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公开(公告)号：US08772492B2
公开(公告)日：2014-07-08
申请号：US12487409
申请日：2009-06-18
IPC分类号： A61K31/47 , C07D217/00 , C07D401/12 , C07D451/06 , C07D405/14 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D451/06
摘要： The invention relates to 6-substituted isoquinoline and isoquinoline derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉衍生物， 化合物。
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2.发明授权公开(公告)号：US08710077B2
公开(公告)日：2014-04-29
申请号：US12487503
申请日：2009-06-18
申请人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
发明人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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公开(公告)号：US08399482B2
公开(公告)日：2013-03-19
申请号：US12970376
申请日：2010-12-16
IPC分类号： A61K31/4725 , C07D217/24 , C07D405/12
CPC分类号： C07D417/12 , C07D217/02 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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4.发明申请公开(公告)号：US20110190340A1
公开(公告)日：2011-08-04
申请号：US13000202
申请日：2009-06-18
IPC分类号： A61K31/4725 , C07D217/24 , A61K31/472 , A61P9/12 , A61P9/10 , A61P13/12 , A61P35/00 , A61P25/00
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的双和多环取代的异喹啉和异喹啉酮，其中R 1至R 12如本申请中所定义，可用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的相关疾病 肌球蛋白轻链磷酸酶的磷酸化，以及含有这些化合物的组合物。
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公开(公告)号：US08742116B2
公开(公告)日：2014-06-03
申请号：US12487479
申请日：2009-06-18
申请人： Oliver Plettenburg , Armin Hofmeister , Katrin Lorenz , Joachim Brendel , Matthias Löhn , John Weston
发明人： Oliver Plettenburg , Armin Hofmeister , Katrin Lorenz , Joachim Brendel , Matthias Löhn , John Weston
IPC分类号： A61K31/445 , C07D211/32
CPC分类号： C07D217/24 , C07D401/12
摘要： The invention relates to 6-substituted isoquinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹诺酮衍生物和含有这些化合物的组合物。
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6.发明授权公开(公告)号：US08541449B2
公开(公告)日：2013-09-24
申请号：US13000754
申请日：2009-06-19
申请人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
发明人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
IPC分类号： C07D217/24 , A61K31/472
CPC分类号： C07D217/24
摘要： The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的式（I）的取代异喹啉和异喹啉酮，以及含有这些化合物的组合物。
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7.发明授权公开(公告)号：US08524737B2
公开(公告)日：2013-09-03
申请号：US13000202
申请日：2009-06-18
IPC分类号： C07D495/08 , C07D217/24 , A61K31/47
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的双和多环取代的异喹啉和异喹啉酮，其中R 1至R 12如本申请中所定义，可用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的相关疾病 肌球蛋白轻链磷酸酶的磷酸化，以及含有这些化合物的组合物。
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8.发明申请公开(公告)号：US20110190341A1
公开(公告)日：2011-08-04
申请号：US13000754
申请日：2009-06-19
申请人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
发明人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
IPC分类号： A61K31/472 , C07D217/24 , A61P9/12 , A61P9/10 , A61P25/00 , A61P13/12 , A61P11/00 , A61P35/00 , A61P25/28
CPC分类号： C07D217/24
摘要： The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的式（I）的取代异喹啉和异喹啉酮，以及含有这些化合物的组合物。
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![Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them](/abs-image/US/2015/09/08/US09127001B2/abs.jpg.150x150.jpg)
9.发明授权Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them 有权取代的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶，它们作为药物的用途，以及包含它们的药物制剂公开(公告)号：US09127001B2
公开(公告)日：2015-09-08
申请号：US14342744
申请日：2011-09-16
申请人： Laurent Bialy , Katrin Lorenz , Klaus Wirth , Klaus Steinmeyer , Gerhard Hessler , Josef Pernerstorfer , Joachim Brendel
发明人： Laurent Bialy , Katrin Lorenz , Klaus Wirth , Klaus Steinmeyer , Gerhard Hessler , Josef Pernerstorfer , Joachim Brendel
IPC分类号： C07D513/02 , C07D471/04 , C07D471/18
CPC分类号： C07D471/04 , C07D471/18
摘要： The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines of formula (I), their use as medicament, and pharmaceutical preparations comprising them. The compounds of formula (I) act on the TASK-1 potassium channel. The compounds are particularly suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.
摘要翻译： 本发明涉及式（I）的取代的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶，它们作为药物的用途，以及包含它们的药物制剂。 式（I）化合物作用于TASK-1钾通道。 该化合物特别适用于治疗或预防房性心律失常，例如房颤（AF）或心房扑动。
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