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1.发明申请FLAVANOIDS AND ISOFLAVANOIDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES 有权FLAVANOIDS和ISOFLAVANOIDS预防和治疗心血管疾病公开(公告)号：US20090259048A1
公开(公告)日：2009-10-15
申请号：US12369296
申请日：2009-02-11
申请人： Norman C.W. Wong , Joseph E.L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
发明人： Norman C.W. Wong , Joseph E.L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
IPC分类号： C07D405/14
CPC分类号： C07D213/64 , A61K31/05 , A61K31/055 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/216 , A61K31/265 , A61K31/352 , A61K31/353 , A61K31/357 , A61K31/382 , A61K31/435 , A61K31/4375 , A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4433 , A61K31/465 , A61K31/47 , A61K31/536 , C07C37/003 , C07C37/055 , C07C37/18 , C07C39/14 , C07C39/15 , C07C39/21 , C07C43/23 , C07C46/00 , C07C49/83 , C07C49/835 , C07C50/32 , C07C205/22 , C07C311/29 , C07C317/22 , C07C327/28 , C07D213/65 , C07D213/80 , C07D213/89 , C07D215/233 , C07D217/16 , C07D217/22 , C07D217/24 , C07D265/22 , C07D311/30 , C07D311/32 , C07D311/36 , C07D311/60 , C07D319/20 , C07D335/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/052
摘要： The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
摘要翻译： 本公开提供了上调载脂蛋白A-I（ApoA-I）表达的非天然存在的多酚化合物。 所公开的组合物和方法可用于治疗和预防心血管疾病和相关疾病状态，包括胆固醇或脂质相关疾病，例如动脉粥样硬化。
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公开(公告)号：US20080188467A1
公开(公告)日：2008-08-07
申请号：US11670238
申请日：2007-02-01
申请人： Norman C.W. Wong , Joseph E.L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
发明人： Norman C.W. Wong , Joseph E.L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
IPC分类号： A61K31/44 , A61K31/47 , A61K31/497 , A61K31/517 , A61K31/519 , A61K31/535 , A61K31/54 , A61P9/00
CPC分类号： A61K31/517 , A61K31/4375 , A61K31/44 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/535 , A61K31/5377 , A61K31/54 , A61K31/695 , A61L29/16 , A61L31/16 , A61L2300/204 , A61L2300/606 , A61L2420/00 , C07D217/24 , C07D239/91 , C07D279/02 , C07D401/04 , C07D403/12 , C07D405/04 , C07D471/04 , C07F7/1804
摘要： The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.
摘要翻译： 本公开涉及可用于调节载脂蛋白AI（ApoA-I）的表达的化合物及其用于治疗和预防心血管疾病和相关疾病状态的用途，包括胆固醇或脂质相关疾病，例如， 例如动脉粥样硬化。
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3.发明申请Stilbenes and Chalcones for the Prevention and Treatment of Cardiovascular Diseases 有权用于预防和治疗心血管疾病的Stilbenes和Chalcones公开(公告)号：US20110082176A1
公开(公告)日：2011-04-07
申请号：US12905500
申请日：2010-10-15
申请人： Norman C.W. Wong , Joseph E.L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
发明人： Norman C.W. Wong , Joseph E.L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
IPC分类号： A61K31/44 , C07C49/835 , C07C245/08 , A61K31/655 , C07C39/16 , A61K31/05 , A61K31/12 , A61K31/166 , C07C233/65 , C07C233/25 , A61K31/167 , A61K31/136 , C07C215/76 , C07C317/22 , A61K31/10 , C07C69/767 , A61K31/235 , A61K31/06 , C07C205/22 , C07C65/19 , A61K31/192 , C07C43/23 , A61K31/085 , C07D213/64 , A61P9/00 , A61P3/06
CPC分类号： C07D213/64 , A61K31/05 , A61K31/055 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/216 , A61K31/265 , A61K31/352 , A61K31/353 , A61K31/357 , A61K31/382 , A61K31/435 , A61K31/4375 , A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4433 , A61K31/465 , A61K31/47 , A61K31/536 , C07C37/003 , C07C37/055 , C07C37/18 , C07C39/14 , C07C39/15 , C07C39/21 , C07C43/23 , C07C46/00 , C07C49/83 , C07C49/835 , C07C50/32 , C07C205/22 , C07C311/29 , C07C317/22 , C07C327/28 , C07D213/65 , C07D213/80 , C07D213/89 , C07D215/233 , C07D217/16 , C07D217/22 , C07D217/24 , C07D265/22 , C07D311/30 , C07D311/32 , C07D311/36 , C07D311/60 , C07D319/20 , C07D335/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/052
摘要： The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
摘要翻译： 本公开提供了上调载脂蛋白A-I（ApoA-I）表达的非天然存在的多酚化合物。 所公开的组合物和方法可用于治疗和预防心血管疾病和相关疾病状态，包括胆固醇或脂质相关疾病，例如动脉粥样硬化。
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4.发明申请Pharmaceutical Compositions for the Prevention and Treatment of Complex Diseases and Their Delivery by Insertable Medical Devices 有权用于预防和治疗复杂疾病及其可插入医疗器械的输送的药物组合物公开(公告)号：US20090029987A1
公开(公告)日：2009-01-29
申请号：US11990162
申请日：2006-07-28
IPC分类号： A61K31/5377 , C07D491/052 , A61P29/00 , C07D405/04 , C07D215/20 , C07D217/12 , C07D471/04 , A61K31/496 , C07D217/22 , A61K31/436 , A61K31/4375 , A61K31/472 , A61K31/47
CPC分类号： C07D471/04 , A61K31/352 , A61K31/435 , A61K31/4353 , C07D215/233 , C07D217/16 , C07D217/22 , C07D217/24 , C07D405/04 , C07D413/04 , C07D491/04
摘要： The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and/or SMC proliferation in a mammal. The disclosed compounds are useful for regulating markers of inflammatory conditions, including vascular inflammation, and for treatment and prevention of inflammatory and cardiovascular diseases and related disease states.
摘要翻译： 本发明涉及可用于抑制哺乳动物中VCAM-1表达，MCP-1表达和/或SMC增殖的多酚样化合物。 所公开的化合物可用于调节炎性病症的标志物，包括血管炎症，以及用于治疗和预防炎性和心血管疾病及相关疾病状态。
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5.发明授权Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases 有权用于预防和治疗心血管疾病的Stilbenes和沙洛酮公开(公告)号：US07846915B2
公开(公告)日：2010-12-07
申请号：US11254420
申请日：2005-10-20
申请人： Norman C. W. Wong , Joseph E. L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
发明人： Norman C. W. Wong , Joseph E. L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
IPC分类号： A01N57/00 , A01N43/00 , A01N43/16 , A01N43/40 , A61K31/67 , A61K31/33 , A61K31/35 , A61K31/44
CPC分类号： C07D213/64 , A61K31/05 , A61K31/055 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/216 , A61K31/265 , A61K31/352 , A61K31/353 , A61K31/357 , A61K31/382 , A61K31/435 , A61K31/4375 , A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4433 , A61K31/465 , A61K31/47 , A61K31/536 , C07C37/003 , C07C37/055 , C07C37/18 , C07C39/14 , C07C39/15 , C07C39/21 , C07C43/23 , C07C46/00 , C07C49/83 , C07C49/835 , C07C50/32 , C07C205/22 , C07C311/29 , C07C317/22 , C07C327/28 , C07D213/65 , C07D213/80 , C07D213/89 , C07D215/233 , C07D217/16 , C07D217/22 , C07D217/24 , C07D265/22 , C07D311/30 , C07D311/32 , C07D311/36 , C07D311/60 , C07D319/20 , C07D335/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/052
摘要： The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
摘要翻译： 本公开提供了上调载脂蛋白A-I（ApoA-I）表达的非天然存在的多酚化合物。 所公开的组合物和方法可用于治疗和预防心血管疾病和相关疾病状态，包括胆固醇或脂质相关疾病，例如动脉粥样硬化。
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6.发明授权Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases 有权用于预防和治疗心血管疾病的Stilbenes和沙洛酮公开(公告)号：US08242144B2
公开(公告)日：2012-08-14
申请号：US12905500
申请日：2010-10-15
申请人： Norman C. W. Wong , Joseph E. L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
发明人： Norman C. W. Wong , Joseph E. L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
IPC分类号： A01N43/40 , A01N33/26 , A61K31/44 , A61K31/655 , C09B29/00 , C07C39/00 , C07C39/12 , C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00 , C07C215/00
CPC分类号： C07D213/64 , A61K31/05 , A61K31/055 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/216 , A61K31/265 , A61K31/352 , A61K31/353 , A61K31/357 , A61K31/382 , A61K31/435 , A61K31/4375 , A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4433 , A61K31/465 , A61K31/47 , A61K31/536 , C07C37/003 , C07C37/055 , C07C37/18 , C07C39/14 , C07C39/15 , C07C39/21 , C07C43/23 , C07C46/00 , C07C49/83 , C07C49/835 , C07C50/32 , C07C205/22 , C07C311/29 , C07C317/22 , C07C327/28 , C07D213/65 , C07D213/80 , C07D213/89 , C07D215/233 , C07D217/16 , C07D217/22 , C07D217/24 , C07D265/22 , C07D311/30 , C07D311/32 , C07D311/36 , C07D311/60 , C07D319/20 , C07D335/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/052
摘要： The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
摘要翻译： 本公开提供了上调载脂蛋白A-I（ApoA-I）表达的非天然存在的多酚化合物。 所公开的组合物和方法可用于治疗和预防心血管疾病和相关疾病状态，包括胆固醇或脂质相关疾病，例如动脉粥样硬化。
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7.发明授权Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases 有权类黄酮和异黄酮用于预防和治疗心血管疾病公开(公告)号：US08242130B2
公开(公告)日：2012-08-14
申请号：US12369296
申请日：2009-02-11
申请人： Norman C. W. Wong , Joseph E. L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
发明人： Norman C. W. Wong , Joseph E. L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
IPC分类号： A01N43/40 , A01N43/02 , A61K31/435 , A61K31/335
CPC分类号： C07D213/64 , A61K31/05 , A61K31/055 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/216 , A61K31/265 , A61K31/352 , A61K31/353 , A61K31/357 , A61K31/382 , A61K31/435 , A61K31/4375 , A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4433 , A61K31/465 , A61K31/47 , A61K31/536 , C07C37/003 , C07C37/055 , C07C37/18 , C07C39/14 , C07C39/15 , C07C39/21 , C07C43/23 , C07C46/00 , C07C49/83 , C07C49/835 , C07C50/32 , C07C205/22 , C07C311/29 , C07C317/22 , C07C327/28 , C07D213/65 , C07D213/80 , C07D213/89 , C07D215/233 , C07D217/16 , C07D217/22 , C07D217/24 , C07D265/22 , C07D311/30 , C07D311/32 , C07D311/36 , C07D311/60 , C07D319/20 , C07D335/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/052
摘要： The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
摘要翻译： 本公开提供了上调载脂蛋白A-I（ApoA-I）表达的非天然存在的多酚化合物。 所公开的组合物和方法可用于治疗和预防心血管疾病和相关疾病状态，包括胆固醇或脂质相关疾病，例如动脉粥样硬化。
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公开(公告)号：US08093273B2
公开(公告)日：2012-01-10
申请号：US11255103
申请日：2005-10-20
申请人： Norman C. W. Wong , Joseph E. L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
发明人： Norman C. W. Wong , Joseph E. L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
CPC分类号： C07D213/64 , A61K31/05 , A61K31/055 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/216 , A61K31/265 , A61K31/352 , A61K31/353 , A61K31/357 , A61K31/382 , A61K31/435 , A61K31/4375 , A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4433 , A61K31/465 , A61K31/47 , A61K31/536 , C07C37/003 , C07C37/055 , C07C37/18 , C07C39/14 , C07C39/15 , C07C39/21 , C07C43/23 , C07C46/00 , C07C49/83 , C07C49/835 , C07C50/32 , C07C205/22 , C07C311/29 , C07C317/22 , C07C327/28 , C07D213/65 , C07D213/80 , C07D213/89 , C07D215/233 , C07D217/16 , C07D217/22 , C07D217/24 , C07D265/22 , C07D311/30 , C07D311/32 , C07D311/36 , C07D311/60 , C07D319/20 , C07D335/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/052
摘要： The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
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9.发明授权Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices 有权用于预防和治疗复杂疾病及其可插入医疗器械的输送的药物组合物公开(公告)号：US08410109B2
公开(公告)日：2013-04-02
申请号：US11990162
申请日：2006-07-28
IPC分类号： A61K31/497
CPC分类号： C07D471/04 , A61K31/352 , A61K31/435 , A61K31/4353 , C07D215/233 , C07D217/16 , C07D217/22 , C07D217/24 , C07D405/04 , C07D413/04 , C07D491/04
摘要： The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and/or SMC proliferation in a mammal. The disclosed compounds are useful for regulating markers of inflammatory conditions, including vascular inflammation, and for treatment and prevention of inflammatory and cardiovascular diseases and related disease states.
摘要翻译： 本发明涉及可用于抑制哺乳动物中VCAM-1表达，MCP-1表达和/或SMC增殖的多酚样化合物。 所公开的化合物可用于调节炎性病症的标志物，包括血管炎症，以及用于治疗和预防炎性和心血管疾病及相关疾病状态。
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公开(公告)号：US20120015905A1
公开(公告)日：2012-01-19
申请号：US13243776
申请日：2011-09-23
申请人： Henrik C. Hansen
发明人： Henrik C. Hansen
IPC分类号： A61K31/695 , A61K31/5377 , A61P3/00 , A61P9/00 , A61P3/06 , A61K31/517 , A61K31/519
CPC分类号： A61K31/517 , A61K31/4375 , A61K31/44 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/535 , A61K31/5377 , A61K31/54 , A61K31/695 , A61L29/16 , A61L31/16 , A61L2300/204 , A61L2300/606 , A61L2420/00 , C07D217/24 , C07D239/91 , C07D279/02 , C07D401/04 , C07D403/12 , C07D405/04 , C07D471/04 , C07F7/1804
摘要： The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.
摘要翻译： 本公开涉及可用于调节载脂蛋白AI（ApoA-I）的表达的化合物及其用于治疗和预防心血管疾病和相关疾病状态的用途，包括胆固醇或脂质相关疾病，例如， 例如动脉粥样硬化。
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