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1.发明授权Phospho-N-acetylmuramoyl-pentapeptide transferase of Streptococcus pneumoniae 失效肺炎链球菌的磷酸-N-乙酰基胞壁酰胺 - 五肽转移酶
公开(公告)号：US6156537A
公开(公告)日：2000-12-05
申请号：US61156
申请日：1998-04-16
申请人： Joanna Lynn Fueyo , Deborah Dee Jaworski , Anna Lisa Kosmatka , Michael Arthur Lonetto , Christopher Michael Traini , Min Wang
发明人： Joanna Lynn Fueyo , Deborah Dee Jaworski , Anna Lisa Kosmatka , Michael Arthur Lonetto , Christopher Michael Traini , Min Wang
IPC分类号： G01N33/15 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K38/45 , A61K38/55 , A61K39/395 , A61K48/00 , C07K14/315 , C07K16/12 , C12N1/21 , C12N9/10 , C12N15/09 , C12N15/31 , C12N15/54 , C12P21/02 , C12Q1/68 , C12N15/52 , C12N15/62 , C12N15/63
摘要： The invention provides mraY polypeptides and polynucleotides encoding mraY polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mraY polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了mraY多肽和编码mraY多肽的多核苷酸以及通过重组技术产生这种多肽的方法。 还提供了利用mraY多肽筛选抗菌化合物的方法。
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公开(公告)号：US06284878B1
公开(公告)日：2001-09-04
申请号：US08991023
申请日：1997-12-15
申请人： Michael Arthur Lonetto , Deborah Dee Jaworski , Min Wang , Richard Lloyd Warren , Christopher Michael Traini , Anna Lisa Kosmatka , David Justin Charles Knowles , John Edward Hodgson , Michael Terence Black , David J. Holmes , Richard Oakley Nicholas , Robert King Stodola
发明人： Michael Arthur Lonetto , Deborah Dee Jaworski , Min Wang , Richard Lloyd Warren , Christopher Michael Traini , Anna Lisa Kosmatka , David Justin Charles Knowles , John Edward Hodgson , Michael Terence Black , David J. Holmes , Richard Oakley Nicholas , Robert King Stodola
IPC分类号： C07H2102
CPC分类号： C12N9/1205 , A61K38/00 , A61K39/00 , C07K14/3156 , C12N9/78 , C12N9/80 , C12Y207/01002
摘要： The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了def1多肽和编码def1多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用def1多肽筛选抗菌化合物的方法。
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公开(公告)号：US06280971B1
公开(公告)日：2001-08-28
申请号：US09227806
申请日：1999-01-11
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Y Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Y Zhong
IPC分类号： C12N1231
CPC分类号： C12Y305/04025 , C07K2319/00 , C12N9/78
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06171598B2
公开(公告)日：2001-01-09
申请号：US09225967
申请日：1999-01-06
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
IPC分类号： A61K3850
CPC分类号： C12Y305/04025 , C07K2319/00 , C12N9/78
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号：US5891672A
公开(公告)日：1999-04-06
申请号：US977554
申请日：1997-11-25
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/43 , A61K39/085 , A61K39/395 , A61K48/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P11/02 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P43/00 , C07H21/04 , C07K14/31 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/78 , C12N9/86 , C12N15/09 , C12N15/31 , C12P21/02 , C12R1/445 , C07H21/00 , C12N15/63
CPC分类号： C12Y305/04025 , C12N9/78 , C07K2319/00
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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6.发明授权Recombinant expression of polynucleotides encoding the UDP-N-acetylmuramoylalanine:D-glutamate ligase (MurD) of Streptococcus pneumoniae 失效编码链球菌肺炎链球菌UDP-N-乙酰谷氨酰丙氨酸：D-谷氨酸连接酶（MurD）的多核苷酸的重组表达
公开(公告)号：US5929045A
公开(公告)日：1999-07-27
申请号：US934481
申请日：1997-09-19
IPC分类号： G01N33/50 , A61K31/00 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P27/00 , A61P27/16 , A61P31/00 , A61P31/04 , A61P43/00 , C07K16/40 , C12N1/21 , C12N9/00 , C12N15/00 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/46 , G01N33/15 , G01N33/566 , C12N5/10 , C12N15/31 , C12N15/63
摘要： The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了MurD多肽和编码MurD多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了利用MurD多肽筛选抗菌化合物的方法。
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公开(公告)号：US06350598B1
公开(公告)日：2002-02-26
申请号：US09290602
申请日：1999-04-13
IPC分类号： C12N900
摘要： The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了MurD多肽和编码MurD多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了利用MurD多肽筛选抗菌化合物的方法。
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公开(公告)号：US06197300B1
公开(公告)日：2001-03-06
申请号：US09120426
申请日：1998-07-22
IPC分类号： A61K3900
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00
摘要： The invention provides ftsZ polypeptides and polynucleotides encoding ftsZ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ftsZ polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ftsZ多肽和编码ftsZ多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ftsZ多肽筛选抗菌化合物的方法。
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公开(公告)号：US6017728A
公开(公告)日：2000-01-25
申请号：US978454
申请日：1997-11-25
申请人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Michael Arthur Lonetto
发明人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Michael Arthur Lonetto
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K38/45 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , C07K14/315 , C07K16/12 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/10 , C12P21/06 , C07H17/00 , C12N9/00 , C12N15/00
CPC分类号： C12N9/1085 , C07K14/3156 , C12Y205/01009 , A61K38/00 , A61K39/00
摘要： The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribH多肽和编码ribH多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribH多肽筛选抗菌化合物的方法。
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公开(公告)号：US5932701A
公开(公告)日：1999-08-03
申请号：US978458
申请日：1997-11-25
申请人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
发明人： Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P31/04 , A61P43/00 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12N9/78 , C12N9/80 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/46 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C12N9/1077 , C07K14/3156 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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