公开(公告)号：US20220192583A1

公开(公告)日：2022-06-23

申请号：US17568335

申请日：2022-01-04

申请人： Mohammad Abdolahad ,  Ashkan Zandi ,  Amir Mamdouh ,  Alireza Madannejad ,  Yasin Kordehlachin ,  Seyed Mohammad Sadegh Mousavi-Kiasary ,  Fereshteh Abbasvandi

发明人： Mohammad Abdolahad ,  Ashkan Zandi ,  Amir Mamdouh ,  Alireza Madannejad ,  Yasin Kordehlachin ,  Seyed Mohammad Sadegh Mousavi-Kiasary ,  Fereshteh Abbasvandi

IPC分类号： A61B5/00 ,  A61B5/0507 ,  C12Q1/6886

摘要： A method for detecting sentinel lymph nodes during surgery. The method includes injecting a crystalloid solution into a region, measuring a plurality of electrical parameters utilizing a sensor, and detecting a sentinel lymph node among a plurality of lymph nodes based on the plurality of electrical parameters. The region is associated with a tumor in a patient's body. Measuring the plurality of electrical parameters includes measuring each respective electrical parameter of a respective lymph node of the plurality of lymph nodes. The plurality of lymph nodes are associated with the tumor. The sentinel lymph node is located at a shortest distance from the tumor among the plurality of lymph nodes.

公开(公告)号：US11630079B2

公开(公告)日：2023-04-18

申请号：US17207653

申请日：2021-03-20

申请人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Hassan Sanati koloukhi ,  Fatemeh Zahra Shojaeian Zanjani ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Ashkan Zandi ,  Fereshteh Abbasvandi

发明人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Hassan Sanati koloukhi ,  Fatemeh Zahra Shojaeian Zanjani ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Ashkan Zandi ,  Fereshteh Abbasvandi

IPC分类号： G01N33/487 ,  G01N27/327 ,  G01N27/48 ,  A61B10/00

摘要： A method for diagnosing COVID-19 infection of a person. The method includes acquiring a sputum sample of the person, measuring a level of reactive oxygen species (ROS) in the sputum sample, and detecting a COVID-19 infection status of the person based on the measured level of ROS. Measuring the level of ROS in the sputum sample includes recording a cyclic voltammetry (CV) pattern from the sputum sample and measuring a current peak of the recorded CV pattern. Detecting the COVID-19 infection status of the person based on the measured level of ROS includes detecting the person is infected with COVID-19 if the measured current peak is in a first range of current peaks and detecting the person is not infected with COVID-19 if the measured current peak is in a second range of current peaks.

公开(公告)号：US20210231638A1

公开(公告)日：2021-07-29

申请号：US17207653

申请日：2021-03-20

申请人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Hassan Sanati koloukhi ,  Fatemeh Zahra Shojaeian Zanjani ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Ashkan Zandi ,  Fereshteh Abbasvandi

发明人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Hassan Sanati koloukhi ,  Fatemeh Zahra Shojaeian Zanjani ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Ashkan Zandi ,  Fereshteh Abbasvandi

IPC分类号： G01N33/487 ,  G01N27/48 ,  G01N27/327

摘要： A method for diagnosing COVID-19 infection of a person. The method includes acquiring a sputum sample of the person, measuring a level of reactive oxygen species (ROS) in the sputum sample, and detecting a COVID-19 infection status of the person based on the measured level of ROS. Measuring the level of ROS in the sputum sample includes recording a cyclic voltammetry (CV) pattern from the sputum sample and measuring a current peak of the recorded CV pattern. Detecting the COVID-19 infection status of the person based on the measured level of ROS includes detecting the person is infected with COVID-19 if the measured current peak is in a first range of current peaks and detecting the person is not infected with COVID-19 if the measured current peak is in a second range of current peaks.

公开(公告)号：US20210386330A1

公开(公告)日：2021-12-16

申请号：US17207616

申请日：2021-03-20

申请人： Mohammad Abdolahad ,  Naser Namdar Habashi ,  Zohreh Sadat Miripour ,  Hadi Ghafari ,  Fereshteh Abbasvandi ,  Parisa Aghaee ,  Mahsa Faramarzpour Darzini ,  Pooneh Mohaghegh

发明人： Mohammad Abdolahad ,  Naser Namdar Habashi ,  Zohreh Sadat Miripour ,  Hadi Ghafari ,  Fereshteh Abbasvandi ,  Parisa Aghaee ,  Mahsa Faramarzpour Darzini ,  Pooneh Mohaghegh

IPC分类号： A61B5/1473 ,  A61B5/00 ,  G01N27/327 ,  G01N27/30

摘要： An apparatus for in-vivo measuring H2O2 oxidation within a living tissue. The apparatus includes an electrochemical probe and an electrochemical stimulator-analyzer. The electrochemical probe includes a sensing part and a handle. The sensing part includes a working electrode, a counter electrode, and a reference electrode. The working electrode includes a first biocompatible conductive needle coated with a layer of vertically aligned multi-walled carbon nanotubes. The counter electrode includes a second biocompatible conductive needle. The reference electrode includes a third biocompatible conductive needle. The electrochemical stimulator-analyzer is configured to generate a set of electrical currents in a portion of the living tissue.

公开(公告)号：US20220022946A1

公开(公告)日：2022-01-27

申请号：US17492654

申请日：2021-10-03

申请人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Mohammad Ali Khayamian ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi ,  Reyhaneh Mahdavi ,  Narges Yousefpour ,  Hossein Ataee ,  Sajad Mehrvarz

发明人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Mohammad Ali Khayamian ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi ,  Reyhaneh Mahdavi ,  Narges Yousefpour ,  Hossein Ataee ,  Sajad Mehrvarz

IPC分类号： A61B18/14 ,  A61B18/12

摘要： A system for destroying a cancerous tumor. The system includes an electrical probe, an impedance analyzer device configured to be connected to the electrical probe, a DC voltage generator configured to be connected to the electrical probe, and a processing unit connected to the impedance analyzer device and the DC voltage generator. The electrical probe includes a first electrode including a first electrically conductive needle, a second electrode including a second electrically conductive needle with a nanoporous surface placed inside the first electrode, a first electrically insulating layer placed around the first electrode except a first distal end portion of the first electrode, and a second electrically insulating layer placed between the first electrode and the second electrode. The processing unit configured to perform destroying the cancerous tumor by executing processor-readable instructions utilizing the impedance analyzer device and the DC voltage generator.

公开(公告)号：US11179076B2

公开(公告)日：2021-11-23

申请号：US17035663

申请日：2020-09-28

申请人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Hadi Ghafari ,  Fereshteh Abbasvandi ,  Pooneh Mohaghegh ,  Parisa Aghaee ,  Mahsa Faramarzpour Darzini

发明人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Hadi Ghafari ,  Fereshteh Abbasvandi ,  Pooneh Mohaghegh ,  Parisa Aghaee ,  Mahsa Faramarzpour Darzini

IPC分类号： C12Q1/02 ,  A61B5/1459 ,  C23C14/14 ,  C23C14/30 ,  C23C14/58 ,  G01N33/50 ,  C23C16/02 ,  C23C16/26 ,  A61B5/00 ,  G01N33/574

摘要： An electrochemical probe for in-vivo measurement of H2O2 oxidation within a living tissue. The electrochemical probe includes a sensing part and a handle. The sensing part includes a working electrode including a first biocompatible conductive needle, a counter electrode including a second biocompatible conductive needle, and a reference electrode including a third biocompatible conductive needle. The working electrode, the counter electrode, and the reference electrode are configured to be put in contact with the living tissue by inserting the sensing part into the living tissue. The handle includes an insertion part that may be configured to insert the sensing part into the living tissue. The sensing part is attached to the insertion part.

公开(公告)号：US20210022650A1

公开(公告)日：2021-01-28

申请号：US17035663

申请日：2020-09-28

申请人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Hadi Ghafari ,  Fereshteh Abbasvandi ,  Pooneh Mohaghegh ,  Parisa Aghaee ,  Mahsa Faramarzpour Darzini

发明人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Hadi Ghafari ,  Fereshteh Abbasvandi ,  Pooneh Mohaghegh ,  Parisa Aghaee ,  Mahsa Faramarzpour Darzini

IPC分类号： A61B5/1459 ,  C23C14/14 ,  C23C14/30 ,  C23C14/58 ,  G01N33/50 ,  C23C16/02 ,  C23C16/26 ,  A61B5/00 ,  G01N33/574

摘要： An electrochemical probe for in-vivo measurement of H2O2 oxidation within a living tissue. The electrochemical probe includes a sensing part and a handle. The sensing part includes a working electrode including a first biocompatible conductive needle, a counter electrode including a second biocompatible conductive needle, and a reference electrode including a third biocompatible conductive needle. The working electrode, the counter electrode, and the reference electrode are configured to put in contact with the living tissue by inserting the sensing part into the living tissue. The handle includes an insertion part that may be configured to insert the sensing part into the living tissue. The sensing part is attached to the insertion part.

公开(公告)号：US11898981B2

公开(公告)日：2024-02-13

申请号：US17228859

申请日：2021-04-13

申请人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi

发明人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi

IPC分类号： G01N27/327 ,  G01N27/48 ,  A61B5/1473 ,  A61B5/00 ,  G01N33/483

CPC分类号： G01N27/3278 ,  A61B5/14735 ,  A61B5/6849 ,  G01N27/48 ,  G01N33/4833 ,  A61B2562/0285 ,  A61B2562/046 ,  G01N27/3277

摘要： A method for non-invasive detecting and tracing cancer. The method includes fabricating a probe including two reference electrodes, a working electrode located inside a first reference electrode of the two reference electrodes, and a counter electrode located inside a second reference electrode of the two reference electrodes, putting the probe on a part of skin adjacent to a target location inside a patient's body, inserting the two reference electrodes inside the target location through the part of skin, inserting the working electrode and the counter electrode into the target location by releasing the working electrode and the counter electrode through the two reference electrodes, recording a cyclic voltammetry (CV) response of hypoxia-related hydrogen peroxide (H2O2) release in the target location by applying a set of electrical potentials to the probe, measuring an oxidation current peak of the recorded CV response, and detecting a cancerous tumor at the target location by comparing the measured oxidation current peak with a set of reference values.

公开(公告)号：US20220022947A1

公开(公告)日：2022-01-27

申请号：US17492659

申请日：2021-10-03

申请人： Mohammad Abdolahad ,  Reyhaneh Mahdavi ,  Mohammad Ali Khayamian ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi ,  Zohreh Sadat Miripour ,  Narges Yousefpour ,  Hossein Ataee ,  Sajad Mehrvarz

发明人： Mohammad Abdolahad ,  Reyhaneh Mahdavi ,  Mohammad Ali Khayamian ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi ,  Zohreh Sadat Miripour ,  Narges Yousefpour ,  Hossein Ataee ,  Sajad Mehrvarz

IPC分类号： A61B18/14

摘要： A method for destroying a cancerous tumor. The method includes putting two electrodes of an electrical probe in contact with a portion of the cancerous tumor, plotting an impedance phase diagram by measuring a set of electrical impedance phase values from the portion of the cancerous tumor at end of a respective set of pre-determined time steps, destroying cancer cells of the portion of the cancerous tumor within each time step of the respective set of pre-determined time steps by electrolyzing peripheral medium surrounding the cancer cells of the portion of the cancerous tumor by applying a direct current (DC) voltage between the two electrodes, and stopping destroying of the cancer cells responsive to a complete destruction of the portion of the cancerous tumor, where the complete destruction includes obtaining a positive slope of the impedance phase diagram (IPS).

公开(公告)号：US20210231600A1

公开(公告)日：2021-07-29

申请号：US17228859

申请日：2021-04-13

申请人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi

发明人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi

IPC分类号： G01N27/327 ,  G01N27/48 ,  A61B5/1473 ,  A61B5/00 ,  G01N33/483

摘要： A method for non-invasive detecting and tracing cancer. The method includes fabricating a probe including two reference electrodes, a working electrode located inside a first reference electrode of the two reference electrodes, and a counter electrode located inside a second reference electrode of the two reference electrodes, putting the probe on a part of skin adjacent to a target location inside a patient's body, inserting the two reference electrodes inside the target location through the part of skin, inserting the working electrode and the counter electrode into the target location by releasing the working electrode and the counter electrode through the two reference electrodes, recording a cyclic voltammetry (CV) response of hypoxia-related hydrogen peroxide (H2O2) release in the target location by applying a set of electrical potentials to the probe, measuring an oxidation current peak of the recorded CV response, and detecting a cancerous tumor at the target location by comparing the measured oxidation current peak with a set of reference values.