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公开(公告)号：US10407655B2
公开(公告)日：2019-09-10
申请号：US15403944
申请日：2017-01-11
Applicant: President and Fellows of Harvard College
Inventor： Christopher David Hinojosa , Josiah Sliz , Daniel Levner , Guy Thompson , Hubert Geisler , Jose Fernandez-Alcon , Donald E. Ingber
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
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公开(公告)号：US20170121663A1
公开(公告)日：2017-05-04
申请号：US15403949
申请日：2017-01-11
Applicant: President and Fellows of Harvard College
Inventor： Christopher David Hinojosa , Josiah Sliz , Daniel Levner , Guy Thompson , Hubert Geisler , Jose Fernandez-Alcon , Donald E. Ingber
CPC classification number: C12M23/16 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2300/044 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/14 , B01L2400/0487 , B01L2400/084 , B82Y15/00 , C12M21/08 , C12M33/12 , C12M41/00 , C12M41/40 , C12M41/46 , G01N33/5005
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
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公开(公告)号：US20170121658A1
公开(公告)日：2017-05-04
申请号：US15403942
申请日：2017-01-11
Applicant: President and Fellows of Harvard College
Inventor： Christopher David Hinojosa , Josiah Sliz , Daniel Levner , Guy Thompson , Hubert Geisler , Jose Fernandez-Alcon , Donald E. Ingber
CPC classification number: C12M23/16 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2300/044 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/14 , B01L2400/0487 , B01L2400/084 , B82Y15/00 , C12M21/08 , C12M33/12 , C12M41/00 , C12M41/40 , C12M41/46 , G01N33/5005
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
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公开(公告)号：US20220364030A1
公开(公告)日：2022-11-17
申请号：US17876283
申请日：2022-07-28
Applicant: President and Fellows of Harvard College
Inventor： Christopher David Hinojosa , Josiah Sliz , Daniel Levner , Guy Thompson , Hubert Geisler , Jose Fernandez-Alcon , Donald E. Ingber
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
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公开(公告)号：US20160187636A1
公开(公告)日：2016-06-30
申请号：US14899550
申请日：2014-06-26
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Daniel Levner , Guy Thompson , Christopher D. Hinojosa , Jose Fernandez-Alcon
CPC classification number: G02B21/24 , G02B7/04 , G02B21/02 , G02B21/06 , G02B21/14 , G02B21/16 , G02B21/26 , G02B21/34 , G02B21/36
Abstract: A microscopy system for monitoring of one or more specimens includes a plurality of microscope blades, each microscope blade having at least one objective, at least one illuminator, and at least one detector. The microscopy system also includes a plurality of carriages, each carriage being connected to one or more of the microscope blades, and one or more actuators configured to drive the plurality of carriages along one or more axes, at least some of the plurality of carriages having at least partially overlapping ranges of motion along at least one of the one or more axes. The microscopy system also includes a master controller configured to drive each of the carriages, using the actuator(s), along the one or more axes.
Abstract translation: 用于监测一个或多个标本的显微镜系统包括多个显微镜刀片，每个显微镜刀片具有至少一个物镜，至少一个照明器和至少一个检测器。 显微镜系统还包括多个滑架，每个滑架连接到一个或多个显微镜刀片，以及一个或多个致动器，其配置成沿着一个或多个轴线驱动多个滑架，多个滑架中的至少一些具有 沿所述一个或多个轴中的至少一个轴线的至少部分重叠的运动范围。 显微镜系统还包括主控制器，该主控制器被配置成沿着一个或多个轴使用致动器驱动每个托架。
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Patent Agency Ranking
公开(公告)号：US11434458B2
公开(公告)日：2022-09-06
申请号：US15403942
申请日：2017-01-11
Applicant: President and Fellows of Harvard College
Inventor： Christopher David Hinojosa , Josiah Sliz , Daniel Levner , Guy Thompson , Hubert Geisler , Jose Fernandez-Alcon , Donald E. Ingber
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
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公开(公告)号：US11034926B2
公开(公告)日：2021-06-15
申请号：US15403949
申请日：2017-01-11
Applicant: President and Fellows of Harvard College
Inventor： Christopher David Hinojosa , Josiah Sliz , Daniel Levner , Guy Thompson , Hubert Geisler , Jose Fernandez-Alcon , Donald E. Ingber
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
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公开(公告)号：US10086372B2
公开(公告)日：2018-10-02
申请号：US14650735
申请日：2013-12-10
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Guy Thompson , Daniel Levner , Christopher David Hinojosa
Abstract: Described herein are fluid-flow control devices for transferring a fluid from a place to another and/or controlling a fluid flow. In some embodiments, fluid-flow control devices described herein can be used as pumping devices to transfer a fluid by peristaltic motion and/or as valve devices to control fluid flow for various applications, e.g., in a microfluidic platform.
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公开(公告)号：US20170327781A1
公开(公告)日：2017-11-16
申请号：US15601430
申请日：2017-05-22
Applicant: President and Fellows of Harvard College
Inventor： Jose Fernandez-Alcon , Norman Wen , Richard Novak , Donald E. Ingber , Geraldine A. Hamilton , Christopher Hinojosa , Karel Domansky , Daniel Levner , Guy Thompson , Kambez Hajipouran Benam , Remi Villenave , Thomas Umundum , Alfred Paris , Georg Bauer
CPC classification number: C12M23/16 , C12M21/08 , C12M23/26 , C12M25/02 , C12M35/04 , C12M41/00 , C12M41/46
Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
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公开(公告)号：US20170121659A1
公开(公告)日：2017-05-04
申请号：US15403944
申请日：2017-01-11
Applicant: President and Fellows of Harvard College
Inventor： Christopher David Hinojosa , Josiah Sliz , Daniel Levner , Guy Thompson , Hubert Geisler , Jose Fernandez-Alcon , Donald E. Ingber
CPC classification number: C12M23/16 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2300/044 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/14 , B01L2400/0487 , B01L2400/084 , B82Y15/00 , C12M21/08 , C12M33/12 , C12M41/00 , C12M41/40 , C12M41/46 , G01N33/5005
Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.
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