公开(公告)号：US20060223921A1

公开(公告)日：2006-10-05

申请号：US11398039

申请日：2006-04-05

申请人： Monika Bauer ,  Berthold Just

发明人： Monika Bauer ,  Berthold Just

IPC分类号： C08K5/50

CPC分类号： C08G59/1488 ,  C08G8/10 ,  C08G59/4021 ,  C08G59/50 ,  C08G63/692 ,  C08G63/91 ,  C08K5/5313 ,  C08L63/00 ,  C08L67/00

摘要： The present invention relates to prepolymers produced by reacting resins with phosphororganic compounds obtained from phosphinic acid derivatives, and their use for producing flame resistant polymers, in particular duromers, and the polymers produced therewith. In particular, the present invention relates to a prepolymer for flame resistant polymers, particularly duromers, which is obtained by reacting at least one phosphinic acid derivative of formula I (R1O)(R2)P(O)—R3, wherein R1 and R2 independently of one another represent an optionally substituted alkyl, aryl, arylalkyl, alkylaryl or alkylarylalkyl group with 1 to 20 carbon atoms, R3 represents hydrogen or an optionally substituted alkyl, aryl, arylalkyl, alkylaryl or alkylarylalkyl group with 1 to 20 carbon atoms, with at least one resin preferably selected from the group consisting of an epoxy resin, cyanate resin, an unsaturated polyester, vinyl ester, phenol resin and a bismaleimide.

摘要翻译： 本发明涉及通过使树脂与从次膦酸衍生物获得的磷有机化合物反应制备的预聚物及其制备阻燃聚合物，特别是丁二烯的用途，以及由其制备的聚合物。 特别地，本发明涉及通过使至少一种式I的次膦酸衍生物<？in-line-formula description =“In-Line Formulas”end =“...”得到的阻燃聚合物，特别是丁二酸甘油酯的预聚物， （R 1 O）（R 2）P（O）-R 3，<β在线公式描述 其中R 1和R 2彼此独立地表示任选取代的烷基，芳基，芳基烷基，烷基芳基或烷基芳基， 具有1至20个碳原子的烷基芳基烷基，R 3表示氢或任选取代的具有1至20个碳原子的烷基，芳基，芳基烷基，烷基芳基或烷基芳基烷基，以及至少一种优选选自 由环氧树脂，氰酸酯树脂，不饱和聚酯，乙烯基酯，酚醛树脂和双马来酰亚胺组成的组。

公开(公告)号：US09328236B2

公开(公告)日：2016-05-03

申请号：US14131773

申请日：2012-07-05

申请人： Monika Bauer ,  Hans-Juergen Glasel ,  Daniel Decker

发明人： Monika Bauer ,  Hans-Juergen Glasel ,  Daniel Decker

IPC分类号： C08L83/04 ,  C08L61/06 ,  C08L61/14 ,  C08G77/60 ,  C08G77/42 ,  C08L83/14 ,  C08L83/10 ,  C08G77/62 ,  C08K7/04

CPC分类号： C08L61/06 ,  C08G77/42 ,  C08G77/60 ,  C08G77/62 ,  C08K7/04 ,  C08L61/14 ,  C08L83/10 ,  C08L83/14 ,  C08L2205/16

摘要： The present invention relates to a resol resin consisting of at least one aromatic component with a phenolic OH group and at least one aldehyde component, wherein areas embedded in the resol resin matrix consisting of organically-modified polysiloxane, with said polysiloxane containing hydrocarbon groups that are at least partially bonded to said silicon in the form of non-substituted or substituted alkyl, alkenyl, aryl, arylalkyl or alkyl-aryl groups and that are not linked by covalent bonds to reactive groups of said resol resin. The invention additionally relates to molded articles manufactured from said resin, composites from a sheet material impregnated with said resin, which was subsequently hardened, as well as methods for manufacturing said resin, said molded articles, and said composites.

摘要翻译： 本发明涉及由至少一种芳族组分与酚OH基团和至少一种醛组分组成的甲阶酚醛树脂，其中包含在由有机改性聚硅氧烷组成的甲阶酚醛树脂基质中的区域，所述聚硅氧烷含有烃基， 至少部分地以未取代或取代的烷基，烯基，芳基，芳基烷基或烷基 - 芳基的形式键合到所述硅上，并且不与所述甲阶酚醛树脂的反应性基团共价键连接。 本发明还涉及由所述树脂制成的模制品，从浸渍有所述树脂的片材的复合材料，随后硬化​​，以及制造所述树脂，所述模制品和所述复合材料的方法。

公开(公告)号：US20140275373A1

公开(公告)日：2014-09-18

申请号：US14131773

申请日：2012-07-05

申请人： Monika Bauer ,  Hans-Juergen Glasel ,  Daniel Decker

发明人： Monika Bauer ,  Hans-Juergen Glasel ,  Daniel Decker

IPC分类号： C08L61/06

CPC分类号： C08L61/06 ,  C08G77/42 ,  C08G77/60 ,  C08G77/62 ,  C08K7/04 ,  C08L61/14 ,  C08L83/10 ,  C08L83/14 ,  C08L2205/16

摘要： The present invention relates to a resol resin consisting of at least one aromatic component with a phenolic OH group and at least one aldehyde component, wherein areas embedded in the resol resin matrix consisting of organically-modified polysiloxane, with said polysiloxane containing hydrocarbon groups that are at least partially bonded to said silicon in the form of non-substituted or substituted alkyl, alkenyl, aryl, arylalkyl or alkyl-aryl groups and that are not linked by covalent bonds to reactive groups of said resol resin. The invention additionally relates to moulded articles manufactured from said resin, composites from a sheet material impregnated with said resin, which was subsequently hardened, as well as methods for manufacturing said resin, said moulded articles, and said composites.

摘要翻译： 本发明涉及由至少一种芳族组分与酚OH基团和至少一种醛组分组成的甲阶酚醛树脂，其中包含在由有机改性聚硅氧烷组成的甲阶酚醛树脂基质中的区域，所述聚硅氧烷含有烃基， 至少部分地以未取代或取代的烷基，烯基，芳基，芳基烷基或烷基 - 芳基的形式键合到所述硅上，并且不与所述甲阶酚醛树脂的反应性基团共价键连接。 本发明还涉及由所述树脂制成的模制品，从浸渍有所述树脂的片材的复合材料，随后硬化​​，以及制造所述树脂，所述模制品和所述复合材料的方法。

公开(公告)号：US20110045013A1

公开(公告)日：2011-02-24

申请号：US12785174

申请日：2010-05-21

申请人： Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

发明人： Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

IPC分类号： A61K39/35 ,  C12N7/00 ,  A61P37/08

CPC分类号： C07K14/005 ,  A61K39/35 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55505 ,  C07K2319/00

摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

摘要翻译： 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明提供包含病毒样颗粒（VLP）或病毒颗粒和至少一种抗原，特别是至少一种猫科动物抗原，更特别是至少一种作为人类变应原的猫科动物抗原的组合物。 在某些实施方案中，抗原是与VLP共价连接的Fel d1抗原或其片段。 本发明还提供了用于制备组合物的方法。 本发明的组合物在哺乳动物，特别是人类中诱导有效的免疫应答，特别是抗体应答。 本发明的组合物和方法可用于疫苗的制备，特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。

公开(公告)号：US20100292089A1

公开(公告)日：2010-11-18

申请号：US12312372

申请日：2007-10-26

申请人： Martin F. Bachmann ,  Monika Bauer ,  Roger Beerli

发明人： Martin F. Bachmann ,  Monika Bauer ,  Roger Beerli

IPC分类号： C40B30/04

CPC分类号： C07K16/00 ,  C07K16/082 ,  C07K16/10 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/92 ,  C12N15/1037

摘要： The application provides a method of isolating a eukaryotic cell expressing an antibody of desired specificity, preferably a monoclonal single chain antibody (scFv). The application further provides methods which allow to clone the variable regions of said antibody from that isolated eukaryotic cell and to recombinantly produce antibodies comprising said variable regions as fusion protein with a purification tag, eg. as Fc-fusion, as a Fab fragment, or as whole antibodies, such as IgG, IgE, IgD, IgA and IgM. Said methods also allows to recombinantly produce antibodies with desired specificity in a fully species specific form, preferably as fully human antibodies.

摘要翻译： 本申请提供了分离表达具有所需特异性的抗体的真核细胞的方法，优选单克隆单链抗体（scFv）。 本申请还提供允许克隆来自该分离的真核细胞的所述抗体的可变区的方法，并重组产生包含所述可变区作为融合蛋白的抗体与纯化标签，例如， 作为Fc融合体，Fab片段，或作为完整抗体，例如IgG，IgE，IgD，IgA和IgM。 所述方法还允许以完全物种特异性形式重组产生具有所需特异性的抗体，优选作为完全人抗体。

公开(公告)号：US20090054540A1

公开(公告)日：2009-02-26

申请号：US12197257

申请日：2008-08-24

申请人： Siegfried Vieth ,  Monika Bauer

发明人： Siegfried Vieth ,  Monika Bauer

IPC分类号： C08L79/04 ,  C08G73/06 ,  C08J9/00

CPC分类号： C08J9/0066 ,  C08G73/0655 ,  C08J9/02 ,  C08J9/125 ,  C08J2205/052 ,  C08J2379/04

摘要： The present invention concerns a polycyanurate foam with a structural element A and either terminal amino groups and/or at least one of the following structural elements B, C, or D: wherein the foam has closed pores that contain carbon dioxide. This foam can be produced in that a substance is worked into the starting material for the polycyanurate that releases water or alcohol approximately at the start of polymerization either spontaneously or thermally or catalytically induced. The water/alcohol reacts with free cyanate groups under cleavage of CO2. The resulting amino groups can react further in the polymerization.

摘要翻译： 本发明涉及具有结构元件A和末端氨基和/或至少一种以下结构元素B，C或D的聚氰化脲泡沫体：其中泡沫具有包含二氧化碳的封闭孔。 该泡沫体可以通过以下方式制备：将物质加入聚氰化脲的起始原料中，该聚氰化脲在聚合开始时大约在自发或热或催化诱导下释放水或醇。 在二氧化碳切割下，水/醇与游离的氰酸酯基团反应。 所得的氨基可在聚合反应中进一步反应。

公开(公告)号：US10214691B2

公开(公告)日：2019-02-26

申请号：US14740534

申请日：2015-06-16

申请人： Harald Hirschmann ,  Monika Bauer ,  Martina Windhorst ,  Marcus Reuter ,  Constanze Brocke ,  Rocco Fortte ,  Matthias Bremer ,  Sabine Schoen

发明人： Harald Hirschmann ,  Monika Bauer ,  Martina Windhorst ,  Marcus Reuter ,  Constanze Brocke ,  Rocco Fortte ,  Matthias Bremer ,  Sabine Schoen

IPC分类号： G02F1/1333 ,  C09K19/34 ,  C09K19/04 ,  C09K19/14 ,  C09K19/20 ,  C07C69/52 ,  C07C69/602 ,  C07D311/18 ,  C09K19/30 ,  C09K19/54 ,  G02F1/1362 ,  G02F1/137 ,  G02F1/1337 ,  C09K19/12 ,  C09K19/16

摘要： The invention relates to a liquid-crystalline medium which comprises at least one compound of the formula I, in which R1, R1*, Z1, Z2 and L1-3 have the meanings defined herein, and to the use thereof for an active-matrix display, in particular based on the VA, PSA, PS-VA, PALC, FFS, PS-FFS, PS-IPS or IPS effect.

公开(公告)号：US08962138B2

公开(公告)日：2015-02-24

申请号：US13377064

申请日：2010-06-10

申请人： Monika Bauer ,  Hans-Juergen Glaesel

发明人： Monika Bauer ,  Hans-Juergen Glaesel

IPC分类号： B32B5/16 ,  C08G77/04 ,  C08G77/06 ,  C08G77/20 ,  C08G77/54 ,  C08G77/62 ,  C08K5/544 ,  C08L33/18

CPC分类号： C08G77/04 ,  C08G77/54 ,  C08G77/62 ,  C08K5/544 ,  C08L33/18 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2998 ,  Y10T428/31663 ,  C08L2666/44

摘要： The present invention relates to polysiloxane nanoparticles having the following properties: an average particle size d50 (measured using REM recordings) in the range of 10-200 nm, a specific surface area Ao of at least 50 m2/g, a pore volume of at least 0.2 cm3/g, an average pore volume d50 of at least 0.8 nm, wherein the particles have groups that contain carbon, which groups are bonded to the silicon at least partially in the form of unsubstituted or substituted alkyl, alkenyl, aryl, arylalkyl, or alkylaryl groups. Said polysiloxane nanoparticles can be produced, among other things, in that either a silazane or a mixture of different silazanes having one or more —[Si(R)(R1)—NR2]— units and/or a silane or a mixture of different silanes having the formula R′x—SiX4-a or an oligosiloxane obtainable by means of hydrolytic condensation of said silane/said silanes or a mixture of such oligosiloxanes are provided in a solvent and brought in contact with a strongly alkaline medium in such a way that the pH is not below 13 after the addition thereof. In specific embodiments, synthesis in acid is also successful.

摘要翻译： 本发明涉及具有以下特性的聚硅氧烷纳米粒子：10-200nm范围内的平均粒径d50（使用REM记录测定），比表面积Ao为至少50m 2 / g，孔体积为 至少0.2cm 3 / g，平均孔体积d50至少为0.8nm，其中所述颗粒具有含有碳的基团，所述基团至少部分地以未取代或取代的烷基，烯基，芳基，芳烷基 ，或烷基芳基。 可以制备所述聚硅氧烷纳米颗粒，其特征在于，硅氮烷或具有一个或多个 - [Si（R）（R 1）-NR 2] - 单元和/或硅烷或不同的混合物的不同硅氮烷的混合物 具有式R'x-SiX4-a的硅烷或通过所述硅烷/所述硅烷或这种低聚硅氧烷的混合物的水解缩合得到的低聚硅氧烷在溶剂中提供，并以这种方式与强碱性介质接触 加入后pH不低于13。 在具体实施方案中，酸中的合成也是成功的。

公开(公告)号：US20130338309A1

公开(公告)日：2013-12-19

申请号：US13825929

申请日：2011-09-13

申请人： Monika Bauer ,  Sebastian Steffen ,  Daniel Decker ,  Frank Richter

发明人： Monika Bauer ,  Sebastian Steffen ,  Daniel Decker ,  Frank Richter

IPC分类号： C08G63/91 ,  C08K7/06

CPC分类号： C08G63/918 ,  C08K7/06 ,  C08L67/06

摘要： The invention relates to an unsaturated polyester resin containing a polyester or a polyester mixture, produced from at least one unsaturated dicarboxylic acid and at least one diol; and at least one silazane which is accessible for copolymerization with a C═C double bond of the dicarboxylic acid. The invention also relates to an unsaturated polyester resin moulding material which can be obtained or is obtained by cross-linking an unsaturated polyester resin as defined above. Said moulding material can optionally contain reinforcing materials. Said unsaturated polyester resin can be produced using the following steps: (a) a polyester from at least one diol and at least one unsaturated dicarboxylic acid is provided; (b) at least one silazane which is accessible for copolymerization which a C═C double bond of the dicarboxylic acid is provided; (c) the components are mixed according to (a) and (b). The unsaturated polyester resin moulding material can be produced from the above-mentioned polyester resin by hardening thereof by means of a radical initiator.

摘要翻译： 本发明涉及含有由至少一种不饱和二羧酸和至少一种二醇制成的聚酯或聚酯混合物的不饱和聚酯树脂; 和至少一个可与二羧酸的C = C双键共聚的硅氮烷。 本发明还涉及一种不饱和聚酯树脂成型材料，其可以通过交联如上所述的不饱和聚酯树脂获得或获得。 所述模制材料可任选地包含增强材料。 所述不饱和聚酯树脂可以使用以下步骤制备：（a）提供至少一种二醇和至少一种不饱和二羧酸的聚酯; （b）提供二羧酸的C = C双键的至少一种可用于共聚的硅氮烷; （c）根据（a）和（b）将组分混合。 不饱和聚酯树脂成型材料可以通过使用自由基引发剂进行硬化而由上述聚酯树脂制造。

公开(公告)号：US08460670B2

公开(公告)日：2013-06-11

申请号：US13132658

申请日：2009-11-30

申请人： Martin F. Bachmann ,  Monika Bauer ,  Roger Beerli ,  Nicole Schmitz

发明人： Martin F. Bachmann ,  Monika Bauer ,  Roger Beerli ,  Nicole Schmitz

IPC分类号： A61K39/145 ,  C12N5/10

CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to human antibodies, preferably to fully human antibodies, which are specifically binding to influenza M2e antigen. The invention further relates to individual light- and/or heavy chains of such antibodies, to nucleic acids encoding said antibodies or their light- and/or heavy chain, and to expression vectors for the expression of said anti-bodies. Furthermore, the invention relates to the use of said antibodies in the treatment and/or prevention of influenza A virus infection, preferably in humans.

摘要翻译： 本发明涉及与流感M2e抗原特异性结合的人抗体，优选完全人抗体。 本发明还涉及这些抗体的各个轻链和/或重链，编码所述抗体或其轻链和/或重链的核酸，以及用于表达所述抗体的表达载体。 此外，本发明涉及所述抗体在治疗和/或预防甲型流感病毒感染中的应用，优选在人类中。