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公开(公告)号：US20070244197A1
公开(公告)日：2007-10-18
申请号：US11417346
申请日：2006-05-03
申请人： Niels Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith Pfister , Ribhi Shawar , Allan Wagman , Asha Yabannavar
发明人： Niels Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith Pfister , Ribhi Shawar , Allan Wagman , Asha Yabannavar
IPC分类号： A61K31/19 , C07C259/04
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 提供式I的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：US20080269221A1
公开(公告)日：2008-10-30
申请号：US11837327
申请日：2007-08-10
申请人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： A61K31/5375 , C07C233/04 , A61K31/166 , C07D207/09 , A61P43/00 , A61K31/4015 , C07D265/30
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 提供式I的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：US08101640B2
公开(公告)日：2012-01-24
申请号：US11981279
申请日：2007-10-31
申请人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： A61K31/44 , C07D213/56
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
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公开(公告)号：US07989660B2
公开(公告)日：2011-08-02
申请号：US11837327
申请日：2007-08-10
申请人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： C07C259/06 , A61K31/19
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 提供式I的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：US20110172174A1
公开(公告)日：2011-07-14
申请号：US11981279
申请日：2007-10-31
申请人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice Erwin , Eric Harwood , Toni Kline , Khisimuzi Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： A61K31/166 , C07C259/04 , C07D207/16 , A61K31/40 , A61K31/165 , C07D265/30 , A61K31/5375 , C07D213/56 , A61K31/4406 , C07D413/04 , A61K31/5377 , C07D241/04 , A61K31/495 , C07D211/32 , A61K31/4453 , C07C275/64 , A61K31/17 , C07D401/04 , A61K31/55 , A61K31/7048 , A61P31/04
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
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公开(公告)号：US20090247506A1
公开(公告)日：2009-10-01
申请号：US11894208
申请日：2007-08-20
申请人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： A61K31/55 , C07C237/48 , C07D223/04 , A61K31/496 , A61K31/164 , C07D241/04 , A61P31/04
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 提供式I的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：US08153843B2
公开(公告)日：2012-04-10
申请号：US12563697
申请日：2009-09-21
申请人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： C07C259/04 , A61K31/19
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 提供式I的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：US08084615B2
公开(公告)日：2011-12-27
申请号：US11928122
申请日：2007-10-30
申请人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： C07D213/00 , C07D213/24 , C07D333/22 , C07D413/04 , C07D239/10 , C07D239/02 , C07D241/12 , C07D401/04 , A61K31/55 , A61K31/535 , A61K31/497 , A61K31/505 , A61K31/44 , A61K31/38 , A61K31/445
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
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公开(公告)号：US20100324025A1
公开(公告)日：2010-12-23
申请号：US12563697
申请日：2009-09-21
申请人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
发明人： Niels H. Andersen , Jason Bowman , Alice L. Erwin , Eric A. Harwood , Toni Kline , Khisimuzi E. Mdluli , Simon Ng , Keith B. Pfister , Ribhi Shawar , Allan S. Wagman , Asha Yabannavar
IPC分类号： A61K31/55 , C07C259/06 , A61K31/16 , C07D295/155 , A61K31/5375 , C07D213/56 , A61K31/4406 , C07D413/04 , A61K31/5377 , A61K31/495 , C07D211/34 , A61K31/4453 , C07D207/27 , A61K31/40 , C07D207/16 , C07D401/06 , A61K31/4439 , C07D233/64 , A61K31/4164 , C07D217/26 , A61K31/472 , C07D241/04 , C07D401/04 , A61K31/4545 , C07D263/14 , A61K31/421 , C07D409/06 , A61K31/497 , A61K31/175 , C07C281/12 , C07C337/10 , C07D223/04 , C07D453/02 , A61K31/439 , C07D239/42 , A61K31/505 , C07D241/12 , A61K31/4965 , A61P31/04 , A61P11/00
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 提供式I的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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10.发明授权5-substituted-2-imino-thiazolidinone compounds and their use as inhibitors of bacterial infection 失效5-取代-2-亚氨基 - 噻唑烷酮化合物及其作为细菌感染抑制剂的用途公开(公告)号：US08252940B2
公开(公告)日：2012-08-28
申请号：US12856986
申请日：2010-08-16
申请人： Heather B. Felise , Samuel I. Miller , Toni Kline
发明人： Heather B. Felise , Samuel I. Miller , Toni Kline
IPC分类号： C07D417/06 , C07D277/04 , A61K31/445 , A61K31/427
CPC分类号： C07D277/54 , C07D417/06 , C07K5/06026 , C07K5/06034 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/06139 , C12Q1/18
摘要： A method for inhibiting Gram-negative bacterial pathogenesis, a method of screening for compounds that inhibit type III secretion in Gram-negative bacteria, and compounds that inhibit type III secretion in Gram-negative bacteria.
摘要翻译： 用于抑制革兰氏阴性细菌发病的方法，筛选在革兰氏阴性菌中抑制III型分泌的化合物的方法，以及抑制革兰氏阴性菌中III型分泌的化合物。
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