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公开(公告)号：US08772492B2
公开(公告)日：2014-07-08
申请号：US12487409
申请日：2009-06-18
IPC分类号： A61K31/47 , C07D217/00 , C07D401/12 , C07D451/06 , C07D405/14 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D451/06
摘要： The invention relates to 6-substituted isoquinoline and isoquinoline derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉衍生物， 化合物。
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2.发明授权公开(公告)号：US08710077B2
公开(公告)日：2014-04-29
申请号：US12487503
申请日：2009-06-18
申请人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
发明人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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公开(公告)号：US08748614B2
公开(公告)日：2014-06-10
申请号：US12487455
申请日：2009-06-18
IPC分类号： A61K31/535 , C07D217/00
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物， 化合物。
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公开(公告)号：US08461144B2
公开(公告)日：2013-06-11
申请号：US13586468
申请日：2012-08-15
IPC分类号： A61K31/397
CPC分类号： C07D401/12 , C07D401/14
摘要： A method for the treatment or prevention in a mammal of a disease associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase comprising administering to the mammal in need thereof at least one compound of the formula (I).
摘要翻译： 一种用于治疗或预防哺乳动物与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的方法，包括向有需要的哺乳动物施用至少一种式（I）的化合物。
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5.发明授权Substituted isoquinoline and isoquinolinone derivatives as inhibitors of Rho-kinase 有权取代的异喹啉和异喹啉酮衍生物作为Rho激酶的抑制剂公开(公告)号：US08278294B2
公开(公告)日：2012-10-02
申请号：US12487403
申请日：2009-06-18
IPC分类号： A61K31/397
CPC分类号： C07D401/12 , C07D401/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物， 化合物。
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公开(公告)号：US08399482B2
公开(公告)日：2013-03-19
申请号：US12970376
申请日：2010-12-16
IPC分类号： A61K31/4725 , C07D217/24 , C07D405/12
CPC分类号： C07D417/12 , C07D217/02 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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7.发明申请公开(公告)号：US20110190340A1
公开(公告)日：2011-08-04
申请号：US13000202
申请日：2009-06-18
IPC分类号： A61K31/4725 , C07D217/24 , A61K31/472 , A61P9/12 , A61P9/10 , A61P13/12 , A61P35/00 , A61P25/00
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的双和多环取代的异喹啉和异喹啉酮，其中R 1至R 12如本申请中所定义，可用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的相关疾病 肌球蛋白轻链磷酸酶的磷酸化，以及含有这些化合物的组合物。
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8.发明申请公开(公告)号：US20110190341A1
公开(公告)日：2011-08-04
申请号：US13000754
申请日：2009-06-19
申请人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
发明人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
IPC分类号： A61K31/472 , C07D217/24 , A61P9/12 , A61P9/10 , A61P25/00 , A61P13/12 , A61P11/00 , A61P35/00 , A61P25/28
CPC分类号： C07D217/24
摘要： The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的式（I）的取代异喹啉和异喹啉酮，以及含有这些化合物的组合物。
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公开(公告)号：US08742116B2
公开(公告)日：2014-06-03
申请号：US12487479
申请日：2009-06-18
申请人： Oliver Plettenburg , Armin Hofmeister , Katrin Lorenz , Joachim Brendel , Matthias Löhn , John Weston
发明人： Oliver Plettenburg , Armin Hofmeister , Katrin Lorenz , Joachim Brendel , Matthias Löhn , John Weston
IPC分类号： A61K31/445 , C07D211/32
CPC分类号： C07D217/24 , C07D401/12
摘要： The invention relates to 6-substituted isoquinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹诺酮衍生物和含有这些化合物的组合物。
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10.发明授权公开(公告)号：US08541449B2
公开(公告)日：2013-09-24
申请号：US13000754
申请日：2009-06-19
申请人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
发明人： Oliver Plettenburg , Katrin Lorenz , John Weston , Matthias Loehn , Heinz-Werner Kleemann , Olivier Duclos , Frederic Jeannot
IPC分类号： C07D217/24 , A61K31/472
CPC分类号： C07D217/24
摘要： The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关疾病的式（I）的取代异喹啉和异喹啉酮，以及含有这些化合物的组合物。
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