公开(公告)号：US10441613B2

公开(公告)日：2019-10-15

申请号：US15754687

申请日：2016-08-23

Applicant: OSAKA UNIVERSITY ,  GenomIdea Inc.

Inventor： Yasufumi Kaneda ,  Toshihiro Nakajima

IPC: A61K39/00 ,  A61K48/00 ,  C12Q1/68 ,  A61K38/00 ,  A61K35/76 ,  A61K38/19 ,  A61K45/00 ,  A61K31/7088 ,  A61K31/713 ,  A61K31/739 ,  A61P35/00 ,  C12N7/00

Abstract: The present invention provides, as a new anti-cancer agent obtained by combining HVJ-E and a molecule synergistically acting therewith, an anti-cancer agent containing the following (1) and (2): (1) HVJ-E (hemagglutinating virus of Japan envelope), (2) CXCL2, a nucleic acid comprising a base sequence encoding CXCL2 or a CXCL2 expression inducing agent.

公开(公告)号：US11166995B2

公开(公告)日：2021-11-09

申请号：US16346576

申请日：2017-11-01

Applicant: OSAKA UNIVERSITY ,  GENOMIDEA INC.

Inventor： Yasufumi Kaneda ,  Kazuma Sakura ,  Tomoyuki Nishikawa ,  Masanori Fukushima ,  Toshihiro Nakajima

IPC: A61K35/76 ,  A61P35/00 ,  C12N7/00 ,  A61K39/395 ,  A61K31/7105 ,  A61K45/00 ,  A61P43/00 ,  A61K31/711 ,  A61P35/02 ,  A61P37/04

Abstract: The present invention provides an anticancer agent containing the following (1) and (2):
(1) HVJ-E (hemagglutinating virus of Japan envelope),
(2) an inhibitor of an immune checkpoint protein.

公开(公告)号：US09623078B2

公开(公告)日：2017-04-18

申请号：US14436906

申请日：2013-10-24

Applicant: GENOMIX CO., LTD ,  OSAKA UNIVERSITY

Inventor： Katsuto Tamai ,  Sokichi Kamata ,  Yasufumi Kaneda ,  Shigeru Miyagawa ,  Yoshiki Sawa ,  Takehiko Yamazaki

IPC: A61K38/17 ,  C07K14/47

CPC classification number: A61K38/1709 ,  C07K14/4718

Abstract: A fragment peptide having a proper length composed of a part of an HMGB1 protein was synthesized and the peptide was confirmed to exhibit therapeutic effects on myocardial infarction.

公开(公告)号：US20160367616A1

公开(公告)日：2016-12-22

申请号：US15244284

申请日：2016-08-23

Applicant: Pias Corporation ,  Osaka University

Inventor： Keiko Kitamura ,  Yuta Inami ,  Koichi Nakaoji ,  Kazuhiko Hamada ,  Akito Maeda ,  Tadashi Furumoto ,  Yasufumi Kaneda ,  Katsuto Tamai

IPC: A61K36/60 ,  A61K36/65 ,  A61K36/74 ,  A61K36/736 ,  A61K36/47 ,  C12N5/0775 ,  A61K36/185

CPC classification number: A61K36/60 ,  A61K36/185 ,  A61K36/47 ,  A61K36/65 ,  A61K36/736 ,  A61K36/74 ,  C12N5/0662 ,  C12N5/0663

Abstract: The present invention aims to provide a mesenchymal stem cell attractant capable of attracting a mesenchymal stem cell; and others. The present invention provides a mesenchymal stem cell attractant containing at least one selected from the group consisting of an extract of a Bodhi tree, an extract of the root bark of Paeonia suffruticosa Andrews, an extract of Mallotus philippinensis, an extract of Uncaria gambir, an extract of Pashanbheda, and an extract of a plant belonging to the genus Prunus.

Abstract translation: 本发明旨在提供能够吸引间充质干细胞的间充质干细胞引诱剂; 和别的。 本发明提供一种间充质干细胞引诱剂，其含有至少一种选自菩提树提取物，芍药芍药提取物，马鞭草提取物，甘草提取物， 蒲公英提取物，属于李属植物的提取物。

公开(公告)号：US20150111842A1

公开(公告)日：2015-04-23

申请号：US14396142

申请日：2013-05-31

Applicant: PIAS CORPORATION ,  OSAKA UNIVERSITY

Inventor： Tadashi Furumoto ,  Koichi Nakaoji ,  Kazuhiko Hamada ,  Noriyasu Ozawa ,  Yuta Inami ,  Misaki Toyoshima ,  Kosuke Fujita ,  Akito Maeda ,  Yasufumi Kaneda ,  Katsuto Tamai

IPC: A61K31/7032 ,  A61K31/353

CPC classification number: A61K31/7032 ,  A61K31/353 ,  A61K31/7024 ,  A61K36/00 ,  A61K2300/00

Abstract: Provided are an attractant for bone marrow stem cells containing at least one of cinnamtannin B1 and pentagalloylglucose, and a method for attracting bone marrow stem cells in which bone marrow stem cells are attracted by the attractant.

Abstract translation: 提供含有肉桂酸蛋白B1和五葡萄糖葡萄糖中的至少一种的骨髓干细胞的引诱剂，以及用于吸引骨髓干细胞的方法，其中骨髓干细胞被引诱剂吸引。

公开(公告)号：US11197895B2

公开(公告)日：2021-12-14

申请号：US15674835

申请日：2017-08-11

Applicant: STEMRIM INC. ,  OSAKA UNIVERSITY

Inventor： Katsuto Tamai ,  Takehiko Yamazaki ,  Takenao Chino ,  Yasufumi Kaneda

IPC: A61K35/28 ,  C12N5/0775 ,  A61K35/12

Abstract: Biologically low invasive vessels are filled with biological factors that have the activity of mobilizing specific functional cells in the body. The vessels are indwelled in the body. After specific functional cells are mobilized into the vessels, the vessels are removed from the body to collect functional cell populations mobilized to the vessels. Alternatively, the cells are directly collected from the vessels indwelled in the body.

公开(公告)号：US09486465B2

公开(公告)日：2016-11-08

申请号：US14396142

申请日：2013-05-31

Applicant: PIAS CORPORATION ,  OSAKA UNIVERSITY

Inventor： Tadashi Furumoto ,  Koichi Nakaoji ,  Kazuhiko Hamada ,  Noriyasu Ozawa ,  Yuta Inami ,  Misaki Toyoshima ,  Kosuke Fujita ,  Akito Maeda ,  Yasufumi Kaneda ,  Katsuto Tamai

IPC: A61K31/7032 ,  A61K31/353 ,  A61K31/7024 ,  A61K36/00

CPC classification number: A61K31/7032 ,  A61K31/353 ,  A61K31/7024 ,  A61K36/00 ,  A61K2300/00

Abstract: Provided are an attractant for bone marrow stem cells containing at least one of cinnamtannin B1 and pentagalloylglucose, and a method for attracting bone marrow stem cells in which bone marrow stem cells are attracted by the attractant.

Abstract translation: 提供含有肉桂酸蛋白B1和五葡萄糖葡萄糖中的至少一种的骨髓干细胞的引诱剂，以及用于吸引骨髓干细胞的方法，其中骨髓干细胞被引诱剂吸引。

公开(公告)号：US20150273017A1

公开(公告)日：2015-10-01

申请号：US14436906

申请日：2013-10-24

Applicant: GENOMIX CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Katsuto Tamai ,  Sokichi Kamata ,  Yasufumi Kaneda ,  Shigeru Miyagawa ,  Yoshiki Sawa ,  Takehiko Yamazaki

IPC: A61K38/17

CPC classification number: A61K38/1709 ,  C07K14/4718

Abstract: A fragment peptide having a proper length composed of a part of an HMGB1 protein was synthesized and the peptide was confirmed to exhibit therapeutic effects on myocardial infarction.

Abstract translation: 合成具有由HMGB1蛋白的一部分组成的适当长度的片段肽，并确认该肽对心肌梗死具有治疗效果。