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1.发明申请公开(公告)号：US20180223267A1
公开(公告)日：2018-08-09
申请号：US15877980
申请日：2018-01-23
申请人： Promega Corporation
发明人： Aldis Darzins , Lance P. Encell , Rachel Friedman Ohana , Paul Otto , Michael R. Slater , Gediminas Vidugiris , Keith V. Wood , Monika G. Wood , Kate Qin Zhao , Kris Zimmerman
CPC分类号： C12N9/14 , C12N9/96 , C12N11/00 , C12Q1/34 , C12Y308/01 , G01N33/581
摘要： The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.
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2.发明授权Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression 有权编码突变体水解酶蛋白的多核苷酸具有增强的动力学和功能表达公开(公告)号：US08748148B2
公开(公告)日：2014-06-10
申请号：US13863924
申请日：2013-04-16
申请人： Promega Corporation
发明人： Aldis Darzins , Lance P. Encell , Rachel Friedman Ohana , Paul Otto , Gediminas Vidugiris , Keith V. Wood , Monika G. Wood , Kris Zimmerman , Michael R. Slater , Kate Qin Zhao
CPC分类号： C12N9/14 , C12N9/96 , C12N11/00 , C12Q1/34 , C12Y308/01 , G01N33/581
摘要： The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.
摘要翻译： 本发明提供具有增强的动力学和功能表达的突变水解酶蛋白质，以及编码突变蛋白质的多核苷酸以及使用多核苷酸和突变蛋白质的方法。
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3.发明授权Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression 有权编码突变体水解酶蛋白的多核苷酸具有增强的动力学和功能表达公开(公告)号：US09593316B2
公开(公告)日：2017-03-14
申请号：US14285327
申请日：2014-05-22
申请人： Promega Corporation
发明人： Aldis Darzins , Lance P. Encell , Rachel Friedman Ohana , Paul Otto , Michael R. Slater , Gediminas Vidugiris , Keith V. Wood , Monika G. Wood , Kate Qin Zhao , Kris Zimmerman
CPC分类号： C12N9/14 , C12N9/96 , C12N11/00 , C12Q1/34 , C12Y308/01 , G01N33/581
摘要： The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.
摘要翻译： 本发明提供具有增强的动力学和功能表达的突变水解酶蛋白，以及编码突变蛋白的多核苷酸以及使用多核苷酸和突变蛋白的方法。
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4.发明申请公开(公告)号：US20080145882A1
公开(公告)日：2008-06-19
申请号：US11978950
申请日：2007-10-30
申请人： Aldis Darzins , Lance P. Encell , Rachel Friedman Ohana , Paul Otto , Gediminas Vidugiris , Keith V. Wood , Monika G. Wood , Kris Zimmerman , Michael R. Slater , Kate Qin Zhao
发明人： Aldis Darzins , Lance P. Encell , Rachel Friedman Ohana , Paul Otto , Gediminas Vidugiris , Keith V. Wood , Monika G. Wood , Kris Zimmerman , Michael R. Slater , Kate Qin Zhao
CPC分类号： C12N9/14 , C12N9/96 , C12N11/00 , C12Q1/34 , C12Y308/01 , G01N33/581
摘要： The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.
摘要翻译： 本发明提供具有增强的动力学和功能表达的突变水解酶蛋白，以及编码突变蛋白的多核苷酸以及使用多核苷酸和突变蛋白的方法。
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公开(公告)号：US20240132859A1
公开(公告)日：2024-04-25
申请号：US18312441
申请日：2023-05-04
申请人： Promega Corporation
发明人： Michael P. Killoran , Lance P. Encell , Thomas Kirkland , Thomas Machleidt , Rachel Friedman Ohana , Robin Hurst , Mark A. Klein , Karilyn Porter , Rahele Esmatpour , Debayan De Bakshi
IPC分类号： C12N9/14
CPC分类号： C12N9/14 , C12Y308/01
摘要： Provided herein modified dehalogenases have extended surface loop regions that provide a location for internal fusion insertions and modulate binding interaction and activation of environmentally-sensitive chemistries.
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6.发明申请公开(公告)号：US20170137793A1
公开(公告)日：2017-05-18
申请号：US15414291
申请日：2017-01-24
申请人： Promega Corporation
发明人： Aldis Darzins , Lance P. Encell , Rachel Friedman Ohana , Paul Otto , Michael R. Slater , Gediminas Vidugiris , Keith V. Wood , Monika G. Wood , Kate Qin Zhao , Kris Zimmerman
CPC分类号： C12N9/14 , C12N9/96 , C12N11/00 , C12Q1/34 , C12Y308/01 , G01N33/581
摘要： The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.
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公开(公告)号：US20160115492A1
公开(公告)日：2016-04-28
申请号：US14759878
申请日：2014-01-06
申请人： NOVOGY, INC.
发明人： Colin R. South , Arthur J. Shaw, IV
CPC分类号： C12N15/815 , C12N1/20 , C12N9/14 , C12N9/88 , C12N15/70 , C12N15/81 , C12P3/00 , C12Y308/01 , C12Y402/01069
摘要： Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical nitrogen sources, such as melamine and cyanamide. Fermentation methods using the genetically engineered organisms are also described. The methods of the invention are robust processes for the industrial bioproduction of a variety of compounds, including commodities, fine chemicals, and pharmaceuticals.
摘要翻译： 公开了具有代谢非典型氮源的能力的基因工程生物，如酵母和细菌，如三聚氰胺和氨腈。 还描述了使用遗传工程生物的发酵方法。 本发明的方法是用于各种化合物（包括商品，精细化学品和药物）的工业生物生产的可靠工艺。
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公开(公告)号：US20180051294A1
公开(公告)日：2018-02-22
申请号：US15679312
申请日：2017-08-17
申请人： Novogy, Inc.
发明人： Colin South , Arthur J Shaw, IV
CPC分类号： C12N15/815 , C12N1/20 , C12N9/14 , C12N9/88 , C12N15/70 , C12N15/81 , C12P3/00 , C12Y308/01 , C12Y402/01069
摘要： Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical nitrogen sources, such as melamine and cyanamide. Fermentation methods using the genetically engineered organisms are also described. The methods of the invention are robust processes for the industrial bioproduction of a variety of compounds, including commodities, fine chemicals, and pharmaceuticals.
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公开(公告)号：US09873866B2
公开(公告)日：2018-01-23
申请号：US15414291
申请日：2017-01-24
申请人： Promega Corporation
发明人： Aldis Darzins , Lance P. Encell , Rachel Friedman Ohana , Paul Otto , Michael R. Slater , Gediminas Vidugiris , Keith V. Wood , Monika G. Wood , Kate Qin Zhao , Kris Zimmerman
CPC分类号： C12N9/14 , C12N9/96 , C12N11/00 , C12Q1/34 , C12Y308/01 , G01N33/581
摘要： The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.
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公开(公告)号：US09765348B2
公开(公告)日：2017-09-19
申请号：US14759878
申请日：2014-01-06
申请人： Novogy, Inc.
发明人： Colin R. South , Arthur J. Shaw, IV
CPC分类号： C12N15/815 , C12N1/20 , C12N9/14 , C12N9/88 , C12N15/70 , C12N15/81 , C12P3/00 , C12Y308/01 , C12Y402/01069
摘要： Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical nitrogen sources, such as melamine and cyanamide. Fermentation methods using the genetically engineered organisms are also described. The methods of the invention are robust processes for the industrial bioproduction of a variety of compounds, including commodities, fine chemicals, and pharmaceuticals.
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