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    Exon Skipping Therapy for Functional Amelioration of Semifunctional Dystrophin in Becker and Duchenne Muscular Dystrophy
    2.
    发明申请
    Exon Skipping Therapy for Functional Amelioration of Semifunctional Dystrophin in Becker and Duchenne Muscular Dystrophy 审中-公开
    Becker和Duchenne肌营养不良功能改善半功能肌营养不良蛋白的外显子跳过疗法

    公开(公告)号：US20120172415A1

    公开(公告)日：2012-07-05

    申请号：US13393004

    申请日：2010-08-31

    申请人： Thomas Voit ,  Luis Garcia ,  Valerie Robin ,  Patrick Dreyfus

    发明人： Thomas Voit ,  Luis Garcia ,  Valerie Robin ,  Patrick Dreyfus

    IPC分类号： A61K31/7088 ,  A61P9/00 ,  A61P21/00 ,  C12N15/113 ,  C07K14/47

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2320/33 ,  C12N2310/3521

    摘要： Methods for stabilizing unstable proteins or for restoring functionality to non-functional or poorly functioning (semi-functional) proteins using exon skipping technology are provided. The methods involve the administration of antisense oligonucleotides to cause exon skipping, thereby removing one or more exons responsible for protein instability or lack of functionality. For example, exons encoding protease recognition sites may be removed. The method is useful for treating diseases caused by protein instability, such as Becker Muscular Dystrophy, or for treating Duchenne Muscular Distrophy patients with semi-functional dystrophin due to treatment with other exon skipping or stop codon readthrough therapies.

    摘要翻译： 提供了使用外显子跳过技术来稳定不稳定蛋白质或恢复非功能或功能不良（半功能）蛋白功能的方法。 所述方法包括给予反义寡核苷酸引起外显子跳跃，从而去除负责蛋白质不稳定或缺乏功能的一个或多个外显子。 例如，可以去除编码蛋白酶识别位点的外显子。 该方法可用于治疗由蛋白质不稳定性引起的疾病，例如贝克肌营养不良症，或用于治疗具有半功能性肌营养不良蛋白的Duchenne肌肉萎缩症患者，这是由于其他外显子跳过或终止密码子阅读疗法治疗。

    Nucleic acid molecules and methods for exchanging exon(s) by transsplicing
    3.
    发明授权
    Nucleic acid molecules and methods for exchanging exon(s) by transsplicing 有权
    核酸分子和通过transsplicing交换外显子的方法

    公开(公告)号：US09303078B2

    公开(公告)日：2016-04-05

    申请号：US13500612

    申请日：2010-10-08

    申请人： Luis Garcia ,  Stéphanie Lorain

    发明人： Luis Garcia ,  Stéphanie Lorain

    IPC分类号： C12N15/00 ,  C12N5/00 ,  C07K14/47 ,  A61K48/00 ,  C12N15/85

    CPC分类号： C07K14/4708 ,  A61K48/005 ,  C12N15/85 ,  C12N2840/445 ,  C12N2840/85

    摘要： The present invention provided methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated simple or double trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and to mediate a simple or double trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (Chimeric RNA).

    摘要翻译： 本发明提供了通过靶向剪接体介导的简单或双转录产生新型核酸分子的方法和组合物。 本发明的组合物包括被设计为与靶前体信使RNA分子（靶前mRNA）相互作用并且介导简单或双重反式剪接反应的预转录分子（PTM），导致产生新的嵌合 RNA分子（嵌合RNA）。

    Mechanism for aggregating uplink interference information for use in multi-carrier systems
    4.
    发明授权
    Mechanism for aggregating uplink interference information for use in multi-carrier systems 有权
    用于聚合用于多载波系统的上行链路干扰信息的机制

    公开(公告)号：US09198185B2

    公开(公告)日：2015-11-24

    申请号：US13577979

    申请日：2010-02-10

    申请人： Istvan Zsolt Kovacs ,  Frank Frederiksen ,  Klaus Ingemann Pedersen ,  Luis Garcia

    发明人： Istvan Zsolt Kovacs ,  Frank Frederiksen ,  Klaus Ingemann Pedersen ,  Luis Garcia

    IPC分类号： H04B7/216 ,  H04W72/08 ,  H04B1/707 ,  H04W24/02 ,  H04W72/04 ,  H04W84/04 ,  H04L5/00

    CPC分类号： H04W72/082 ,  H04B1/707 ,  H04L5/001 ,  H04L5/0073 ,  H04L5/0091 ,  H04W24/02 ,  H04W72/0413 ,  H04W84/045

    摘要： There is proposed a mechanism by means of which information can be generated and used for estimating and identifying at each base transceiver station of a communication network the set of other base transceiver stations generating interference on certain monitored component carriers used by the base transceiver station, i.e. information for the generation of the incoming uplink background interference matrix. For this purpose, a specific communication information set, referred to as uplink radio load map, is determined which informs about an average (time/frequency) and aggregated (over all or group of served UEs) uplink load measure per component carrier. Based on the uplink radio load map received via suitable signaling from other base transceiver stations, each base transceiver station can determine the incoming uplink background interference matrix and initiate, if necessary, suitable measures for reducing interference per component carrier.

    摘要翻译： 提出了一种机制，通过该机制可以产生信息并用于在通信网络的每个基站收发台处估计和识别该基站收发信机所使用的特定监视分量载波上的干扰的其他基站收发信机的集合，即 用于生成输入上行背景干扰矩阵的信息。 为此，确定称为上行链路无线电负载映射的特定通信信息集，其通知关于每个分量载波的上行链路负载测量的平均（时间/频率）和聚合（在全部或一组被服务UE上）。 基于通过来自其他基站收发台的适当信令接收的上行链路无线电负载图，每个基站收发台可以确定输入的上行链路背景干扰矩阵，并且如有必要，启动减少每个分量载波干扰的适当措施。

    Methods and apparatus for supporting multiple types of connections to a core network
    5.
    发明授权
    Methods and apparatus for supporting multiple types of connections to a core network 有权
    用于支持与核心网络的多种连接的方法和装置

    公开(公告)号：US09113405B2

    公开(公告)日：2015-08-18

    申请号：US13574882

    申请日：2010-01-25

    申请人： Luis Garcia ,  Oumer Teyeb ,  Simone Redana ,  Vinh Van Phan ,  Jeroen Wigard ,  Bernhard Raaf

    发明人： Luis Garcia ,  Oumer Teyeb ,  Simone Redana ,  Vinh Van Phan ,  Jeroen Wigard ,  Bernhard Raaf

    IPC分类号： H04W72/00 ,  H04W48/20 ,  H04L12/54 ,  H04L12/66 ,  H04W88/10 ,  H04W84/04

    CPC分类号： H04W48/20 ,  H04L12/5692 ,  H04L12/66 ,  H04W84/045 ,  H04W88/10

    摘要： There is proposed a mechanism providing functions of a so-called hybrid home node B (HHNB) where subscribers, depending on their belonging to a specific subscriber group, such as a closed subscriber group or an open subscriber group, are admitted for a connection to the communication network via different connection routes and systems. After a request for connecting a subscriber is received, an identification process is performed whether the subscriber belongs to a first subscriber group (CSG) or to a second subscriber group (OSG). On the basis of this identification, the subscriber is assigned to a first connection route or a second connection route. It is then checked whether available resources on the assigned connection route are sufficient, wherein on the basis of this check the request for connecting is allowed or rejected.

    摘要翻译： 提出了一种提供所谓的混合家庭节点B（HHNB）的功能的机制，其中根据其属于特定用户组（诸如封闭用户组或开放用户组）的用户被允许用于连接到 通信网络通过不同的连接路由和系统。 在接收到用户连接请求之后，执行用户是属于第一用户组（CSG）还是第二用户组（OSG）的识别处理。 基于该识别，用户被分配到第一连接路由或第二连接路由。 然后检查分配的连接路由上的可用资源是否足够，其中基于该检查允许或拒绝请求连接。

    Carrier selection
    6.
    发明授权
    Carrier selection 有权
    运营商选择

    公开(公告)号：US09100959B2

    公开(公告)日：2015-08-04

    申请号：US13808768

    申请日：2010-07-08

    申请人： Istvan Zsolt Kovacs ,  Frank Frederiksen ,  Luis Garcia

    发明人： Istvan Zsolt Kovacs ,  Frank Frederiksen ,  Luis Garcia

    IPC分类号： H04W72/04 ,  H04W16/06 ,  H04W72/08

    CPC分类号： H04W72/0426 ,  H04W16/06 ,  H04W72/082

    摘要： The invention relates generally to mobile communication networks. More particularly, the invention relates to interference management and carrier selection for transmitting data. There is provided a solution for improved selection of a cell-specific base carrier, the solution utilizing a timing framework for the carrier selection. The solution includes determining a maximum allowed time duration, and performing within the determined maximum allowed time duration: obtaining information related to one or more selected carriers from at least one neighboring base station, selecting the at least one cell-specific base carrier for data transmission on the basis of the obtained information, and informing the at least one neighboring base station of the selected cell specific base carrier.

    摘要翻译： 本发明一般涉及移动通信网络。 更具体地，本发明涉及用于发送数据的干扰管理和载波选择。 提供了一种用于改进小区特定基站载波选择的解决方案，该解决方案利用用于载波选择的定时框架。 该解决方案包括确定最大允许持续时间，以及在所确定的最大允许持续时间内执行：从至少一个相邻基站获得与一个或多个选定载波相关的信息，选择所述至少一个小区特定基站载波进行数据传输 基于所获得的信息，并且向所述至少一个相邻基站通知所选择的小区特定基站载波。

    Releasing a radio resource (e.g. primary component carrier) based on capacities of base stations
    7.
    发明授权
    Releasing a radio resource (e.g. primary component carrier) based on capacities of base stations 有权
    基于基站的容量来释放无线电资源（例如主分量载波）

    公开(公告)号：US08913575B2

    公开(公告)日：2014-12-16

    申请号：US13639360

    申请日：2010-04-08

    申请人： Klaus I. Pedersen ,  Luis Garcia ,  Gustavo Wagner

    发明人： Klaus I. Pedersen ,  Luis Garcia ,  Gustavo Wagner

    IPC分类号： H04W4/00 ,  H04W72/04 ,  H04W16/10 ,  G08C17/00 ,  H04W24/02

    CPC分类号： H04W72/0426 ,  H04W16/10 ,  H04W24/02

    摘要： The present invention relates to optimized radio resource utilization in a cellular telecommunication system. A base station of such a system evaluate a capacity metric of the base station and capacity metrics of neighboring base stations. In response to detecting that the capacity metric of the base station is below a threshold with respect to the capacity metrics of the neighboring base stations, the base station enters a stand-by mode and releases its radio resources that essentially define a cell associated with the base station so that the released radio resources become available for allocation to at least one of the neighboring base stations.

    摘要翻译： 本发明涉及蜂窝电信系统中优化的无线电资源利用。 这种系统的基站评估基站的容量度量和相邻基站的容量度量。 响应于检测到基站的容量度量相对于相邻基站的容量度量低于阈值，基站进入待机模式并且释放其无线电资源，其基本上定义与该相邻基站相关联的小区 使得发布的无线电资源变得可用于分配给至少一个相邻基站。

    Releasing a Radio Resource (e.g. Primary Component Carrier) Based on Capacities of Base Stations
    9.
    发明申请
    Releasing a Radio Resource (e.g. Primary Component Carrier) Based on Capacities of Base Stations 有权
    基于基站的能力释放无线电资源（例如主分量载波）

    公开(公告)号：US20130142133A1

    公开(公告)日：2013-06-06

    申请号：US13639360

    申请日：2010-04-08

    申请人： Klaus I. Pedersen ,  Luis Garcia ,  Gustavo Wagner

    发明人： Klaus I. Pedersen ,  Luis Garcia ,  Gustavo Wagner

    IPC分类号： H04W72/04

    CPC分类号： H04W72/0426 ,  H04W16/10 ,  H04W24/02

    摘要： The present invention relates to optimized radio resource utilization in a cellular telecommunication system. A base station of such a system evaluate a capacity metric of the base station and capacity metrics of neighboring base stations. In response to detecting that the capacity metric of the base station is below a threshold with respect to the capacity metrics of the neighboring base stations, the base station enters a stand-by mode and releases its radio resources that essentially define a cell associated with the base station so that the released radio resources become available for allocation to at least one of the neighboring base stations.

    摘要翻译： 本发明涉及蜂窝电信系统中优化的无线电资源利用。 这种系统的基站评估基站的容量度量和相邻基站的容量度量。 响应于检测到基站的容量度量相对于相邻基站的容量度量低于阈值，基站进入待机模式并且释放其无线电资源，其基本上定义与该相邻基站相关联的小区 使得发布的无线电资源变得可用于分配给至少一个相邻基站。