公开(公告)号：US07521580B1

公开(公告)日：2009-04-21

申请号：US12032955

申请日：2008-02-18

Applicant: Muhammed Majeed ,  Rajinder Kumar Bammi ,  Natarajan Sankaran ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Susmitha Anand ,  Geetha Kanhangad-Gangadharan

Inventor： Muhammed Majeed ,  Rajinder Kumar Bammi ,  Natarajan Sankaran ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Susmitha Anand ,  Geetha Kanhangad-Gangadharan

IPC: C07C49/203 ,  C07C49/215 ,  A61K31/12

CPC classification number: C07C49/248 ,  A61K31/12 ,  C07C45/74

Abstract: Disclosed are novel, synthetic analogues of (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione and the therapeutic applications for cystic fibrosis thereof in correcting altered CFTR trafficking and the associated impaired chloride (Cl−) ion transport. Introduction of branched-alkyl groups ortho to the phenolic groups gave rise to clinical compounds with vastly improved trafficking of delF508CFTR and with no cytotoxicity.

Abstract translation: 公开了（1E，6E）-1,7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮的新型合成类似物，以及用于其改变的囊性纤维化的治疗应用 CFTR贩运和相关的氯化物（Cl - ）离子迁移。 引入酚基团邻位的支链烷基产生临床化合物，其具有大大改善的delF508CFTR的运输并且没有细胞毒性。

公开(公告)号：US07014874B1

公开(公告)日：2006-03-21

申请号：US10605578

申请日：2003-10-09

Applicant: Muhammed Majeed ,  Rajinder Kumar Bammi ,  Vladimir Badmaev ,  Subbalakshmi Prakash ,  Nagabhushanam Kalyanam

Inventor： Muhammed Majeed ,  Rajinder Kumar Bammi ,  Vladimir Badmaev ,  Subbalakshmi Prakash ,  Nagabhushanam Kalyanam

IPC: A61K35/78

CPC classification number: A61K36/8962

Abstract: The invention discloses a method to prepare concentrates from Allium sativum Linn. (Garlic) bulbs naturally enriched with an unique composition of organic selenium compounds and the use of such concentrates in nutritional supplement compositions for human and animal use. The resulting compositions provide a safe and efficacious means of providing supplemental amounts of the essential trace mineral nutrient selenium for diverse health benefits.

Abstract translation: 本发明公开了一种从葱属中制备浓缩物的方法。 （大蒜）灯泡天然富含有机硒化合物的独特组合物，以及这些浓缩物用于人类和动物使用的营养补充剂组合物中的用途。 所得组合物提供了一种安全有效的手段，提供补充量的必需痕量矿物营养硒，以获得不同的健康益处。

公开(公告)号：US08394852B2

公开(公告)日：2013-03-12

申请号：US12872675

申请日：2010-08-31

Applicant: Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Subbalakshmi Prakash

Inventor： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Subbalakshmi Prakash

IPC: A61K31/34

CPC classification number: C07D307/58 ,  A23L31/00 ,  A23L33/10 ,  A61K31/341

Abstract: Optimal compositions of derivatives of 5-methyl-3(2H)-furanone compounds and phenylpropanoid polyketides related to inotilone, that exert biological response modification in health and disease, and their method of preparation, are disclosed. Methods of treating degenerative conditions stemming from over-expression of inducible nitric oxide synthase (iNOS) using these compositions are also disclosed.

Abstract translation: 本发明公开了5-甲基-3（2H） - 呋喃酮化合物和苯丙素类聚酮化合物与艾吐子酮有关的衍生物的最佳组合物，其在健康和疾病中发挥生物反应修饰及其制备方法。 还公开了使用这些组合物治疗由诱导型一氧化氮合酶（iNOS）过表达引起的退行性病症的方法。

公开(公告)号：US07582314B2

公开(公告)日：2009-09-01

申请号：US10710778

申请日：2004-08-02

Applicant: Muhammed Majeed ,  Subbalakshmi Prakash

Inventor： Muhammed Majeed ,  Subbalakshmi Prakash

IPC: A61K36/324 ,  A61K36/00

CPC classification number: A61K31/704 ,  A61K31/198 ,  A61K36/324 ,  A61K2300/00

Abstract: The invention describes compositions and methods for the management of hyperproliferative skin conditions such as psoriasis. The preferential composition contains a natural leukotriene inhibitor selected from Boswellia serrata gum resin, its extractives, isolates or derivatives in combination with a bioavailable organic selenium nutritional supplement. These compositions are administered orally and topically to the individual human or animal in need of treatment at optimal levels to manifest the desired benefits, with no untoward side effects

Abstract translation: 本发明描述了用于治疗过度增生性皮肤病症如牛皮癣的组合物和方法。 优选组合物含有天然白三烯抑制剂，其选自芥子油树胶，其提取物，分离物或衍生物与生物可利用的有机硒营养补充剂组合。 将这些组合物口服和局部给予需要以最佳水平治疗的个体人或动物，以表现出期望的益处，而没有不利的副作用

公开(公告)号：US20080255377A1

公开(公告)日：2008-10-16

申请号：US11733772

申请日：2007-04-11

Applicant: Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivaprskash Kurumanghat Balakrishnan ,  Savita Ganjihal ,  Rajendran Ramanujam ,  Rattan Sood ,  Subbalakshmi Prakash

Inventor： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivaprskash Kurumanghat Balakrishnan ,  Savita Ganjihal ,  Rajendran Ramanujam ,  Rattan Sood ,  Subbalakshmi Prakash

IPC: C07D307/02

CPC classification number: C07D307/22

Abstract: A novel process for the synthesis of (S)-3-Amino-tetrahydrofuran and (R)-3-Amino-tetrahydrofuran is described. The process is applicable for substituted chiral-3-aminotetrahydrofuran derivatives.

Abstract translation: 描述了（S）-3-氨基 - 四氢呋喃和（R）-3-氨基 - 四氢呋喃的合成的新方法。 该方法适用于取代的手性3-氨基四氢呋喃衍生物。

公开(公告)号：US07378442B1

公开(公告)日：2008-05-27

申请号：US11871253

申请日：2007-10-12

Applicant: Muhammed Majeed ,  Kalyanam Nagabushnam ,  Rajendran Ramanujam ,  Subbalakshmi Prakash

Inventor： Muhammed Majeed ,  Kalyanam Nagabushnam ,  Rajendran Ramanujam ,  Subbalakshmi Prakash

IPC: A61K31/315 ,  A61K31/121

CPC classification number: A61K47/554

Abstract: The invention relates to methods of treatment and pharmaceutical compositions of new chemical compounds that inhibit the various enzymes in the arachidonic acid pathway implicated in inflammatory disease conditions.

Abstract translation: 本发明涉及抑制涉及炎性疾病病症的花生四烯酸途径中的各种酶的新化合物的治疗方法和药物组合物。

公开(公告)号：US07160562B2

公开(公告)日：2007-01-09

申请号：US10709726

申请日：2004-05-25

Applicant: Muhammed Majeed ,  Subbalakshmi Prakash ,  Shipra Roy ,  Venu Agarwal

Inventor： Muhammed Majeed ,  Subbalakshmi Prakash ,  Shipra Roy ,  Venu Agarwal

IPC: A16K36/00

CPC classification number: A61K36/185 ,  A61K36/48 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention describes compositions and methods containing nonconventional plant materials, and more particularly the species Flemingia macrophylla and Careya arborea, that help to maintain normal blood sugar levels in humans and animals. The method of preparation of such compositions and methods of quantifying active principles therein are also described. A Metformin-like compound were found to be the active hypoglycemic principle in Flemingia macrophylla and Careya arborea root bark. The compositions of the invention were found to be safe for therapeutic use.

Abstract translation: 本发明描述了含有非常规植物材料的组合物和方法，特别是有助于维持人和动物中正常血糖水平的物种Flemingia macrophylla和Careya arborea。 还描述了制备这种组合物的方法和量化其中的活性成分的方法。 发现二甲双胍类化合物在弗莱明亚大叶和桂树根皮中是活性低血糖原理。 发现本发明的组合物对于治疗用途是安全的。

公开(公告)号：US20060240126A1

公开(公告)日：2006-10-26

申请号：US11164787

申请日：2005-12-06

Applicant: Muhammed Majeed ,  Rajinder Bammi ,  Vladimir Badmaev ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam

Inventor： Muhammed Majeed ,  Rajinder Bammi ,  Vladimir Badmaev ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam

IPC: A61K36/8962 ,  A61K33/04

CPC classification number: A61K31/197 ,  A61K31/198 ,  A61K33/04 ,  A61K36/8962 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention discloses selenium enriched garlic compositions that are a safe and efficacious means of providing supplemental amounts of the essential trace mineral nutrient selenium, to humans and animals.

Abstract translation: 本发明公开了富硒大蒜组合物，其是向人类和动物提供补充量的必需痕量矿物质营养硒的安全有效手段。

公开(公告)号：US20060003035A1

公开(公告)日：2006-01-05

申请号：US10709726

申请日：2004-05-25

Applicant: Muhammed Majeed ,  Subbalakshmi Prakash ,  Shipra Roy ,  Venu Agarwal

Inventor： Muhammed Majeed ,  Subbalakshmi Prakash ,  Shipra Roy ,  Venu Agarwal

IPC: A61K35/78

CPC classification number: A61K36/185 ,  A61K36/48 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention describes compositions and methods containing nonconventional plant materials, and more particularly the species Flemingia macrophylla and Careya arborea, that help to maintain normal blood sugar levels in humans and animals. The method of preparation of such compositions and methods of quantifying active principles therein are also described. A Metformin-like compound were found to be the active hypoglycemic principle in Flemingia macrophylla and Careya arborea root bark. The compositions of the invention were found to be safe for therapeutic use.

Abstract translation: 本发明描述了含有非常规植物材料的组合物和方法，特别是有助于维持人和动物中正常血糖水平的物种Flemingia macrophylla和Careya arborea。 还描述了制备这种组合物的方法和量化其中的活性成分的方法。 发现二甲双胍类化合物在弗莱明亚大叶和桂树根皮中是活性低血糖原理。 发现本发明的组合物对于治疗用途是安全的。

公开(公告)号：US20050284812A1

公开(公告)日：2005-12-29

申请号：US11215040

申请日：2005-08-31

Applicant: Muhammed Majeed ,  Arvind Kumar ,  Kalyanam Nagabhushanam ,  Subbalakshmi Prakash

Inventor： Muhammed Majeed ,  Arvind Kumar ,  Kalyanam Nagabhushanam ,  Subbalakshmi Prakash

IPC: A23L1/30 ,  A61K9/00 ,  A61K31/352 ,  A61K45/06 ,  A61K47/40 ,  C07D311/92 ,  B01D11/04

CPC classification number: A61K9/0014 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0019 ,  A61K31/352 ,  A61K45/06 ,  A61K47/40 ,  C07D311/92 ,  Y10S514/909 ,  Y10S514/913 ,  A61K2300/00 ,  A23V2250/21 ,  A23V2250/5112

Abstract: Aqueous solutions of diterpenes such as Forskolin, its congeners, analogs and derivatives, up to approximately 6% concentration, are prepared using suitably substituted cyclodextrin as a solubilizing agents. In the absence of cyclodextrin, some diterpenes such as Forskolin are soluble in water only to concentrations of about 0.001%. Such aqueous solutions find applications in topical and systemic use, as pharmaceutical, cosmeceutical, nutraceutical preparations containing diterpenes such as Forskolin and congeners.