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公开(公告)号:US4446141A
公开(公告)日:1984-05-01
申请号:US191339
申请日:1980-02-02
IPC分类号: A61K31/41 , A61P9/12 , C07D401/04 , C07D405/14 , A61K31/445
CPC分类号: C07D401/04 , C07D405/14
摘要: The present invention relates to a novel compound represented by the general formula: ##STR1## wherein Ar represents a naphthyl, phenyl or substituted phenyl group, Q represents ##STR2## wherein R.sub.1 represents a hydrogen atom, or an alkyl, alkanoyl or alkoxycarbonyl group, R represents a hydrogen atom or an alkyl group, and Z represents a substituted benzimidazolinyl group; the broken line in piperidine ring means that 3,4-positions in the piperidine ring are saturated or form a double bond. Said compound and the pharmaceutically acceptable acid addition salts thereof have a hypotensive action and therefore are useful as medicine.
摘要翻译: PCT No.PCT / JP79 / 00141 Sec。 371日期1980年2月2日 102(e)日期1980年1月31日PCT申请日1979年6月1日PCT公布。 出版物WO80 / 1980年1月10日。本发明涉及以下通式表示的新化合物:其中Ar表示萘基,苯基或取代苯基,Q表示其中R1表示氢原子,或 烷基,烷酰基或烷氧基羰基,R表示氢原子或烷基,Z表示取代的苯并咪唑啉基; 哌啶环中的虚线表示哌啶环中的3,4-位饱和或形成双键。 所述化合物及其药学上可接受的酸加成盐具有降血压作用,因此可用作药物。
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公开(公告)号:US4410528A
公开(公告)日:1983-10-18
申请号:US264810
申请日:1981-05-18
IPC分类号: C07D211/58 , A61K31/505 , C07D401/04
CPC分类号: C07D211/58
摘要: A new piperidine derivative represented by the formula: ##STR1## wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R.sub.1 is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); (A).sub.m and R.sub.2 are usually used substituents; and Y is a monovalent group or a divalent group and is one of the following three groups: ##STR2## wherein when p is 0, B is --N.dbd.N--, ##STR3## and when p is 1, B is ##STR4## wherein (R.sub.3).sub.n is a usually used substituent, has hypotensive activity.
摘要翻译: 由下式表示的新的哌啶衍生物:其中X是氧,硫,羰基,羟基亚甲基或亚甲基; R1是具有或不具有低级烷基取代基的具有1-4个碳原子的直链亚烷基; (A)m和R 2通常是取代基; (1)其中当p为0时,B为-N = N-,
,当p为1时,B为 (3)其中(R3)n是通常使用的取代基,具有降血压作用。 -
3.
公开(公告)号:US4344948A
公开(公告)日:1982-08-17
申请号:US209284
申请日:1980-11-21
IPC分类号: A61K31/505 , A61P1/04 , A61P7/02 , A61P9/12 , C07D211/58 , C07D211/72 , C07D401/04 , C07D405/14
CPC分类号: C07D211/58
摘要: A new piperidine derivative represented by the formula: ##STR1## wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); m and n are 0 or 1, and are different from each other (i.e., both m and n are not 0 or 1); and (D).sub.m', R.sup.1 and (R.sup.2)n' are usually used as substituents, has a hypotensive activity.
摘要翻译: 由下式表示的新的哌啶衍生物:其中X是氧,硫,羰基,羟基亚甲基或亚甲基; R是具有或不具有低级烷基取代基的具有1-4个碳原子的直链亚烷基; m和n为0或1,并且彼此不同(即,m和n均不为0或1); 和(D)m',R1和(R2)n'通常用作取代基,具有降血压活性。
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公开(公告)号:US4390536A
公开(公告)日:1983-06-28
申请号:US352762
申请日:1982-02-26
IPC分类号: C07D211/58 , C07D417/04 , A61K31/54
CPC分类号: C07D211/58
摘要: New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.
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公开(公告)号:US4344945A
公开(公告)日:1982-08-17
申请号:US241727
申请日:1981-03-09
IPC分类号: C07D211/58 , C07D413/04 , A61K31/445 , A61K31/535 , C07D498/14
CPC分类号: C07D211/58
摘要: New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.
摘要翻译: 制备具有有用药理活性如降血压活性的新的哌啶衍生物。
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公开(公告)号:US5302602A
公开(公告)日:1994-04-12
申请号:US884208
申请日:1992-05-18
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
IPC分类号: C07D211/14 , C07D313/12 , C07D333/34 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10 , A61K31/445 , C07D211/22
CPC分类号: C07D405/06 , C07D211/14 , C07D313/12 , C07D333/34 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
摘要: Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译: 具有由式(I)表示的TXA2拮抗活性的新型三环化合物:具有对血栓素A2的有效拮抗作用,还具有抗过敏和/或抗组胺活性,并且预期对缺血性疾病具有预防和治疗作用 脑血管疾病等
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公开(公告)号:US5143922A
公开(公告)日:1992-09-01
申请号:US616095
申请日:1990-11-20
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
IPC分类号: C07D211/14 , C07D313/12 , C07D333/34 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
CPC分类号: C07D405/06 , C07D211/14 , C07D313/12 , C07D333/34 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
摘要: Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing action against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic acitvity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译: 具有由式(I)表示的TXA2拮抗活性的新型三环化合物:对抗凝血恶烷A2具有有效的拮抗作用,并且还具有抗过敏和/或抗组胺活性,并且预期对缺血性具有预防和治疗作用 疾病,脑血管疾病等
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8.
公开(公告)号:US5010087A
公开(公告)日:1991-04-23
申请号:US381330
申请日:1989-07-18
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
IPC分类号: C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D313/12 , C07D337/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D495/04
CPC分类号: C07D405/12 , C07C311/16 , C07C323/44 , C07C323/48 , C07C323/49 , C07D313/12 , C07D337/12 , C07D407/12 , C07D409/12 , C07D495/04 , C07C2103/32
摘要: Novel tricyclic compounds having a TXA.sub.2 -antagonizing activity represented by formula (I): ##STR1## which strongly antagonize an action of thromboxane A.sub.2 and are expected to have preventive and therapeutic effects on ischemica diseases, cerebro-vascular diseases, etc.
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公开(公告)号:US4999363A
公开(公告)日:1991-03-12
申请号:US368242
申请日:1989-06-06
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
IPC分类号: A61K31/19 , A61K31/00 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/505 , A61P7/02 , A61P9/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C57/46 , C07C59/13 , C07C63/49 , C07C65/26 , C07C67/00 , C07C229/50 , C07C233/52 , C07C233/81 , C07C235/14 , C07C235/40 , C07C235/54 , C07C235/62 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/04 , C07C237/24 , C07C237/38 , C07C241/00 , C07C251/20 , C07C317/44 , C07C323/61 , C07D235/06 , C07D313/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/056 , C07D521/00
CPC分类号: C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/12 , C07D405/12 , C07D417/12 , C07D471/04 , Y10S514/824 , Y10S514/826
摘要: Novel tricyclic compound represented by formula ##STR1## possess a TXA.sub.2 biosynthesis inhibiting activity and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
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公开(公告)号:US5118701A
公开(公告)日:1992-06-02
申请号:US612446
申请日:1990-11-14
申请人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
发明人: Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
IPC分类号: A61K31/19 , A61K31/00 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/505 , A61P7/02 , A61P9/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C57/46 , C07C59/13 , C07C63/49 , C07C65/26 , C07C67/00 , C07C229/50 , C07C233/52 , C07C233/81 , C07C235/14 , C07C235/40 , C07C235/54 , C07C235/62 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/04 , C07C237/24 , C07C237/38 , C07C241/00 , C07C251/20 , C07C317/44 , C07C323/61 , C07D235/06 , C07D313/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/056 , C07D521/00
CPC分类号: C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/12 , C07D405/12 , C07D417/12 , C07D471/04 , Y10S514/824 , Y10S514/826
摘要: Novel tricyclic compound represented by formula (I): ##STR1## possess a TXA.sub.2 biosynthesis inhibiting activity and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
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