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1.发明申请HOLLOW FIBER MEMBRANE MODULE FOR USE IN PRODUCTION OF CHEMICAL SUBSTANCE, AND PROCESS FOR PRODUCTION OF CHEMICAL SUBSTANCE 审中-公开用于生产化学物质的中空纤维膜模块，以及生产化学物质的方法公开(公告)号：US20120270286A1
公开(公告)日：2012-10-25
申请号：US13508918
申请日：2010-11-10
申请人： Norihiro Takeuchi , Shin-ichi Minegishi , Jihoon Cheon , Makoto Nishida , Takashi Mimitsuka , Hironobu Suzuki , Katsushige Yamada , Hideki Sawai , Ichiro Kumo
发明人： Norihiro Takeuchi , Shin-ichi Minegishi , Jihoon Cheon , Makoto Nishida , Takashi Mimitsuka , Hironobu Suzuki , Katsushige Yamada , Hideki Sawai , Ichiro Kumo
CPC分类号： B01D63/04 , B01D63/022 , B01D63/023 , C12M29/16 , C12P7/56
摘要： A hollow fiber membrane module for use in production of a chemical substance, which is used in continuous fermentation including filtering a fermentation broth of a microorganism or a cultured cell through a hollow fiber membrane, collecting a chemical substance from a filtrate, retaining a concentrated solution in the fermentation broth or refluxing the concentrated solution, and adding a fermentation raw material to the fermentation broth, wherein a large number of hollow fiber membrane bundles are accommodated in a tubular case, at least one end part of each of the bundles is fixed on the tubular case by a hollow fiber membrane bundling member with an end face of each of the hollow fiber membranes open, and the hollow fiber membrane bundling member is made of a synthetic resin having a hardness retention rate after contact with saturated steam at 121° C. for 24 hours of 95% or more.
摘要翻译： 一种用于生产化学物质的中空纤维膜组件，用于连续发酵，包括通过中空纤维膜过滤微生物或培养细胞的发酵液，从滤液中收集化学物质，保留浓缩溶液 在发酵液中或回流浓缩溶液，向发酵液中加入发酵原料，其中将大量中空纤维膜束容纳在管状壳体中，每个束的至少一个端部固定在 通过中空纤维膜捆扎构件的中空纤维膜捆扎构件的中空纤维膜的端面打开，中空纤维膜束紧构件由在121℃的饱和蒸气接触后的硬度保持率的合成树脂制成， 持续24小时95％以上。
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2.发明申请公开(公告)号：US20110263811A1
公开(公告)日：2011-10-27
申请号：US13142062
申请日：2009-12-25
申请人： Kenji Sawai , Hideki Sawai , Takashi Mimitsuka , Ito Masateru , Katsushige Yamada , Kenji Kawamura , Shin-ichi Minegishi , Izumi Nakagawa , Tatsuya Nagano
发明人： Kenji Sawai , Hideki Sawai , Takashi Mimitsuka , Ito Masateru , Katsushige Yamada , Kenji Kawamura , Shin-ichi Minegishi , Izumi Nakagawa , Tatsuya Nagano
IPC分类号： C08G63/78 , C07D319/12 , C12P7/56
摘要： Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.
摘要翻译： 乳酸通过以下方法获得：（A）连续发酵步骤，其中具有乳酸发酵能力的微生物的发酵培养基通过平均孔径不小于0.01μm的多孔膜过滤 超过1μm，跨膜压力差在0.1〜20kPa的范围内，并收集渗透物，同时将非渗透液体保留在或将非渗透液体返回到培养物中，并向培养物中加入发酵原料 ; （B）通过纳滤膜对步骤（A）中得到的渗透物进行过滤的工序; 和（C）在25℃至200℃下，在不低于1Pa且不大于大气压的压力下，将步骤（B）中得到的渗透物蒸馏的步骤，以回收乳酸。
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公开(公告)号：US20110004018A1
公开(公告)日：2011-01-06
申请号：US12920891
申请日：2009-03-11
申请人： Masateru Ito , Izumi Nakagawa , Koya Kato , Takashi Mimitsuka , Kenji Sawai , Shin-ichi Minegishi , Hideki Sawai , Katsushige Yamada
发明人： Masateru Ito , Izumi Nakagawa , Koya Kato , Takashi Mimitsuka , Kenji Sawai , Shin-ichi Minegishi , Hideki Sawai , Katsushige Yamada
IPC分类号： C07C231/02 , C07C209/84
CPC分类号： C07C209/84 , B01D61/025 , B01D61/027 , B01D61/58 , B01D71/60 , B01D2317/022 , C08G69/26 , C08G69/28 , C07C211/09 , C07C211/12
摘要： A method for producing a diamine includes purifying a diamine from an aqueous solution containing a diamine salt by adding an alkaline substance to the aqueous solution and then filtering the resulting solution by allowing the solution to pass through a nanofiltration membrane to remove the salt, thereby obtaining an aqueous diamine solution.
摘要翻译： 二胺的制造方法包括：通过向水溶液中添加碱性物质，从含有二胺盐的水溶液中纯化二胺，然后通过使溶液通过纳滤膜除去盐而过滤所得溶液，从而得到 二胺水溶液。
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公开(公告)号：US10683254B2
公开(公告)日：2020-06-16
申请号：US13142062
申请日：2009-12-25
申请人： Kenji Sawai , Hideki Sawai , Takashi Mimitsuka , Ito Masateru , Katsushige Yamada , Kenji Kawamura , Shin-ichi Minegishi , Izumi Nakagawa , Tatsuya Nagano
发明人： Kenji Sawai , Hideki Sawai , Takashi Mimitsuka , Ito Masateru , Katsushige Yamada , Kenji Kawamura , Shin-ichi Minegishi , Izumi Nakagawa , Tatsuya Nagano
摘要： Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.
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公开(公告)号：US08334411B2
公开(公告)日：2012-12-18
申请号：US12920891
申请日：2009-03-11
申请人： Masateru Ito , Izumi Nakagawa , Koya Kato , Takashi Mimitsuka , Kenji Sawai , Shin-ichi Minegishi , Hideki Sawai , Katsushige Yamada
发明人： Masateru Ito , Izumi Nakagawa , Koya Kato , Takashi Mimitsuka , Kenji Sawai , Shin-ichi Minegishi , Hideki Sawai , Katsushige Yamada
IPC分类号： C07C209/84 , C07C209/86 , C07C231/02
CPC分类号： C07C209/84 , B01D61/025 , B01D61/027 , B01D61/58 , B01D71/60 , B01D2317/022 , C08G69/26 , C08G69/28 , C07C211/09 , C07C211/12
摘要： A method for producing a diamine includes purifying a diamine from an aqueous solution containing a diamine salt by adding an alkaline substance to the aqueous solution and then filtering the resulting solution by allowing the solution to pass through a nanofiltration membrane to remove the salt, thereby obtaining an aqueous diamine solution.
摘要翻译： 二胺的制造方法包括：通过向水溶液中添加碱性物质，从含有二胺盐的水溶液中纯化二胺，然后通过使溶液通过纳滤膜除去盐而过滤所得溶液，从而得到 二胺水溶液。
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公开(公告)号：US09365876B2
公开(公告)日：2016-06-14
申请号：US13992443
申请日：2011-12-08
申请人： Satoko Kanamori , Jihoon Cheon , Takashi Mimitsuka , Norihiro Takeuchi , Makoto Nishida , Yuji Tanaka
发明人： Satoko Kanamori , Jihoon Cheon , Takashi Mimitsuka , Norihiro Takeuchi , Makoto Nishida , Yuji Tanaka
IPC分类号： C12P1/00 , C12P13/04 , C12P13/08 , C12P7/40 , C12P7/56 , C12P13/00 , C12M1/00 , C12M1/26 , C12M1/34
CPC分类号： C12P13/08 , C12M29/02 , C12M29/18 , C12M33/14 , C12M41/40 , C12M47/10 , C12P7/40 , C12P7/56 , C12P13/001 , C12P13/04
摘要： A method produces a chemical through continuous fermentation including: (a) culturing a cell in a culture medium in a fermentor to ferment a feedstock to produce a chemical; (b) conducting filtration of the culture medium with a separation membrane module; (c) separating a permeate containing the chemical from the culture medium while retaining a non-permeated liquid in the fermentor, and (d) supplying a gas from at least one of a lower portion of the separation membrane module and a pipe communicating between the fermentor and the separation membrane module to adjust a gas linear velocity in the separation membrane module to 0.15 cm/s to 70 cm/s while supplying the separation membrane module with a liquid.
摘要翻译： 方法通过连续发酵生产化学品，包括：（a）在发酵罐中培养培养基中的细胞以发酵原料以生产化学品; （b）用分离膜组件对培养基进行过滤; （c）将含有化学物质的渗透物从培养基中分离，同时将不渗透的液体保持在发酵罐中，和（d）从分离膜组件的下部中的至少一个供给气体， 发酵罐和分离膜组件，将分离膜组件中的气体线速度调节至0.15厘米/秒至70厘米/秒，同时向分离膜组件供应液体。
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公开(公告)号：US20130330787A1
公开(公告)日：2013-12-12
申请号：US13992443
申请日：2011-12-08
申请人： Satoko Kanamori , Jihoon Cheon , Takashi Mimitsuka , Norihiro Takeuchi , Makoto Nishida , Yuji Tanaka
发明人： Satoko Kanamori , Jihoon Cheon , Takashi Mimitsuka , Norihiro Takeuchi , Makoto Nishida , Yuji Tanaka
CPC分类号： C12P13/08 , C12M29/02 , C12M29/18 , C12M33/14 , C12M41/40 , C12M47/10 , C12P7/40 , C12P7/56 , C12P13/001 , C12P13/04
摘要： A method produces a chemical through continuous fermentation including: (a) culturing a cell in a culture medium in a fermentor to ferment a feedstock to produce a chemical; (b) conducting filtration of the culture medium with a separation membrane module; (c) separating a permeate containing the chemical from the culture medium while retaining a non-permeated liquid in the fermentor, and (d) supplying a gas from at least one of a lower portion of the separation membrane module and a pipe communicating between the fermentor and the separation membrane module to adjust a gas linear velocity in the separation membrane module to 0.15 cm/s to 70 cm/s while supplying the separation membrane module with a liquid.
摘要翻译： 方法通过连续发酵生产化学品，包括：（a）在发酵罐中培养培养基中的细胞以发酵原料以生产化学品; （b）用分离膜组件对培养基进行过滤; （c）将含有化学物质的渗透物从培养基中分离，同时将不渗透的液体保持在发酵罐中，和（d）从分离膜组件的下部中的至少一个供给气体， 发酵罐和分离膜组件，将分离膜组件中的气体线速度调节至0.15厘米/秒至70厘米/秒，同时向分离膜组件供应液体。
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公开(公告)号：US20140017746A1
公开(公告)日：2014-01-16
申请号：US14027754
申请日：2013-09-16
IPC分类号： C12P7/56
CPC分类号： C12P7/56
摘要： A method of producing lactic acid by continuous fermentation includes filtering a culture of polyploidy prototrophic yeast having a capacity to produce lactic acid by introduction of a lactate dehydrogenase gene through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm; and recovering the lactic acid from filtrate while the unfiltered liquid is retained in or returned to the culture and a fermentation feedstock is added to the culture.
摘要翻译： 通过连续发酵生产乳酸的方法包括通过将平均孔径不小于0.01μm和小于1的多孔膜引入乳酸脱氢酶基因来过滤具有产生乳酸能力的多倍体原养酵母的培养物 妈妈 并从滤液中回收乳酸，同时将未过滤的液体保留在培养物中或返回到培养物中，向培养物中加入发酵原料。
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9.发明授权公开(公告)号：US09587253B2
公开(公告)日：2017-03-07
申请号：US12280197
申请日：2007-02-16
申请人： Hideki Sawai , Katsushige Yamada , Takashi Mimitsuka , Kenji Sawai , Tetsu Yonehara , Yohito Ito , Masahiro Henmi
发明人： Hideki Sawai , Katsushige Yamada , Takashi Mimitsuka , Kenji Sawai , Tetsu Yonehara , Yohito Ito , Masahiro Henmi
IPC分类号： C12P13/04 , C12P7/06 , C12M1/00 , C12M1/34 , C12P7/18 , C12P7/46 , C12P7/50 , C12P7/56 , C12P13/00 , C12P13/08 , C12P19/30
CPC分类号： C12P7/06 , C12M29/04 , C12M29/18 , C12M41/40 , C12M47/10 , C12P7/18 , C12P7/46 , C12P7/50 , C12P7/56 , C12P13/001 , C12P13/005 , C12P13/04 , C12P13/08 , C12P19/30 , Y02E50/17
摘要： The invention provides a method of producing a chemical product through continuous fermentation which includes filtering a culture of a microorganism or cultured cells with a separation membrane to recover a product from a filtrate and simultaneously retaining a nonfiltered fluid in, or refluxing it to, the culture, and adding fermentation materials to the culture, wherein a porous membrane having an average pore size of 0.01 μm or more to less than 1 μm is used as the separation membrane and the filtration is conducted with a transmembrane pressure difference in the range of 0.1 to 20 kPa. According to this method, the fermentation productivity of the chemical product can be largely elevated at high stability and a low cost.
摘要翻译： 本发明提供了一种通过连续发酵生产化学产品的方法，包括用分离膜过滤微生物培养物或培养细胞，从滤液中回收产物，同时将非过滤液体保留在培养基中或将其回流至培养物中 将发酵材料添加到培养物中，其中使用平均孔径为0.01μm以上且小于1μm的多孔膜作为分离膜，并且以跨膜压差为0.1〜 20 kPa。 根据该方法，化学产品的发酵生产率可以在高稳定性和低成本的情况下大大提高。
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公开(公告)号：US20110053231A1
公开(公告)日：2011-03-03
申请号：US12865934
申请日：2009-02-03
IPC分类号： C12P7/56
CPC分类号： C12P7/56
摘要： A method of producing lactic acid continuous fermentation including filtering a culture of polyploid yeast having a capacity to produce lactic acid through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm, and recovering the product from the filtrate while the unfiltered liquid is retained in or returned to the culture and a fermentation feedstock is added to the culture.
摘要翻译： 一种生产乳酸连续发酵的方法，包括通过平均孔径不小于0.01μm且小于1μm的多孔膜过滤具有生产乳酸能力的多倍体酵母的培养物，并从滤液中回收产物 而未过滤的液体保留在或返回到培养物中，并且向培养物中加入发酵原料。
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