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    Annuloplasty rings for repair of abnormal mitral valves
    1.
    发明申请
    Annuloplasty rings for repair of abnormal mitral valves 有权
    用于修复异常二尖瓣的瓣环成形术环

    公开(公告)号：US20050131533A1

    公开(公告)日：2005-06-16

    申请号：US10882031

    申请日：2004-06-30

    申请人： Ottavio Alfieri ,  Alain Carpentier ,  Francesco Maisano ,  Patrick McCarthy ,  Alberto Redaelli

    发明人： Ottavio Alfieri ,  Alain Carpentier ,  Francesco Maisano ,  Patrick McCarthy ,  Alberto Redaelli

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2448 ,  A61F2/2409

    摘要： A remodeling mitral annuloplasty ring with a reduced anterior-to-posterior dimension to restore coaptation between the mitral leaflets in mitral valve insufficiency (IMVI). The ring has a generally oval shaped body with a major axis perpendicular to a minor axis, both perpendicular to a blood flow axis. An anterior section lies between anteriolateral and posteriomedial trigones, while a posterior section defines the remaining ring body and is divided into P1, P2, and P3 segments corresponding to the three scallops of the same nomenclature in the posterior leaflet of the mitral valve. The anterior-to-posterior dimension of the ring body is reduced from conventional rings; such as by providing, in atrial plan view, a pulled-in P3 segment. Viewed another way, the convexity of the P3 segment is less pronounced than the convexity of the P1 segment. In addition, the ring body may have a downwardly deflected portion in the posterior section, preferably within the P2 and P3 segments. The downwardly deflected portion may have an apex which is the lowest elevation of the ring body and may be offset with respect to the center of the downwardly deflected portion toward the P1 segment. A sewing cuff may have an enlarged radial dimension of between 5-10 cm, or only a portion of the sewing cuff may be enlarged.

    摘要翻译： 重建二尖瓣瓣环成形术环，具有减小的前后尺寸，以恢复二尖瓣关闭不全（IMVI）中的二尖瓣小叶之间的接合。 环具有大致椭圆形的主体，其长轴垂直于短轴，两者垂直于血流轴线。 前段位于前外侧和后内侧三角形之间，而后段限定剩余的环体，并分为对应于二尖瓣后叶中相同命名的三扇贝的P 1，P 2和P 3段 。 环体的前后尺寸从常规环减少; 例如通过在心房平面图中提供一个拉入的P 3区段。 换句话说，P 3段的凸度比P 1段的凸度更不明显。 此外，环体可以在后部中具有向下偏转的部分，优选地在P 2和P 3段内。 向下偏转的部分可以具有顶点，其是环体的最低高度，并且可以相对于朝向P 1段的向下偏转部分的中心偏移。 缝制袖口可以具有在5-10cm之间的放大的径向尺寸，或者仅可以扩大一部分缝合袖口。

    Annuloplasty Rings for Repair of Abnormal Mitral Valves
    2.
    发明申请
    Annuloplasty Rings for Repair of Abnormal Mitral Valves 审中-公开
    用于修复异常二尖瓣的瓣环成形术环

    公开(公告)号：US20110301704A1

    公开(公告)日：2011-12-08

    申请号：US13094145

    申请日：2011-04-26

    申请人： Ottavio Alfieri ,  Alain F. Carpentier ,  Francesco Maisano ,  Patrick McCarthy ,  Alberto Redaelli

    发明人： Ottavio Alfieri ,  Alain F. Carpentier ,  Francesco Maisano ,  Patrick McCarthy ,  Alberto Redaelli

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2448 ,  A61F2/2409 ,  A61F2/246

    摘要： A remodeling mitral annuloplasty ring with a reduced anterior-to-posterior dimension to restore coaptation between the mitral leaflets in mitral valve insufficiency (IMVI). The ring has a generally oval shaped body with a major axis perpendicular to a minor axis, both perpendicular to a blood flow axis. An anterior section lies between anteriolateral and posteriomedial trigones, while a posterior section defines the remaining ring body and is divided into P1, P2, and P3 segments corresponding to the three scallops of the same nomenclature in the posterior leaflet of the mitral valve. The anterior-to-posterior dimension of the ring body is reduced from conventional rings; such as by providing, in atrial plan view, a pulled-in P3 segment. Viewed another way, the convexity of the P3 segment is less pronounced than the convexity of the P1 segment. In addition, the ring body may have a downwardly deflected portion in the posterior section, preferably within the P2 and P3 segments. The downwardly deflected portion may have an apex which is the lowest elevation of the ring body and may be offset with respect to the center of the downwardly deflected portion toward the P1 segment. A sewing cuff may have an enlarged radial dimension of between 5-10 cm, or only a portion of the sewing cuff may be enlarged.

    摘要翻译： 重建二尖瓣瓣环成形术环，具有减小的前后尺寸，以恢复二尖瓣关闭不全（IMVI）中的二尖瓣小叶之间的接合。 环具有大致椭圆形的主体，其长轴垂直于短轴，两者垂直于血流轴线。 前部位于前外侧和后内侧三角形之间，而后段限定剩余的环体，并分为对应于二尖瓣后叶中相同命名的三扇贝的P1，P2和P3段。 环体的前后尺寸从常规环减少; 例如通过在心房平面图中提供一个拉入的P3段。 换句话说，P3段的凸度比P1段的凸度更不明显。 此外，环体可以在后部中具有向下偏转的部分，优选地在P2和P3段内。 向下偏转的部分可以具有作为环主体的最低高度的顶点，并且可以相对于朝向P1段的向下偏转部分的中心偏移。 缝制袖口可以具有在5-10cm之间的放大的径向尺寸，或者仅可以扩大一部分缝合袖口。

    Annuloplasty ring for ischemic mitral valve insuffuciency
    3.
    发明授权
    Annuloplasty ring for ischemic mitral valve insuffuciency 有权
    用于缺血性二尖瓣闭锁的瓣环成形术环

    公开(公告)号：US07935145B2

    公开(公告)日：2011-05-03

    申请号：US10882031

    申请日：2004-06-30

    申请人： Ottavio Alfieri ,  Alain F. Carpentier ,  Francesco Maisano ,  Patrick McCarthy ,  Alberto Redaelli

    发明人： Ottavio Alfieri ,  Alain F. Carpentier ,  Francesco Maisano ,  Patrick McCarthy ,  Alberto Redaelli

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2448 ,  A61F2/2409

    摘要： A remodeling mitral annuloplasty ring with a reduced anterior-to-posterior dimension to restore coaptation between the mitral leaflets in mitral valve insufficiency (IMVI). The ring has a generally oval shaped body with a major axis perpendicular to a minor axis, both perpendicular to a blood flow axis. An anterior section lies between anteriolateral and posteriomedial trigones, while a posterior section defines the remaining ring body and is divided into P1, P2, and P3 segments corresponding to the three scallops of the same nomenclature in the posterior leaflet of the mitral valve. The anterior-to-posterior dimension of the ring body is reduced from conventional rings; such as by providing, in atrial plan view, a pulled-in P3 segment. Viewed another way, the convexity of the P3 segment is less pronounced than the convexity of the P1 segment. In addition, the ring body may have a downwardly deflected portion in the posterior section, preferably within the P2 and P3 segments. The downwardly deflected portion may have an apex which is the lowest elevation of the ring body and may be offset with respect to the center of the downwardly deflected portion toward the P1 segment. A sewing cuff may have an enlarged radial dimension of between 5-10 cm, or only a portion of the sewing cuff may be enlarged.

    摘要翻译： 重建二尖瓣瓣环成形术环，具有减小的前后尺寸，以恢复二尖瓣关闭不全（IMVI）中的二尖瓣小叶之间的接合。 环具有大致椭圆形的主体，其长轴垂直于短轴，两者垂直于血流轴线。 前部位于前外侧和后内侧三角形之间，而后段限定剩余的环体，并分为对应于二尖瓣后叶中相同命名的三扇贝的P1，P2和P3段。 环体的前后尺寸从常规环减少; 例如通过在心房平面图中提供一个拉入的P3段。 换句话说，P3段的凸度比P1段的凸度更不明显。 此外，环体可以在后部中具有向下偏转的部分，优选地在P2和P3段内。 向下偏转的部分可以具有作为环主体的最低高度的顶点，并且可以相对于朝向P1段的向下偏转部分的中心偏移。 缝制袖口可以具有在5-10cm之间的放大的径向尺寸，或者仅可以扩大一部分缝合袖口。

    Scintillation hardened semi-active laser sensor
    7.
    发明申请
    Scintillation hardened semi-active laser sensor 有权
    闪烁硬化半激光传感器

    公开(公告)号：US20070290120A1

    公开(公告)日：2007-12-20

    申请号：US11206980

    申请日：2005-08-18

    申请人： Scott Sparrold ,  R. Shepard ,  Patrick McCarthy ,  Richard Juergens

    发明人： Scott Sparrold ,  R. Shepard ,  Patrick McCarthy ,  Richard Juergens

    IPC分类号： H01J3/14 ,  H01J40/14

    CPC分类号： G02B3/00 ,  F41G7/226 ,  F41G7/2293 ,  G02B5/02

    摘要： The disclosed system, device and method for spatial homogenization and focusing of electromagnetic radiation over an aperture to reduce the effects of atmospheric scintillation generally includes an optical lens having an at least partially undulating pattern mapped onto a curvilinear surface. Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to eliminate or otherwise reduce the effects of atmospheric scintillation as well as other optical aberrations. Exemplary embodiments of the present invention generally provide improved systems and methods for the acquisition, tracking and engagement of military targets with missiles or other guided ordinance.

    摘要翻译： 所公开的用于空间均匀化和电磁辐射聚焦在孔径上以减少大气闪烁的影响的系统，装置和方法通常包括具有映射到曲线表面上的至少部分起伏的图案的光学透镜。 公开的特征和规格可以被不同地控制，适应或以其他方式任意地修改以消除或以其他方式减小大气闪烁的影响以及其它光学像差。 本发明的示例性实施例通常提供改进的系统和方法，用于采集，跟踪和接合军事目标与导弹或其他指导条例。

    Annuloplasty ring for mitral valve prolapse
    8.
    发明申请
    Annuloplasty ring for mitral valve prolapse 有权
    用于二尖瓣脱垂的瓣环成形术环

    公开(公告)号：US20060129236A1

    公开(公告)日：2006-06-15

    申请号：US11345936

    申请日：2006-02-02

    申请人： Patrick McCarthy

    发明人： Patrick McCarthy

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2445 ,  A61F2/2448

    摘要： A mitral annuloplasty ring that has an outward and an upward posterior bow. The ring defines a closed, modified oval shape with a minor-major axis dimension ratio of between about 3.3:4 to 4:4. The ring is made of a material that will substantially resist distortion when subjected to the stress imparted thereon after implantation in the mitral valve annulus of an operating human heart. The outward and upward posterior bow of the annuloplasty ring corrects for pathologies associated with mitral valve prolapse, as seen with Barlow's syndrome for instance, in which the leaflets tend to be elongated or floppy. Desirably, the outward bow includes a more pronounced outward bulge having an angular extent that approximately equals the angular extent of the upward bow. Sections adjacent the outward bulge may be relatively straight.

    摘要翻译： 具有向外和向上后弓的二尖瓣环成形术环。 该环限定了一个封闭的，改进的椭圆形形状，其具有在大约3.3：4至4：4之间的次长轴尺寸比。 该环由材料制成，当被植入在操作的人心脏的二尖瓣环中时，其受到施加于其上的应力时将基本上抵抗变形。 瓣膜成形术环的向外和向后的后弓修正与二尖瓣脱垂相关的病变，如Barlow综合征所见，其中小叶倾向于伸长或软化。 理想地，向外的弓包括更明显的向外凸起，其具有大致等于向上弓的角度范围的角度范围。 与外部凸起相邻的部分可以是相对直的。

    Mitral valve annuloplasty ring having a posterior bow
    9.
    发明授权
    Mitral valve annuloplasty ring having a posterior bow 有权

    公开(公告)号：US06858039B2

    公开(公告)日：2005-02-22

    申请号：US10192516

    申请日：2002-07-08

    申请人： Patrick McCarthy

    发明人： Patrick McCarthy

    IPC分类号： A61F2/00 ,  A61F2/24 ,  A61F2/06

    CPC分类号： A61F2/2448 ,  A61F2250/0018

    摘要： A mitral heart valve annuloplasty ring having a posterior bow that conforms to an abnormal posterior aspect of the mitral annulus. The ring may be generally oval having a major axis and a minor axis, wherein the posterior bow may be centered along the minor axis or offset in a posterior section. The ring may be substantially planar, or may include upward bows on either side of the posterior bow. The ring may include a ring body surrounded by a suture-permeable fabric sheath, and the ring body may be formed of a plurality of concentric ring elements. The ring is semi-rigid and the posterior bow is stiff enough to withstand deformation once implanted and subjected to normal physiologic stresses. The ring elements may be bands of semi-rigid material. A method of repairing an abnormal mitral heart valve annulus having a depressed posterior aspect includes providing a ring with a posterior bow and implanting the ring to support the annulus without unduly stressing the attachment sutures.

    Multi-Functional Nano-Device
    10.
    发明申请
    Multi-Functional Nano-Device 审中-公开
    多功能纳米器件

    公开(公告)号：US20110286935A1

    公开(公告)日：2011-11-24

    申请号：US13109256

    申请日：2011-05-17

    申请人： Patrick McCarthy ,  James Spanswick

    发明人： Patrick McCarthy ,  James Spanswick

    IPC分类号： A61K49/18 ,  A61K39/395 ,  A61P35/00 ,  A61K9/00 ,  A61K49/00 ,  B82Y15/00 ,  B82Y5/00

    CPC分类号： B82Y5/00 ,  A61K47/6921 ,  A61K47/6933 ,  B82Y15/00 ,  C08F230/08 ,  C08F2220/281 ,  C08F2220/286 ,  C08F2438/01

    摘要： A universal drug delivery platform for monoclonal antibody-based therapeutics is described. This universal platform resolves the problems of immunogenic response associated with the present monoclonal antibody based therapeutics by providing a multifunctional nano-device which comprises a well defined core/shell nano-structure that can function as a drug delivery platform linked to a monoclonal antibody through a single linking group.

    摘要翻译： 描述了用于基于单克隆抗体的治疗剂的通用药物递送平台。 该通用平台通过提供多功能纳米装置来解决与本发明的基于单克隆抗体的治疗相关的免疫原性应答的问题，该多功能纳米装置包含明确定义的核/壳纳米结构，其可以作为通过以下方式与单克隆抗体连接的药物递送平台 单链接组。