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1.发明授权Isopropyl alcohol-producing bacterium and method of producing isopropyl alcohol using the same 有权产生异丙醇的细菌和使用其的异丙醇的生产方法公开(公告)号：US09074226B2
公开(公告)日：2015-07-07
申请号：US12452564
申请日：2008-07-04
申请人： Nozomi Takebayashi , Mitsufumi Wada , Daisuke Mochizuki , Fuminobu Yoshimi , Seiichi Watanabe , Hitoshi Takahashi , Takashi Morishige
发明人： Nozomi Takebayashi , Mitsufumi Wada , Daisuke Mochizuki , Fuminobu Yoshimi , Seiichi Watanabe , Hitoshi Takahashi , Takashi Morishige
IPC分类号： C12N1/20 , C12P7/04 , C12P7/02 , C12P7/28 , C07H21/04 , C12N9/04 , C12N9/10 , C12N9/88 , C12M1/00
CPC分类号： C12P7/04 , C12M21/12 , C12M47/10 , C12M47/20 , C12N9/0006 , C12N9/1029 , C12N9/13 , C12N9/88
摘要： The invention provides: an isopropyl alcohol-producing bacterium which has an acetoacetate decarboxylase activity, an isopropyl alcohol dehydrogenase activity, a CoA transferase activity and a thiolase activity having been imparted thereto and is capable of producing isopropyl alcohol from a plant-derived material; a method of producing isopropyl alcohol whereby isopropyl alcohol is produced from a plant-derived material by using this isopropyl alcohol-producing bacterium; and an apparatus therefor.
摘要翻译： 本发明提供：具有乙酰乙酸脱羧酶活性，异丙醇脱氢酶活性，CoA转移酶活性和硫硫酸酶活性的异丙醇生产细菌，并且能够从植物来源的材料生产异丙醇; 通过使用该异丙醇生产菌从植物来源的材料制造异丙醇的方法; 及其装置。
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2.发明申请公开(公告)号：US20100311135A1
公开(公告)日：2010-12-09
申请号：US12452564
申请日：2008-07-04
申请人： Nozomi Takebayashi , Mitsufumi Wada , Daisuke Mochizuki , Fuminobu Yoshimi , Seiichi Watanabe , Hitoshi Takahashi , Takashi Morishige
发明人： Nozomi Takebayashi , Mitsufumi Wada , Daisuke Mochizuki , Fuminobu Yoshimi , Seiichi Watanabe , Hitoshi Takahashi , Takashi Morishige
CPC分类号： C12P7/04 , C12M21/12 , C12M47/10 , C12M47/20 , C12N9/0006 , C12N9/1029 , C12N9/13 , C12N9/88
摘要： The invention provides: an isopropyl alcohol-producing bacterium which has an acetoacetate decarboxylase activity, an isopropyl alcohol dehydrogenase activity, a CoA transferase activity and a thiolase activity having been imparted thereto and is capable of producing isopropyl alcohol from a plant-derived material; a method of producing isopropyl alcohol whereby isopropyl alcohol is produced from a plant-derived material by using this isopropyl alcohol-producing bacterium; and an apparatus therefor.
摘要翻译： 本发明提供：具有乙酰乙酸脱羧酶活性，异丙醇脱氢酶活性，CoA转移酶活性和硫硫酸酶活性的异丙醇生产细菌，并且能够从植物来源的材料生产异丙醇; 通过使用该异丙醇生产菌从植物来源的材料制造异丙醇的方法; 及其装置。
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公开(公告)号：US20130005008A1
公开(公告)日：2013-01-03
申请号：US13583184
申请日：2011-03-04
申请人： Yoshiko Matsumoto , Junichiro Hirano , Takashi Morishige , Tomokazu Shirai , Hitoshi Takahashi , Koh Amano , Nozomi Takebayashi , Mitsufumi Wada , Hiroshi Shimizu , Chikara Furusawa , Takashi Hirasawa
发明人： Yoshiko Matsumoto , Junichiro Hirano , Takashi Morishige , Tomokazu Shirai , Hitoshi Takahashi , Koh Amano , Nozomi Takebayashi , Mitsufumi Wada , Hiroshi Shimizu , Chikara Furusawa , Takashi Hirasawa
CPC分类号： C12P7/04 , C12N9/0006 , C12N9/0036 , C12N9/1029 , C12N15/70
摘要： An isopropyl alcohol-producing Escherichia coli equipped with an isopropyl alcohol production system, having at least one enhanced enzyme activity selected from the group consisting of an enhanced malate dehydrogenase activity, an enhanced NAD(P)+ transhydrogenase (AB-specific) activity, and an enhanced thiolase activity, and an isopropyl alcohol producing method including producing isopropyl alcohol from a plant-derived raw material using the isopropyl alcohol-producing Escherichia coli.
摘要翻译： 装有异丙醇生产系统的异丙醇产生大肠杆菌具有选自增强的苹果酸脱氢酶活性，增强的NAD（P）+转氢酶（AB-特异性）活性的至少一种增强的酶活性，以及 增强的硫柳酸酶活性和异丙醇的制造方法，其包括使用产生异丙醇的大肠杆菌从植物来源的原料生产异丙醇。
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公开(公告)号：US08932845B2
公开(公告)日：2015-01-13
申请号：US13583184
申请日：2011-03-04
申请人： Yoshiko Matsumoto , Junichiro Hirano , Takashi Morishige , Tomokazu Shirai , Hitoshi Takahashi , Koh Amano , Nozomi Takebayashi , Mitsufumi Wada , Hiroshi Shimizu , Chikara Furusawa , Takashi Hirasawa
发明人： Yoshiko Matsumoto , Junichiro Hirano , Takashi Morishige , Tomokazu Shirai , Hitoshi Takahashi , Koh Amano , Nozomi Takebayashi , Mitsufumi Wada , Hiroshi Shimizu , Chikara Furusawa , Takashi Hirasawa
CPC分类号： C12P7/04 , C12N9/0006 , C12N9/0036 , C12N9/1029 , C12N15/70
摘要： An isopropyl alcohol-producing Escherichia coli equipped with an isopropyl alcohol production system, having at least one enhanced enzyme activity selected from the group consisting of an enhanced malate dehydrogenase activity, an enhanced NAD(P)+ transhydrogenase (AB-specific) activity, and an enhanced thiolase activity, and an isopropyl alcohol producing method including producing isopropyl alcohol from a plant-derived raw material using the isopropyl alcohol-producing Escherichia coli.
摘要翻译： 装有异丙醇生产系统的异丙醇产生大肠杆菌具有选自增强的苹果酸脱氢酶活性，增强的NAD（P）+转氢酶（AB-特异性）活性的至少一种增强的酶活性，以及 增强的硫柳酸酶活性和异丙醇的制造方法，其包括使用产生异丙醇的大肠杆菌从植物来源的原料生产异丙醇。
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公开(公告)号：US09822387B2
公开(公告)日：2017-11-21
申请号：US14235756
申请日：2012-07-27
申请人： Ryota Fujii , Tomokazu Shirai , Tadashi Araki , Koh Amano , Yoshiko Matsumoto , Toshihiro Tateno , Nozomi Takebayashi , Takashi Morishige , Hitoshi Takahashi , Mitsufumi Wada , Hiroshi Shimizu , Chikara Furusawa , Takashi Hirasawa , Tomonori Hidesaki , Ayako Endo , Dominik Lukas Jürgen-Lohmann , Anjali Madhavan , Su Sun Chong
发明人： Ryota Fujii , Tomokazu Shirai , Tadashi Araki , Koh Amano , Yoshiko Matsumoto , Toshihiro Tateno , Nozomi Takebayashi , Takashi Morishige , Hitoshi Takahashi , Mitsufumi Wada , Hiroshi Shimizu , Chikara Furusawa , Takashi Hirasawa , Tomonori Hidesaki , Ayako Endo , Dominik Lukas Jürgen-Lohmann , Anjali Madhavan , Su Sun Chong
IPC分类号： C12N1/20 , C12N15/00 , C12N9/00 , C12N9/88 , C12N9/02 , C07H21/04 , C12P19/40 , C12P13/14 , C12N9/04 , C12P7/04 , C12P7/28 , C12P19/32
CPC分类号： C12P19/40 , C12N1/20 , C12N9/0006 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/28 , C12P13/14 , C12P19/32 , C12Y101/0106 , C12Y101/01081 , C12Y401/01047 , C12Y401/03024 , C12Y602/01009
摘要： An acetyl-CoA-producing microorganism, which is capable of efficiently synthesizing acetyl-CoA using carbon dioxide, and a substance production method using the same are provided. An acetyl-CoA-producing microorganism including an acetyl-CoA production cycle obtained by imparting at least one type of enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism.
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6.发明授权Isopropyl alcohol-producing bacterium and method for producing isopropyl alcohol 有权产生异丙醇的细菌和异丙醇的生产方法公开(公告)号：US09096842B2
公开(公告)日：2015-08-04
申请号：US13496194
申请日：2010-09-13
CPC分类号： C12N9/88 , C12N9/0008 , C12N9/1029 , C12P7/04 , C12Y203/01016 , C12Y401/01004
摘要： The present invention provides an isopropyl alcohol-producing Escherichia coli that includes at least a sucrose hydrolase gene that belongs to a sucrose non-PTS gene group, and an imparted or enhanced isopropyl alcohol production system, and an isopropyl alcohol production method of producing isopropyl alcohol from a sucrose-containing plant-derived raw material using the isopropyl alcohol-producing Escherichia coli.
摘要翻译： 本发明提供了产生异丙醇的大肠杆菌，其至少包含属于蔗糖非PTS基因组的蔗糖水解酶基因，以及赋予或增强的异丙醇生产系统和产生异丙醇的异丙醇生产方法 来自含蔗糖的植物来源的原料，使用产生异丙醇的大肠杆菌。
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7.发明申请ISOPROPYL ALCOHOL-PRODUCING BACTERIUM AND METHOD FOR PRODUCING ISOPROPYL ALCOHOL 有权异丙醇生产细菌和生产异丙醇的方法公开(公告)号：US20120237992A1
公开(公告)日：2012-09-20
申请号：US13496194
申请日：2010-09-13
CPC分类号： C12N9/88 , C12N9/0008 , C12N9/1029 , C12P7/04 , C12Y203/01016 , C12Y401/01004
摘要： The present invention provides an isopropyl alcohol-producing Escherichia coli that includes at least a sucrose hydrolase gene that belongs to a sucrose non-PTS gene group, and an imparted or enhanced isopropyl alcohol production system, and an isopropyl alcohol production method of producing isopropyl alcohol from a sucrose-containing plant-derived raw material using the isopropyl alcohol-producing Escherichia coli.
摘要翻译： 本发明提供了产生异丙醇的大肠杆菌，其至少包含属于蔗糖非PTS基因组的蔗糖水解酶基因，以及赋予或增强的异丙醇生产系统和产生异丙醇的异丙醇生产方法 来自含蔗糖的植物来源的原料，使用产生异丙醇的大肠杆菌。
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8.发明申请公开(公告)号：US20140363847A1
公开(公告)日：2014-12-11
申请号：US14235756
申请日：2012-07-27
申请人： Ryota Fujii , Tomokazu Shirai , Tadashi Araki , Koh Amano , Yoshiko Matsumoto , Toshihiro Tateno , Nozomi Takebayashi , Takashi Morishige , Hitoshi Takahashi , Mitsufumi Wada , Hiroshi Shimizu , Chikara Furusawa , Takashi Hirasawa , Tomonori Hidesaki , Ayako Endo , Dominik Lukas Jürgen-Lohmann , Anjali Madhavan
发明人： Ryota Fujii , Tomokazu Shirai , Tadashi Araki , Koh Amano , Yoshiko Matsumoto , Toshihiro Tateno , Nozomi Takebayashi , Takashi Morishige , Hitoshi Takahashi , Mitsufumi Wada , Hiroshi Shimizu , Chikara Furusawa , Takashi Hirasawa , Tomonori Hidesaki , Ayako Endo , Dominik Lukas Jürgen-Lohmann , Anjali Madhavan
CPC分类号： C12P19/40 , C12N1/20 , C12N9/0006 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/28 , C12P13/14 , C12P19/32 , C12Y101/0106 , C12Y101/01081 , C12Y401/01047 , C12Y401/03024 , C12Y602/01009
摘要： An acetyl-CoA-producing microorganism, which is capable of efficiently synthesizing acetyl-CoA using carbon dioxide, and a substance production method using the same are provided. An acetyl-CoA-producing microorganism including an acetyl-CoA production cycle obtained by imparting at least one type of enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism.
摘要翻译： 提供了能够使用二氧化碳有效地合成乙酰辅酶A的乙酰辅酶A产生微生物和使用其的物质制备方法。 一种乙酰辅酶A生产微生物，其包括通过赋予选自苹果酸硫激酶，丙烯酰辅酶A裂解酶，乙醛酸卡巴肼，2-羟基-3-氧代丙酸酯还原酶， 和羟丙酮酸还原酶。
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9.发明授权Method for producing hydroxycarboxylic acid by enhancing synthesis of coenzyme 有权通过增强辅酶的合成生产羟基羧酸的方法公开(公告)号：US09133444B2
公开(公告)日：2015-09-15
申请号：US13618898
申请日：2012-09-14
CPC分类号： C12N9/1077 , C12P7/42 , C12Y204/02011
摘要： Hydroxycarboxylic acids are produced by using a microorganism that is improved in ability to produce nicotinamide adenine dinucleotide by deleting, mutating or substituting nadR gene in the microorganism or introducing a gene encoding nicotinic acid phosphoribosyltransferase.
摘要翻译： 通过使用通过在微生物中缺失，突变或取代nadR基因或引入编码烟酸磷酸核糖转移酶的基因来提高生产烟酰胺腺嘌呤二核苷酸能力的微生物来产生羟基羧酸。
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公开(公告)号：US08728780B2
公开(公告)日：2014-05-20
申请号：US11587806
申请日：2005-04-19
申请人： Mitsufumi Wada , Daisuke Mochizuki , Hitoshi Takahashi , Takashi Morishige , Katsuyuki Takahashi
发明人： Mitsufumi Wada , Daisuke Mochizuki , Hitoshi Takahashi , Takashi Morishige , Katsuyuki Takahashi
IPC分类号： C12P7/42
CPC分类号： C12P7/42
摘要： An object of the invention is to produce a microorganism which yields high amounts in a short time of a hydroxycarboxylic acid reduced in impurity content. This invention further provides a process for producing a hydroxycarboxylic acid, including glycolic acid, using the microorganism. This process enables a hydroxycarboxylic acid having high purity to be supplied at low cost.
摘要翻译： 本发明的目的是产生微生物，其在短时间内在杂质含量降低的羟基羧酸中产生大量的量。 本发明还提供使用该微生物生产羟基羧酸（包括乙醇酸）的方法。 该方法能够以低成本提供具有高纯度的羟基羧酸。
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