-
1.发明授权公开(公告)号：US09598698B2
公开(公告)日：2017-03-21
申请号：US14421330
申请日：2013-08-16
Applicant: NOVOZYMES A/S
Inventor： Howard Brody , Evee Ricacho , Hiroshi Teramoto
IPC: C12N15/80 , C12N15/113 , C12N15/10
CPC classification number: C12N15/80 , C12N15/1086 , C12N15/113 , C12N2310/14 , C12N2310/53 , C12N2320/12 , C12N2330/51
Abstract: The present invention relates to methods for co-silencing expression of genes in a filamentous fungal strain by transitive RNA interference. The present invention also relates to methods for identifying a gene encoding a biological substance of interest.
-
公开(公告)号：US20190169238A1
公开(公告)日：2019-06-06
申请号：US16319780
申请日：2017-07-19
Applicant: Novozymes A/S
Inventor： Hiroshi Teramoto , Kaihei Kojima , Preethi Ramaiya
Abstract: The instant invention relates to filamentous fungal host cells producing and secreting a heterologous polypeptide of interest, said mutant host cell comprising and expressing a mutated ireA gene or a homologue thereof encoding a modified IreA polypeptide or a homologue thereof, said modified IreA polypeptide or homologue thereof comprising amino acid substitutions in 5 positions corresponding to positions 81 and 84 in the Aspergillus niger IreA amino acid sequence shown in SEQ ID NO:16, as well as methods of producing a polypeptide of interest in said cells and methods for constructing said cells.
-
公开(公告)号：US20160244737A1
公开(公告)日：2016-08-25
申请号：US14913967
申请日：2014-08-22
Applicant: Novozymes A/S
Inventor： Hiroshi Teramoto , Hiroaki Udagawa , Jan Lehmbeck , Michael Lynge Nielsen
CPC classification number: C12N9/62 , C07K14/38 , C12N9/0036 , C12N9/18 , C12N9/20 , C12N9/58 , C12N9/82 , C12N15/80 , C12P21/02
Abstract: The present invention relates to a recombinant fungal host cell comprising at least one first polynucleotide encoding a polypeptide of interest; and one or more second polynucleotide encoding a fungal PepC protease, wherein the one or more second polynucleotide is operably linked to a regulated heterologous promoter, as well as a method for producing a polypeptide of interest, comprising cultivating said fungal host cell.
Abstract translation: 本发明涉及重组真菌宿主细胞，其包含至少一种编码目的多肽的第一多核苷酸; 和编码真菌PepC蛋白酶的一种或多种第二多核苷酸，其中所述一种或多种第二多核苷酸可操作地连接到受调节的异源启动子，以及用于产生感兴趣多肽的方法，包括培养所述真菌宿主细胞。
-
4.发明申请Methods for Co-Silencing Expression of Genes in Filamentous Fungal Strains and Uses Thereof 有权在丝状真菌菌株中共沉默基因表达的方法及其用途公开(公告)号：US20160002646A1
公开(公告)日：2016-01-07
申请号：US14421330
申请日：2013-08-16
Applicant: NOVOZYMES A/S
Inventor： Howard Brody , Evee Ricacho , Hiroshi Teramoto
CPC classification number: C12N15/80 , C12N15/1086 , C12N15/113 , C12N2310/14 , C12N2310/53 , C12N2320/12 , C12N2330/51
Abstract: The present invention relates to methods for co-silencing expression of genes in a filamentous fungal strain by transitive RNA interference. The present invention also relates to methods for identifying a gene encoding a biological substance of interest.
Abstract translation: 本发明涉及通过传递性RNA干扰共同沉默丝状真菌菌株中基因表达的方法。 本发明还涉及用于鉴定编码感兴趣的生物物质的基因的方法。
-
Patent Agency Ranking
公开(公告)号：US20220340843A1
公开(公告)日：2022-10-27
申请号：US17763592
申请日：2020-10-01
Applicant: Novozymes A/S
Inventor： Lone Baunsgaard , Michael Lynge Nielsen , Kenneth Jensen , Hiroshi Teramoto , Keiichi Ayabe
Abstract: Disclosed are fusion polypeptides comprising at least two carbohydrate binding modules (CBMs), wherein the polypeptide has carbohydrate binding activity. Also disclosed is the use of such polypeptides for reducing the wrinkles in laundry, as well as detergent compositions and laundry booster compositions comprising the same. Also disclosed are polynucleotides encoding the variants, nucleic acid constructs, vectors, and host cells comprising the variants and methods of making the variants.
-
公开(公告)号：US20190119690A1
公开(公告)日：2019-04-25
申请号：US16094795
申请日：2017-04-18
Applicant: Novozymes A/S
Inventor： Hiroshi Teramoto
CPC classification number: C12N15/80 , C07K14/37 , C07K14/38 , C12N9/2428 , C12P21/02
Abstract: The present invention relates to RImA-inactivated filamentous fungal cells secreting a polypeptide of interest and methods of producing a secreted polypeptide of interest in said cells as well as methods of producing said cells.
-
公开(公告)号：US11046736B2
公开(公告)日：2021-06-29
申请号：US16319780
申请日：2017-07-19
Applicant: Novozymes A/S
Inventor： Hiroshi Teramoto , Kaihei Kojima , Preethi Ramaiya
Abstract: The instant invention relates to filamentous fungal host cells producing and secreting a heterologous polypeptide of interest, said mutant host cell comprising and expressing a mutated ireA gene or a homologue thereof encoding a modified IreA polypeptide or a homologue thereof, said modified IreA polypeptide or homologue thereof comprising amino acid substitutions in 5 positions corresponding to positions 81 and 84 in the Aspergillus niger IreA amino acid sequence shown in SEQ ID NO:16, as well as methods of producing a polypeptide of interest in said cells and methods for constructing said cells.
-
公开(公告)号：US20240271175A1
公开(公告)日：2024-08-15
申请号：US18251533
申请日：2021-11-02
Applicant: Novozymes A/S
Inventor： Aki Tomiki-Hashizume , Hiroshi Teramoto
CPC classification number: C12P21/02 , C07K7/06 , C12N1/14 , C12N9/2428 , C12N15/625 , C12N15/80 , C07K2319/02 , C12R2001/685
Abstract: The present invention relates to leader peptides, leader peptide fusion proteins, signal peptides, polynucleotides encoding the leader peptides and signal peptides, and to nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing a polypeptide of interest in host cells expressing the leader peptides in translational fusion with the polypeptide of interest.
-
公开(公告)号：US10550398B2
公开(公告)日：2020-02-04
申请号：US16094795
申请日：2017-04-18
Applicant: Novozymes A/S
Inventor： Hiroshi Teramoto
Abstract: The present invention relates to RImA-inactivated filamentous fungal cells secreting a polypeptide of interest and methods of producing a secreted polypeptide of interest in said cells as well as methods of producing said cells.
-
-
-
-
-
-
-
-
Search Results
9
records
(took 0.015 seconds)
