公开(公告)号：US20050141671A1

公开(公告)日：2005-06-30

申请号：US10495967

申请日：2002-10-23

申请人： Otto Pastyr ,  Gernot Echner ,  Wolfgang Schlegel ,  Gunther Hartmann

发明人： Otto Pastyr ,  Gernot Echner ,  Wolfgang Schlegel ,  Gunther Hartmann

IPC分类号： A61N5/10 ,  G21K1/04 ,  G21K1/02

CPC分类号： G21K1/04 ,  A61N5/1042 ,  G21K1/046

摘要： The invention relates to a collimator (1) for defining a beam of energetic rays (2) which is emitted from an essentially punctiform radiation source (3) and is oriented onto an object (1) to be treated. The collimator is especially used for the stereotactic conformation radiotherapy of tumors. The collimator (1) is embodied in such a way that an irregular object (4) can be scanned by rays (2, 2′) which are defined by an opening in the collimator. The invention also relates to a program for controlling the collimator. In order to define the contours (29, 29′, 29″) of the objects (4) to be irradiated in a simple but highly accurate manner, especially with a precise definition of the irradiation fields, the collimator comprises a plurality of different sized openings (5, 5′ 5″). One of the openings (5, 5′, 5″) can be selectively displaced in a polydirectional manner on a strip (6) having a spherical surface, and the central axis (7) thereof is oriented towards the radiation source (3). The other collimator openings (5′, 5″) are shielded form the rays (2). A control system (9) acts on the drives (23, 24, 25) of a drive device (8) in such a way that large openings (5, 5′) are used to scan large irradiation surfaces (26) of the object to be treated (4), and small openings (5′, 5″) are used for precise definition at the edge of the irradiation surfaces (26) of the object to be treated (4), especially in the event of irregular contours (29, 29′, 29″).

摘要翻译： 本发明涉及一种用于限定从基本上点状辐射源（3）发射并且被定向到待处理物体（1）上的能量射线束（2）的准直器（1）。 准直器特别用于肿瘤的立体定向构象放射治疗。 准直器（1）以这样的方式实现，使得不规则物体（4）可以被由准直器中的开口限定的射线（2,2'）扫描。 本发明还涉及一种用于控制准直仪的程序。 为了以简单但高度准确的方式（特别是对照射场的精确定义）限定要照射的物体（4）的轮廓（29,29'，29“），准直器包括多个不同的 （5,5'5“）。 开口（5,5'，5“）中的一个可以以多方向方式选择性地移位在具有球形表面的条带（6）上，并且其中心轴线（7）朝向辐射源（3）定向， 。 另一个准直器开口（5'，5“）由光线（2）屏蔽。 控制系统（9）作用在驱动装置（8）的驱动器（23,24,25）上，使得大的开口（5,5'）用于扫描物体的大的照射表面（26） 待处理物体（4）的照射表面（26）的边缘处使用小开口（5'，5“），特别是在不规则轮廓的情况下 （29,29'，29“）。

公开(公告)号：US20070041493A1

公开(公告)日：2007-02-22

申请号：US10555916

申请日：2004-05-10

申请人： Steve Webb ,  Wolfgang Schlegel ,  Gernot Echner ,  Gunther Hartmann

发明人： Steve Webb ,  Wolfgang Schlegel ,  Gernot Echner ,  Gunther Hartmann

IPC分类号： A61N5/10 ,  G21K1/02

CPC分类号： A61N5/1042 ,  G21K1/04 ,  G21K1/046

摘要： A method of intensity-modulating a beam of radiation from a radiation source is provided, the method including the steps of: a) providing a collimator having a window which allows the passage of radiation from the radiation source and which defines when viewed from the radiation source a two-dimensional array of bixels, the collimator further having a plurality of independently movable radiation attenuators which are constrained to move along columns or rows of the array to block selected bixels thereof, whereby, within each column or row along which the attenuators are movable, at least one arrangement of the respective attenuator(s) results in a pair of open bixels sandwiching a blocked bixel or line of blocked bixels; b) positioning the collimator in the path of the radiation source; and c) repeatedly: positioning the radiation attenuators within the window to form at each repeat a different pattern of bixels; and irradiating the collimator, until a predetermined pattern of radiation intensities for the beam of radiation has been delivered through the collimator. A corresponding apparatus for producing an intensity-modulated beam of radiation which is operable in accordance with the above method, and a method of radiotherapy treatment performed on a human or animal body comprising subjecting the body to an intensity-modulated beam of radiation formed using the above method are also provided.

摘要翻译： 提供了一种对来自辐射源的辐射束进行强度调制的方法，所述方法包括以下步骤：a）提供具有窗口的准直仪，该窗口允许来自辐射源的辐射通过，并且当从辐射观察时限定 源极化二维阵列，准直器进一步具有多个可独立移动的辐射衰减器，该辐射衰减器被限制为沿阵列的列或行移动以阻挡其所选择的像素，从而在衰减器沿其中的每个列或行内 各个衰减器的至少一个排列导致一对打开的双焦块，夹着一个阻挡的双像素或一束阻挡的双体晶体; b）将准直器定位在辐射源的路径中; 和c）重复地：将辐射衰减器定位在窗口内，以在每个重复不同的单体图案时形成; 并照射准直仪，直到用于辐射束的辐射强度的预定图案已经通过准直器传送。 用于产生根据上述方法可操作的强度调制的辐射束的相应装置，以及对人体或动物体进行的放射治疗处理方法，包括使身体经受强度调制的辐射束，其使用 还提供了上述方法。

公开(公告)号：US09409941B2

公开(公告)日：2016-08-09

申请号：US12993420

申请日：2009-05-20

申请人： Gunther Hartmann ,  Martin Schlee

发明人： Gunther Hartmann ,  Martin Schlee

IPC分类号： A61K31/713 ,  A61K48/00 ,  A61P31/12 ,  A61P37/04 ,  C07H21/00 ,  A61K31/7088 ,  C12N15/113 ,  C12N15/117

摘要： The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells expressing RIG-I. The present invention further provides an oligonucleotide which is capable of activating RIG-I and which has target gene-silencing activity. The oligonucleotide of the present invention has a double-stranded section of at least 19, preferably at least 21 bp, at least one 5′ triphosphate, and at least one blunt end which bears a 5′ triphosphate. The present invention further provides the use said oligonucleotide for inducing an anti-viral, in particular, an IFN, response in vitro and in vivo. The present invention additionally provides the use of said oligonucleotide for preventing and/or treating diseases or conditions such as infections, tumors/cancers, and immune disorders.

公开(公告)号：US20110033421A1

公开(公告)日：2011-02-10

申请号：US12835000

申请日：2010-07-13

申请人： Gunther Hartmann ,  Robert L. Bratzler ,  Arthur M. Krieg

发明人： Gunther Hartmann ,  Robert L. Bratzler ,  Arthur M. Krieg

IPC分类号： A61K38/21 ,  A61K35/14 ,  A61P35/00 ,  A61P31/14 ,  A61P31/20 ,  A61P31/22 ,  A61P31/18 ,  C12N5/0784 ,  C07H21/04

CPC分类号： C12N15/117 ,  A61K38/21 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55561 ,  C12N5/0639 ,  C12N2501/056 ,  C12N2501/22 ,  C12N2501/23 ,  A61K2300/00

摘要： Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-α treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.

摘要翻译： 提供了用于延长IFN-α在治疗各种病毒和增殖性疾病中的临床效用的方法和组合物。 在其它方面，本发明提供了增加IFN-α治疗功效并降低IFN-α治疗相关副作用的方法。 此外，提供了用于在体外支持生存和激活天然干扰素产生细胞（IPC）的方法，而没有外源IL-3或GM-CSF的方法。 本发明基于某些CpG和非CpG ISNA促进IPC的存活和刺激的发现。

公开(公告)号：US20060107717A1

公开(公告)日：2006-05-25

申请号：US11284454

申请日：2005-11-21

申请人： Gunther Hartmann ,  Wolfgang Sommer ,  Mario Braun ,  Matthias Becker

发明人： Gunther Hartmann ,  Wolfgang Sommer ,  Mario Braun ,  Matthias Becker

IPC分类号： B21H1/00

CPC分类号： B21H1/00 ,  B21H3/00 ,  B21H3/02 ,  B21H3/06 ,  B21H5/00 ,  B21H5/022 ,  B21H9/02

摘要： An apparatus (1) and a method serve for precision rolling of a surface area (2) of a rotationally symmetrical component (3), especially a screw. The apparatus (1) includes at least two spaced apart rolling tools (4, 5), a measuring unit (9) for determining an actual blank diameter of the component (3), an evaluating unit (10) for comparing the determined actual blank diameter of the component (3) with a predetermined blank diameter and for determining an adjustment value from the result of the comparison, and a control unit (11) for adjusting a distance between the at least two rolling tools (4, 5) in response to the adjustment value.

摘要翻译： 一种装置（1）和一种用于精密滚动旋转对称部件（3）的表面区域（2）的方法，特别是螺杆。 所述设备（1）包括至少两个间隔开的滚动工具（4,5），用于确定所述部件（3）的实际坯料直径的测量单元（9），用于将所确定的实际空白 具有预定坯料直径的组件（3）的直径和用于根据比较结果确定调节值的控制单元（11），用于响应于调整至少两个轧制工具（4,5）之间的距离的控制单元（11） 到调整值。

公开(公告)号：US06736831B1

公开(公告)日：2004-05-18

申请号：US09913001

申请日：2001-11-14

申请人： Gunther Hartmann ,  Peter Heeg ,  Oliver Jaekel ,  Christian Karger

发明人： Gunther Hartmann ,  Peter Heeg ,  Oliver Jaekel ,  Christian Karger

IPC分类号： A61N100

CPC分类号： G21K5/04 ,  A61N5/1043 ,  A61N5/1048 ,  A61N2005/1074 ,  A61N2005/1087

摘要： A method for operation of an ion beam therapy system that comprises a grid scanner device, arranged in a beam guidance system (6, 8), having vertical deflection means (13) and horizontal deflection means (14) for the vertical and horizontal deflection of a treatment beam (11) perpendicular to its beam direction, with the result that the treatment beam (11) is deflected by the grid scanner device to an isocentre (10) of the irradiation site and scans a specific area surrounding the isocentre (10) using a specific radiation dose. Both the depth dose distribution and the transverse dose distribution of the grid scanner device (13, 14) at various positions in the region of the isocentre (10) are measured and evaluated, it being concluded that the radiation dose distribution is adequately homogeneous if the degree of variation in the radiation dose values measured at the individual positions does not exceed a specific tolerance limit value.

摘要翻译： 一种用于操作离子束治疗系统的方法，其包括布置在光束引导系统（6,8）中的网格扫描器装置，其具有垂直偏转装置（13）和用于垂直和水平偏转的水平偏转装置（14） 垂直于其光束方向的处理光束（11），结果是处理光束（11）被栅格扫描器装置偏转到照射部位的等角（10）并且扫描等中心（10）周围的特定区域， 使用特定的辐射剂量。 测量和评估在等中心（10）区域中的各种位置处的栅格扫描器装置（13,14）的深度剂量分布和横向剂量分布，得出如下结论：辐射剂量分布足够均匀 在各个位置测量的辐射剂量值的变化程度不超过特定的耐受极限值。

公开(公告)号：US06670618B1

公开(公告)日：2003-12-30

申请号：US09913109

申请日：2001-11-20

申请人： Gunther Hartmann ,  Peter Heeg ,  Oliver Jaekel ,  Christian Karger

发明人： Gunther Hartmann ,  Peter Heeg ,  Oliver Jaekel ,  Christian Karger

IPC分类号： G01N2300

CPC分类号： A61N5/1049 ,  A61B2090/101 ,  A61N5/1043 ,  A61N5/1075 ,  A61N2005/1076 ,  A61N2005/1087

摘要： The present invention relates to a method of checking an isocentre and a patient-positioning device of an ion beam therapy system that comprises a grid scanner device, arranged in a beam guidance system, having vertical deflection means and horizontal deflection means for the vertical and horizontal deflection of a treatment beam perpendicular to its beam direction, with the result that the treatment beam is deflected by the grid scanner device onto an isocentre of the irradiation site, and a specific area surrounding the isocentre is scanned, wherein a check of the isocentre and a patient-positioning device is carried out and the patient-positioning device comprises a patient table rotatable about an axis of rotation of the table. For the checking, a target point within a spherical phantom is represented by means of a special specimen body and the centre point of the specimen body is visibly represented by means of several image-forming methods. On departure of the measurement results in respect of the spatial position of the centre point under the image-forming methods from a predetermined intervention threshold, the ion beam therapy system is subjected to an inspection and/or maintenance.

摘要翻译： 本发明涉及一种检查离子束治疗系统的等中心和患者定位装置的方法，其包括布置在光束引导系统中的网格扫描器装置，其具有垂直偏转装置和用于垂直和水平的水平偏转装置 处理光束垂直于其光束方向的偏转，结果是处理光束被栅格扫描器装置偏转到照射部位的等中心上，并且扫描周围等中心的特定区域，其中检查等中心和 执行患者定位装置，并且患者定位装置包括可围绕桌子的旋转轴线旋转的患者台。 对于检查，球形体模中的目标点通过特殊的样本体表示，并且通过几种成像方法可见地表示样本体的中心点。 在从图像形成方法的中心点的空间位置从预定干预阈值开始的测量结果离开时，对离子束治疗系统进行检查和/或维护。

公开(公告)号：US20120045461A1

公开(公告)日：2012-02-23

申请号：US13179421

申请日：2011-07-08

申请人： Gunther Hartmann ,  Antonin de Fougerolles ,  Veit Hornung ,  Stefan Endres

发明人： Gunther Hartmann ,  Antonin de Fougerolles ,  Veit Hornung ,  Stefan Endres

IPC分类号： A61K31/7088 ,  A61P37/04 ,  A61K39/00 ,  C07H1/06 ,  C07H21/02

CPC分类号： C12N15/117 ,  A61K39/00 ,  A61K39/39 ,  A61K2039/53 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2310/3231

摘要： Tis invention provides oligonucleotide agents that modulate an immune response by stimulating IFN production and methods of using such agents for therapeutic treatments of mammals.

摘要翻译： 本发明提供了通过刺激IFN产生来调节免疫应答的寡核苷酸试剂和使用这些试剂用于哺乳动物的治疗性处理的方法。

公开(公告)号：US20110184045A1

公开(公告)日：2011-07-28

申请号：US13002101

申请日：2009-06-30

申请人： Gunther Hartmann

发明人： Gunther Hartmann

IPC分类号： A61K31/713 ,  C12Q1/68 ,  A61P35/00

CPC分类号： C12N15/111 ,  C12N2310/14 ,  C12N2320/11

摘要： The invention describes a method of determining whether a double stranded RNA (dsRNA) silences gene expression in a cell in vivo by an RNA interference (RNAi) mechanism by performing 5′-rapid amplification of cDNA ends (5′RACE) to detect the cleavage site of the mRNA in the RNA sample.

摘要翻译： 本发明描述了一种确定双链RNA（dsRNA）是否通过RNA干扰（RNAi）机制在细胞内沉默基因表达的方法，通过进行cDNA末端的5'快速扩增（5'RACE）以检测切割 RNA样品中mRNA的位点。

公开(公告)号：US20110165123A1

公开(公告)日：2011-07-07

申请号：US12993420

申请日：2009-05-20

申请人： Gunther Hartmann ,  Martin Schlee

发明人： Gunther Hartmann ,  Martin Schlee

IPC分类号： A61K38/21 ,  C07H21/02 ,  A61K31/713 ,  A61K39/00 ,  C12N5/071 ,  C07H1/00 ,  A61P35/00 ,  A61P37/04 ,  A61P31/12 ,  A61P31/04

CPC分类号： C12N15/1135 ,  A61K31/7088 ,  A61K31/713 ,  A61K45/06 ,  C07H21/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/117 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/531 ,  C12N2320/31 ,  Y02A50/465

摘要： The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells expressing RIG-I. The present invention further provides an oligonucleotide which is capable of activating RIG-I and which has target gene-silencing activity. The oligonucleotide of the present invention has a double-stranded section of at least 19, preferably at least 21 bp, at least one 5′ triphosphate, and at least one blunt end which bears a 5′ triphosphate. The present invention further provides the use said oligonucleotide for inducing an anti-viral, in particular, an IFN, response in vitro and in vivo. The present invention additionally provides the use of said oligonucleotide for preventing and/or treating diseases or conditions such as infections, tumors/cancers, and immune disorders.

摘要翻译： 本发明提供能够激活RIG-1并在表达RIG-1的细胞中诱导抗病毒特别是IFN的应答的寡核苷酸。 本发明还提供能够活化RIG-1并具有靶基因沉默活性的寡核苷酸。 本发明的寡核苷酸具有至少19个，优选至少21个碱基对，至少一个5'-三磷酸和至少一个带有5'三磷酸的平端的双链段。 本发明进一步提供所述寡核苷酸用于在体外和体内诱导抗病毒特别是IFN的应答。 本发明还提供了所述寡核苷酸用于预防和/或治疗疾病或病症如感染，肿瘤/癌症和免疫疾病的用途。