公开(公告)号：US20030054515A1

公开(公告)日：2003-03-20

申请号：US10024595

申请日：2001-12-21

Applicant: MYRIAD GENETICS, INC.

Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

IPC: G01N033/53 ,  C12N009/00 ,  C07K016/40 ,  C12Q001/68

CPC classification number: G01N33/68 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2267/03 ,  C07K14/4711 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/74 ,  G01N2500/02

Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

公开(公告)号：US20030068630A1

公开(公告)日：2003-04-10

申请号：US10105959

申请日：2002-03-21

Applicant: Myriad Genetics, Inc.

Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

IPC: C12Q001/68 ,  G01N033/53 ,  C12N009/00 ,  C07K016/40

CPC classification number: C07K14/721 ,  A01K2217/05 ,  C07K14/4705 ,  C07K2319/00

Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

公开(公告)号：US20030055219A1

公开(公告)日：2003-03-20

申请号：US10014799

申请日：2001-12-14

Applicant: MYRIAD GENETICS, INC.

Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

IPC: C07K014/435 ,  G01N033/53

CPC classification number: G01N33/6893 ,  G01N2500/00

Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

公开(公告)号：US20020197626A1

公开(公告)日：2002-12-26

申请号：US10098192

申请日：2002-03-15

Applicant: Myriad Genetics, Inc.

Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

IPC: C12Q001/68 ,  G01N033/53 ,  C12N009/00 ,  C07K016/40

CPC classification number: C07K14/4702 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705

Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

公开(公告)号：US20020165352A1

公开(公告)日：2002-11-07

申请号：US10024599

申请日：2001-12-21

Applicant: MYRIAD GENETICS, INC.

Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

IPC: C07K001/00 ,  C07K014/00 ,  C07K017/00

CPC classification number: C12N15/1055 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2267/03 ,  A01K2267/0331 ,  C07K14/4711 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57415 ,  G01N2500/02

Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitis (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

Abstract translation: 本发明涉及涉及哺乳动物生理学途径（包括生理疾病或疾病）的新蛋白质 - 蛋白质相互作用的发现。 生理疾病和疾病的实例包括非胰岛素依赖性糖尿病（NIDDM），神经变性疾病如阿尔茨海默病（AD）等。 因此，本发明涉及这些蛋白质和/或其片段的复合物，复合物的抗体，生理生成障碍的诊断（包括诊断易感和诊断病症存在的诊断），药物筛选 调节本文所述蛋白质的相互作用，以及鉴定本文所述蛋白质共有的途径中的其它蛋白质。

公开(公告)号：US20030064408A1

公开(公告)日：2003-04-03

申请号：US10035343

申请日：2002-01-04

Applicant: MYRIAD GENETICS, INC.

Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

IPC: G01N033/53 ,  G01N033/537 ,  G01N033/543 ,  C12N009/12 ,  C07K016/40

CPC classification number: C12N9/1205 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47

Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

公开(公告)号：US20020164647A1

公开(公告)日：2002-11-07

申请号：US10035344

申请日：2002-01-04

Applicant: MYRIAD GENETICS, INC.

Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

IPC: G01N033/53

CPC classification number: C12N9/1085 ,  C07K2319/00 ,  C12N9/1205 ,  C12N15/1055 ,  C12Y205/01029 ,  C12Y207/01037

Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

公开(公告)号：US20030032058A1

公开(公告)日：2003-02-13

申请号：US10014814

申请日：2001-12-14

Applicant: MYRIAD GENETICS, INC.

Inventor： Daniel M. Cimbora ,  Karen Heichman ,  Paul L. Bartel

IPC: G01N033/53 ,  G01N033/569

CPC classification number: C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00

Abstract: The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.