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45 条记录 (耗时 0.025 秒)

    Method and device for revealing a catalytic activity by solid materials
    3.
    发明授权
    Method and device for revealing a catalytic activity by solid materials 失效
    用固体材料显示催化活性的方法和装置

    公开(公告)号：US06576197B1

    公开(公告)日：2003-06-10

    申请号：US09284115

    申请日：1999-04-08

    申请人： Norbert Windhab ,  Christian Miculka ,  Hans-Ulrich Hoppe

    发明人： Norbert Windhab ,  Christian Miculka ,  Hans-Ulrich Hoppe

    IPC分类号： G01N3196

    CPC分类号： B01J8/001 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  H01J49/40 ,  Y10T436/24

    摘要： The invention relates to a process for detecting the catalytic activity of solid materials, in which process one or more starting materials are brought to reaction in the presence of the solid materials, characterized in that the solid materials are present, spatially separated from one another, on a support, in that the starting materials are brought into contact with the solid materials and in that the resultant product or products are analyzed by a mass spectrometer, with resolution of location regarding the solid materials on the support. The advantages of the process according to the invention are essentially that a rapid serial or parallel detection of the catalytic activity of solid materials under identical conditions is now possible.

    摘要翻译： 本发明涉及一种用于检测固体材料的催化活性的方法，其中一种或多种原料在固体材料存在下进行反应，其特征在于固体材料存在，空间上彼此分离， 在支撑体上，起始材料与固体材料接触，并且通过质谱仪分析得到的产物或产物，其中解决与载体上固体物质有关的位置。该方法的优点在于 本发明基本上是在相同条件下快速连续或平行地检测固体材料的催化活性现在是可能的。

    Network for evaluating data obtained in a biochip measurement device
    6.
    发明授权
    Network for evaluating data obtained in a biochip measurement device 失效
    用于评估在生物芯片测量装置中获得的数据的网络

    公开(公告)号：US07315784B2

    公开(公告)日：2008-01-01

    申请号：US09784720

    申请日：2001-02-15

    申请人： Klaus Abraham-Fuchs ,  Arne Hengerer ,  Norbert Windhab ,  Kieran T. Gallahue ,  James P. O'Connell ,  Greg Gosch

    发明人： Klaus Abraham-Fuchs ,  Arne Hengerer ,  Norbert Windhab ,  Kieran T. Gallahue ,  James P. O'Connell ,  Greg Gosch

    IPC分类号： G06F19/00 ,  G01N33/48 ,  A61B5/00 ,  C12Q1/00

    CPC分类号： G06F19/28 ,  G06F19/24 ,  G16H10/20

    摘要： In a method and a network for evaluating medical data in a clinical study, biochips containing patient samples with multiple biomolecular markers are tested in a number of point of care test devices respectively at point of care sites. Each test of each biochip sample produces a diagnostic result, which is entered into the electronic patient record for the patient who produced the sample. A follow-up examination is subsequently conducted for each patient, and the results of the follow-up examination are also entered into that patient's electronic patient record. The follow-up results indicate whether the diagnostic test result was a false positive, a false negative or correct. The follow-up data and the original diagnostic results from all point of care sites are electronically transmitted to a remote server, which has access to an expert system which uses the test results and the follow-up data to automatically devise a measurement protocol for a selected pathology.

    摘要翻译： 在临床研究中用于评估医学数据的方法和网络中，分别在护理部位的许多点护理测试装置中测试含有具有多个生物分子标记的患者样品的生物芯片。 每个生物芯片样品的每个测试产生诊断结果，其被输入到生产样品的患者的电子病人记录中。 随后对每名患者进行随访检查，随访检查结果也纳入该患者的电子病历。 随访结果表明诊断检查结果是假阳性，假阴性或正确。 来自所有护理点的后续数据和原始诊断结果被电子传输到远程服务器，该远程服务器可以访问使用测试结果的专家系统和后续数据来自动设计测量协议 选择病理学。

    Biomolecules having multiple attachment moieties for binding to a substrate surface
    8.
    发明授权
    Biomolecules having multiple attachment moieties for binding to a substrate surface 有权
    具有多个附着部分的生物分子用于结合底物表面

    公开(公告)号：US07833715B1

    公开(公告)日：2010-11-16

    申请号：US11655009

    申请日：2007-01-18

    申请人： Markus Schweitzer ,  Norbert Windhab ,  John R. Havens ,  Thomas J. Onofrey ,  Charles Greef ,  Daguang Wang

    发明人： Markus Schweitzer ,  Norbert Windhab ,  John R. Havens ,  Thomas J. Onofrey ,  Charles Greef ,  Daguang Wang

    IPC分类号： C12Q1/68 ,  C07H21/00 ,  C07H21/02

    CPC分类号： C07H19/04 ,  C07H21/00 ,  C12Q1/68 ,  G01N33/54353

    摘要： Methods of binding biomolecules to a substrate are provided that include contacting the biomolecule with a branched linking moiety to form a branched linking structure. The branched linking structure is then contacted with a binding moiety on the substrate to form a coupled substrate binding structure, thereby binding the biomolecule to the substrate. The biomolecule may contain a Lewis base or a nucleophile to react with a Lewis acid or electrophile in the branched linking moiety. Alternatively, the biomolecule may contain a Lewis acid or electrophile that can react with a Lewis base or nucleophile in the branched linking moiety. Additionally, the biomolecule can be bound to the substrate through a covalent or non-covalent bond.

    摘要翻译： 提供了将生物分子与底物结合的方法，包括使生物分子与支链连接部分接触以形成支链结构。 然后将支链连接结构与基底上的结合部分接触以形成偶联的底物结合结构，从而将生物分子结合到底物上。 生物分子可以含有路易斯碱或亲核试剂以与支链连接部分中的路易斯酸或亲电子试剂反应。 或者，生物分子可以含有路易斯酸或亲电子试剂，其可以与支链连接部分中的路易斯碱或亲核试剂反应。 此外，生物分子可以通过共价或非共价键与底物结合。

    BIOMOLECULES HAVING MULTIPLE ATTACHMENT MOIETIES FOR BINDING TO A SUBSTRATE SURFACE
    9.
    发明申请
    BIOMOLECULES HAVING MULTIPLE ATTACHMENT MOIETIES FOR BINDING TO A SUBSTRATE SURFACE 有权
    具有多个附着力的生物分子结合到基底表面

    公开(公告)号：US20100286377A1

    公开(公告)日：2010-11-11

    申请号：US11655009

    申请日：2007-01-18

    申请人： Markus Schweitzer ,  Norbert Windhab ,  John R. Havens ,  Thomas J. Onofrey ,  Charles Greef ,  Daguang Wang

    发明人： Markus Schweitzer ,  Norbert Windhab ,  John R. Havens ,  Thomas J. Onofrey ,  Charles Greef ,  Daguang Wang

    IPC分类号： C07H21/02 ,  C07H21/00 ,  C07H21/04

    CPC分类号： C07H19/04 ,  C07H21/00 ,  C12Q1/68 ,  G01N33/54353

    摘要： Methods of binding biomolecules to a substrate are provided that include contacting the biomolecule with a branched linking moiety to form a branched linking structure. The branched linking structure is then contacted with a binding moiety on the substrate to form a coupled substrate binding structure, thereby binding the biomolecule to the substrate. The biomolecule may contain a Lewis base or a nucleophile to react with a Lewis acid or electrophile in the branched linking moiety. Alternatively, the biomolecule may contain a Lewis acid or electrophile that can react with a Lewis base or nucleophile in the branched linking moiety. Additionally, the biomolecule can be bound to the substrate through a covalent or non-covalent bond.

    摘要翻译： 提供了将生物分子与底物结合的方法，包括使生物分子与支链连接部分接触以形成支链结构。 然后将支链连接结构与基底上的结合部分接触以形成偶联的底物结合结构，从而将生物分子结合到底物上。 生物分子可以含有路易斯碱或亲核试剂以与支链连接部分中的路易斯酸或亲电子试剂反应。 或者，生物分子可以含有路易斯酸或亲电子试剂，其可以与支链连接部分中的路易斯碱或亲核试剂反应。 此外，生物分子可以通过共价或非共价键与底物结合。