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    Devices and methods for improved placement of implantable medical devices
    1.
    发明授权
    Devices and methods for improved placement of implantable medical devices 有权
    用于改善植入式医疗装置的放置的装置和方法

    公开(公告)号：US09199082B1

    公开(公告)日：2015-12-01

    申请号：US13560945

    申请日：2012-07-27

    申请人： Nadim Yared ,  Robert S. Kieval ,  Adam Cates

    发明人： Nadim Yared ,  Robert S. Kieval ,  Adam Cates

    IPC分类号： A61B5/05 ,  A61N1/36 ,  A61N1/05

    CPC分类号： A61N1/36117 ,  A61N1/05 ,  A61N1/36114

    摘要： Devices and methods are provided for selecting a location to implant an electrode as part of a baroreflex activation therapy system. Images of a target blood vessel may be obtained with an imaging device, and the image used as part of or in conjunction with a patient-response-mapping procedure to determine a favorable location on the blood vessel to implant the electrode. Alternately, temperature measurements may be taken of a target vessel and utilized as part of or in conjunction with a patient-response-mapping procedure to determine a favorable location on the blood vessel to implant the electrode.

    摘要翻译： 提供了用于选择植入电极的位置作为压力反射激活治疗系统的一部分的装置和方法。 可以用成像装置获得目标血管的图像，并且将图像用作患者 - 响应 - 映射程序的一部分或与患者 - 应答 - 映射程序结合，以确定在血管上植入电极的有利位置。 或者，可以对目标血管进行温度测量，并且作为患者 - 应答 - 映射程序的一部分或结合使用，以确定在血管上植入电极的有利位置。

    Electrode array structures and methods of use for cardiovascular reflex control
    2.
    发明授权
    Electrode array structures and methods of use for cardiovascular reflex control 有权
    用于心血管反射控制的电极阵列结构和使用方法

    公开(公告)号：US08620422B2

    公开(公告)日：2013-12-31

    申请号：US11862508

    申请日：2007-09-27

    申请人： Robert S. Kieval ,  Martin Rossing ,  Adam Cates ,  Alejandro Covalin

    发明人： Robert S. Kieval ,  Martin Rossing ,  Adam Cates ,  Alejandro Covalin

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0551 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117

    摘要： A tissue stimulation device includes an electrode array having at least four independently switchable electrodes. In one embodiment, the electrode array comprises a flexible base to which the electrodes are fixed that flexes to encompass at least a portion of an artery or other elongate biological structure. The electrodes are electrically coupled to and energized by a signal generator coupled to a control system. In one embodiment, the array of electrodes are configured such that a suitable signal pattern for stimulation pulses between or among a set of the switchable electrodes may be determined without having to reposition the electrode assembly by using a series of signal patterns activating different combinations of switchable electrodes in response to sub-stimulation test signals to determine a signal pattern that provides suitable patient response. In another embodiment, the array of electrodes includes an array of selectively activatable multi-polar electrodes.

    摘要翻译： 组织刺激装置包括具有至少四个可独立切换的电极的电极阵列。 在一个实施例中，电极阵列包括柔性基座，电极被固定到柔性基座上，该电极弯曲以包围动脉或其他细长生物结构的至少一部分。 电极电耦合到耦合到控制系统的信号发生器并由其激励。 在一个实施例中，电极阵列被配置为使得可以确定用于在一组可切换电极之间或之间进行刺激脉冲的合适信号图案，而不必通过使用一系列信号图案来激活电极组件，所述信号图案激活不同的可切换组合 电极响应亚刺激测试信号以确定提供合适的患者反应的信号图案。 在另一个实施例中，电极阵列包括可选择性激活的多极电极的阵列。

    Implantable medical device minimizing rotation and dislocation
    3.
    发明申请
    Implantable medical device minimizing rotation and dislocation 审中-公开
    植入式医疗器械减少旋转和脱位

    公开(公告)号：US20070123923A1

    公开(公告)日：2007-05-31

    申请号：US11290355

    申请日：2005-11-30

    申请人： Curtis Lindstrom ,  Ronald Heil ,  Jason Shiroff ,  Paul Haefner ,  Adam Cates ,  Darrell Wagner

    发明人： Curtis Lindstrom ,  Ronald Heil ,  Jason Shiroff ,  Paul Haefner ,  Adam Cates ,  Darrell Wagner

    IPC分类号： A61N1/375 ,  A61F2/04

    CPC分类号： A61F2/0095 ,  A61N1/375

    摘要： Housings for implantable medical devices are configured so as to engage with surrounding tissues inside of a body and resist both rotation in place and movement through the body. Device housings include shapes, surface features, and/or standard surfaces and may include attached implements that engage the surrounding tissue. Shapes include elongated members, flared ends, and so forth. Surface features include pores, grooves, through-holes, and so forth. Attached implements include needles, barbs, tension springs, and so forth. Also provided are methods for engaging an implantable medical device with surrounding tissues.

    摘要翻译： 用于可植入医疗装置的壳体构造成与身体内的周围组织接合并抵抗适当位置的旋转和穿过身体的运动。 设备外壳包括形状，表面特征和/或标准表面，并且可以包括接合周围组织的附接工具。 形状包括细长构件，扩口端等。 表面特征包括孔，槽，通孔等。 附件包括针，倒钩，拉伸弹簧等。 还提供了用于使可植入医疗装置与周围组织接合的方法。

    Implant tool and improved electrode design for minimally invasive procedure
    6.
    发明授权
    Implant tool and improved electrode design for minimally invasive procedure 有权
    植入物工具和改进的电极设计用于微创手术

    公开(公告)号：US08788066B2

    公开(公告)日：2014-07-22

    申请号：US13540218

    申请日：2012-07-02

    申请人： Adam Cates ,  Eric Lovett ,  Loren Murney ,  Kip Ludwig ,  Paul Pignato ,  Brian Soltis

    发明人： Adam Cates ,  Eric Lovett ,  Loren Murney ,  Kip Ludwig ,  Paul Pignato ,  Brian Soltis

    IPC分类号： A61N1/18 ,  A61N1/05 ,  A61N1/36

    CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/36157 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36182

    摘要： Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. An implantable baroreflex activation system includes a control system having an implantable housing, an electrical lead, attachable to the control system, and an electrode structure. The electrode structure is near one end of the electrical lead, and includes a monopolar electrode, a backing material having an effective surface area larger than the electrode, and a releasable pivotable interface to mate with an implant tool. The electrode is configured for implantation on an outer surface of a blood vessel and the control system is programmed to deliver a baroreflex therapy via the monopolar electrode to a baroreceptor within a wall of the blood vessel.

    摘要翻译： 用于引入和植入电极作为微创技术的一部分的装置和方法。 可植入压力反射激活系统包括具有可植入壳体，可引导到控制系统的电引线和电极结构的控制系统。 电极结构靠近电引线的一端，并且包括单极电极，具有大于电极的有效表面积的背衬材料以及与植入工具配合的可释放的可枢转接口。 电极被配置为植入在血管的外表面上，并且控制系统被编程为通过单极电极将压力反射治疗递送到血管壁内的压力感受器。

    METHOD AND APPARATUS FOR PREVENTING CARDIAC ARRHYTHMIAS WITH ENDOVASCULAR STIMULATION
    7.
    发明申请
    METHOD AND APPARATUS FOR PREVENTING CARDIAC ARRHYTHMIAS WITH ENDOVASCULAR STIMULATION 有权
    用于预防内分泌刺激性心脏病的方法和装置

    公开(公告)号：US20070129763A1

    公开(公告)日：2007-06-07

    申请号：US11549704

    申请日：2006-10-16

    申请人： Adam Cates

    发明人： Adam Cates

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36114 ,  A61N1/3962

    摘要： Certain cardiac arrhythmias can be prevented by appropriate electrical stimulation of autonomic nerves innervating the heart. An implantable cardiac rhythm management device is configured to deliver such stimulation when an autonomic imbalance is predicted to be present via an endovascular electrode. Autonomic imbalance may be predicted to be present based upon circadian rhythms, detected heart rates, or detected heart rate variability.

    摘要翻译： 某些心律失常可以通过适当的电刺激自主神经来保护心脏来预防。 植入式心律管理装置被配置为当预测通过血管内电极存在自主神经不平衡时递送这种刺激。 可以基于昼夜节律，检测到的心率或检测到的心率变异性来预测自主不平衡存在。

    Active can with dedicated defibrillation and sensing electrodes
    8.
    发明申请
    Active can with dedicated defibrillation and sensing electrodes 审中-公开
    具有专门的除颤和感应电极

    公开(公告)号：US20070049975A1

    公开(公告)日：2007-03-01

    申请号：US11218383

    申请日：2005-09-01

    申请人： Adam Cates ,  Curtis Lindstrom

    发明人： Adam Cates ,  Curtis Lindstrom

    IPC分类号： A61N1/39

    CPC分类号： A61N1/375 ,  A61N1/3756 ,  A61N1/3918 ,  A61N1/3956 ,  A61N1/3968

    摘要： Cardiac devices employing an active can and/or electrode assembly with dedicated defibrillation and sensing electrodes. A housing is configured for subcutaneous non-intrathoracic placement in a patient, the housing having a first face and a second face. One of the first and second face is directed away from the patient's heart, and the other of the first and second face is directed towards the patient's heart. A cardiac arrhythmia may be sensed using an electrode assembly positioned in or on the first face of the housing. A cardiac defibrillation therapy may be delivered to the patient's heart using an electrode assembly positioned in or on the second face of the housing in response to the detected arrhythmia.

    摘要翻译： 使用具有专用除颤和感测电极的活性罐和/或电极组件的心脏装置。 外壳被配置为用于皮下非胸腔内放置在患者体内，所述外壳具有第一面和第二面。 第一面和第二面之一被引导离开患者的心脏，第一和第二面中的另一个面向患者的心脏。 可以使用位于壳体的第一面中或其上的电极组件来感测心律失常。 响应于检测到的心律失常，可以使用位于壳体的第二面中或其上的电极组件将心脏除颤疗法递送至患者的心脏。

    IMPLANT TOOL AND IMPROVED ELECTRODE DESIGN FOR MINIMALLY INVASIVE PROCEDURE
    9.
    发明申请
    IMPLANT TOOL AND IMPROVED ELECTRODE DESIGN FOR MINIMALLY INVASIVE PROCEDURE 有权
    嵌入式工具和改进的电极设计，用于最小的入侵程序

    公开(公告)号：US20120271389A1

    公开(公告)日：2012-10-25

    申请号：US13540218

    申请日：2012-07-02

    申请人： Adam Cates ,  Eric Lovett ,  Loren Murney ,  Kip Ludwig ,  Paul Pignato ,  Brian Soltis

    发明人： Adam Cates ,  Eric Lovett ,  Loren Murney ,  Kip Ludwig ,  Paul Pignato ,  Brian Soltis

    IPC分类号： A61N1/375

    CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/36157 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36182

    摘要： Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. An implantable baroreflex activation system includes a control system having an implantable housing, an electrical lead, attachable to the control system, and an electrode structure. The electrode structure is near one end of the electrical lead, and includes a monopolar electrode, a backing material having an effective surface area larger than the electrode, and a releasable pivotable interface to mate with an implant tool. The electrode is configured for implantation on an outer surface of a blood vessel and the control system is programmed to deliver a baroreflex therapy via the monopolar electrode to a baroreceptor within a wall of the blood vessel.

    摘要翻译： 用于引入和植入电极作为微创技术的一部分的装置和方法。 可植入压力反射激活系统包括具有可植入壳体，可引导到控制系统的电引线和电极结构的控制系统。 电极结构靠近电引线的一端，并且包括单极电极，具有大于电极的有效表面积的背衬材料以及与植入工具配合的可释放的可枢转接口。 电极被配置为植入在血管的外表面上，并且控制系统被编程为通过单极电极将压力反射治疗递送到血管壁内的压力感受器。

    DEVICES AND METHODS FOR TREATMENT OF HEART FAILURE AND ASSOCIATED CONDITIONS
    10.
    发明申请
    DEVICES AND METHODS FOR TREATMENT OF HEART FAILURE AND ASSOCIATED CONDITIONS 有权
    用于治疗心力衰竭和相关条件的装置和方法

    公开(公告)号：US20120123506A1

    公开(公告)日：2012-05-17

    申请号：US13360339

    申请日：2012-01-27

    申请人： Dimitrios Gerogakopoulos ,  Eric Grant Lovett ,  Adam Cates

    发明人： Dimitrios Gerogakopoulos ,  Eric Grant Lovett ,  Adam Cates

    IPC分类号： A61N1/372

    CPC分类号： A61N1/36139 ,  A61N1/372 ,  F01K25/005 ,  F02C3/22 ,  F02C3/30 ,  F05D2220/31

    摘要： Devices and methods of use identification, treatment, and/or management of heart failure and/or associated conditions. Methods may include providing a baroreflex therapy system, providing an implantable measurement device proximate a blood vessel of a patient, the implantable measurement device including a plurality of electrodes, determining an impedance of the blood vessel with the implantable measurement device over a time period of at least one cardiac cycle, generating at least one signal representative of a pressure waveform based on the impedance, activating, deactivating or otherwise modulating the baroreflex therapy system to deliver a therapy to treat heart failure based at least in part on the at least one signal representative of the pressure waveform.

    摘要翻译： 用于识别，治疗和/或管理心力衰竭和/或相关病症的装置和方法。 方法可以包括提供压力反射治疗系统，提供靠近患者血管的可植入测量装置，所述可植入测量装置包括多个电极，所述可植入测量装置包括多个电极，所述可植入测量装置在一段时间内用所述可植入测量装置确定所述血管的阻抗 至少一个心动周期，基于所述阻抗产生代表压力波形的至少一个信号，激活，去激活或以其他方式调制所述压力反射治疗系统，以至少部分地基于所述至少一个信号代表递送治疗以治疗心力衰竭 的压力波形。