公开(公告)号：US06926692B2

公开(公告)日：2005-08-09

申请号：US10379014

申请日：2003-03-04

申请人： Osamu Katoh ,  Masashi Momota ,  Tomihisa Kato

发明人： Osamu Katoh ,  Masashi Momota ,  Tomihisa Kato

IPC分类号： A61M25/00 ,  A61F2/958 ,  A61M25/01 ,  A61M25/04 ,  A61M5/178 ,  A61M29/00

CPC分类号： A61M25/04 ,  A61M25/0133 ,  A61M25/0155 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/0096 ,  A61M2025/018

摘要： A medicinal liquid injection catheter includes a flexible main body, a needle-like tubular member, a medicinal liquid supply device, and a balloon. The tubular member is inserted in the main body and an end portion of the tubular member projects from a side hole provided in the main body. The medicinal liquid supply device accommodates a medicinal liquid, and is connected to the tubular member to supply the medicinal liquid through the tubular member. The balloon is attached to an outer portion of the main body and the balloon is expansible in substantially the same direction as a direction in which the portion of the tubular member projects. The medicinal liquid injection catheter additionally includes first and second guide wires. The second guide wire projects from the main body in a direction which intersects a direction in which the first guide wire projects from the main body.

摘要翻译： 药液注射导管包括柔性主体，针状管状构件，药液供给装置和气囊。 管状构件插入主体中，并且管状构件的端部从设置在主体中的侧孔突出。 药液供给装置容纳药液，与管状部件连接，通过管状部件供给药液。 气囊附接到主体的外部部分，并且气囊在与管状部件的一部分突出的方向大致相同的方向上是可膨胀的。 药液注入导管另外包括第一和第二引导线。 第二引导线沿着与第一导丝从主体突出的方向相交的方向从主体突出。

公开(公告)号：US07377910B2

公开(公告)日：2008-05-27

申请号：US10793351

申请日：2004-03-04

申请人： Osamu Katoh ,  Masashi Momota ,  Tomihisa Kato

发明人： Osamu Katoh ,  Masashi Momota ,  Tomihisa Kato

IPC分类号： A61M5/178

CPC分类号： A61M25/0084 ,  A61M2025/009

摘要： Embodiments of the present invention relate to an injection devices that inject a specified reagent with cells into lesions and other areas of body tissue. Particular embodiments comprise a main tube with a projection hole on its exterior, an axially-moveable needle tube with a needle at its tip, a reagent supplier configured to supply a specified reagent into the needle tube, and axially-moveable guide wires.

摘要翻译： 本发明的实施方案涉及将特定试剂注射到病变和身体组织的其它区域中的注射装置。 具体实施方式包括在其外部具有突出孔的主管，在其尖端具有针的可轴向移动的针管，被配置为将特定试剂供应到针管中的试剂供应器和可轴向移动的引导线。

公开(公告)号：US20050203462A1

公开(公告)日：2005-09-15

申请号：US11122733

申请日：2005-05-05

申请人： Osamu Katoh ,  Masashi Momota ,  Tomihisa Kato

发明人： Osamu Katoh ,  Masashi Momota ,  Tomihisa Kato

IPC分类号： A61M25/00 ,  A61F2/958 ,  A61M25/01 ,  A61M25/04 ,  A61M5/178

CPC分类号： A61M25/04 ,  A61M25/0133 ,  A61M25/0155 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/0096 ,  A61M2025/018

摘要： A medicinal liquid injection catheter includes a flexible main body, a needle-like tubular member, a medicinal liquid supply device, and a balloon. The tubular member is inserted in the main body and an end portion of the tubular member projects from a side hole provided in the main body. The medicinal liquid supply device accommodates a medicinal liquid, and is connected to the tubular member to supply the medicinal liquid through the tubular member. The balloon is attached to an outer portion of the main body and the balloon is expansible in substantially the same direction as a direction in which the portion of the tubular member projects. The medicinal liquid injection catheter additionally includes first and second guide wires. The second guide wire projects from the main body in a direction which intersects a direction in which the first guide wire projects from the main body.

公开(公告)号：US07442184B2

公开(公告)日：2008-10-28

申请号：US11122733

申请日：2005-05-05

申请人： Osamu Katoh ,  Masashi Momota ,  Tomihisa Kato

发明人： Osamu Katoh ,  Masashi Momota ,  Tomihisa Kato

IPC分类号： A61M29/00

CPC分类号： A61M25/04 ,  A61M25/0133 ,  A61M25/0155 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/0096 ,  A61M2025/018

摘要： A medicinal liquid injection catheter includes a flexible main body, a needle-like tubular member, a medicinal liquid supply device, and a balloon. The tubular member is inserted in the main body and an end portion of the tubular member projects from a side hole provided in the main body. The medicinal liquid supply device accommodates a medicinal liquid, and is connected to the tubular member to supply the medicinal liquid through the tubular member. The balloon is attached to an outer portion of the main body and the balloon is expansible in substantially the same direction as a direction in which the portion of the tubular member projects. The medicinal liquid injection catheter additionally includes first and second guide wires. The second guide wire projects from the main body in a direction which intersects a direction in which the first guide wire projects from the main body.

摘要翻译： 药液注射导管包括柔性主体，针状管状构件，药液供给装置和气囊。 管状构件插入主体中，并且管状构件的端部从设置在主体中的侧孔突出。 药液供给装置容纳药液，与管状部件连接，通过管状部件供给药液。 气囊附接到主体的外部部分，并且气囊在与管状部件的一部分突出的方向大致相同的方向上是可膨胀的。 药液注入导管另外包括第一和第二引导线。 第二引导线沿着与第一导丝从主体突出的方向相交的方向从主体突出。

公开(公告)号：US08551073B2

公开(公告)日：2013-10-08

申请号：US12457379

申请日：2009-06-09

申请人： Osamu Katoh ,  Shinji Ozawa ,  Tomihisa Kato

发明人： Osamu Katoh ,  Shinji Ozawa ,  Tomihisa Kato

IPC分类号： A61M25/00

CPC分类号： A61M25/0012 ,  A61M25/0043 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/008

摘要： A catheter device (K, K1, K2 and K3) has a flexible hollow tube body (1) formed by a plurality of austenitic stainless steel wires (2) cylindrically stranded to provide a hollow structure. An inner surface of the flexible hollow tube body (1) has a convex-concave structure represented by the stainless steel wires (2) to provide helical grooves (30). A leading distal end of the flexible hollow tube body (1) is formed into a knife-edge circle configuration to provide a knife-edge circle front (3), thus imparting a perforative capability to improve its quality and performance.

公开(公告)号：US20090254107A1

公开(公告)日：2009-10-08

申请号：US12457379

申请日：2009-06-09

申请人： Osamu Katoh ,  Shinji Ozawa ,  Tomihisa Kato

发明人： Osamu Katoh ,  Shinji Ozawa ,  Tomihisa Kato

IPC分类号： A61B17/22

CPC分类号： A61M25/0012 ,  A61M25/0043 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/008

摘要： A catheter device (K, K1, K2 and K3) has a flexible hollow tube body (1) formed by a plurality of austenitic stainless steel wires (2) cylindrically stranded to provide a hollow structure. An inner surface of the flexible hollow tube body (1) has a convex-concave structure represented by the stainless steel wires (2) to provide helical grooves (30). A leading distal end of the flexible hollow tube body (1) is formed into a knife-edge circle configuration to provide a knife-edge circle front (3), thus imparting a perforative capability to improve its quality and performance.

摘要翻译： 导管装置（K，K1，K2和K3）具有由多个奥氏体不锈钢丝（2）形成的柔性中空管体（1），所述奥氏体不锈钢丝线（2）圆柱状绞合以提供中空结构。 柔性中空管体（1）的内表面具有由不锈钢丝（2）表示的凸凹结构，以提供螺旋槽（30）。 柔性中空管体（1）的前端部被形成为刀刃圆形构造以提供刀刃圆前面（3），从而赋予其穿孔能力以提高其质量和性能。

公开(公告)号：US20090215132A1

公开(公告)日：2009-08-27

申请号：US10487240

申请日：2002-08-28

申请人： Osamu Katoh ,  Takanori Akiyama ,  Tetsuji Nakamura

发明人： Osamu Katoh ,  Takanori Akiyama ,  Tetsuji Nakamura

IPC分类号： C12P13/08 ,  C07H21/04 ,  C12N1/20 ,  C12N9/10 ,  C12N15/74

CPC分类号： C12P41/006 ,  C12N9/80 ,  C12P13/04

摘要： The present invention relates to an amide hydrolase which is with excellent thermostability and stereoselectively hydrolyzes an α-amino acid amide; a gene encoding the enzyme protein; a novel recombinant vector containing the gene; a transformant containing the recombinant vector; and a process for producing an L-α-amino acid using the transformant.

摘要翻译： 本发明涉及具有优异的热稳定性和立体选择性水解α-氨基酸酰胺的酰胺水解酶; 编码酶蛋白的基因; 含有该基因的新型重组载体; 含有重组载体的转化体; 以及使用该转化体生产L-α-氨基酸的方法。

公开(公告)号：US5938671A

公开(公告)日：1999-08-17

申请号：US970952

申请日：1997-11-14

申请人： Osamu Katoh ,  Mir A. Imran

发明人： Osamu Katoh ,  Mir A. Imran

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B19/00 ,  A61F2/00

CPC分类号： A61B17/3207 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/22077 ,  A61B2090/3782 ,  A61F2002/30098 ,  A61F2210/0033

摘要： Recanalization apparatus for use in crossing a stenosis forming a total occlusion in a vessel formed by a vessel wall, the stenosis having a distal end cap which is convex facing in a proximal direction. The apparatus is comprised of an outer sheath formed of an elongate flexible tubular member having proximal and distal extremities and having a lumen extending from the proximal extremity to the distal extremity. An inner sheath is slidably mounted in the lumen of the outer sheath and is formed of a flexible elongate tubular member having proximal and distal extremities. The distal extremity has a sharpened tip. The inner sheath has a length so that when the sharpened tip is disposed distally of the distal extremity of the outer sheath, the proximal extremity extends proximally of the proximal extremity of the outer sheath. An imaging guide wire is slidably mounted in the lumen of the inner sheath and has proximal and distal extremities. A transducer is mounted on the distal extremity of the imaging guide wire. The he imaging guide wire has a length so that the transducer can extend beyond the distal extremity of the inner sheath with the proximal extremity extending proximally of the proximal extremity of the inner sheath.

摘要翻译： 用于跨越在容器壁形成的容器中形成完全闭塞的狭窄的再通设备，所述狭窄具有在近端方向上呈凸形的远端帽。 该装置包括由具有近端和远端的细长柔性管状构件形成的外护套，并且具有从近端延伸到远端的内腔。 内护套可滑动地安装在外护套的内腔中并且由具有近端和远端的柔性细长管状构件形成。 远端具有尖锐的尖端。 内护套具有长度，使得当锋利的尖端远离外护套的远端设置时，近端延伸到外鞘近端处的近侧。 成像引导线可滑动地安装在内护套的内腔中并且具有近端和远端。 传感器安装在成像导丝的远端上。 成像引导线具有长度，使得换能器可以延伸超出内护套的远端，近端延伸到内鞘的近端的近端处。

公开(公告)号：US09271787B2

公开(公告)日：2016-03-01

申请号：US13639092

申请日：2011-04-01

申请人： Osamu Katoh ,  Wayne Ogata

发明人： Osamu Katoh ,  Wayne Ogata

IPC分类号： A61B18/12 ,  A61B18/18 ,  A61B18/14 ,  A61B5/00 ,  A61B8/12 ,  A61M5/00 ,  A61M13/00 ,  A61B18/24 ,  A61B18/00 ,  A61B19/00 ,  A61N7/02

CPC分类号： A61B18/1492 ,  A61B5/0059 ,  A61B5/0066 ,  A61B8/12 ,  A61B18/18 ,  A61B18/1815 ,  A61B18/24 ,  A61B18/245 ,  A61B90/37 ,  A61B2018/00029 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/0041 ,  A61B2018/00839 ,  A61B2018/00982 ,  A61B2018/1861 ,  A61B2090/378 ,  A61B2090/3782 ,  A61M5/00 ,  A61M13/003 ,  A61N7/022

摘要： A method and systems for treating chronic total occlusions, particularly those that are difficult to treat, is disclosed. In this approach, recanalizing the CTO is achieved using a combined antegrade and retrograde approach. The proximal end of the occlusion is penetrated using an antegrade wire, using a traditional approach. Using collateral vessels, the distal end of the occlusion is crossed in a retrograde fashion. By appropriately maneuvering each member and applying radiofrequency energy between the proximal and distal ends of the occlusion, a continuous channel is created.

摘要翻译： 公开了用于治疗慢性全部闭塞的方法和系统，特别是难以治疗的方法和系统。 在这种方法中，使用组合顺行和逆行方法来实现CTO的再通。 使用传统的方法，使用顺行线将遮挡的近端穿透。 使用侧支血管，闭塞的远端以逆行方式穿过。 通过适当地操纵每个构件并在闭塞的近端和远端之间施加射频能量，产生连续的通道。

公开(公告)号：US09119651B2

公开(公告)日：2015-09-01

申请号：US12150111

申请日：2008-04-23

申请人： Osamu Katoh ,  Wayne Ogata

发明人： Osamu Katoh ,  Wayne Ogata

IPC分类号： A61M29/00 ,  A61B17/22 ,  A61B17/221 ,  A61B17/3207 ,  A61M25/09 ,  A61B19/00 ,  A61B17/00 ,  A61M25/00

CPC分类号： A61B17/221 ,  A61B17/22 ,  A61B17/22031 ,  A61B17/320725 ,  A61B17/32075 ,  A61B17/320758 ,  A61B90/39 ,  A61B2017/00685 ,  A61B2017/00876 ,  A61B2017/22001 ,  A61B2017/22035 ,  A61B2017/22038 ,  A61B2017/22044 ,  A61B2017/22049 ,  A61B2017/22061 ,  A61B2017/22079 ,  A61B2017/22081 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61M25/09 ,  A61M2025/0096 ,  A61M2025/09091 ,  A61M2025/09183

摘要： A method and systems for treating chronic total occlusions, particularly those that are difficult to treat, is disclosed. In this approach, recanalizing the CTO is achieved using a combined antegrade and retrograde approach. The proximal end of the occlusion is penetrated using an antegrade wire, using a traditional approach. Using collateral vessels, the distal end of the occlusion is crossed in a retrograde fashion and by appropriately maneuvering each member, a continuous channel is created. Additional elements such as capture devices, dilators and injection catheters are also disclosed.

摘要翻译： 公开了用于治疗慢性全部闭塞的方法和系统，特别是难以治疗的方法和系统。 在这种方法中，使用组合顺行和逆行方法来实现CTO的再通。 使用传统的方法，使用顺行线将遮挡的近端穿透。 使用侧支血管，阻塞的远端以逆行方式交叉，并且通过适当地操纵每个构件，产生连续的通道。 还公开了诸如捕获装置，扩张器和注射导管的附加元件。