公开(公告)号：US20140171543A1

公开(公告)日：2014-06-19

申请号：US14105295

申请日：2013-12-13

Applicant: Novartis AG

Inventor： Frank Chang ,  Manivakkam J. Shankernarayanan

IPC: G02B1/04

CPC classification number: G02B1/043 ,  B29C35/08 ,  B29C39/006 ,  B29C39/026 ,  B29K2083/00 ,  B29L2011/0041 ,  C08G18/61 ,  C08G18/755 ,  C08G73/0233 ,  C08G73/0246 ,  C08G77/452 ,  G02C7/049 ,  C08L83/04 ,  C08L101/14 ,  C08G18/10 ,  C08G18/6453 ,  C08G18/6415 ,  C08G18/2825 ,  C08G18/4833

Abstract: The invention provide a class of actinically-crosslinkable amphiphilic prepolymers which comprise at least one polysiloxane segment, at least one polyoxazoline segment, and two terminal ene groups. The present invention is also related to a medical device comprising a silicone hydrogel material obtained from step-growth polymerization of a polymerizable material comprising a prepolymer of the invention and to a method for producing contact lenses from a prepolymer of the invention.

Abstract translation: 本发明提供一类包含至少一个聚硅氧烷链段，至少一个聚恶唑啉链段和两个末端烯基的可光化交联的两亲性预聚物。 本发明还涉及包含由包含本发明的预聚物的可聚合材料的步进生长聚合获得的硅酮水凝胶材料和由本发明的预聚物制备隐形眼镜的方法的医疗装置。

公开(公告)号：US20130337160A1

公开(公告)日：2013-12-19

申请号：US13913734

申请日：2013-06-10

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Yongxing Qiu ,  John Dallas Pruitt ,  Chung-Yuan Chiang ,  Manivakkam J. Shankernarayanan ,  Robert Scott ,  Yash Kapoor

IPC: C09D139/04

CPC classification number: C09D133/24 ,  B29D11/00865 ,  C07D205/04 ,  C08F20/00 ,  C08F26/00 ,  C08F220/54 ,  C08F220/56 ,  C08F224/00 ,  C08F283/124 ,  C08F2500/26 ,  C09D133/26 ,  C09D137/00 ,  C09D139/04 ,  C09D151/085

Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

Abstract translation: 本发明涉及含吖啶啶的共聚物和乙烯基单体及其在硅酮水凝胶隐形眼镜上形成非硅氧烷水凝胶涂层的用途。

公开(公告)号：US20140175685A1

公开(公告)日：2014-06-26

申请号：US14108426

申请日：2013-12-17

Applicant: Novartis AG

Inventor： Jinyu Huang ,  Daqing Wu ,  Uwe Haken ,  Horngyih Huang ,  Manivakkam J. Shankernarayanan

IPC: B29D11/00

CPC classification number: B29D11/00192

Abstract: The instant invention pertains to a method and a fluid polymerizable composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a water soluble and/or water dispersible quaternary ammonium cationic group containing silicone surfactant into a fluid polymerizable composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 30% in comparison with that without the water soluble and/or water dispersible quaternary ammonium cationic group containing silicone surfactant.

Abstract translation: 本发明涉及一种用于制造具有改善的镜片质量和增加的产品产率的隐形眼镜的方法和流体可聚合组合物。 本发明的方法包括将含有硅氧烷表面活性剂的水溶性和/或水分散性季铵阳离子基团加入到包含透镜形成材料的流体可聚合组合物中，其量足以将平均的模具分离力减小至少约30％ 与不含水溶性和/或水分散性季铵阳离子基团的硅氧烷表面活性剂相比。

公开(公告)号：US09151873B2

公开(公告)日：2015-10-06

申请号：US14105295

申请日：2013-12-13

Applicant: Novartis AG

Inventor： Frank Chang ,  Manivakkam J. Shankernarayanan

IPC: G02B1/04 ,  C08G73/02 ,  C08G77/452 ,  C08G18/61 ,  C08G18/75

CPC classification number: G02B1/043 ,  B29C35/08 ,  B29C39/006 ,  B29C39/026 ,  B29K2083/00 ,  B29L2011/0041 ,  C08G18/61 ,  C08G18/755 ,  C08G73/0233 ,  C08G73/0246 ,  C08G77/452 ,  G02C7/049 ,  C08L83/04 ,  C08L101/14 ,  C08G18/10 ,  C08G18/6453 ,  C08G18/6415 ,  C08G18/2825 ,  C08G18/4833

Abstract: The invention provide a class of actinically-crosslinkable amphiphilic prepolymers which comprise at least one polysiloxane segment, at least one polyoxazoline segment, and two terminal ene groups. The present invention is also related to a medical device comprising a silicone hydrogel material obtained from step-growth polymerization of a polymerizable material comprising a prepolymer of the invention and to a method for producing contact lenses from a prepolymer of the invention.

Abstract translation: 本发明提供一类包含至少一个聚硅氧烷链段，至少一个聚恶唑啉链段和两个末端烯基的可光化交联的两亲性预聚物。 本发明还涉及包含由包含本发明的预聚物的可聚合材料的步进生长聚合获得的硅酮水凝胶材料和由本发明的预聚物制备隐形眼镜的方法的医疗装置。

公开(公告)号：US09422447B2

公开(公告)日：2016-08-23

申请号：US13913734

申请日：2013-06-10

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Yongxing Qiu ,  John Dallas Pruitt ,  Chung-Yuan Chiang ,  Manivakkam J. Shankernarayanan ,  Robert Scott ,  Yash Kapoor

IPC: C09D139/04 ,  C08F20/00 ,  C08F26/00 ,  B29D11/00

CPC classification number: C09D133/24 ,  B29D11/00865 ,  C07D205/04 ,  C08F20/00 ,  C08F26/00 ,  C08F220/54 ,  C08F220/56 ,  C08F224/00 ,  C08F283/124 ,  C08F2500/26 ,  C09D133/26 ,  C09D137/00 ,  C09D139/04 ,  C09D151/085

Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

Abstract translation: 本发明涉及含吖啶啶的共聚物和乙烯基单体及其在硅酮水凝胶隐形眼镜上形成非硅氧烷水凝胶涂层的用途。