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    Dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides) and x-ray contrast media containing them
    7.
    发明授权
    Dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides) and x-ray contrast media containing them 失效
    二羧酸（3,5-DICARBAMOYL-2,4,6-TRIIODOANILIDES）和含有它们的X射线对比介质

    公开(公告)号：US5073362A

    公开(公告)日：1991-12-17

    申请号：US554948

    申请日：1990-07-16

    申请人： Peter Blaszkiewicz ,  Ulrich Speck

    发明人： Peter Blaszkiewicz ,  Ulrich Speck

    IPC分类号： A61K31/165 ,  A61K31/166 ,  A61K49/04 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/08 ,  C07C233/00 ,  C07C233/12 ,  C07C237/46

    CPC分类号： A61K31/165 ,  A61K31/166 ,  A61K49/04 ,  C07C233/00 ,  C07C233/12

    摘要： Dicarboxylic acid bis-(3,5-dicarbomoyl-2,4,6-triiodoanilides) of general formula I ##STR1## wherein the amide radicals --CONR.sup.1 R.sup.2 and --CONR.sup.3 R.sup.4 are different from one another andR.sup.1 is a hydrogen, a lower alkyl radical or R.sup.2,R.sup.2 is a straight-chain or branched-chain monohydroxy or polyhydroxy alkyl radical,R.sup.3 is hydrogen, a lower alkyl radical or R.sup.4,R.sup.4 is a straight-chain or branched-chain monohydroxy or polyhydroxy alkyl radical,R.sup.5 is hydrogen, a lower alkyl radical or a monohydroxy or polyhydroxy alkyl radical,X is a straight-chain or branched-chain alkylene with 1 to 6 carbon atoms, which optionally can be substituted by 1 to 6 hydroxy or alkoxy groups or interrupted by one or more oxygen atoms,possess good pharmacological and physicochemical properties rendering them outstandingly suitable as radiopaque substances in X-ray contrast media for use in all fields of application for X-ray contrast media.

    摘要翻译： 通式Ⅰ“IMAGE”的二羧酸双 - （3,5-二甲酰基-2,4,6-三碘代酰苯胺），其中酰胺基-CONR1R2和-CONR3R4彼此不同，R1是氢，低级烷基 或R2，R2是直链或支链单羟基或多羟基烷基，R3是氢，低级烷基或R4，R4是直链或支链单羟基或多羟基烷基，R5是氢， 低级烷基或单羟基或多羟基烷基，X是具有1至6个碳原子的直链或支链亚烷基，其任选可被1至6个羟基或烷氧基取代或被一个或多个氧中断 原子具有良好的药理学和物理化学性质，使得它们在X射线造影剂中非常适合用作X射线造影剂的所有应用领域中的不透射线物质。

    Substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), process for their production as well as X-ray contrast media containing them
    8.
    发明授权
    Substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), process for their production as well as X-ray contrast media containing them 失效
    取代的二羧酸 - 双（3​​,5-二氨基甲酰基-2,4,6-三碘苯胺），其制备方法以及含有它们的X射线造影剂

    公开(公告)号：US5004835A

    公开(公告)日：1991-04-02

    申请号：US271464

    申请日：1988-11-15

    申请人： Peter Blaszkiewicz ,  Ulrich Speck

    发明人： Peter Blaszkiewicz ,  Ulrich Speck

    IPC分类号： A61K49/04 ,  B08B3/00 ,  B60S5/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/67 ,  C07C237/46 ,  F02B77/00

    CPC分类号： A61K49/04

    摘要： The invention relates to new substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilines), of general formula I ##STR1## in which R.sup.1 means a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical or R.sup.2, wherein R.sup.1 and R.sup.2 are the same or different,R.sup.2 means a straight-chain or branched-chain C.sub.2 1.varies.C.sub.8 monohydroxyalkyl radical or polyhydroxyalkyl radical,R.sup.3 means a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical or R.sup.2,R.sup.4 means a hydrogen atom or a C.sub.1 -C.sub.4 alkyl radical, andn=1 or 2.The new nonionic compounds of formula I because of their good pharmacological and physiocochemical properties are outstandingly suitable as radiopaque substances in X-ray contrast media for use in all the fields of applications of X-ray contrast media.

    摘要翻译： 本发明涉及通式Ⅰ的新的取代的二羧酸 - 双（3​​,5-二氨基甲酰基-2,4,6-三碘苯胺）（Ⅰ），其中R1表示氢原子，C1-C4烷基 或R 2，其中R 1和R 2相同或不同，R 2表示直链或支链C 21比例C 8单羟基烷基或多羟基烷基，R 3表示氢原子，C 1 -C 4烷基或R 2，R 4表示 氢原子或C 1 -C 4烷基，并且n = 1或2.式I的新型非离子化合物由于其良好的药理学和物理化学性质而非常适合用于所有领域的X射线造影剂中的不透射线物质 的X射线造影剂的应用。