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公开(公告)号：US06943237B2
公开(公告)日：2005-09-13
申请号：US10747133
申请日：2003-12-30
申请人： Nobuo Sakaguchi , Kazuhiko Kuwahara
发明人： Nobuo Sakaguchi , Kazuhiko Kuwahara
CPC分类号： C12N9/1205 , C07K16/40 , C07K2319/00
摘要： The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.
摘要翻译： 本发明的目的是提供具有激酶活性的新型蛋白质和编码所述蛋白质的基因。 根据本发明，提供了由序列表的SEQ ID No.1或3所示的氨基酸序列表示的GANP蛋白质，其涉及异常B细胞分化的信号转导 自身免疫状态，并且具有激酶活性，以及编码所述蛋白质的多核苷酸。
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公开(公告)号：US20060057695A1
公开(公告)日：2006-03-16
申请号：US10961231
申请日：2004-10-12
申请人： Nobuo Sakaguchi , Kazuhiko Kuwahara
发明人： Nobuo Sakaguchi , Kazuhiko Kuwahara
CPC分类号： C12N9/1205 , C07K16/40 , C07K2319/00
摘要： The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.
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公开(公告)号：US20060040372A1
公开(公告)日：2006-02-23
申请号：US11179624
申请日：2005-07-13
申请人： Nobuo Sakaguchi , Kazuhiko Kuwahara
发明人： Nobuo Sakaguchi , Kazuhiko Kuwahara
CPC分类号： C12N9/1205 , C07K16/40 , C07K2319/00
摘要： The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the arnino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.
摘要翻译： 本发明的目的是提供具有激酶活性的新型蛋白质和编码所述蛋白质的基因。 根据本发明，提供了由序列表的序列号1或3所示的氨基酸序列表示的GANP蛋白质，其参与了异常B细胞分化的信号转导 自身免疫状态，并且具有激酶活性，以及编码所述蛋白质的多核苷酸。
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公开(公告)号：US06825020B1
公开(公告)日：2004-11-30
申请号：US10638333
申请日：2003-08-12
申请人： Nobuo Sakaguchi , Kazuhiko Kuwahara
发明人： Nobuo Sakaguchi , Kazuhiko Kuwahara
IPC分类号： C12N912
CPC分类号： C12N9/1205 , C07K16/40 , C07K2319/00
摘要： The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.
摘要翻译： 本发明的目的是提供具有激酶活性的新型蛋白质和编码所述蛋白质的基因。 根据本发明，提供了由序列表的序列号1或3所示的氨基酸序列表示的GANP蛋白质，涉及自身免疫状态的异常B细胞分化的信号转换 并具有激酶活性，以及编码所述蛋白质的多核苷酸。
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公开(公告)号：US07667006B2
公开(公告)日：2010-02-23
申请号：US10582861
申请日：2004-03-09
CPC分类号： C07K16/1063 , C07K2317/76 , C07K2317/92 , G01N2333/16
摘要： The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.0×10−9 (M) or less; a pharmaceutical composition comprising the antibody or fragment thereof; and a method of producing an anti-HIV antibody or a fragment thereof, comprising immunizing a GANP transgenic non-human mammal or a progeny thereof with a polypeptide consisting of the amino acid sequence as shown in SEQ ID NO: 6 as an antigen and collecting the antibody from the resultant mammal or progeny.
摘要翻译： 本发明旨在提供高亲和力的抗HIV抗体。 根据本发明，提供了与HIV的gp12糖蛋白结合并具有1.0×10-9（M）以下的解离常数（KD）值的抗体或其片段; 包含抗体或其片段的药物组合物; 以及产生抗HIV抗体或其片段的方法，包括用由SEQ ID NO：6所示的氨基酸序列组成的多肽免疫GANP转基因非人哺乳动物或其后代作为抗原并收集 来自所得哺乳动物或后代的抗体。
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公开(公告)号：US20080050365A1
公开(公告)日：2008-02-28
申请号：US10582861
申请日：2004-03-09
CPC分类号： C07K16/1063 , C07K2317/76 , C07K2317/92 , G01N2333/16
摘要： The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.0×10−9 (M) or less; a pharmaceutical composition comprising the antibody or fragment thereof; and a method of producing an anti-HIV antibody or a fragment thereof, comprising immunizing a GANP transgenic non-human mammal or a progeny thereof with a polypeptide consisting of the amino acid sequence as shown in SEQ ID NO: 6 as an antigen and collecting the antibody from the resultant mammal or progeny
摘要翻译： 本发明旨在提供高亲和力的抗HIV抗体。 根据本发明，提供了结合HIV的gp12糖蛋白的抗体或其片段，其解离常数（KD）为1.0×10 -9（M）以下; 包含抗体或其片段的药物组合物; 以及产生抗HIV抗体或其片段的方法，包括用由SEQ ID NO：6所示的氨基酸序列组成的多肽免疫GANP转基因非人哺乳动物或其后代作为抗原并收集 来自所得哺乳动物或后代的抗体
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公开(公告)号：US07138509B2
公开(公告)日：2006-11-21
申请号：US10961231
申请日：2004-10-12
申请人： Nobuo Sakaguchi , Kazuhiko Kuwahara
发明人： Nobuo Sakaguchi , Kazuhiko Kuwahara
CPC分类号： C12N9/1205 , C07K16/40 , C07K2319/00
摘要： The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.
摘要翻译： 本发明的目的是提供具有激酶活性的新型蛋白质和编码所述蛋白质的基因。 根据本发明，提供了由序列表的SEQ ID No.1或3所示的氨基酸序列表示的GANP蛋白质，其涉及异常B细胞分化的信号转导 自身免疫状态，并且具有激酶活性，以及编码所述蛋白质的多核苷酸。
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公开(公告)号：US06673913B1
公开(公告)日：2004-01-06
申请号：US09914272
申请日：2001-12-05
申请人： Nobuo Sakaguchi , Kazuhiko Kuwahara
发明人： Nobuo Sakaguchi , Kazuhiko Kuwahara
IPC分类号： C07H2104
CPC分类号： C12N9/1205 , C07K16/40 , C07K2319/00
摘要： The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes the protein.
摘要翻译： 本发明的目的是提供具有激酶活性的新型蛋白质和编码所述蛋白质的基因。 根据本发明，提供了由序列表的SEQ ID No.1或3所示的氨基酸序列表示的GANP蛋白质，其涉及异常B细胞分化的信号转导 自身免疫状态，并且具有激酶活性，以及编码该蛋白质的多核苷酸。
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公开(公告)号：US5597037A
公开(公告)日：1997-01-28
申请号：US532798
申请日：1995-11-07
申请人： Kazuhiko Asada , Koichi Ueno , Shin-ichiro Kashihara , Shigemi Okamoto , Katsuo Kurose , Kazuhiko Kuwahara , Ken-ichiro Mitsuhashi
发明人： Kazuhiko Asada , Koichi Ueno , Shin-ichiro Kashihara , Shigemi Okamoto , Katsuo Kurose , Kazuhiko Kuwahara , Ken-ichiro Mitsuhashi
CPC分类号： F25J1/0022 , F25B39/00 , F25B41/00 , F25J1/0052 , F25J1/0262 , F25J1/0272 , F25J5/002 , F28D9/0062 , F25J2205/02 , F25J2290/32 , F25J2290/50
摘要： An object of the present invention is to minimize a volume of a hollow body by a combination of a horizontal H-letter shaped type gas-liquid separator and a plurality of plate-fin heat exchangers having a larger heat exchange performance per volume. In the present heat exchanging apparatus, fluid and refrigerants flow about in the hollow body through pipes while gas and liquid phases of the refrigerants are repeatedly separated and mixed for heat exchange between the fluid and the refrigerants. The apparatus comprises a plurality of plate-fin heat exchangers for exchanging heat between the refrigerants and the fluid, and a gas-liquid separator including upper and lower accommodation portions which are hollow cylinders laid in a horizontal direction both ends of which are airtightly sealed and an intermediate accommodation portion which connects the upper accommodation portion to the lower accommodation portion so as to form a sideways H-letter shape.
摘要翻译： PCT No.PCT / JP95 / 00360 Sec。 371日期：1995年11月7日 102（e）日期1995年11月7日PCT 1995年3月7日PCT PCT。 公开号WO95 / 24595 日期1995年9月14日本发明的目的是通过水平H字形气液分离器和多个热交换性能较好的板翅式换热器的组合来最小化中空体的体积 每卷。 在本发明的热交换装置中，流体和制冷剂通过管道在中空体中流动，同时制冷剂的气相和液相被重复分离和混合以在流体和制冷剂之间进行热交换。 该装置包括多个用于在制冷剂和流体之间交换热量的板翅式热交换器，以及气水分离器，其包括上下容纳部分，其是沿水平方向放置的中空圆筒，两端气密密封， 中间容纳部，其将上部容纳部连接到下部容纳部，以形成侧面的H字形。
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公开(公告)号：US4766190A
公开(公告)日：1988-08-23
申请号：US917500
申请日：1986-10-10
IPC分类号： C08F214/18 , C08F14/18 , C08F16/14 , C08F214/26 , C08F216/14 , C08F16/24
CPC分类号： C08F214/262 , C08F2438/01
摘要： An elastomeric fluoropolymer comprising 12 to 50% by mole of repeating units derived from a perfluorovinyl ether of the formula:CF.sub.2 .dbd.CFO--(CF.sub.2 CFXO).sub.m --R.sub.f (I)wherein R.sub.f is a C.sub.1 -C.sub.6 perfluoroalkyl group, X is a fluorine atom or a trifluoromethyl group and m is an integer of 1 to 5, 50 to 88% by mole of repeating units derived from tetrafluoroethylene and 0.1 to 5% by mole of repeating units of hexafluoropropylene having improved strength and compression set.
摘要翻译： 包含12-50％（摩尔）衍生自下列通式的全氟乙烯基醚的重复单元：CF 2 = CFO-（CF 2 CFXO）m -R f（I）的弹性体含氟聚合物，其中Rf是C1-C6全氟烷基，X是氟原子 或三氟甲基，m为1至5的整数，50至88摩尔％的衍生自四氟乙烯的重复单元和0.1至5摩尔％的具有改进的强度和压缩永久变形的六氟丙烯的重复单元。
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