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    Dimensionally stable and growth controlled inflatable member for a catheter
    1.
    发明授权
    Dimensionally stable and growth controlled inflatable member for a catheter 有权
    用于导管的尺寸稳定和生长控制的可充气构件

    公开(公告)号：US06875197B1

    公开(公告)日：2005-04-05

    申请号：US09713384

    申请日：2000-11-14

    Applicant: Murthy V. Simhambhatla ,  Robert P. Saltman

    Inventor： Murthy V. Simhambhatla ,  Robert P. Saltman

    IPC: A61F2/958 ,  A61M25/00 ,  A61M29/00 ,  A61M29/02 ,  A61M31/00 ,  A61M37/00

    CPC classification number: A61L29/06 ,  A61M25/1006 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1086 ,  A61M2025/1088

    Abstract: A dimensionally stable and growth controlled inflatable member formed by adding a multifunctional agent to a soft polymer to form a compound, extruding an inflatable member from the compound, and crosslinking the compound. The inflatable member is configured to be formed-in-place with a body lumen. Preferably, the inflatable member is blown to a working diameter prior to use and then heated to the glass transition temperature of the polymer to shrink the diameter of the blown inflatable member back to about the nominal diameter of the tubing. In another embodiment, the invention is a dimensionally stable and growth controlled inflatable member comprising longitudinal zones of crosslinked material symmetrically spaced about the circumference of the inflatable member and a uniform working diameter. Preferably, there are three or more longitudinal zones that run the working length of the inflatable member. The selectively irradiated inflatable members are formed in a mold having symmetrically spaced longitudinal windows.

    Abstract translation: 通过向软质聚合物中添加多官能剂以形成化合物，从化合物挤出可膨胀构件，并使化合物交联而形成尺寸稳定和生长控制的可膨胀构件。 可膨胀构件构造成与体腔成形就位。 优选地，可充气构件在使用之前被吹送到工作直径，然后被加热到聚合物的玻璃化转变温度，以将吹制的可充气构件的直径收缩回到管道的公称直径。 在另一个实施方案中，本发明是尺寸稳定和生长控制的可膨胀构件，其包括围绕可膨胀构件的圆周对称地间隔的交联材料的纵向区域和均匀的加工直径。 优选地，存在延伸可膨胀构件的工作长度的三个或更多个纵向区域。 选择性照射的充气构件形成在具有对称间隔的纵向窗口的模具中。

    Process of making a balloon for an intraluminal catheter
    2.
    发明授权
    Process of making a balloon for an intraluminal catheter 有权
    制作腔内导管球囊的工艺

    公开(公告)号：US06761786B2

    公开(公告)日：2004-07-13

    申请号：US10165916

    申请日：2002-06-10

    Applicant: Murthy V. Simhambhatla ,  Robert D. Ainsworth ,  Robert P. Saltman

    Inventor： Murthy V. Simhambhatla ,  Robert D. Ainsworth ,  Robert P. Saltman

    IPC: B29C4788

    CPC classification number: A61L27/16 ,  A61L29/041 ,  C08L23/06 ,  C08L2207/068 ,  Y10T156/1038 ,  Y10T428/139

    Abstract: Medical devices such as catheter balloons, stent covers and vascular grafts formed of ultrahigh molecular weight polyethylene. The devices are formed from polyethylene that has been processed so that it is microporous and has an oriented node and fibril structure. The balloons expand compliantly at low strains and are substantially less compliant at higher strains. The invention also comprises methods for making such balloons, including the steps of compacting a polyethylene powder and deforming it to impart the oriented structure.

    Abstract translation: 诸如导管球囊，支架盖和由超高分子量聚乙烯形成的血管移植物的医疗装置。 这些装置由聚乙烯形成，其已经被处理以使其是微孔的并且具有定向的节点和原纤维结构。 气球在低应变下柔顺扩张，并且在较高应变下基本上较不顺应。 本发明还包括制造这种气球的方法，包括压制聚乙烯粉末并变形以赋予定向结构的步骤。

    Process of making polymer articles
    5.
    发明授权
    Process of making polymer articles 有权
    制造聚合物制品的方法

    公开(公告)号：US06780361B1

    公开(公告)日：2004-08-24

    申请号：US10174073

    申请日：2002-06-17

    Applicant: Srinivasan Sridharan ,  Murthy V. Simhambhatla

    Inventor： Srinivasan Sridharan ,  Murthy V. Simhambhatla

    IPC: B29C5504

    CPC classification number: B29D7/01 ,  A61L27/16 ,  A61L27/507 ,  A61L27/56 ,  A61L29/041 ,  B29C55/005 ,  B29C55/065 ,  B29K2023/0683 ,  B29K2105/0061 ,  Y10T428/1352 ,  Y10T428/1372 ,  C08L23/06

    Abstract: A method including forming a pseudo-gel of a semi-crystalline polymer material and a solvent. The pseudo-gel is shaped into a first form and stretched. A portion of the solvent is removed to create a second form. The second form is stretched into a microstructure including nodes interconnected by fibrils. A method including forming a first form of a pseudo-gel including an ultra-high molecular weight polyethylene material and a solvent; stretching the first form; removing the solvent to form a second form; stretching the second form into a microstructure including nodes interconnected by fibrils; and annealing the stretched second form. An apparatus including a body portion formed of a dimension suitable for a medical device application and including a polyolefin polymer including a node and a fibril microstructure. An apparatus including a body portion including an ultra-high molecular weight polyolefin material including a node and a fibril microstructure.

    Abstract translation: 一种包括形成半结晶聚合物材料和溶剂的假凝胶的方法。 假凝胶成型为第一种形式并拉伸。 除去一部分溶剂以产生第二种形式。 第二种形式被拉伸成包括由原纤维相互连接的节点的微结构。 一种包括形成包含超高分子量聚乙烯材料和溶剂的第一种形式的假凝胶的方法; 拉伸第一种形式; 除去溶剂以形成第二种形式; 将第二形式拉伸成包括通过纤维互连的节点的微结构; 并退火拉伸的第二种形式。 一种装置，包括由适于医疗装置应用的尺寸形成的主体部分，并且包括包含节点和原纤维微结构的聚烯烃聚合物。 一种包括主体部分的装置，其包括包含节点和原纤维微结构的超高分子量聚烯烃材料。

    Process of making polymer articles
    6.
    发明授权
    Process of making polymer articles 有权
    制造聚合物制品的方法

    公开(公告)号：US06743388B2

    公开(公告)日：2004-06-01

    申请号：US10038816

    申请日：2001-12-31

    Applicant: Srinivasan Sridharan ,  Murthy V. Simhambhatla

    Inventor： Srinivasan Sridharan ,  Murthy V. Simhambhatla

    IPC: B29C5504

    CPC classification number: B29D7/01 ,  A61L27/16 ,  A61L27/507 ,  A61L27/56 ,  A61L29/041 ,  B29C55/005 ,  B29C55/065 ,  B29K2023/0683 ,  B29K2105/0061 ,  Y10T428/1352 ,  Y10T428/1372 ,  C08L23/06

    Abstract: A method including forming a semi-crystalline polymer material into a lamella; and stretching the lamella into a polymer including a node of folded lamella and a fibril orientation. A method including extruding a pseudo-gel including an ultrahigh molecular weight polyethylene material into a lamella; stretching the lamella into a polymer including a node of folded lamella and a fibril orientation; and annealing the polymer at a temperature sufficient to define the node and fibril orientation. An apparatus including a body portion formed of a dimension suitable for a medical device application and including a semi-crystalline polymer arrayed in a node of folded lamella and a fibril orientation. An apparatus including a body portion including an ultra-high molecular polyethylene material arrayed in a node of folded lamella and a fibril orientation.

    Abstract translation: 一种包括将半结晶聚合物材料形成薄片的方法; 并将薄片拉伸成包括折叠薄片的节点和原纤取向的聚合物。 一种包括将包含超高分子量聚乙烯材料的假凝胶挤出到薄片中的方法; 将薄片拉伸成包括折叠薄片的节点和原纤取向的聚合物; 并在足以限定节点和原纤取向的温度下退火聚合物。 一种装置，包括由适于医疗装置应用的尺寸形成的主体部分，并且包括排列在折叠薄片的节点和原纤取向中的半结晶聚合物。 一种装置，包括主体部分，其包括排列在折叠薄片的节点中的超高分子量聚乙烯材料和原纤取向。

    Medical device formed of ultrahigh molecular weight polyolefin
    8.
    发明授权
    Medical device formed of ultrahigh molecular weight polyolefin 有权
    由超高分子量聚烯烃形成的医疗器械

    公开(公告)号：US06602224B1

    公开(公告)日：2003-08-05

    申请号：US09713642

    申请日：2000-11-14

    Applicant: Murthy V. Simhambhatla

    Inventor： Murthy V. Simhambhatla

    IPC: A61M2900

    CPC classification number: A61L27/16 ,  A61L29/041 ,  C08L23/06 ,  C08L2207/068 ,  Y10T156/1038 ,  Y10T428/1352 ,  Y10T428/139

    Abstract: Medical devices having at least a component, such as a catheter balloon, stent cover and vascular graft, formed of ultrahigh molecular weight polyolefin, such as ultrahigh molecular weight polyethylene. The device component is formed from ultrahigh molecular weight polyethylene that has been processed so that it is microporous and has an oriented node and fibril structure. The device component expands compliantly at low strains and are substantially less compliant at higher strains. The invention also comprises methods for making such medical devices, including the steps of compacting a polyethylene powder and deforming it to impart the oriented structure.

    Abstract translation: 至少具有由超高分子量聚烯烃（例如超高分子量聚乙烯）形成的至少一种成分的医疗装置，例如导管球囊，支架盖和血管移植物。 该器件组件由超高分子量聚乙烯形成，该聚乙烯已被加工成微孔并具有取向的节点和原纤维结构。 器件部件在低应变下易于扩展，并且在较高应变下基本不太顺应。 本发明还包括制造这种医疗装置的方法，包括压制聚乙烯粉末并变形以赋予定向结构的步骤。

    High pressure catheter balloon
    9.
    发明授权
    High pressure catheter balloon 有权
    高压导管气囊

    公开(公告)号：US06336936B2

    公开(公告)日：2002-01-08

    申请号：US09880983

    申请日：2001-06-13

    Applicant: Murthy V. Simhambhatla ,  Venu Ghanta ,  Timoteo Tomas

    Inventor： Murthy V. Simhambhatla ,  Venu Ghanta ,  Timoteo Tomas

    IPC: A61F206

    CPC classification number: B29C49/18 ,  A61L29/06 ,  A61L29/14 ,  A61M25/1029 ,  B29C49/6481 ,  B29C2049/0089 ,  B29K2105/258 ,  B29L2022/022 ,  B29L2031/7542 ,  C08L67/02

    Abstract: A balloon formed of a single layer of polybutylene terephthalate and polytetramethylene ether glycol terephthalate copolymer in a substantially unblended form. The copolymer has a flexural modulus of greater than about 150,000 psi. The presently preferred copolymer is Hytrel® 8238 by DuPont. The balloon of the invention would be substantially unblended, defined as greater than about 60% by weight to about 100% by weight of the copolymer. The balloon is formed in a series of molds. The balloon of the invention exhibits high rupture pressure and low compliance coupled with good lesion cross and recross ability.

    Abstract translation: 由单层聚对苯二甲酸丁二醇酯和聚四亚甲基醚二醇对苯二甲酸乙二醇酯共聚物形成的气囊，基本上是非混合形式。 共聚物的挠曲模量大于约150,000psi。 目前优选的共聚物是DuPont的Hytrel 8238。 本发明的气囊将基本上未共混，定义为大于约60重量％至约100重量％的共聚物。 气球形成一系列模具。 本发明的气囊显示出高的破裂压力和低顺应性，同时具有良好的病变交叉和回交能力。

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