摘要:
This invention relates to the compounds represented by a general formula [I]: [in which A1 and A2 represent optionally fluorine-substituted methine or the like; B represents halogen, cyano, lower alkyl or the like; D represents optionally substituted heterocyclic group or the like; and G represents C3-C20 aliphatic group such as alicyclic group]. These compounds inhibit nociceptin activities due to their high affinity to nociceptin receptor, and are useful as analgesic, antiobestic, corebral function improver, drugs for treatment of alzheimer's disease and dementia, remedies for schizophrenia and neurodegenerative diseases, antidepressant, remedies for diabetes insipidus, polyuria, hypotension and so on.
摘要:
This invention provides compounds which are represented by a general formula [I] [in which X stands for hydrogen or halogen; B stands for halogen, cyano or optionally fluorine-substituted lower alkyl; D stands for a 3–10 membered aliphatic nitrogen-containing heterocyclic group; R3, R4 and R5 may be same or different, and each stands for hydrogen, lower alkyl optionally having substituent group(s) and the like; and a is 0 or 1]. These compounds exhibit high affinity to nociceptin receptors and whereby inhibit actions of nociceptin, and are useful as an analgesic, antiobestic, agent for ameliorating brain function, treating agents for Alzheimer's disease and dementia, and therapeutic agents for schizophrenia, neurodegenerative diseases, depression, diabetes insipidus, polyuria, hypotension and the like.
摘要:
Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) [in the formula, A1, A2 and A3 independently represent a carbon atom or a nitrogen atom, and one or two of A1, A2 and A3 represent a carbon atom; R1 represents a lower alkyl group or the like; R2 represents a phenyl group which may be substituted with a halogen atom or the like; R3 represents a hydrogen atom, a lower alkyl group or the like; and R4 represents a lower alkyl group or the like.]
摘要翻译:公开了由下式(I)表示的芳基取代的含氮杂环化合物或其药学上可接受的盐。 该化合物用作伤害感受肽受体拮抗剂,可用作治疗与伤害感受肽受体相关疾病的药剂。 (I)[式中,A1,A2和A3独立地表示碳原子或氮原子,A1,A2和A3中的一个或二个表示碳原子; R1表示低级烷基等; R 2表示可以被卤素原子等取代的苯基; R3表示氢原子,低级烷基等; R4表示低级烷基等。]
摘要:
Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) [in the formula, A1, A2 and A3 independently represent a carbon atom or a nitrogen atom, and one or two of A1, A2 and A3 represent a carbon atom; R1 represents a lower alkyl group or the like; R2 represents a phenyl group which may be substituted with a halogen atom or the like; R3 represents a hydrogen atom, a lower alkyl group or the like; and R4 represents a lower alkyl group or the like.]
摘要翻译:公开了由下式(I)表示的芳基取代的含氮杂环化合物或其药学上可接受的盐。 该化合物用作伤害感受肽受体拮抗剂,可用作治疗与伤害感受肽受体相关疾病的药剂。 (I)[式中,A1,A2和A3独立地表示碳原子或氮原子,A1,A2和A3中的一个或二个表示碳原子; R1表示低级烷基等; R 2表示可以被卤素原子等取代的苯基; R3表示氢原子,低级烷基等; R4表示低级烷基等。]
摘要:
An image heating apparatus includes: a belt member; an inclinable steering roller configured to support the belt member; a heating member configured to contact the belt member and heat an image on a recording material; a detecting member configured to detect a position of a belt end in a widthwise direction of the belt member; a correcting device configured to correct a position of the belt member in the widthwise direction by inclining the steering roller in accordance with a detected position of the belt end by the detecting member; and a supporting device configured to support the detecting member. The supporting device is provided with a contact portion for press-contacting an end surface of one end portion of a pressing roller configured to press the belt member against the heating member.
摘要:
The present invention provides an electrostatic chuck in which the surface can be kept smooth after being exposed to plasma, so as to protect a material to be clamped such as a silicon wafer from being contaminated with particles, and which is excellent in clamping and releasing a material to be clamped and easy to manufacture by low-temperature firing. The electrostatic chuck includes a dielectric material in which alumina is 99.4 wt % or more, and titanium oxide is more than 0.2 wt % and equal to or less than 0.6 wt %, wherein the electrostatic chuck's volume resistivity is 108-1011 Ωcm in room temperature, and wherein the titanium oxide segregates in boundaries of particles of the alumina.
摘要:
An image heating apparatus includes an endless belt; a rotatable member, contactable to an outer surface of the endless belt, for forming a nip in which a recording material is nipped and conveyed; a stretching member for stretching the endless belt; an urging member, contacting an inner surface of the endless belt, for urging the stretching member by movement of the endless belt so as to include a contact portion at which the urging member contacts the stretching member; a lubricant application member for applying a lubricant onto the inner surface of the endless belt; and a collecting member, contacting the stretching member at a position downstream of an area in which the stretching member contacts the endless belt and upstream of the contact portion with respect to a rotational direction of the stretching member, for collecting the lubricant from the stretching member. The collecting member includes a guiding portion for guiding the lubricant, collected from the stretching member, onto the inner surface of the endless belt.
摘要:
An image heating apparatus includes a rotatable member; a belt member contactable to the rotatable member; a pressing member for pressing the belt member against the rotatable member to form a nip in which a recording material is nipped and conveyed; and a sheet member for covering a pressing surface of the pressing member at which the pressing member presses the belt member. The sheet member is mounted on the pressing member so as to have a first area in which an end portion thereof is located outside an end portion of the belt member with respect to a widthwise direction perpendicular to a conveying direction of the recording material and which includes a portion opposing the pressing surface, and so as to have a second area in which the end portion thereof is located inside the end portion of the belt member with respect to the widthwise direction.
摘要:
A composite structure formation method based on an aerosol deposition method by which an aerosol with brittle material fine particles dispersed in a gas is sprayed toward a substrate to form a structure made of the brittle material fine particles, the composite structure formation method includes: storing a plurality of controlled particles in a storage mechanism, the controlled particle being an assembly packed with a plurality of particles including the brittle material fine particles; supplying the controlled particles from the storage mechanism to an aerosolation mechanism; disaggregating the supplied controlled particles in the aerosolation mechanism to form an aerosol; and spraying the aerosol toward the substrate to form a composite structure having the structure and the substrate.
摘要:
The invention relates to 4-oxoimidazolidine-2-spiropiperidine derivatives represented by a general formula [I] [in which A1, A2, A3, A4 and A5 stand for optionally halogen-substituted methine, or nitrogen atom; R1 and R2 stand for lower alkyl or the like; R3 stands for hydrogen or lower alkyl; R4 and R5 stand for hydrogen, or lower alkyl which is optionally substituted with hydroxy, or the like]or salts thereof. These compounds act as nociceptin receptor agonist, and are useful as analgesic, reliever from tolerance to narcotic analgesic, reliever from dependence on narcotic analgesic, analgesic enhancer, antiobestic, drug for ameliorating brain function, remedy for schizophrenia, drug for treating regressive neurodegenerative diseases, antianxiety agent or antidepressant and remedy for diabetes insipidus and polyuria; and the like.