-
公开(公告)号：US20090039811A1
公开(公告)日：2009-02-12
申请号：US11658234
申请日：2005-07-26
CPC分类号： A61K31/416 , C07D231/56
摘要： The invention relates to the use of 1H-indazol-6-ol compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising 1H-indazol-6-ol compounds, novel 1H-indazol-6-ol compounds, and a process for the preparation of the novel 1H-indazol-6-ol compounds.
摘要翻译： 本发明涉及1H-吲唑-6-醇化合物及其盐在治疗增殖性疾病和制备用于治疗所述疾病的药物制剂中的用途，包括1H-吲唑-6-醇化合物的药物制剂， 新的1H-吲唑-6-醇化合物，以及制备新的1H-吲唑-6-醇化合物的方法。
-
公开(公告)号：US20090069341A1
公开(公告)日：2009-03-12
申请号：US11658365
申请日：2005-07-26
IPC分类号： A61K31/497 , C07D235/12 , A61K31/4184 , A61P35/00 , C07D403/10
CPC分类号： A61K31/4184 , C07D235/26
摘要： The invention relates to the use of benzoimidazolone compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising benzoimidazolone compounds, novel benzoimidazolone compounds, and a process for the preparation of the novel benzoimidazolone compounds.
摘要翻译： 本发明涉及苯并咪唑酮化合物及其盐在治疗增殖性疾病中的用途以及制备用于治疗所述疾病的药物制剂，包括苯并咪唑酮化合物的药物制剂，新的苯并咪唑酮化合物，以及制备 新型苯并咪唑酮化合物。
-
公开(公告)号：US07795288B2
公开(公告)日：2010-09-14
申请号：US10578826
申请日：2004-11-12
申请人： Guido Bold , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Keiichi Masuya , Andrea Vaupel , Joseph Schoepfer
发明人： Guido Bold , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Keiichi Masuya , Andrea Vaupel , Joseph Schoepfer
IPC分类号： A61K31/426 , C07D277/20
CPC分类号： C07D277/42 , C07D231/38 , C07D409/04 , C07D417/04 , C07D417/10
摘要： The invention relates to thiazole and pyrazole derivatives of formula (I) wherein Q is S and X is C, or Q is CH and X is N; R1 is unsubstituted or substituted phenyl; and R2 is unsubstituted or substituted aryl or heteroaryl; or a salt of the said compounds, and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour disease, in particular such diseases which respond to an inhibition of the Flt-3 kinase.
摘要翻译： 本发明涉及式（I）的噻唑和吡唑衍生物，其中Q为S且X为C，或Q为CH且X为N; R1是未取代或取代的苯基; 并且R 2是未取代或取代的芳基或杂芳基; 或所述化合物的盐，以及其制备方法，包含该衍生物的药物组合物，以及这些衍生物在制备用于治疗特别是增殖性疾病如肿瘤疾病的药物组合物中的用途， 特别是对Flt-3激酶的抑制作出反应的这些疾病。
-
公开(公告)号：US20070167449A1
公开(公告)日：2007-07-19
申请号：US10578826
申请日：2004-11-12
申请人： Guido Bold , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Keiichi Masuya , Andrea Vaupel , Joseph Schoepfer
发明人： Guido Bold , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Keiichi Masuya , Andrea Vaupel , Joseph Schoepfer
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/427 , A61K31/416 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D277/42 , C07D231/38 , C07D409/04 , C07D417/04 , C07D417/10
摘要： The invention relates to thiazole and pyrazole derivatives of formula (I) wherein Q is S and X is C, or Q is CH and X is N; R1 is unsubstituted or substituted phenyl; and R2 is unsubstituted or substituted aryl or heteroaryl; or a salt of the said compounds, and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour disease, in particular such diseases which respond to an inhibition of the Flt-3 kinase.
摘要翻译： 本发明涉及式（I）的噻唑和吡唑衍生物，其中Q是S，X是C，或Q是CH，X是N; R 1是未取代或取代的苯基; R 2是未取代或取代的芳基或杂芳基; 或所述化合物的盐，以及其制备方法，包含该衍生物的药物组合物，以及这些衍生物在制备用于治疗特别是增殖性疾病如肿瘤疾病的药物组合物中的用途， 特别是对Flt-3激酶的抑制作出反应的这些疾病。
-
公开(公告)号：US20050222171A1
公开(公告)日：2005-10-06
申请号：US11039445
申请日：2005-01-20
申请人： Guido Bold , Andreas Floersheimer , Pascal Furet , Patricia Imbach , Keiichi Masuya , Joseph Schoepfer
发明人： Guido Bold , Andreas Floersheimer , Pascal Furet , Patricia Imbach , Keiichi Masuya , Joseph Schoepfer
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.
摘要翻译： 本发明涉及吡唑并[1,5a]嘧啶-7-基胺化合物及其盐在治疗激酶依赖性疾病中的用途以及用于制备用于治疗所述疾病的药物制剂，新颖的吡唑并[1,5a ]嘧啶-7-基胺化合物，以及制备新的吡唑并[1,5a]嘧啶-7-基胺化合物的方法。
-
6.发明申请Use of 9H-Purine-2,6-Diamine Derivatives in the Treatment of Proliferative Diseases and Novel 9H-Purine-2,6-Diamine Derivatives 审中-公开9H-嘌呤-2,6-二胺衍生物在增殖性疾病和新型9H-嘌呤-2,6-二胺衍生物的治疗中的应用公开(公告)号：US20070249639A1
公开(公告)日：2007-10-25
申请号：US10594412
申请日：2005-04-04
申请人： Rolf Baenteli , Patrick Chene , Stephen Collingwood , Pascal Furet , Peter Meier , Joseph Schoepfer
发明人： Rolf Baenteli , Patrick Chene , Stephen Collingwood , Pascal Furet , Peter Meier , Joseph Schoepfer
IPC分类号： A61K31/52 , C07D473/00
CPC分类号： C07D239/48 , A61K31/52 , C07D473/16
摘要： The invention relates to the use of 9H-purine-2,6-diamine compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising 9H-purine-2,6-diamine compounds, novel 9H-purine-2,6-diamine compounds, and a process for the preparation of the novel 9H-purine-2,6-diamine compounds.
摘要翻译： 本发明涉及9H-嘌呤-2,6-二胺化合物及其盐在治疗增殖性疾病和制备用于治疗所述疾病的药物制剂中的用途，包括9H-嘌呤-2,6 - 二胺化合物，新的9H-嘌呤-2,6-二胺化合物，以及制备新型9H-嘌呤-2,6-二胺化合物的方法。
-
7.发明申请COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 有权抑制ABL1，ABL2和BCR-ABL1活性的化合物和组合物公开(公告)号：US20150183801A1
公开(公告)日：2015-07-02
申请号：US14400987
申请日：2013-05-09
申请人： Pascal Furet , Robert Martin Grotzfeld , Wolfgang Jahnke , Darryl Brynley Jones , Paul William Manley , Andreas Marzinzik , Xavier Francois Andre Pelle , Bahaa Salem , Joseph Schoepfer , Erich Alois Spieser
发明人： Pascal Furet , Robert Martin Grotzfeld , Wolfgang Jahnke , Darryl Brynley Jones , Paul William Manley , Andreas Marzinzik , Xavier Francois Andre Pelle , Bahaa Salem , Joseph Schoepfer , Erich Alois Spieser
IPC分类号： C07D498/08 , A61K31/506 , C07D401/10 , A61K31/4439 , C07D401/14 , C07D487/04 , C07D487/10 , C07D471/04 , C07D405/14 , A61K31/444 , A61K31/4725 , A61K31/498 , C07D491/107 , A61K31/4545 , A61K31/551 , A61K31/553 , A61K45/06 , A61K31/5025 , C07D403/10
CPC分类号： C07D498/08 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/498 , A61K31/5025 , A61K31/506 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/10 , C07D491/107
摘要： The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
摘要翻译： 本发明涉及式（I）化合物：其中Y，Y，R，R 2，R 3和R 4在发明概述中定义; 能够抑制BCR-ABL1及其突变体的活性。 本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂和使用这些化合物治疗癌症的方法。
-
8.发明申请Substituted imidazopyridazines and pyrrolopyrimidines as lipid kinase inhibitors 审中-公开取代的咪唑并哒嗪和吡咯并嘧啶作为脂质激酶抑制剂公开(公告)号：US20100311729A1
公开(公告)日：2010-12-09
申请号：US12599143
申请日：2008-05-09
申请人： Hans-Georg Capraro , Patricia Imbach , Giorgio Caravatti , Pascal Furet , Jiong Lan , Sabrina Pecchi , Joseph Schoepfer
发明人： Hans-Georg Capraro , Patricia Imbach , Giorgio Caravatti , Pascal Furet , Jiong Lan , Sabrina Pecchi , Joseph Schoepfer
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/5025 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds are of the formula I, processes for the preparation thereof, more generally these compounds for use in the treatment of the human or animal body, in the treatment of an inflammatory or obstructive airway disease, disorders commonly occurring in connection with transplantation, or a proliferative disease, which disease responds to an inhibition of kinases of the PI3-kinase-related protein kinase family.
摘要翻译： 本发明涉及式I化合物，其制备方法，更一般地，这些用于治疗人或动物体的化合物，用于治疗炎性或阻塞性气道疾病，通常在连接中发生的疾病 移植或增殖性疾病，该疾病对PI3激酶相关蛋白激酶家族的激酶的抑制作出反应。
-
9.发明授权Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 有权用于抑制ABL1，ABL2和BCR-ABL1活性的化合物和组合物公开(公告)号：US09278981B2
公开(公告)日：2016-03-08
申请号：US14400987
申请日：2013-05-09
申请人： Pascal Furet , Robert Martin Grotzfeld , Wolfgang Jahnke , Darryl Brynley Jones , Paul William Manley , Andreas Marzinzik , Xavier Francois Andre Pelle , Bahaa Salem , Joseph Schoepfer , Erich Alois Spieser
发明人： Pascal Furet , Robert Martin Grotzfeld , Wolfgang Jahnke , Darryl Brynley Jones , Paul William Manley , Andreas Marzinzik , Xavier Francois Andre Pelle , Bahaa Salem , Joseph Schoepfer , Erich Alois Spieser
IPC分类号： A61K31/4439 , C07D498/08 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D401/10 , C07D403/10 , C07D413/10 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/10 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/498 , A61K31/5025 , A61K31/506 , A61K31/551 , A61K31/553 , A61K45/06 , C07D491/107
CPC分类号： C07D498/08 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/498 , A61K31/5025 , A61K31/506 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/10 , C07D491/107
摘要： The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
摘要翻译： 本发明涉及式（I）化合物：其中Y，Y，R，R 2，R 3和R 4在发明概述中定义; 能够抑制BCR-ABL1及其突变体的活性。 本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂和使用这些化合物治疗癌症的方法。
-
公开(公告)号：US08552002B2
公开(公告)日：2013-10-08
申请号：US11570983
申请日：2005-06-23
申请人： Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Taebo Sim , Tetsuo Uno , Guobao Zhang , Carole Pissot Soldermann , Werner Breitenstein , Guido Bold , Giorgio Caravatti , Pascal Furet , Vito Guagnano , Marc Lang , Paul William Manley , Joseph Schoepfer , Carsten Spanka
发明人： Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Taebo Sim , Tetsuo Uno , Guobao Zhang , Carole Pissot Soldermann , Werner Breitenstein , Guido Bold , Giorgio Caravatti , Pascal Furet , Vito Guagnano , Marc Lang , Paul William Manley , Joseph Schoepfer , Carsten Spanka
IPC分类号： A01N43/54 , C07D239/02
CPC分类号： C07D239/48 , C07D251/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
摘要翻译： 本发明涉及式（I）化合物，其中取代基X1，R1，R2，R3和R4具有本发明说明书中阐述和解释的含义，制备这些化合物的方法，含有它们的药物组合物 ，其任选与一种或多种其它药学活性化合物组合用于治疗对蛋白激酶活性的抑制作出反应的疾病的用途，以及治疗这种疾病的方法。
-
-
-
-
-
-
-
-
-
搜索结果
33 条记录 (耗时 0.034 秒)
