2

    公开(公告)日：2009-12-29

    申请号：US10588542

    申请日：2005-02-09

    申请人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Tohru Arai

    发明人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Tohru Arai

    IPC分类号： A61K38/00 ,  A01N37/18

    CPC分类号： A61K38/17 ,  G01N33/566 ,  G01N2500/04 ,  Y02A50/406

    摘要： Relaxin-3 is found to have feeding-stimulating activity, body weight increasing activity, and fat weight increasing activity when intracerebroventricularly administered to rats through observation of amount of feeding, body weight and fat weight after administration of relaxin-3. This invention includes: a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing the polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of the polypeptide; a kit for screening; and an agent with a substance which inhibits expression of the polypeptide, such as a feeding-suppressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.

    摘要翻译： 发现松弛素-3在给予松弛素-3后，通过观察饲喂量，体重和脂肪重量，通过大鼠脑室内施用，具有摄食刺激活性，体重增加活性和脂肪增加活性。 本发明包括：具有刺激喂养，增加体重和育肥的有效作用的多肽; 含有该多肽的治疗剂; 筛选活化或抑制多肽受体的化合物，物质或其盐的方法; 一套筛选工具; 以及具有抑制多肽表达的物质，例如进食抑制剂，治疗肥胖症的治疗剂和用于治疗糖尿病的治疗剂的药剂。

    Screening method
    9.
    发明申请
    Screening method 失效
    筛选方法

    公开(公告)号：US20070054850A1

    公开(公告)日：2007-03-08

    申请号：US10588542

    申请日：2005-02-09

    申请人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Tohru Arai

    发明人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Tohru Arai

    IPC分类号： A61K38/22 ,  G01N33/53

    CPC分类号： A61K38/17 ,  G01N33/566 ,  G01N2500/04 ,  Y02A50/406

    摘要： The present inventors have found that relaxin-3 has a feeding-stimulating activity, a body weight increasing activity, and fat weight increasing activity by intracerebroventricularly administering relaxin-3 to rats and observing the amount of feeding, body weight and fat weight, and so on after the administration. According to the present invention, a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing said polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of said polypeptide; a kit for said screening; and an agent which comprises a substance which inhibits expression of said polypeptide, such as a feeding-surpressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.

    摘要翻译： 本发明人已经发现松弛素-3具有喂养刺激活性，体重增加活性和通过脑内给予松弛素-3对大鼠的体重增加活性，观察喂养量，体重和脂肪重量等 在管理之后。 根据本发明，具有刺激进食，增加体重和育肥的有效作用的多肽; 含有所述多肽的治疗剂; 筛选活化或抑制所述多肽受体的化合物，物质或其盐的方法; 用于筛选的试剂盒; 以及包含抑制所述多肽表达的物质的试剂，例如饲料抑制剂，治疗肥胖症的治疗剂和治疗糖尿病的治疗剂。