Targeting agents for enhancing radiation therapy
    6.
    发明授权
    Targeting agents for enhancing radiation therapy 有权
    用于增强放射治疗的靶向剂

    公开(公告)号:US08709380B1

    公开(公告)日:2014-04-29

    申请号:US11671222

    申请日:2007-02-05

    摘要: Targeting agents are provided that have an affinity for aberrant cells and tissues. These agents are comprised of chelates, ligands, and/or particles combined with high atomic weight elements so that treatment with ionizing electromagnetic radiation (X-rays, or Gamma rays) results in a higher dose to aberrant cells and tissues than other cells and tissues of a host. The invention further provide methods to enhance the tumor to normal tissue damage ratio by concentrating agents with high atomic number elements to the site of the tumor prior to administering radiotherapy. The result is greater therapeutic efficacy with fewer side effects. These compounds also permit diagnostic uses in combination with the therapeutic use.

    摘要翻译: 提供了对异常细胞和组织具有亲和力的靶向剂。 这些试剂由与高原子量元素结合的螯合物,配体和/或颗粒组成,使得用电离电磁辐射(X射线或γ射线)治疗导致比其他细胞和组织更高的异常细胞和组织的剂量 的主机。 本发明还提供了在施用放射治疗之前通过具有高原子序数元素的浓缩剂将肿瘤增强至肿瘤部位的方法。 结果是治疗效果更好,副作用较少。 这些化合物还可以与治疗用途结合使用诊断用途。