公开(公告)号：US20080153118A1

公开(公告)日：2008-06-26

申请号：US11936569

申请日：2007-11-07

申请人： Ortrud Quarder ,  Stefano Ferrari ,  Peter Stephan

发明人： Ortrud Quarder ,  Stefano Ferrari ,  Peter Stephan

IPC分类号： C12Q1/54 ,  C12M1/34

CPC分类号： A61B5/14532 ,  A61B5/14528 ,  A61B5/1473

摘要： The invention relates to a method and a device for determining the glucose concentration in tissue fluid whereby test values for glucose and for an endogenous reference substance are detected in a sample liquid obtained by microdialysis, microperfusion or ultrafiltration, and the glucose value is corrected in accordance with the test value for the reference substance. The recovery rate for glucose is determined from a non-linear relationship with the recovery rate for the ionic reference substance, and the test value for glucose is corrected therewith. In addition, the concentration of lactate and/or pyruvate is used as a further reference substance in the sample liquid to make further corrections.

摘要翻译： 本发明涉及一种用于测定组织液中葡萄糖浓度的方法和装置，其中通过微量透析，微灌注或超滤获得的样品液中检测葡萄糖和内源性参考物质的测试值，并根据 具有参考物质的测试值。 由与离子性参比物质的回收率的非线性关系求出葡萄糖的回收率，用葡萄糖的检测值进行校正。 此外，乳液和/或丙酮酸盐的浓度用作样品液体中的另外的参考物质以进一步校正。

公开(公告)号：US08114623B2

公开(公告)日：2012-02-14

申请号：US11936569

申请日：2007-11-07

申请人： Ortrud Quarder ,  Stefano Ferrari ,  Peter Stephan

发明人： Ortrud Quarder ,  Stefano Ferrari ,  Peter Stephan

IPC分类号： C12Q1/54 ,  C12M1/34

CPC分类号： A61B5/14532 ,  A61B5/14528 ,  A61B5/1473

摘要： The invention relates to a method and a device for determining the glucose concentration in tissue fluid whereby test values for glucose and for an endogenous reference substance are detected in a sample liquid obtained by microdialysis, microperfusion or ultrafiltration, and the glucose value is corrected in accordance with the test value for the reference substance. The recovery rate for glucose is determined from a non-linear relationship with the recovery rate for the ionic reference substance, and the test value for glucose is corrected therewith. In addition, the concentration of lactate and/or pyruvate is used as a further reference substance in the sample liquid to make further corrections.

摘要翻译： 本发明涉及一种用于测定组织液中葡萄糖浓度的方法和装置，其中通过微量透析，微量灌注或超滤获得的样品液中检测葡萄糖和内源性参考物质的测试值，并根据 具有参考物质的测试值。 由与离子性参比物质的回收率的非线性关系求出葡萄糖的回收率，用葡萄糖的检测值进行校正。 此外，乳液和/或丙酮酸盐的浓度用作样品液体中的另外的参考物质以进一步校正。

公开(公告)号：US09757328B2

公开(公告)日：2017-09-12

申请号：US13833773

申请日：2013-03-15

申请人： Stefano Ferrari ,  Roelof Rongen

发明人： Stefano Ferrari ,  Roelof Rongen

IPC分类号： A61K9/06 ,  A61K9/00 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10

CPC分类号： A61K9/0014 ,  A61K9/06 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10

摘要： The present invention relates to formulations of gelled lysozyme achieved by the addition of water to a lysozyme suspension in a solvent, such as an alcohol, with retention of enzymatic activity. It was surprisingly discovered that lysozyme itself is a gelling substance (self-gel) and, therefore, it can be advantageously formulated into topical compositions without the addition of other gelling substances such as cellulose, starch or other polysaccharides. The activity of the lysozyme is enhanced as compared to other formulations of comprising lysozyme. The formulations contained in the present invention are useful in methods in the fields of therapeutics, disinfectants, sanitizers, personal hygiene, and cosmetics for human and veterinary use.

公开(公告)号：US09149514B2

公开(公告)日：2015-10-06

申请号：US12905135

申请日：2010-10-15

申请人： Stefano Ferrari

发明人： Stefano Ferrari

IPC分类号： A61K38/47

CPC分类号： A61K38/47 ,  A61K2300/00

摘要： A composition of lysozyme and a pharmaceutically acceptable carrier is active against the papilloma virus in both humans and animals. The composition can be used to treat women suffering from cervical cancer. The composition can also be used to treat cows and horses suffering sarcoids.

摘要翻译： 溶菌酶和药学上可接受的载体的组合物对人和动物中的乳头状瘤病毒均有活性。 该组合物可用于治疗患有宫颈癌的妇女。 组合物也可用于治疗患有肌病的牛和马。

公开(公告)号：US20070081985A1

公开(公告)日：2007-04-12

申请号：US11244995

申请日：2005-10-06

申请人： Stefano Ferrari ,  Seth Feuerstein

发明人： Stefano Ferrari ,  Seth Feuerstein

IPC分类号： A61K38/47 ,  A61K47/00 ,  A61K35/20

CPC分类号： A61K35/20 ,  A23C9/1216 ,  A23C9/152 ,  A23L33/10 ,  A23L33/17 ,  A23L33/19 ,  A61K38/47

摘要： Milk and/or yogurt fortified with lysozyme for augmentation of the immune system and aid the immune compromised.

摘要翻译： 用溶菌酶强化的牛奶和/或酸奶增强免疫系统，并有助于免疫受损。

公开(公告)号：US06878720B2

公开(公告)日：2005-04-12

申请号：US10180289

申请日：2002-06-26

申请人： Karl-Heinz Altmann ,  Guido Bold ,  Pascal Furet ,  Paul William Manley ,  Jeanette Marjorie Wood ,  Stefano Ferrari ,  Francesco Hofmann ,  Jürgen Mestan ,  Andreas Huth ,  Martin Krüger ,  Dieter Seidelmann ,  Andreas Menrad ,  Martin Haberey ,  Karl-Heinz Thierauch

发明人： Karl-Heinz Altmann ,  Guido Bold ,  Pascal Furet ,  Paul William Manley ,  Jeanette Marjorie Wood ,  Stefano Ferrari ,  Francesco Hofmann ,  Jürgen Mestan ,  Andreas Huth ,  Martin Krüger ,  Dieter Seidelmann ,  Andreas Menrad ,  Martin Haberey ,  Karl-Heinz Thierauch

IPC分类号： C07D233/64 ,  A61K20060101 ,  A61K31/00 ,  A61K31/166 ,  A61K31/167 ,  A61K31/415 ,  A61K31/417 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4745 ,  A61K31/497 ,  A61K31/505 ,  A61P20060101 ,  A61P17/00 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07C20060101 ,  C07C223/02 ,  C07C237/30 ,  C07C317/26 ,  C07D20060101 ,  C07D211/22 ,  C07D213/04 ,  C07D213/38 ,  C07D213/40 ,  C07D213/61 ,  C07D213/64 ,  C07D213/89 ,  C07D215/12 ,  C07D215/14 ,  C07D215/36 ,  C07D215/58 ,  C07D233/54 ,  C07D265/26 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/02

CPC分类号： A61K31/415 ,  A61K31/44 ,  A61K31/47 ,  C07D213/38 ,  C07D213/56 ,  C07D213/64 ,  C07D213/89 ,  C07D215/12 ,  C07D233/54 ,  C07D405/12

摘要： Described are compunds of formula (I), wherein W is O or S; X is NR8; Y is CR9R10—(CH2)n wherein R9 and R10 are independently of each other hydrogen or lower alkyl, and n is an integer of from and including 0 to and including 3; or Y is SO2; R1 is aryl; R2 is a bicyclic heteroaryl group comprising one ring nitrogen atom with the exception that R2 cannot represent 2-phthalimidyl; any of R3, R4, R5 and R6, independently of the other, is H or a substituent other than hydrogen; and R7 and R8, independently of each other, are H or lower alkyl; or a N-oxide or a pharmaceutically acceptable salt thereof for the preparation of a pharmaceutical product for the treatment of a neoplastic disease which responds to an inhibition of the VEGF receptor tyrosine kinase activity. The compounds of formula (I) can be used for the treatment e.g. of a neoplastic disease, such as a tumor disease, of retinopathy and age-related macular degeneration.

摘要翻译： 描述的是式（I）的化合物，其中W是O或S; X为NR8; Y为CR 9 R 10 - （CH 2）n，其中R 9和R 10彼此独立地为氢或低级烷基，n为0〜3的整数。 或Y为SO2; R1是芳基; R2是包含一个环氮原子的二环杂芳基，不同的是R 2不能代表2-邻苯二酰亚氨基; R 3，R 4，R 5和R 6中的任何一个独立地为H或氢以外的取代基; 且R 7和R 8彼此独立地为H或低级烷基; 或N-氧化物或其药学上可接受的盐在制备用于治疗对VEGF受体酪氨酸激酶活性的抑制作出反应的肿瘤疾病的药物产品中的用途。 式（I）化合物可用于治疗，例如， 的肿瘤疾病，如肿瘤疾病，视网膜病变和年龄相关性黄斑变性。

公开(公告)号：US09181765B2

公开(公告)日：2015-11-10

申请号：US13818976

申请日：2011-08-04

申请人： Stefano Ferrari

发明人： Stefano Ferrari

IPC分类号： E21B19/14

CPC分类号： E21B19/146 ,  E21B19/14

摘要： Parking and automatic handling equipment of drilling rods (10) includes a carousel (20) of containers (30) of drilling rods (40); and a rod handling system (100), positioned on a drilling machine. A handling arm (101) transfers the drilling rods (40) out of the carousel (20). The carousel (20) defines a closed path around which are arranged the containers (30) of drilling rods (40); the carousel (20) includes an internal structure (22) for supporting the containers (30) movable on a closed path.

摘要翻译： 钻杆（10）的停放和自动处理设备包括钻杆（40）的容器（30）的转盘（20）; 以及定位在钻机上的杆处理系统（100）。 处理臂（101）将钻杆（40）传送出转盘（20）。 旋转盘（20）限定了一个封闭的路径，围绕这些路径设置有钻杆（40）的容器（30）; 旋转盘（20）包括用于支撑可在封闭路径上移动的容器（30）的内​​部结构（22）。

公开(公告)号：US20080254079A1

公开(公告)日：2008-10-16

申请号：US12100091

申请日：2008-04-09

申请人： Stefano Ferrari

发明人： Stefano Ferrari

IPC分类号： A61K8/02 ,  A61K38/47 ,  A61K38/44 ,  A61K9/70 ,  A61P17/00 ,  A61Q11/00 ,  A61P31/00 ,  A61P43/00 ,  A61K8/66 ,  A61K9/46

CPC分类号： A61K8/736 ,  A61K8/66 ,  A61K38/40 ,  A61K38/44 ,  A61K38/482 ,  A61K38/4873 ,  A61Q19/00 ,  C12Y302/01017 ,  A61K2300/00

摘要： A composition comprising a content of a lysozyme and a content of a C-1/C-4 polysaccharide is useful in oral care, cosmetology and dermatology, contraception, urology and gynecology. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims. 37 CFR § 1.72(b).

摘要翻译： 包含溶菌酶含量和C-1 / C-4多糖含量的组合物可用于口腔护理，美容和皮肤病学，避孕，泌尿和妇科。 要强调的是，该摘要被提供以符合要求抽象的规则，这将允许搜索者或其他读者快速地确定技术公开的主题。 提交它的理解是，它不会用于解释或限制所附权利要求的范围或含义。 37 CFR§1.72（b）。

公开(公告)号：US20130220601A1

公开(公告)日：2013-08-29

申请号：US13820500

申请日：2011-08-24

申请人： Stefano Ferrari

发明人： Stefano Ferrari

IPC分类号： E21B19/20

CPC分类号： E21B19/20 ,  E21B19/00 ,  E21B19/16

摘要： A method for automatic handling of drilling rods includes a step of handling at least one drilling rod (30) by a handler (40) designed for simultaneously clamping and moving the drilling rod (30), and wherein the handler (40) moves the drilling rod (30) from an auxiliary retainer (200) to a main well (100). The handling step takes place automatically and is controlled by a data processing unit, and includes automatic handling of a drill head (20) fitted with a chuck susceptible to being screwed to the drilling rod (30); the automatic handling occurring among a plurality of heights (q1-q6) stored in the data processing unit.

摘要翻译： 一种用于自动处理钻杆的方法包括通过设计用于同时夹紧和移动钻杆（30）的处理器（40）处理至少一个钻杆（30）的步骤，并且其中处理器（40）移动钻孔 杆（30）从辅助保持器（200）到主井（100）。 处理步骤自动进行并由数据处理单元控制，并且包括自动处理装配有易于拧入钻杆（30）的卡盘的钻头（20）; 自动处理发生在存储在数据处理单元中的多个高度（q1-q6）之间。

公开(公告)号：US06448277B2

公开(公告)日：2002-09-10

申请号：US09850434

申请日：2001-05-07

申请人： Karl-Heinz Altmann ,  Guido Bold ,  Pascal Furet ,  Paul William Manley ,  Jeanette Marjorie Wood ,  Stefano Ferrari ,  Francesco Hofmann ,  Jürgen Mestan ,  Andreas Huth ,  Martin Krüger ,  Dieter Seidelmann ,  Andreas Menrad ,  Martin Haberey ,  Karl-Heinz Thierauch

发明人： Karl-Heinz Altmann ,  Guido Bold ,  Pascal Furet ,  Paul William Manley ,  Jeanette Marjorie Wood ,  Stefano Ferrari ,  Francesco Hofmann ,  Jürgen Mestan ,  Andreas Huth ,  Martin Krüger ,  Dieter Seidelmann ,  Andreas Menrad ,  Martin Haberey ,  Karl-Heinz Thierauch

IPC分类号： A61K31166

CPC分类号： A61K31/415 ,  A61K31/44 ,  A61K31/47 ,  C07D213/38 ,  C07D213/56 ,  C07D213/64 ,  C07D213/89 ,  C07D215/12 ,  C07D233/54 ,  C07D405/12

摘要： Described are compounds of formula (I), wherein W is O or S; X is NR8; Y is CR9R10—(CH2)n wherein R9 and R10 are independently of each other hydrogen or lower alkyl, and n is an integer of from and including 0 to and including 3; or Y is S02; R1 is aryl; R2 is a mono- or bicyclic heteroaryl group comprising one or more ring nitrogen atoms with the exception that R2 cannot represent 2-phthalimidyl, and in case of Y=SO2 cannot represent 2,1,3-benzothiadiazol-4-yl; any of R3, R4, R5 and R6, independently of the other, is H or a substituent other than hydrogen; and R7 and R8, independently of each other, are H or lower alkyl; or a N-oxide or a pharmaceutically acceptable salt thereof for the preparation of a pharmaceutical product for the treatment of a neoplastic disease which responds to an inhibition of the VEGF receptor tyrosine kinase activity. The compounds of formula (I) can be used for the treatment e.g. of a neoplastic disease, such as a tumor disease, of retinopathy and age-related macular degeneration.

摘要翻译： 描述了式（I）的化合物，其中W是O或S; X为NR8; Y为CR 9 R 10 - （CH 2）n，其中R 9和R 10彼此独立地为氢或低级烷基，n为0〜3的整数。 或Y为SO2; R1是芳基; R2是包含一个或多个环氮原子的单环或双环杂芳基，除了R 2不能表示2-邻苯二酰亚氨基，并且在Y = SO 2的情况下不能代表2,1,3-苯并噻二唑-4-基; R 3，R 4，R 5和R 6中的任何一个独立地为H或氢以外的取代基; 且R 7和R 8彼此独立地为H或低级烷基; 或N-氧化物或其药学上可接受的盐在制备用于治疗对VEGF受体酪氨酸激酶活性的抑制作出反应的肿瘤疾病的药物产品中的用途。 式（I）化合物可用于治疗，例如， 的肿瘤疾病，如肿瘤疾病，视网膜病变和年龄相关性黄斑变性。