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公开(公告)号：US4306043A
公开(公告)日：1981-12-15
申请号：US140834
申请日：1980-04-16
申请人： Mitsuo Abe , Masamichi Iwama , Syuji Tsuchikawa , Takao Morikawa
发明人： Mitsuo Abe , Masamichi Iwama , Syuji Tsuchikawa , Takao Morikawa
IPC分类号： C08F212/12 , C08F257/02 , C08F2/22
CPC分类号： C08F257/02 , C08F212/12
摘要： A process for producing a resin having a high heat resistance with a high polymerization conversion by emulsion-polymerizing .alpha.-methylstyrene (AMS), methyl methacrylate (MMA) and acrylonitrile (AN), characterized in that the polymerization is conducted in two steps; A monomer mixture consisting of 60-85% by weight of AMS, 2-30% by weight of MMA and 5-20% by weight of AN is subjected to copolymerization in the first step until 25-85% by weight, based on the weight of the final copolymer, of a copolymer is formed, and in the second step, at least one monomer of the above three monomers is added to the polymerization system to adjust the composition ratio of the three monomers in the polymerization system so as to fall in the region surrounded by the lines connecting points A, B, C, D and E in the triangular coordinate graph indicating the quantitative relationship of the three monomers, and the resulting monomer mixture is subjected to polymerization conditions to complete the polymerization.
摘要翻译： 一种通过乳液聚合α-甲基苯乙烯（AMS），甲基丙烯酸甲酯（MMA）和丙烯腈（AN））制备具有高聚合转化率的高耐热性树脂的方法，其特征在于聚合分两步进行; 将由60-85重量％的AMS，2-30重量％的MMA和5-20重量％的AN组成的单体混合物在第一步中进行共聚合，直到25-85重量％，基于 形成共聚物的最终共聚物的重量，在第二步骤中，将上述三种单体的至少一种单体加入到聚合体系中，以调节聚合体系中三种单体的组成比，使其下降 在由表示三种单体的定量关系的三角坐标图中连接点A，B，C，D和E的线所包围的区域中，并将所得单体混合物进行聚合条件以完成聚合。
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公开(公告)号：US08075882B2
公开(公告)日：2011-12-13
申请号：US12653090
申请日：2009-12-08
CPC分类号： C12N5/0068 , A61K2039/5154 , C12N2533/70
摘要： Adoptive immune cells obtained by a method including (a) obtaining mammalian antigen-presenting associated cells; (b) culturing the resulting cells from step (a) in a culture liquid contained in a culture vessel coated with a sugar chain-containing polymer; and (c) detaching the cells from step (b) by shaking the culture vessel without treating the cells with an enzyme and without using a cell detaching tool. A method for treating a malignant tumor, type I diabetes, an atopic allergic disease or an infection, by administering the adoptive immune cells to a patient. A pharmaceutical composition for treating a malignant tumor, type I diabetes, an atopic allergic disease or an infection, including the adoptive immune cells and a pharmaceutically acceptable carrier.
摘要翻译： 通过包括（a）获得哺乳动物抗原呈递相关细胞的方法获得的免疫免疫细胞; （b）从包含在含有糖链的聚合物的培养容器中的培养液中培养来自步骤（a）的所得细胞; 和（c）通过摇动培养容器从步骤（b）中分离细胞而不用酶处理细胞，而不使用细胞分离工具。 通过向患者施用过继免疫细胞来治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的方法。 用于治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的药物组合物，包括过继免疫细胞和药学上可接受的载体。
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公开(公告)号：US20100092445A1
公开(公告)日：2010-04-15
申请号：US12653090
申请日：2009-12-08
IPC分类号： A61K45/00 , C12N5/0786 , A61P35/00 , A61P3/10 , A61P37/08
CPC分类号： C12N5/0068 , A61K2039/5154 , C12N2533/70
摘要： Adoptive immune cells obtained by a method including (a) obtaining mammalian antigen-presenting associated cells; (b) culturing the resulting cells from step (a) in a culture liquid contained in a culture vessel coated with a sugar chain-containing polymer; and (c) detaching the cells from step (b) by shaking the culture vessel without treating the cells with an enzyme and without using a cell detaching tool. A method for treating a malignant tumor, type I diabetes, an atopic allergic disease or an infection, by administering the adoptive immune cells to a patient. A pharmaceutical composition for treating a malignant tumor, type I diabetes, an atopic allergic disease or an infection, including the adoptive immune cells and a pharmaceutically acceptable carrier.
摘要翻译： 通过包括（a）获得哺乳动物抗原呈递相关细胞的方法获得的免疫免疫细胞; （b）从包含在含有糖链的聚合物的培养容器中的培养液中培养来自步骤（a）的所得细胞; 和（c）通过摇动培养容器从步骤（b）中分离细胞而不用酶处理细胞，而不使用细胞分离工具。 通过向患者施用过继免疫细胞来治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的方法。 用于治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的药物组合物，包括过继免疫细胞和药学上可接受的载体。
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公开(公告)号：US20110129434A1
公开(公告)日：2011-06-02
申请号：US12991835
申请日：2009-04-27
申请人： Mitsuaki Goto , Masamichi Iwama , Yumi Anan
发明人： Mitsuaki Goto , Masamichi Iwama , Yumi Anan
CPC分类号： A61K31/702 , A61K8/8111 , A61K8/8117 , A61K8/8129 , A61Q19/08
摘要： Disclosed is a moisturizing agent comprising a copolymer represented by formula (1). [In formula (1), A represents a substituent containing an oligosaccharide composed of 2 to 6 monosaccharide molecules bound to each other; B represents a group represented by formula (2); m and n represent numbers which meet the following equation m:n=9:1 to 1:9; and Z represents a hydrogen group, a methyl group or an ethyl group.] [In formula (2), X represents a saturated or unsaturated monocyclic or dicyclic ring having 5 to 10 ring-constituting members, or a molecule containing a nitrogen or an oxygen, provided that the ring may contain 1 to 3 atoms independently selected from the group consisting of a nitrogen, a sulfur and an oxygen; n represents a number of 0 or 1; Y represents —NHCO—, —CONH—, —NHCONH—, —NH—, —CO, or an alkyl group having 0 or more carbon atoms; and R represents a linear or branched alkyl, alkenyl or alkynyl having 1 to 20 carbon atoms which, if required, may be substituted by one or two hydroxy, mercapto, amino, cyano, heterocyclyl, heterocyclyloxy, phenyl, benzyl, heteroaryl, phenoxy, benzyloxy or heteroaryloxy groups.]
摘要翻译： 公开了包含由式（1）表示的共聚物的保湿剂。 [式（1）中，A表示含有由相互结合的2〜6个单糖分子构成的寡糖的取代基。 B表示式（2）表示的基团。 m和n表示满足以下等式m的数：n = 9：1至1：9; Z表示氢原子，甲基或乙基。] [式（2）中，X表示具有5〜10个环构成成分的饱和或不饱和的单环或双环，或含有氮或 氧，条件是环可以含有1-3个独立地选自氮，硫和氧的原子; n表示0或1的数; Y表示-NHCO-，-CONH-，-NHCONH-，-NH-，-CO或具有0个或更多个碳原子的烷基; 并且R表示具有1至20个碳原子的直链或支链烷基，烯基或炔基，如果需要，其可以被一个或两个羟基，巯基，氨基，氰基，杂环基，杂环基氧基，苯基，苄基，杂芳基，苯氧基， 苄氧基或杂芳氧基。
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公开(公告)号：US07655393B2
公开(公告)日：2010-02-02
申请号：US11579280
申请日：2004-05-11
IPC分类号： A01N1/02
CPC分类号： C12N5/0068 , A61K2039/5154 , C12N2533/70
摘要： The present invention provides a method for preparing adoptive immune cells comprising the following steps of a) obtaining mammalian antigen-presenting associated cells; b) culturing the resulting cells in a culture vessel coated with a sugar chain-containing polymer; and c) detaching the cells by shaking the culture vessel without treating the cells with enzyme and without using a cell detaching tool; adoptive immune cells obtained by this preparing method; a culture vessel coated with a sugar chain-containing polymer for use in this preparation method; a kit for preparing an adoptive immune cell vaccine; and a method and a medicine for treating a malignant tumor, type I diabetes, atopic allergic diseases or infections using the adoptive immune cells.
摘要翻译： 本发明提供一种制备过继免疫细胞的方法，包括以下步骤：a）获得哺乳动物抗原呈递相关细胞; b）将所得细胞培养在涂有含糖链的聚合物的培养容器中; 和c）通过摇动培养容器而不用酶处理细胞并且不使用细胞分离工具来分离细胞; 通过该制备方法获得的过继免疫细胞; 用该制备方法使用的含糖链聚合物的培养容器; 用于制备过继性免疫细胞疫苗的试剂盒; 以及使用过继免疫细胞治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的方法和药物。
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6.发明申请CONTACT LENS SOLUTION AND METHOD FOR HYDROPHILIZING CONTACT LENS BY USING THE SAME 审中-公开接触透镜解决方案和使用相同方式对接触镜进行加氢处理公开(公告)号：US20090124706A1
公开(公告)日：2009-05-14
申请号：US12348935
申请日：2009-01-06
申请人： Satoru MATSUMOTO , Yasuyuki Kato , Naoki Anan , Yumi Anan Executrix , Mitsuaki Goto , Masamichi Iwama
发明人： Satoru MATSUMOTO , Yasuyuki Kato , Naoki Anan , Yumi Anan Executrix , Mitsuaki Goto , Masamichi Iwama
CPC分类号： C11D3/0078 , A61L12/08 , C11D3/3773
摘要： It is an object of the present invention to provide a contact lens solution that imparts stable hydrophilicity even to a surface of a contact lens having strong water repellency. There was prepared a contact lens solution comprising a copolymer of N-p-vinylbenzyl-D-lactonamide and at least one monomer copolymerizable therewith. The copolymer is present in the solution in an amount of 0.0001 to 5 w/v %.
摘要翻译： 本发明的目的是提供即使对具有强斥水性的隐形眼镜的表面也具有稳定亲水性的隐形眼镜溶液。 制备了包含N-对乙烯基苄基-D-内酰胺和至少一种可与其共聚的单体的共聚物的隐形眼镜溶液。 该溶液中共聚物的存在量为0.0001至5w / v％。
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公开(公告)号：US20070286847A1
公开(公告)日：2007-12-13
申请号：US11579280
申请日：2004-05-11
CPC分类号： C12N5/0068 , A61K2039/5154 , C12N2533/70
摘要： The present invention provides a method for preparing adoptive immune cells comprising the following steps of a) obtaining mammalian antigen-presenting associated cells; b) culturing the resulting cells in a culture vessel coated with a sugar chain-containing polymer; and c) detaching the cells by shaking the culture vessel without treating the cells with enzyme and without using a cell detaching tool; adoptive immune cells obtained by this preparing method; a culture vessel coated with a sugar chain-containing polymer for use in this preparation method; a kit for preparing an adoptive immune cell vaccine; and a method and a medicine for treating a malignant tumor, type I diabetes, atopic allergic diseases or infections using the adoptive immune cells.
摘要翻译： 本发明提供一种制备过继免疫细胞的方法，包括以下步骤：a）获得哺乳动物抗原呈递相关细胞; b）将所得细胞培养在涂有含糖链的聚合物的培养容器中; 和c）通过摇动培养容器而不用酶处理细胞并且不使用细胞分离工具来分离细胞; 通过该制备方法获得的过继免疫细胞; 用该制备方法使用的含糖链聚合物的培养容器; 用于制备过继性免疫细胞疫苗的试剂盒; 以及使用过继免疫细胞治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的方法和药物。
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公开(公告)号：US4313193A
公开(公告)日：1982-01-26
申请号：US101692
申请日：1979-12-10
申请人： Tokutaka Nakano , Takao Sakata , Masamichi Iwama , Takao Isago
发明人： Tokutaka Nakano , Takao Sakata , Masamichi Iwama , Takao Isago
CPC分类号： H04J3/1647 , H04L5/22
摘要： A time division multiplex transmission apparatus which transmits low-speed data and telegraph signals of a maximum of n.times.m channels as high-speed data in a multiplexed manner based on a time division system. The apparatus also separates received high-speed data into low-speed data and telegraph signals. The time division multiplex transmission apparatus includes m input/output units each comprising: a level converter circuit for converting the subscriber's line level signals of n channels to an internal logic level, a first microprocessor for regenerating the start-stop of n channels of signals and a function to regenerate telex signals, a programmable timer circuit for controlling the interruption time of n channels of signals into the first microprocessor, an interruption control circuit for determining the priority order of interruption of n channel of signals into the first microprocessor, a setting switch for setting a self-address to transfer the data to a time slot to which the high-speed data has been allotted, an address decoder for decoding address signals from the setting switch and a common bus, and a first bus driver receiver for transferring the data from the first microprocessor via the common bus; and a high-speed data processing device comprising: a second microprocessor for multiplexing and separating signals of a maximum of m.times.n channels, for generating and detecting the frame patterns and keeping frame synchronization, and for generating adresses of m.times.n channels, an address encoder for encoding address signals of the second microprocessor, and a second bus driver receiver for transferring the data from the second microprocessor into each of said input/output devices via the common bus.
摘要翻译： 一种时分复用传输装置，其以基于时分系统的多路复用方式发送最高n个信道的低速数据和电报信号作为高速数据。 该装置还将接收到的高速数据分离成低速数据和电报信号。 时分复用传输装置包括m个输入/输出单元，每个输入/输出单元包括：电平转换器电路，用于将n个通道的用户线路电平信号转换为内部逻辑电平;第一微处理器，用于再生n个信道的开始停止;以及 用于再生电传信号的功能，用于控制n个信道到第一微处理器的中断时间的可编程定时器电路，用于确定信号到第一微处理器的n个信道的中断的优先顺序的中断控制电路，设置开关 用于设置自身地址以将数据传送到已经分配高速数据的时隙，地址解码器，用于解码来自设置开关的地址信号和公共总线;以及第一总线驱动器接收器，用于传送 来自第一微处理器的数据通过公共总线; 以及高速数据处理装置，包括：第二微处理器，用于复用和分离最大mxn个信道的信号，用于生成和检测帧模式并保持帧同步，以及用于生成m×n个信道的地址，编码器 第二微处理器的地址信号，以及用于经由公共总线将数据从第二微处理器传送到每个所述输入/输出设备的第二总线驱动器接收器。
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