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    Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences
    1.
    发明授权
    Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences 失效
    Collapsin应答介质蛋白-1（CRMP-1）转录调控核酸序列

    公开(公告)号：US07655779B2

    公开(公告)日：2010-02-02

    申请号：US11785701

    申请日：2007-04-19

    申请人： Pan-Chyr Yang ,  Tse-Ming Hong ,  Jeremy J. W. Chen ,  Cheng-Chung Wu ,  Jin-Yuan Shin ,  Yi-Jen Lee

    发明人： Pan-Chyr Yang ,  Tse-Ming Hong ,  Jeremy J. W. Chen ,  Cheng-Chung Wu ,  Jin-Yuan Shin ,  Yi-Jen Lee

    IPC分类号： C07H21/02

    CPC分类号： C12N15/85 ,  A61K48/00 ,  C12N2830/00

    摘要： This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to enhance the expression of the CRMP-1 and/or a reporter protein. The invention also provides a DNA construct containing this transcription unit which can be transfected into a host cell. Additionally, the invention provides methods to enhance the expression of CRMP-1 and/or the reporter protein. The over-expression of CRMP-1 in a cancer cell can inhibit the metastasis of the cancer cell.

    摘要翻译： 本发明提供了从塌陷反应介质蛋白-1（CRMP-1）基因的上游核酸序列，侵袭抑制基因中分离的转录单位。 转录单元含有证明启动子和/或调节活性（例如提供转录因子结合位点）以增强CRMP-1和/或报道蛋白表达的核酸调节序列。 本发明还提供含有该转录单位的DNA构建体，其可转染入宿主细胞。 另外，本发明提供了增强CRMP-1和/或报道蛋白表达的方法。 癌细胞中CRMP-1的过度表达可以抑制癌细胞的转移。

    Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences
    2.
    发明授权
    Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences 失效
    Collapsin应答介质蛋白-1（CRMP-1）转录调控核酸序列

    公开(公告)号：US07211660B2

    公开(公告)日：2007-05-01

    申请号：US11051328

    申请日：2005-02-07

    申请人： Pan-Chyr Yang ,  Tse-Ming Hong ,  Jeremy J. W. Chen ,  Cheng-Chung Wu ,  Jin-Yuan Shin ,  Yi-Jen Lee

    发明人： Pan-Chyr Yang ,  Tse-Ming Hong ,  Jeremy J. W. Chen ,  Cheng-Chung Wu ,  Jin-Yuan Shin ,  Yi-Jen Lee

    IPC分类号： C07H21/04 ,  C12P21/04 ,  C12N15/86

    CPC分类号： C12N15/85 ,  A61K48/00 ,  C12N2830/00

    摘要： This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to enhance the expression of the CRMP-1 and/or a reporter protein. The invention also provides a DNA construct containing this transcription unit which can be transfected into a host cell. Additionally, the invention provides methods to enhance the expression of CRMP-1 and/or the reporter protein. The over-expression of CRMP-1 in a cancer cell can inhibit the metastasis of the cancer cell.

    摘要翻译： 本发明提供了从塌陷反应介质蛋白-1（CRMP-1）基因的上游核酸序列，侵袭抑制基因中分离的转录单位。 转录单元含有证明启动子和/或调节活性（例如提供转录因子结合位点）以增强CRMP-1和/或报道蛋白表达的核酸调节序列。 本发明还提供含有该转录单位的DNA构建体，其可转染入宿主细胞。 另外，本发明提供了增强CRMP-1和/或报道蛋白表达的方法。 癌细胞中CRMP-1的过度表达可以抑制癌细胞的转移。

    Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences
    3.
    发明申请
    Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences 失效
    Collapsin应答介质蛋白-1（CRMP-1）转录调控核酸序列

    公开(公告)号：US20050182016A1

    公开(公告)日：2005-08-18

    申请号：US11051328

    申请日：2005-02-07

    申请人： Pan-Chyr Yang ,  Tse-Ming Hong ,  Jeremy Chen ,  Cheng-Chung Wu ,  Jin-Yuan Shin ,  Yi-Jen Lee

    发明人： Pan-Chyr Yang ,  Tse-Ming Hong ,  Jeremy Chen ,  Cheng-Chung Wu ,  Jin-Yuan Shin ,  Yi-Jen Lee

    IPC分类号： A61K48/00 ,  C12N5/08 ,  C12N15/85 ,  C12P33/10

    CPC分类号： C12N15/85 ,  A61K48/00 ,  C12N2830/00

    摘要： This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to enhance the expression of the CRMP-1 and/or a reporter protein. The invention also provides a DNA construct containing this transcription unit which can be transfected into a host cell. Additionally, the invention provides methods to enhance the expression of CRMP-1 and/or the reporter protein. The over-expression of CRMP-1 in a cancer cell can inhibit the metastasis of the cancer cell.

    摘要翻译： 本发明提供了从塌陷反应介质蛋白-1（CRMP-1）基因的上游核酸序列，侵袭抑制基因中分离的转录单位。 转录单元含有证明启动子和/或调节活性（例如提供转录因子结合位点）以增强CRMP-1和/或报道蛋白表达的核酸调节序列。 本发明还提供含有该转录单位的DNA构建体，其可转染入宿主细胞。 另外，本发明提供了增强CRMP-1和/或报道蛋白表达的方法。 癌细胞中CRMP-1的过度表达可以抑制癌细胞的转移。