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公开(公告)号：US20130330792A1
公开(公告)日：2013-12-12
申请号：US13976786
申请日：2011-09-15
申请人： Norihiro Takeuchi , Masahiro Henmi , Jihoon Cheon , Masateru Ito , Hiroshi Hayakawa , Makoto Nishida
发明人： Norihiro Takeuchi , Masahiro Henmi , Jihoon Cheon , Masateru Ito , Hiroshi Hayakawa , Makoto Nishida
IPC分类号： C12P7/56
CPC分类号： C12P7/56 , B01D61/025 , B01D65/02 , B01D2311/06 , B01D2311/2642 , B01D2311/2669 , B01D2321/12 , B01D2321/162 , B01D2321/164 , B01D2321/168 , C12M47/10
摘要： A method of producing a chemical by continuous fermentation includes a fermentation step of converting a fermentation feedstock to a fermentation liquid containing a chemical by fermentation on cultivation of a microorganism; a membrane separation step of recovering the chemical as a filtrate by a separation membrane from the fermentation liquid; a concentrating step of obtaining a permeate and a concentrate containing the chemical by a reverse osmosis membrane from the filtrate; and/or a purification step of distilling the filtrate to increase a purity of the chemical, in which, cleaning etc. of the separation membrane in the membrane separation step is preformed by using the permeated liquid from the reverse osmosis membrane in the concentrating step and/or the condensed liquid in the purification step.
摘要翻译： 通过连续发酵生产化学品的方法包括发酵步骤，其通过在培养微生物时通过发酵将发酵原料转化成含有化学品的发酵液; 膜分离步骤，通过分离膜从发酵液中回收作为滤液的化学品; 浓缩步骤，从滤液中通过反渗透膜获得含有该化学物质的渗透物和浓缩物; 和/或纯化步骤，蒸馏滤液以提高化学品的纯度，其中通过在浓缩步骤中使用来自反渗透膜的透过液体来进行膜分离步骤中的分离膜的清洗等，以及 /或纯化步骤中的冷凝液体。
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2.发明申请METHOD FOR STERILIZING SEPARATION MEMBRANE MODULES, STERILIZATION DEVICE, AND APPARATUS FOR PRODUCING CHEMICALS 审中-公开灭菌分离膜模块灭菌方法，灭菌装置及生产化学品的装置公开(公告)号：US20130302882A1
公开(公告)日：2013-11-14
申请号：US13997094
申请日：2011-12-22
IPC分类号： A61L2/04
CPC分类号： A61L2/04 , B01D65/022 , B01D71/024 , B01D2321/08
摘要： A method of sterilizing a separation membrane module reduces damage of a ceramic separation membrane, a sterilization process device achieves the method of sterilizing, and an apparatus produces chemicals. The method of sterilizing the separation membrane module includes a ceramic-containing separation membrane including a temperature raise step of raising the temperature of the separation membrane module to a predetermined sterilization temperature by feeding sterilization water having a controlled temperature and pressure so that a rate of temperature change of the separation membrane module is 6.0° C. or less per minute, and a sterilization step of sterilizing the separation membrane module at a predetermined temperature for a predetermined time.
摘要翻译： 对分离膜组件进行灭菌的方法减少了陶瓷分离膜的损伤，灭菌处理装置实现了灭菌方法，并且设备产生化学品。 对分离膜组件进行灭菌的方法包括：含陶瓷分离膜，其包括通过供给具有受控温度和压力的灭菌水将分离膜组件的温度升高到预定灭菌温度的升温步骤，使得温度 分离膜组件的改变为每分钟6.0℃或更低，以及在预定温度下将分离膜组件灭菌预定时间的灭菌步骤。
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公开(公告)号：US20130280773A1
公开(公告)日：2013-10-24
申请号：US13996241
申请日：2011-12-21
IPC分类号： C12P7/56
摘要： A method of producing a chemical includes a fermentation step that converts a fermentation feedstock, through fermentation by culturing a microorganism or culture cells, into a fermented liquid containing the chemical, and a membrane separation step that collects the chemical, as a filtrate, from the fermented liquid with the use of two or more separation membrane modules, and returning the non-filtered liquid to the fermented liquid, wherein in the membrane separation step, timing of the filtration-stop treatment for each separation membrane module is controlled when an intermittent filtration operation including alternately repeating a filtration treatment and a filtration-stop treatment is performed with plural separation membrane modules.
摘要翻译： 制造化学品的方法包括发酵步骤，其通过将微生物或培养细胞培养发酵成发酵液，将发酵原料转化成含有该化学品的发酵液，以及膜分离步骤，将滤液中的化学物质从 使用两个或更多个分离膜组件的发酵液体，并将未过滤的液体返回到发酵液中，其中在膜分离步骤中，当间歇过滤时，控制每个分离膜组件的过滤停止处理的时间 用多个分离膜组件进行交替重复过滤处理和过滤停止处理的操作。
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公开(公告)号：US09365876B2
公开(公告)日：2016-06-14
申请号：US13992443
申请日：2011-12-08
申请人： Satoko Kanamori , Jihoon Cheon , Takashi Mimitsuka , Norihiro Takeuchi , Makoto Nishida , Yuji Tanaka
发明人： Satoko Kanamori , Jihoon Cheon , Takashi Mimitsuka , Norihiro Takeuchi , Makoto Nishida , Yuji Tanaka
IPC分类号： C12P1/00 , C12P13/04 , C12P13/08 , C12P7/40 , C12P7/56 , C12P13/00 , C12M1/00 , C12M1/26 , C12M1/34
CPC分类号： C12P13/08 , C12M29/02 , C12M29/18 , C12M33/14 , C12M41/40 , C12M47/10 , C12P7/40 , C12P7/56 , C12P13/001 , C12P13/04
摘要： A method produces a chemical through continuous fermentation including: (a) culturing a cell in a culture medium in a fermentor to ferment a feedstock to produce a chemical; (b) conducting filtration of the culture medium with a separation membrane module; (c) separating a permeate containing the chemical from the culture medium while retaining a non-permeated liquid in the fermentor, and (d) supplying a gas from at least one of a lower portion of the separation membrane module and a pipe communicating between the fermentor and the separation membrane module to adjust a gas linear velocity in the separation membrane module to 0.15 cm/s to 70 cm/s while supplying the separation membrane module with a liquid.
摘要翻译： 方法通过连续发酵生产化学品，包括：（a）在发酵罐中培养培养基中的细胞以发酵原料以生产化学品; （b）用分离膜组件对培养基进行过滤; （c）将含有化学物质的渗透物从培养基中分离，同时将不渗透的液体保持在发酵罐中，和（d）从分离膜组件的下部中的至少一个供给气体， 发酵罐和分离膜组件，将分离膜组件中的气体线速度调节至0.15厘米/秒至70厘米/秒，同时向分离膜组件供应液体。
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公开(公告)号：US20130330787A1
公开(公告)日：2013-12-12
申请号：US13992443
申请日：2011-12-08
申请人： Satoko Kanamori , Jihoon Cheon , Takashi Mimitsuka , Norihiro Takeuchi , Makoto Nishida , Yuji Tanaka
发明人： Satoko Kanamori , Jihoon Cheon , Takashi Mimitsuka , Norihiro Takeuchi , Makoto Nishida , Yuji Tanaka
CPC分类号： C12P13/08 , C12M29/02 , C12M29/18 , C12M33/14 , C12M41/40 , C12M47/10 , C12P7/40 , C12P7/56 , C12P13/001 , C12P13/04
摘要： A method produces a chemical through continuous fermentation including: (a) culturing a cell in a culture medium in a fermentor to ferment a feedstock to produce a chemical; (b) conducting filtration of the culture medium with a separation membrane module; (c) separating a permeate containing the chemical from the culture medium while retaining a non-permeated liquid in the fermentor, and (d) supplying a gas from at least one of a lower portion of the separation membrane module and a pipe communicating between the fermentor and the separation membrane module to adjust a gas linear velocity in the separation membrane module to 0.15 cm/s to 70 cm/s while supplying the separation membrane module with a liquid.
摘要翻译： 方法通过连续发酵生产化学品，包括：（a）在发酵罐中培养培养基中的细胞以发酵原料以生产化学品; （b）用分离膜组件对培养基进行过滤; （c）将含有化学物质的渗透物从培养基中分离，同时将不渗透的液体保持在发酵罐中，和（d）从分离膜组件的下部中的至少一个供给气体， 发酵罐和分离膜组件，将分离膜组件中的气体线速度调节至0.15厘米/秒至70厘米/秒，同时向分离膜组件供应液体。
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6.发明申请公开(公告)号：US20130280767A1
公开(公告)日：2013-10-24
申请号：US13976642
申请日：2011-12-22
IPC分类号： C12M1/00
摘要： A hollow fiber membrane module includes a housing, a hollow fiber membrane sealed in the housing and a sealing agent in a space between the hollow fiber membrane and the housing, wherein 1) the hollow fiber membrane is made of a polysulfone based resin; 2) a membrane surface average pore diameter is 5 nm or more and 500 nm or less; 3) a pure water permeability coefficient under 50 kPa at 25° C. is 0.05 m3/m2/hour or more and 5 m3/m2/hour or less; 4) the sealing agent is at least one selected from the group consisting of a polyurethane resin and an epoxy resin; and 5) a decrease in tensile strength after bringing the sealing agent into contact with saturated steam at 121° C. for 24 hours is 25% or less.
摘要翻译： 中空纤维膜组件包括壳体，密封在壳体中的中空纤维膜和在中空纤维膜和壳体之间的空间中的密封剂，其中1）中空纤维膜由聚砜基树脂制成; 2）膜表面平均孔径为5nm以上且500nm以下; 3）在25℃下50kPa下的纯水渗透系数为0.05m 3 / m 2 /小时以上，5m 3 / m 2 /小时以下; 4）密封剂是选自聚氨酯树脂和环氧树脂中的至少一种; 和5）使密封剂在121℃与饱和蒸汽接触24小时后的拉伸强度降低为25％以下。
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公开(公告)号：US20130323805A1
公开(公告)日：2013-12-05
申请号：US13823433
申请日：2011-09-05
申请人： Atsushi Kobayashi , Jihoon Cheon , Norihiro Takeuchi , Makoto Nishida , Yuji Tanaka , Shin-ichi Minegishi
发明人： Atsushi Kobayashi , Jihoon Cheon , Norihiro Takeuchi , Makoto Nishida , Yuji Tanaka , Shin-ichi Minegishi
CPC分类号： C12P7/56 , B01D61/18 , B01D63/02 , B01D65/02 , B01D71/34 , B01D2311/10 , B01D2321/04 , B01D2321/08 , B01D2321/168 , C12M33/14 , C12M39/00 , C12P1/00 , C12P7/40
摘要： A method of producing chemicals through continuous fermentation includes washing a membrane with a washing liquid supplied from a permeate side of a membrane unit in a continuous fermentation; filtering a culture medium containing a fermentation feedstock, a chemical and a microbe or a cultured cell through a separation membrane; collecting the chemical from a filtrate; retaining or refluxing unfiltered remains in the culture medium; and adding a fermentation feedstock to the culture medium, wherein the washing liquid is high-temperature water having a temperature higher than a temperature of the culture medium and of 150° C. or less, and a concentration of the microbe in a fermenter is controlled by supplying the washing liquid.
摘要翻译： 通过连续发酵生产化学品的方法包括在连续发酵中用从膜单元的渗透侧供给的洗涤液洗涤膜; 通过分离膜过滤含有发酵原料，化学品和微生物或培养细胞的培养基; 从滤液中收集化学物质; 在培养基中保留或回流未过滤的残留物; 向培养基中添加发酵原料，其中，洗涤液是温度高于培养基温度且150℃以下的高温水，控制发酵罐中微生物的浓度 通过供给洗涤液。
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公开(公告)号：US20130149745A1
公开(公告)日：2013-06-13
申请号：US13575039
申请日：2011-01-24
CPC分类号： C12P7/56 , B01D63/02 , B01D69/02 , B01D69/081 , B01D69/084 , B01D71/34 , B01D2325/20 , B01D2325/24 , C12P7/06 , C12P7/14 , C12P7/46 , Y02E50/17
摘要： A method produces a chemical by fermentation including: filtering a liquid containing a feedstock, the chemical, and bacterial, microbial or cultured cells through a membrane to recover the chemical from the filtrate; retaining or refluxing unfiltered liquid in the liquid; and adding the feedstock to the liquid, wherein the membrane is a porous hollow-fiber membrane including a polyvinylidene fluoride resin, the porous hollow-fiber membrane having an average pore size of 0.001 μm to 10.0 μm, pure water permeability coefficient at 50 kPa at 25° C. of 0.5 m3/m2/hr to 15 m3/m2/hr, breaking strength of 5 MPa to 20 MPa, elongation at break of 30% to 200%, crimping degree of 1.3 to 2.5, porosity of not less than 40%, and critical surface tension of 45 mN/m to 75 mN/m.
摘要翻译： 一种方法通过发酵生产化学品，包括：通过膜过滤含有原料，化学和细菌，微生物或培养细胞的液体，以从滤液中回收化学品; 在液体中保留或回流未过滤的液体; 并将原料添加到液体中，其中所述膜是包含聚偏二氟乙烯树脂的多孔中空纤维膜，所述多孔中空纤维膜的平均孔径为0.001μm至10.0μm，在50kPa下的纯水渗透系数为 25℃为0.5m 3 / m 2 / hr〜15m 3 / m 2 / hr，断裂强度为5MPa〜20MPa，断裂伸长率为30〜200％，卷曲度为1.3〜2.5，孔隙率为 40％，临界表面张力为45mN / m至75mN / m。
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9.发明申请HOLLOW FIBER MEMBRANE MODULE FOR USE IN PRODUCTION OF CHEMICAL SUBSTANCE, AND PROCESS FOR PRODUCTION OF CHEMICAL SUBSTANCE 审中-公开用于生产化学物质的中空纤维膜模块，以及生产化学物质的方法公开(公告)号：US20120270286A1
公开(公告)日：2012-10-25
申请号：US13508918
申请日：2010-11-10
申请人： Norihiro Takeuchi , Shin-ichi Minegishi , Jihoon Cheon , Makoto Nishida , Takashi Mimitsuka , Hironobu Suzuki , Katsushige Yamada , Hideki Sawai , Ichiro Kumo
发明人： Norihiro Takeuchi , Shin-ichi Minegishi , Jihoon Cheon , Makoto Nishida , Takashi Mimitsuka , Hironobu Suzuki , Katsushige Yamada , Hideki Sawai , Ichiro Kumo
CPC分类号： B01D63/04 , B01D63/022 , B01D63/023 , C12M29/16 , C12P7/56
摘要： A hollow fiber membrane module for use in production of a chemical substance, which is used in continuous fermentation including filtering a fermentation broth of a microorganism or a cultured cell through a hollow fiber membrane, collecting a chemical substance from a filtrate, retaining a concentrated solution in the fermentation broth or refluxing the concentrated solution, and adding a fermentation raw material to the fermentation broth, wherein a large number of hollow fiber membrane bundles are accommodated in a tubular case, at least one end part of each of the bundles is fixed on the tubular case by a hollow fiber membrane bundling member with an end face of each of the hollow fiber membranes open, and the hollow fiber membrane bundling member is made of a synthetic resin having a hardness retention rate after contact with saturated steam at 121° C. for 24 hours of 95% or more.
摘要翻译： 一种用于生产化学物质的中空纤维膜组件，用于连续发酵，包括通过中空纤维膜过滤微生物或培养细胞的发酵液，从滤液中收集化学物质，保留浓缩溶液 在发酵液中或回流浓缩溶液，向发酵液中加入发酵原料，其中将大量中空纤维膜束容纳在管状壳体中，每个束的至少一个端部固定在 通过中空纤维膜捆扎构件的中空纤维膜捆扎构件的中空纤维膜的端面打开，中空纤维膜束紧构件由在121℃的饱和蒸气接触后的硬度保持率的合成树脂制成， 持续24小时95％以上。
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公开(公告)号：US20130266991A1
公开(公告)日：2013-10-10
申请号：US13991686
申请日：2011-12-07
CPC分类号： C12P19/14 , B01D61/025 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/58 , B01D2311/04 , B01D2311/06 , B01D2311/25 , C12N1/38 , C12P7/10 , C12P7/14 , C13K1/04 , C13K13/002 , Y02E50/16 , B01D2311/2634
摘要： A method produces a concentrated aqueous sugar solution using a cellulose-containing biomass as a raw material, including: (1) hydrolyzing a cellulose-containing biomass to produce an aqueous sugar solution; (2) filtering the aqueous sugar solution obtained in (1) through a microfiltration membrane and/or an ultrafiltration membrane, and recovering an aqueous sugar solution from the permeate side; and (3) filtering the aqueous sugar solution obtained in (2) through a reverse osmosis membrane, recovering a permeate from the permeate side and recovering a concentrated aqueous sugar solution from the feed side; wherein at least a part of the permeate from the reverse osmosis membrane is used as a hydrothermal treatment liquid, biomass-suspending, liquid, enzyme-diluting liquid, acid-diluting liquid and/or alkali-diluting liquid in (1).
摘要翻译： 一种方法使用含纤维素的生物质作为原料产生浓缩的糖水溶液，其包括：（1）水解含纤维素的生物质以产生糖水溶液; （2）通过微滤膜和/或超滤膜过滤由（1）得到的糖水溶液，从渗透侧回收糖溶液; （3）通过反渗透膜过滤（2）得到的糖水溶液，从渗透侧回收渗透物，从进料侧回收浓缩的糖水溶液; 其中来自反渗透膜的渗透物的至少一部分在（1）中用作水热处理液，生物质悬浮液，液体，酶稀释液，酸稀释液和/或碱稀释液。
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