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公开(公告)号：US20120225454A1
公开(公告)日：2012-09-06
申请号：US13380736
申请日：2010-06-25
申请人： Mohammed Benghezal , Yakhya Dieye , Carola Schwann , Miriam Sehnal , Alma Fulurija , Barry J. Marshall
发明人： Mohammed Benghezal , Yakhya Dieye , Carola Schwann , Miriam Sehnal , Alma Fulurija , Barry J. Marshall
CPC分类号： C12N15/68 , C12N9/80 , C12N15/52 , C12N15/74 , C12Y305/01005
摘要： The present invention relates to synthetic operons. In particular, the present invention relates to a synthetic operon for integration into a bacterial chromosome of a bacterium comprising a promoter operably-linked to at least two genes, wherein at least one gene is a gene of interest and at least one gene is a gene essential to said bacterium.
摘要翻译： 本发明涉及合成操纵子。 特别地，本发明涉及用于整合到细菌细菌染色体中的合成操纵子，其包含与至少两个基因可操作地连接的启动子，其中至少一个基因是目的基因，并且至少一个基因是基因 对所述细菌至关重要。
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公开(公告)号：US08715929B2
公开(公告)日：2014-05-06
申请号：US13380736
申请日：2010-06-25
申请人： Mohammed Benghezal , Yakhya Dieye , Carola Schwann , Miriam Sehnal , Alma Fulurija , Barry J. Marshall
发明人： Mohammed Benghezal , Yakhya Dieye , Carola Schwann , Miriam Sehnal , Alma Fulurija , Barry J. Marshall
CPC分类号： C12N15/68 , C12N9/80 , C12N15/52 , C12N15/74 , C12Y305/01005
摘要： The present invention relates to synthetic operons. In particular, the present invention relates to a synthetic operon for integration into a bacterial chromosome of a bacterium comprising a promoter operably-linked to at least two genes, wherein at least one gene is a gene of interest and at least one gene is a gene essential to said bacterium.
摘要翻译： 本发明涉及合成操纵子。 特别地，本发明涉及用于整合到细菌细菌染色体中的合成操纵子，其包含与至少两个基因可操作地连接的启动子，其中至少一个基因是目的基因，并且至少一个基因是基因 对所述细菌至关重要。
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公开(公告)号：US09115363B2
公开(公告)日：2015-08-25
申请号：US14003786
申请日：2012-03-09
申请人： Mohammed Benghezal , Aleksandra Weronika Debowski , Miriam Sehnal , Yakhya Dieye , Se-Hoon Park , Barry Marshall
发明人： Mohammed Benghezal , Aleksandra Weronika Debowski , Miriam Sehnal , Yakhya Dieye , Se-Hoon Park , Barry Marshall
CPC分类号： C12N15/74 , A61K2035/11
摘要： The present invention relates to a gene expression and eradication system for Helicobacter pylori (H. pylori). In particular, the present invention relates to a genetic construct comprising, in the 5′-3′ direction: (a) a promoter sequence and (b) a DNA sequence of interest, wherein the promoter sequence comprises a polynucleotide sequence capable of regulating expression of the DNA sequence of interest in Helicobacter pylori and wherein said promoter sequence is modified to comprise a tetracycline (tet) operator sequence.
摘要翻译： 本发明涉及幽门螺杆菌（H.pylori）的基因表达和根除系统。 特别地，本发明涉及包含在5'-3'方向上的（a）启动子序列和（b）感兴趣的DNA序列的遗传构建体，其中启动子序列包含能够调节表达的多核苷酸序列 的幽门螺杆菌感兴趣的DNA序列，其中所述启动子序列被修饰为包含四环素（tet）操纵子序列。
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4.发明申请公开(公告)号：US20140072595A1
公开(公告)日：2014-03-13
申请号：US14003786
申请日：2012-03-09
申请人： Mohammed Benghezal , Aleksandra Weronika Debowski , Miriam Sehnal , Yakhya Dieye , Se-Hoon Park , Barry Marshall
发明人： Mohammed Benghezal , Aleksandra Weronika Debowski , Miriam Sehnal , Yakhya Dieye , Se-Hoon Park , Barry Marshall
IPC分类号： C12N15/74
CPC分类号： C12N15/74 , A61K2035/11
摘要： The present invention relates to a gene expression and eradication system for Helicobacter pylori (H. pylori). In particular, the present invention relates to a genetic construct comprising, in the 5′-3′ direction: (a) a promoter sequence and (b) a DNA sequence of interest, wherein the promoter sequence comprises a polynucleotide sequence capable of regulating expression of the DNA sequence of interest in Helicobacter pylori and wherein said promoter sequence is modified to comprise a tetracycline (tet) operator sequence.
摘要翻译： 本发明涉及幽门螺杆菌（H.pylori）的基因表达和根除系统。 特别地，本发明涉及包含在5'-3'方向上的（a）启动子序列和（b）感兴趣的DNA序列的遗传构建体，其中启动子序列包含能够调节表达的多核苷酸序列 的幽门螺杆菌感兴趣的DNA序列，其中所述启动子序列被修饰为包含四环素（tet）操纵子序列。
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公开(公告)号：US08992935B2
公开(公告)日：2015-03-31
申请号：US13806084
申请日：2011-06-24
IPC分类号： C07K14/195 , A61K39/02 , C12N1/36 , C12N9/80 , A61K39/00
CPC分类号： A61K39/105 , A61K2039/522 , C12N1/36 , C12N9/80 , C12Y305/01005 , Y02A50/412 , Y02A50/466 , Y02A50/467
摘要： The present invention relates to a means of controlling infection persistence of Helicobacter pylori (H. pylori). In particular, the present invention relates to an isolated, genetically modified Helicobacter pylori comprising a functional urease, wherein the contiguous amino acid sequence between amino acid 529 and amino acid 555 of SEQ ID NO:1 is altered to produce said modified Helicobacter pylori which is unable to establish or maintain a persistent infection.
摘要翻译： 本发明涉及一种控制幽门螺杆菌（幽门螺杆菌）感染持久性的方法。 特别地，本发明涉及一种分离的经遗传修饰的幽门螺杆菌，其包含功能性脲酶，其中SEQ ID NO：1的氨基酸529和氨基酸555之间的连续氨基酸序列被改变以产生所述修饰的幽门螺杆菌 无法建立或维持持续感染。
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公开(公告)号：US08790909B2
公开(公告)日：2014-07-29
申请号：US13376377
申请日：2010-06-03
IPC分类号： C12N1/00
CPC分类号： C12R1/01 , A61K39/105 , A61K2039/52
摘要： The present invention relates to strains of Helicobacter pylori useful for the delivery of biologically active agents. In particular, the present invention provides an isolated strain of H. pylori having: (a) low pathogenicity; (b) ability to naturally transform; and (c) ability to colonise mouse stomach mucosa without host adaptation.
摘要翻译： 本发明涉及可用于递送生物活性剂的幽门螺杆菌菌株。 特别地，本发明提供了幽门螺杆菌的分离菌株，其具有：（a）低致病性; （b）自然转化的能力; 和（c）没有宿主适应的定殖小鼠胃粘膜的能力。
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7.发明申请公开(公告)号：US20130259888A1
公开(公告)日：2013-10-03
申请号：US13806084
申请日：2011-06-24
CPC分类号： A61K39/105 , A61K2039/522 , C12N1/36 , C12N9/80 , C12Y305/01005 , Y02A50/412 , Y02A50/466 , Y02A50/467
摘要： The present invention relates to a means of controlling infection persistence of Helicobacter pylori (H. pylori). In particular, the present invention relates to an isolated, genetically modified Helicobacter pylori comprising a functional urease, wherein the contiguous amino acid sequence between amino acid 529 and amino acid 555 of SEQ ID NO:1 is altered to produce said modified Helicobacter pylori which is unable to establish or maintain a persistent infection.
摘要翻译： 本发明涉及一种控制幽门螺杆菌（幽门螺杆菌）感染持久性的方法。 特别地，本发明涉及一种分离的经遗传修饰的幽门螺杆菌，其包含功能性脲酶，其中SEQ ID NO：1的氨基酸529和氨基酸555之间的连续氨基酸序列被改变以产生所述修饰的幽门螺杆菌 无法建立或维持持续感染。
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公开(公告)号：US20120144509A1
公开(公告)日：2012-06-07
申请号：US13376377
申请日：2010-06-03
申请人： Mohammed Benghezal , Alma Fulurija , Wei Lu , Hans-Olof Nilsson , Barry Marshall
发明人： Mohammed Benghezal , Alma Fulurija , Wei Lu , Hans-Olof Nilsson , Barry Marshall
CPC分类号： C12R1/01 , A61K39/105 , A61K2039/52
摘要： The present invention relates to strains of Helicobacter pylori useful for the delivery of biologically active agents. In particular, the present invention provides an isolated strain of H. pylori having: (a) low pathogenicity; (b) ability to naturally transform; and (c) ability to colonise mouse stomach mucosa without host adaptation.
摘要翻译： 本发明涉及可用于递送生物活性剂的幽门螺杆菌菌株。 特别地，本发明提供了幽门螺杆菌的分离菌株，其具有：（a）低致病性; （b）自然转化的能力; 和（c）没有宿主适应的定殖小鼠胃粘膜的能力。
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公开(公告)号：US20090203062A1
公开(公告)日：2009-08-13
申请号：US12096286
申请日：2006-12-06
申请人： Mohammed Benghezal , Eric Adam , Stephanie Braillard , Christine Burn , Aurore Lucas , Jean-Pierre Paccaud , Emilio Valentino , Pierre Cosson
发明人： Mohammed Benghezal , Eric Adam , Stephanie Braillard , Christine Burn , Aurore Lucas , Jean-Pierre Paccaud , Emilio Valentino , Pierre Cosson
IPC分类号： C12Q1/02
CPC分类号： C12Q1/18 , C12Q1/04 , G01N2333/44
摘要： The present invention relates to a method for identifying and/or quantifying an anti-infective compound. Furthermore it relates to a method for identifying and/or quantifying a mutation in a virulence factor of a pathogen of a host organism that reduces the virulence of the pathogen to a unicellular test organism.
摘要翻译： 本发明涉及用于鉴定和/或定量抗感染化合物的方法。 此外，它涉及用于鉴定和/或定量宿主生物体病原体的毒力因子中的突变的方法，其将病原体的毒力降低到单细胞测试生物。
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公开(公告)号：US20060171959A1
公开(公告)日：2006-08-03
申请号：US10536606
申请日：2003-12-19
IPC分类号： A61K39/02 , A61K39/108 , C12N1/21
CPC分类号： C07K14/26 , A61K2039/522 , C07K14/21
摘要： A series of genes from Pseudomonas aeruginosa and Klebsiella are shown to encode products that are implicated in virulence. The identification of theses genes therefore allows attenuated microorganisms to be produced. Furthermore, the genes or their encoded products can be used to identify antimicrobial drugs, diagnostic methods for the identification of a pathogen-associated disease, and in the manufacture of vaccines.
摘要翻译： 来自铜绿假单胞菌和克雷伯菌的一系列基因显示出编码与毒力有关的产物。 因此，这些基因的鉴定允许产生减毒的微生物。 此外，基因或其编码产物可用于鉴定抗微生物药物，用于鉴定病原体相关疾病的诊断方法和疫苗的制造。
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