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公开(公告)号：US06456909B1
公开(公告)日：2002-09-24
申请号：US09651721
申请日：2000-08-30
IPC分类号： B60L700
CPC分类号： B60L7/26 , B60L2200/26 , Y02T10/7258
摘要： To determine the timing of the electrical brake for completely stopping in electrical braking control, and also to achieve both sure stopping and good riding comfort in an electric vehicle powered by the motor by decreasing the braking force at a prescribed rate of change, the torque of the electric motor is controlled by controlling the power converter which powers the motor using a power converter controller. The deceleration of the motor is computed based on the detected speed of the electric motor which is as an output of the speed detection means, the subsequent speed of the electric motor is estimated based on the detected speed and the deceleration rate of the electric motor at the time the detected rotational speed of the electric motor falls below a prescribed speed, and torque control is carried out using an electric power converter controller, based on the estimated speed.
摘要翻译： 为了确定在电制动控制中完全停止的电动制动器的时机，并且通过以规定的变化率减小制动力，也能够实现由电动机驱动的电动车辆的确定停止和良好的乘坐舒适性， 通过控制使用功率转换器控制器为电机供电的功率转换器来控制电动机。 基于作为速度检测装置的输出的电动机的检测速度来计算电动机的减速度，基于电动机的检测速度和减速度来估计电动机的后续速度 电动机的检测转速下降到低于规定速度的时间，并且使用电力转换控制器基于估计速度进行转矩控制。
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公开(公告)号：US06642689B2
公开(公告)日：2003-11-04
申请号：US09956088
申请日：2001-09-20
申请人： Seiji Ishida , Toshiaki Okuyama , Takashi Ogawa , Tetsuo Kojima , Kiyoshi Nakata
发明人： Seiji Ishida , Toshiaki Okuyama , Takashi Ogawa , Tetsuo Kojima , Kiyoshi Nakata
IPC分类号： H02P763
CPC分类号： H02M7/53803 , B60L9/22 , B60L15/025 , B60L2200/26 , H02M7/53871 , Y02T10/643
摘要： Filter capacitor voltage “Ecf1” is detected and then after d-axis voltage correction value “dvd”, q-axis voltage correction value “dvq”, q-axis current correction value “diq”, and frequency correction value “d&ohgr;1” have been computed from the AC components of “Ecf1” and the results have been added to the corresponding d-axis voltage command, q-axis voltage command, q-axis current, and frequency command, the DC current of the power converter is controlled. Thus, the AC components included in the DC current are offset and the AC components are suppressed effectively.
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公开(公告)号：US06633495B2
公开(公告)日：2003-10-14
申请号：US10101529
申请日：2002-03-20
申请人： Seiji Ishda , Toshiaki Okuyama , Tetsuo Kojima , Kiyoshi Nakata , Akira Horie
发明人： Seiji Ishda , Toshiaki Okuyama , Tetsuo Kojima , Kiyoshi Nakata , Akira Horie
IPC分类号： H02M324
CPC分类号： H02M1/143
摘要： The voltage applied to a power converter is detected by a voltage detector, a function generator produces a voltage proportional to this detected voltage, and a high-pass filter detects an AC component superimposed on the voltage. An adder adds a bias voltage to this AC component, and an adder adds the output from the adder and the output from the function generator. The output from the adder is compared with a triangular wave produced from a rectangular wave generator, and a switching element is controlled to make switching operation according to the compared result. When a DC current is decreased by the AC component, a resistance current Ib is increased so that the AC components superimposed on the current and resistance current can be cancelled out.
摘要翻译： 施加到功率转换器的电压由电压检测器检测，功能发生器产生与该检测电压成比例的电压，高通滤波器检测叠加在电压上的AC分量。 加法器向该AC分量加上偏置电压，加法器将来自加法器的输出和来自函数发生器的输出相加。 将来自加法器的输出与由矩形波发生器产生的三角波进行比较，并且根据比较结果控制开关元件进行开关操作。 当直流电流被交流分量降低时，电阻电流Ib增加，从而可以消除叠加在电流和电阻电流上的交流分量。
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4.发明授权公开(公告)号：US06556460B2
公开(公告)日：2003-04-29
申请号：US10212841
申请日：2002-08-07
申请人： Seiji Ishida , Toshiaki Okuyama , Tetsuo Kojima , Kiyoshi Nakata , Akira Horie
发明人： Seiji Ishida , Toshiaki Okuyama , Tetsuo Kojima , Kiyoshi Nakata , Akira Horie
IPC分类号： H02M114
CPC分类号： H02M1/143
摘要： The voltage applied to a power converter is detected by a voltage detector, a function generator produces a voltage proportional to this detected voltage, and a high-pass filter detects an AC component superimposed on the voltage. An adder adds a bias voltage to this AC component, and an adder adds the output from the adder and the output from the function generator. The output from the adder is compared with a triangular wave produced from a rectangular wave generator, and a switching element is controlled to make switching operation according to the compared result. When a DC current is decreased by the AC component, a resistance current Ib is increased so that the AC components superimposed on the current and resistance current can be cancelled out.
摘要翻译： 施加到功率转换器的电压由电压检测器检测，功能发生器产生与该检测电压成比例的电压，高通滤波器检测叠加在电压上的AC分量。 加法器向该AC分量加上偏置电压，加法器将来自加法器的输出和来自函数发生器的输出相加。 将来自加法器的输出与由矩形波发生器产生的三角波进行比较，并且根据比较结果控制开关元件进行开关操作。 当通过AC分量减小DC电流时，电阻电流Ib增加，从而可以消除叠加在电流和电阻电流上的AC分量。
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公开(公告)号：US09334331B2
公开(公告)日：2016-05-10
申请号：US13885421
申请日：2011-11-17
申请人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
发明人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
摘要翻译： 各种双特异性抗体特异性结合血液凝固因子IX /活化血液凝固因子IX和血液凝固因子X，并功能取代血液凝固因子VIII的辅因子功能，即促进凝血因子X活化的功能 活化血液凝固因子IX。 从这些抗体中，成功发现了具有高功能取代凝血因子VIII活性的多特异性抗原结合分子。
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6.发明授权公开(公告)号：US08964414B2
公开(公告)日：2015-02-24
申请号：US13480503
申请日：2012-05-25
CPC分类号： H02M3/33576 , Y02B70/1433
摘要： A DC power supply including a resonant circuit on a secondary side of a transformer suppresses a surge voltage during power recovery of diodes constituting a rectifier circuit, correctly estimates a load current from a secondary current of the transformer, and adjusts supplied power when a load is light. The DC power supply includes a DC voltage source, a converter, a transformer, a rectifier circuit, a resonant circuit composed of a resonant switch and a resonant capacitor, a filter reactor, a filter capacitor, a snubber diode, a snubber capacitor, a load, first and second voltage sensors, a current sensor, and a controller for controlling gate pulses of semiconductor devices constituting a converter and the resonant switch and a signal for adjusting operation timings of A/D converters converting the signals of these sensors.
摘要翻译： 包括变压器次级侧的谐振电路的直流电源在构成整流电路的二极管的功率恢复期间抑制浪涌电压，正确地估计来自变压器的次级电流的负载电流，并且当负载为负载时，调整供电电力 光。 直流电源包括直流电压源，转换器，变压器，整流电路，由谐振开关和谐振电容器组成的谐振电路，滤波电抗器，滤波电容器，缓冲二极管，缓冲电容器，缓冲电容器 负载，第一和第二电压传感器，电流传感器和用于控制构成转换器的半导体器件的门脉冲和谐振开关的控制器，以及用于调整转换这些传感器的信号的A / D转换器的操作定时的信号。
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公开(公告)号：US20140029640A1
公开(公告)日：2014-01-30
申请号：US14110378
申请日：2011-04-08
IPC分类号： H01S3/094
CPC分类号： H01S3/094 , H01S3/025 , H01S3/0405 , H01S3/042 , H01S3/061 , H01S3/07 , H01S3/08054 , H01S3/08072 , H01S3/09408 , H01S3/094084 , H01S3/0941 , H01S3/1022 , H01S3/1611 , H01S3/1643 , H01S5/02415 , H01S5/02438
摘要： In a conventional solid-state laser device, uniformity of an excitation distribution around the axis of a solid-state laser medium is only considered, and symmetry of the excitation distribution in the optical axis direction of the solid-state laser device as a whole is not considered. Therefore, there has been a problem that it is difficult to generate a high-power and high-quality laser beam with high efficiency. In order to solve the problem, in the present invention, excitation modules 51, 52 of an even number is provided, along the optical axis of a solid-state laser beam 18, near the center of a resonator, and semiconductor lasers 21-28 serving as excitation light sources and solid-state laser media 11, 12 provided in the excitation module 51 or in the excitation module 52 are arranged to be symmetrical with respect to a virtual symmetry plane 61 located at a center gap between the excitation modules of the even number.
摘要翻译： 在现有的固态激光装置中，仅考虑固体激光介质轴的激发分布的均匀性，固体激光装置的光轴方向的激发分布的整体的对称性为 不考虑。 因此，存在难以以高效率生成高功率和高质量的激光束的问题。 为了解决这个问题，在本发明中，沿着固体激光束18的光轴，靠近谐振器的中心设置有偶数的激励模块51,52，半导体激光器21-28 用作激发光源的激光模块51或激励模块52中设置的固体激光介质11,12被布置成相对于虚拟对称平面61对称，虚拟对称平面61位于激光模块51的激励模块之间的中心间隙 偶数。
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公开(公告)号：US08562991B2
公开(公告)日：2013-10-22
申请号：US12680087
申请日：2009-09-25
申请人： Tomoyuki Igawa , Shinya Ishii , Atsuhiko Maeda , Mika Sakurai , Tetsuo Kojima , Tatsuhiko Tachibana , Hirotake Shiraiwa , Hiroyuki Tsunoda , Yoshinobu Higuchi
发明人： Tomoyuki Igawa , Shinya Ishii , Atsuhiko Maeda , Mika Sakurai , Tetsuo Kojima , Tatsuhiko Tachibana , Hirotake Shiraiwa , Hiroyuki Tsunoda , Yoshinobu Higuchi
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K39/00 , A61K2039/505 , C07K16/461 , C07K2317/24 , C07K2317/41 , C07K2317/76 , C07K2317/92
摘要： The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.
摘要翻译： 本发明通过改变作为人源化抗IL-6受体IgG1抗体的TOCILIZUMAB的可变区和恒定区的氨基酸序列来提供优于TOCILIZUMAB的第二代分子的药物组合物，以增强抗原 - 中和能力增强，药代动力学改善，治疗效果较差，免疫原性，安全性和物理化学性质（稳定性和均一性）均有改善。 本发明还提供了制备这些药物组合物的方法。 通过适当地组合CDR结构域，可变区和恒定区中的氨基酸序列改变，本发明人成功地生产出优于TOCILIZUMAB的第二代分子。
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公开(公告)号：US20120237517A1
公开(公告)日：2012-09-20
申请号：US13434643
申请日：2012-03-29
IPC分类号： C07K16/36 , A61P7/02 , A61K39/395
CPC分类号： C07K16/36 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/75
摘要： The present inventors produced a variety of bispecific antibodies that specifically bind to both F. IX/F. IXa and F. X, and functionally substitute for F. VIIIa, i.e., have a cofactor function to promote F. X activation via F. IXa. Among these antibodies, the antibody A44/B26 reduced coagulation time by 50 seconds or more as compared to that observed when the antibody was not added. The present inventors produced a commonly shared L chain antibody from this antibody using L chains of A44, and showed that A44L can be used as commonly shared L chains, although the activity of the resulting antibody is reduced compared to the original antibody (A44HL-B26HL). Further, with appropriate CDR shuffling, the present inventors successfully produced highly active multispecific antibodies that functionally substitute for coagulation factor VIII.
摘要翻译： 本发明人生产了特异性结合F.IX / F两种的各种双特异性抗体。 IXa和F.X，并且功能上替代F.CⅧa，即具有辅因子功能以通过F.Ixa促进F.X活化。 在这些抗体中，与未添加抗体时相比，抗体A44 / B26的凝固时间缩短了50秒以上。 本发明人使用A44的L链从该抗体生产共同的L链抗体，并且表明尽管与原始抗体（A44HL-B26HL）相比，所得抗体的活性降低，但A44L可以用作共同的L链 ）。 此外，通过适当的CDR改组，本发明人成功地制备了功能性替代凝血因子VIII的高活性多特异性抗体。
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公开(公告)号：US07936804B2
公开(公告)日：2011-05-03
申请号：US12513176
申请日：2007-12-06
IPC分类号： H01S3/08
CPC分类号： H01S3/08045 , G02F1/353 , G02F1/37 , G02F2001/3503 , G02F2001/3507 , G02F2001/354 , H01S3/08 , H01S3/08072
摘要： Two convex lenses (61, 62), each of which has a focal length “f”, and a 90 degree polarization rotator (5) are interposed between solid-state laser elements (21, 22) of a symmetrical resonator having the two solid-state laser elements (21, 22); a space between the two lenses (61, 62) is made shorter than 2f; and distances between the respective lenses (61, 62) and centers of their adjacent solid-state laser elements (21, 22) are set substantially to “f”, to thus achieve a solid-state laser capable of stably performing high power transverse single mode oscillation desirably having power of 100 W or more. There is acquired a wavelength conversion laser that is further provided with a Q switch (3) and a polarization element (4) and that causes an output fundamental wave laser beam to enter nonlinear elements (91, 92) so as to undergo wavelength conversion, thereby producing a high power harmonic laser beam having a high frequency of; desirably, about 100 kHz.
摘要翻译： 在具有两个固体的对称共振器的固体激光元件（21,22）之间插入两个具有焦距“f”的凸透镜（61,62）和90度偏振旋转器（5） 状态激光元件（21,22）; 使两个透镜（61,62）之间的空间短于2f; 并且各透镜（61,62）与其相邻的固体激光元件（21,22）的中心之间的距离设定为大致为“f”，从而实现能够稳定地执行大功率横向单 期望具有100W或更大的功率的模式振荡。 获得进一步设置有Q开关（3）和偏振元件（4）的波长转换激光器，并且使得输出基波激光束进入非线性元件（91,92）以进行波长转换， 从而产生具有高频率的高功率谐波激光束; 理想地，约100kHz。
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