公开(公告)号：US08865170B2

公开(公告)日：2014-10-21

申请号：US13876265

申请日：2011-09-27

申请人： Naoki Nishiguchi ,  Akiyoshi Hirayama ,  Masahiro Furutani ,  Tatsuo Shimizu ,  Kiyoshi Takayama ,  Tomoko Shimizu ,  Kazuya Suzuki

发明人： Naoki Nishiguchi ,  Akiyoshi Hirayama ,  Masahiro Furutani ,  Tatsuo Shimizu ,  Kiyoshi Takayama ,  Tomoko Shimizu ,  Kazuya Suzuki

IPC分类号： C07K16/28 ,  A61K31/713 ,  A61K39/00

CPC分类号： C07K16/2866 ,  A61K31/713 ,  A61K2039/505 ,  C07K2317/70 ,  C07K2317/76

摘要： The present invention is novel anti-human-CC-motif-receptor-7 (anti-human-CCR7) antibodies useful for treating tissue fibrosis or cancer, and pharmaceutical compositions containing the anti-human-CCR7 antibodies. The invention includes an anti-human-CCR7 antibody specifically binding to an extracellular domain of human CCR7, having a heavy chain CDR3 containing an amino acid sequence represented by SEQ ID NO: 7, SEQ ID NO: 17, SEQ ID NO: 27, SEQ ID NO: 37, SEQ ID NO: 47, SEQ ID NO: 57, SEQ ID NO: 67, or SEQ ID NO: 77. The invention also includes an anti-human-CCR7 antibody having heavy chain CDRs 1-3 and light chain CDRs 1-3 containing amino acid sequences represented by SEQ ID NOs: 5-10, 15-20, 25-30, 35-40, 45-50, 55-60, 65-70, or 75-80. Preferably, the antibody has an activity of interfering with a CCR7-dependent intracellular signal transduction mechanism caused by CCR7 ligand stimulation.

摘要翻译： 本发明是可用于治疗组织纤维化或癌症的新型抗人CC-基质受体-7（抗人CCR7）抗体，以及含有抗人CCR7抗体的药物组合物。 本发明包括与人CCR7的细胞外结构域特异性结合的抗人CCR7抗体，其具有含有SEQ ID NO：7，SEQ ID NO：17，SEQ ID NO：27所示氨基酸序列的重链CDR3， SEQ ID NO：37，SEQ ID NO：47，SEQ ID NO：57，SEQ ID NO：67或SEQ ID NO：77.本发明还包括具有重链CDR 1-3的抗人CCR7抗体， 含有由SEQ ID NO：5-10，15-20,25-30,35-40,45-50,55-60,65-70或75-80表示的氨基酸序列的轻链CDR1-3。 优选地，抗体具有干扰由CCR7配体刺激引起的CCR7依赖性细胞内信号转导机制的活性。

公开(公告)号：US20130195869A1

公开(公告)日：2013-08-01

申请号：US13876265

申请日：2011-09-27

申请人： Naoki Nishiguchi ,  Akiyoshi Hirayama ,  Masahiro Furutani ,  Tatsuo Shimizu ,  Kiyoshi Takayama ,  Tomoko Shimizu ,  Kazuya Suzuki

发明人： Naoki Nishiguchi ,  Akiyoshi Hirayama ,  Masahiro Furutani ,  Tatsuo Shimizu ,  Kiyoshi Takayama ,  Tomoko Shimizu ,  Kazuya Suzuki

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  A61K31/713 ,  A61K2039/505 ,  C07K2317/70 ,  C07K2317/76

摘要： An object of the present invention is to provide a novel anti-human CCR7 antibody useful as a therapeutic agent for tissue fibrosis or cancer, and a pharmaceutical composition containing the anti-human CCR7 antibody, and the like. An anti-human CCR7 antibody specifically binding to an extracellular domain of human CCR7, having a heavy chain CDR3 containing an amino acid sequence represented by SEQ ID NO: 7, SEQ ID NO: 17, SEQ ID NO: 27, SEQ ID NO: 37, SEQ ID NO: 47, SEQ ID NO: 57, SEQ ID NO: 67, or SEQ ID NO: 77 is provided. Also provided is an anti-human CCR7 antibody having heavy chain CDRs 1-3 and light chain CDRs 1-3 containing amino acid sequences represented by SEQ ID NOs: 5-10, 15-20, 25-30, 35-40, 45-50, 55-60, 65-70, or 75-80. Preferably, the antibody has an activity of interfering with a CCR7-dependent intracellular signal transduction mechanism caused by CCR7 ligand stimulation. The anti-human CCR7 antibody of the present invention may be used as an active ingredient of a therapeutic agent for tissue fibrosis or cancer.

公开(公告)号：US08349807B2

公开(公告)日：2013-01-08

申请号：US11665270

申请日：2005-10-14

申请人： Joe Chiba ,  Jun-ichi Hata ,  Naoki Nishiguchi ,  Masahiro Furutani

发明人： Joe Chiba ,  Jun-ichi Hata ,  Naoki Nishiguchi ,  Masahiro Furutani

IPC分类号： A61K48/00 ,  C12N5/04 ,  C12N15/06

CPC分类号： A61K39/00 ,  A61K39/0005 ,  A61K39/385 ,  A61K2039/53 ,  A61K2039/6068 ,  C07K16/2869 ,  C07K2319/35

摘要： It is an object of the present invention to a method whereby a humoral immune response is induced more efficiently in producing an antibody against an antigen protein by gene immunization. A fusion gene composed of a gene encoding the full-length of a part of the antigen protein or a gene encoding a chaperonin subunit or a chaperonin subunit linkage linked thereto is administered to express the fusion gene in the animal, thereby inducing a humoral immune response to an antigen protein by administering. An example of the chaperonin includes Escherichia coli GroEL. There is also provided with a composition for immunization, a method for producing an antibody, a method for producing a hybridoma, and a method for producing a monoclonal antibody.

公开(公告)号：US20090041761A1

公开(公告)日：2009-02-12

申请号：US11665270

申请日：2005-10-14

申请人： Joe Chiba ,  Jun-ichi Hata ,  Naoki Nishiguchi ,  Masahiro Furutani

发明人： Joe Chiba ,  Jun-ichi Hata ,  Naoki Nishiguchi ,  Masahiro Furutani

IPC分类号： A61K39/395 ,  A61K39/00 ,  C12N5/16 ,  A61P31/00 ,  C12P21/08

CPC分类号： A61K39/00 ,  A61K39/0005 ,  A61K39/385 ,  A61K2039/53 ,  A61K2039/6068 ,  C07K16/2869 ,  C07K2319/35

摘要： It is an object of the present invention to a method whereby a humoral immune response is induced more efficiently in producing an antibody against an antigen protein by gene immunization. A fusion gene composed of a gene encoding the full-length of a part of the antigen protein or a gene encoding a chaperonin subunit or a chaperonin subunit linkage linked thereto is administered to express the fusion gene in the animal, thereby inducing a humoral immune response to an antigen protein by administering. An example of the chaperonin includes Escherichia coli GroEL. There is also provided with a composition for immunization, a method for producing an antibody, a method for producing a hybridoma, and a method for producing a monoclonal antibody.

摘要翻译： 本发明的目的是提供一种通过基因免疫在产生针对抗原蛋白的抗体中更有效地诱导体液免疫应答的方法。 施用由编码全长一部分抗原蛋白的基因或编码伴侣伴侣亚基的基因或与其相连的伴侣伴侣亚基的基因组成的融合基因，以表达动物中的融合基因，由此诱导体液免疫应答 通过给予抗原蛋白。 伴侣蛋白的一个实例包括大肠杆菌GroEL。 还提供了用于免疫的组合物，抗体的制备方法，杂交瘤的制备方法和单克隆抗体的制备方法。

公开(公告)号：US08397232B2

公开(公告)日：2013-03-12

申请号：US12492449

申请日：2009-06-26

申请人： Noboru Iwamatsu ,  Naoki Nishiguchi ,  Masatomo Yasaki

发明人： Noboru Iwamatsu ,  Naoki Nishiguchi ,  Masatomo Yasaki

IPC分类号： G06F9/455 ,  G06F9/46 ,  G06F1/00

CPC分类号： G06F9/45533 ,  G06F1/3203 ,  G06F9/5077 ,  G06F9/5094 ,  G06F2209/504 ,  Y02D10/22 ,  Y02D10/26 ,  Y02D10/28 ,  Y02D10/36

摘要： A virtual machine system includes a virtual battery manager, a discharge calculator, and a discharger. The virtual battery manager manages a virtual battery for running a virtual machine. The virtual battery holds electric energy used by the virtual machine. The virtual battery is capable of discharging and being charged. The discharge calculator calculates a discharged amount of the virtual battery by calculating energy consumption of the virtual machine with reference to a consumption policy and a consumption allocation table when a resource quota for the virtual machine satisfies a predefined condition for discharging. The consumption policy defines a maximum amount of total energy consumption of the plurality of virtual machines. The consumption allocation table contains an allocated ratio of energy consumption for each of the plurality of virtual machines. The discharger decreases a battery level of the virtual battery.

摘要翻译： 虚拟机系统包括虚拟电池管理器，放电计算器和放电器。 虚拟电池管理器管理用于运行虚拟机的虚拟电池。 虚拟电池保存虚拟机使用的电能。 虚拟电池能够放电并充电。 当虚拟机的资源配额满足预定的放电条件时，放电计算器通过参考消费策略和消耗分配表计算虚拟机的能量消耗来计算虚拟电池的放电量。 消费策略定义了多个虚拟机的总能量消耗的最大量。 消耗分配表包含多个虚拟机中的每一个的分配的能量消耗比率。 放电器降低虚拟电池的电池电量。

公开(公告)号：US08261267B2

公开(公告)日：2012-09-04

申请号：US12501892

申请日：2009-07-13

申请人： Noboru Iwamatsu ,  Naoki Nishiguchi

发明人： Noboru Iwamatsu ,  Naoki Nishiguchi

IPC分类号： G06F9/46 ,  G06F12/08

CPC分类号： G06F12/145 ,  G06F9/45558 ,  G06F12/109 ,  G06F2009/45583

摘要： A mapping data generator determines a virtual page number of a virtual page where an executable code in an object file is mapped. A virtual page manager manages a virtual page record containing the virtual page number, a first object ID corresponding to the virtual page number, and a detection flag indicative of existence of another virtual page record containing a second object ID identical with the first object ID. A machine page manager manages a machine page record containing the first object ID, and a machine page number to which the virtual page number is mapped. A sharable page detector determines whether a detection flag indicates existence of another virtual page record containing the first object ID and determines whether a machine page number has been set. A page mapper maps a set machine page number to the virtual page number of the access page.

摘要翻译： 映射数据生成器确定对象文件中的可执行代码被映射的虚拟页面的虚拟页面号。 虚拟页面管理器管理虚拟页面记录，该虚拟页面记录包含虚拟页面号码，对应于虚拟页面编号的第一对象ID，以及指示存在包含与第一对象ID相同的第二对象ID的另一个虚拟页面记录的检测标志。 机器页面管理器管理包含第一对象ID的机器页面记录和映射了虚拟页面号的机器页面编号。 共享页面检测器确定检测标志是否指示包含第一对象ID的另一个虚拟页面记录的存在，并确定机器页码是否已经被设置。 页面映射器将设置的机器页面编号映射到访问页面的虚拟页面编号。

公开(公告)号：US20120011506A1

公开(公告)日：2012-01-12

申请号：US13097272

申请日：2011-04-29

申请人： Noboru Iwamatsu ,  Naoki Nishiguchi

发明人： Noboru Iwamatsu ,  Naoki Nishiguchi

IPC分类号： G06F9/455

CPC分类号： G06F9/45541 ,  G06F1/3215 ,  G06F1/3287 ,  Y02D10/171 ,  Y02D50/20

摘要： A computer is provided with a measuring unit that measures elapsed time at a non-access state between one of the guest virtual machines and the devices as a non-access time with respect to each of the guest virtual machines accessing the devices via the device driver virtual machine; a storage unit that stores the operation profile information that matches the non-access time with the operation mode information representing the operation modes of the devices; a decision unit that decides the operation mode with reference to the operation profile information on the basis of the measured access time; and a transition control unit that transits the devices to the operation mode, so that this makes it possible to appropriately carry out power saving management of the devices not depending on a power saving function of the guest OS.

摘要翻译： 计算机设置有测量单元，该测量单元在访客虚拟机和设备之间的非访问状态下测量相对于经由设备驱动程序访问设备的每个访客虚拟机的非访问时间的经过时间 虚拟机; 存储单元，其将与所述非访问时间匹配的操作简档信息与表示所述设备的操作模式的操作模式信息相对应; 决定单元，基于测量的访问时间参考操作简档信息来决定操作模式; 以及将设备转换到操作模式的转移控制单元，使得可以适当地进行不依赖于客户OS的省电功能的设备的节电管理。

公开(公告)号：US07925879B2

公开(公告)日：2011-04-12

申请号：US11537829

申请日：2006-10-02

申请人： Kouichi Yasaki ,  Naoki Nishiguchi ,  Isamu Yamada

发明人： Kouichi Yasaki ,  Naoki Nishiguchi ,  Isamu Yamada

IPC分类号： H04L29/06 ,  G06F7/00 ,  G06F17/00

CPC分类号： G06F12/0844 ,  G06F12/1408 ,  G06F12/1466

摘要： An information processing unit is an unit which has an information division recording function in which a file is divided and stored. The information processing unit includes a first storage section for storing a first partial file of a file divided, a second storage section for storing a second partial file, a state detection section for checking an operating state of the information processing unit and detecting that the operating state has changed in a specific manner, and a control section for performing a lock processing in accordance with the state detected to the second partial file stored on the second storage section when the state detected by the state detection section is determined as a risky state in which unauthorized access can be performed.

摘要翻译： 信息处理单元是具有分割和存储文件的信息分割记录功能的单元。 信息处理单元包括：第一存储部分，用于存储分割的文件的第一部分文件;存储第二部分文件的第二存储部分;用于检查信息处理单元的操作状态的状态检测部分， 状态以特定的方式发生变化，以及控制部分，当由状态检测部分检测到的状态被确定为危险状态时，根据对存储在第二存储部分上的第二部分文件检测到的状态进行锁定处理 可以执行未经授权的访问。

公开(公告)号：US20080229106A1

公开(公告)日：2008-09-18

申请号：US12075417

申请日：2008-03-10

申请人： Naoki Nishiguchi ,  Eiji Hasegawa ,  Noboru Iwamatsu

发明人： Naoki Nishiguchi ,  Eiji Hasegawa ,  Noboru Iwamatsu

IPC分类号： H04L9/00

CPC分类号： G06F21/57 ,  G06F21/575 ,  G06F2221/2103 ,  G06F2221/2105 ,  H04L9/085 ,  H04L9/0891 ,  H04L9/0894 ,  H04L63/0442 ,  H04L63/061 ,  H04L63/0869

摘要： An apparatus stores first divided trust information which is one portion resulting from division of trust information generated by a transmission target apparatus that is a transmission target for data, receives a transmission request for the data from the target apparatus and receives second divided trust information which is the other portion resulting from division of the trust information of the target apparatus and verification information generated using information indicating a state of the target apparatus that made the request, recovers the trust information using the first divided trust information stored and the received second divided trust information, verifies trustworthiness of the target apparatus using the recovered trust information and the received verification information, transmits the data indicated by the request to the target apparatus when the verification of trustworthiness is successful.

摘要翻译： 装置存储作为由作为数据的发送对象的发送对象装置生成的信任信息分割的一部分的第一分割信任信息，从目标装置接收对该数据的发送请求，并接收第二被分割的信任信息， 由目标设备的信任信息分割产生的另一部分和使用指示进行请求的目标设备的状态的信息产生的验证信息，使用存储的第一分割信任信息和接收到的第二分割信任信息来恢复信任信息 使用恢复的信任信息和接收到的验证信息来验证目标设备的可靠性，当可信赖性的验证成功时，将由请求指示的数据发送到目标设备。

公开(公告)号：US20060265562A1

公开(公告)日：2006-11-23

申请号：US11210658

申请日：2005-08-25

申请人： Naoki Nishiguchi ,  Jun Kawai

发明人： Naoki Nishiguchi ,  Jun Kawai

IPC分类号： G06F12/14

CPC分类号： G06F12/1441 ,  G06F21/51 ,  G06F21/52

摘要： Provided is information processing apparatus, information processing method and a record medium, which can prevent occurrence of manipulation, in a case of accessing a memory, without consuming the access band of the memory. A main-processing unit, a sub-processing unit and a memory for loading a program are provided and process limit information stored in the memory is stored in storing means. The sub-processing unit judges whether a program to be executed is manipulated or not, and loads a program to be executed in the memory in case that the program is not manipulated. The sub-processing unit refers to the process limit information before execution of a program, and not permits execution of the program of the main-processing unit in case that a process by the main-processing unit for information stored in the memory accords with a process included in the process limit information.

摘要翻译： 提供了在访问存储器的情况下可以防止操作发生的信息处理装置，信息处理方法和记录介质，而不消耗存储器的访问带。 提供主处理单元，子处理单元和用于加载程序的存储器，并且存储在存储器中的处理限制信息被存储在存储装置中。 子处理单元判断要执行的程序是否被操纵，并且在不处理程序的情况下将要执行的程序加载到存储器中。 在执行程序之前，子处理单元参考处理限制信息，并且在存储在存储器中的信息的主处理单元的处理符合一个处理单元的情况下，不执行主处理单元的程序 流程中包含的流程限制信息。