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    Method of mass spectrometry
    2.
    发明申请
    Method of mass spectrometry 有权
    质谱法

    公开(公告)号：US20080142696A1

    公开(公告)日：2008-06-19

    申请号：US10893415

    申请日：2004-07-16

    申请人： Scott Geromanos ,  Ashok R. Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    发明人： Scott Geromanos ,  Ashok R. Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    IPC分类号： B01D59/44

    CPC分类号： G01N33/6848 ,  C12Q1/6872 ,  G01N33/6842 ,  G01N33/6851 ,  H01J49/0031 ,  Y10T436/24

    摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.

    摘要翻译： 公开了鉴定生物来源分子的方法。 鉴定分子以及精确确定分子的质荷比和至少另外的物理化学性质如洗脱时间或电荷状态的基础。 可以使用进一步的物理化学性质。 然后可以将实验确定的精确质量和物理化学性质与信息查找表进行比较。 可以生成查找表，也可以计算常规数据库中的数据的物理化学性质。 可以使用在两个不同样品中识别和优选鉴定相同分子的能力来确定特定生物分子是否在实验样品中相对于对照样品表达不同。

    Method of mass spectrometry
    4.
    发明申请
    Method of mass spectrometry 审中-公开
    质谱法

    公开(公告)号：US20050092910A1

    公开(公告)日：2005-05-05

    申请号：US10497896

    申请日：2002-12-09

    申请人： Scott Geromanos ,  Ashok Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    发明人： Scott Geromanos ,  Ashok Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    IPC分类号： G01N27/62 ,  B01D59/44 ,  C12Q1/68 ,  G01N27/447 ,  G01N30/72 ,  G01N30/88 ,  G01N33/483 ,  G01N33/53 ,  G01N33/68 ,  H01J49/00 ,  H01J49/04

    CPC分类号： G01N33/6848 ,  C12Q1/6872 ,  G01N33/6842 ,  G01N33/6851 ,  H01J49/0031 ,  Y10T436/24

    摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.

    摘要翻译： 公开了鉴定生物来源分子的方法。 鉴定分子和准确确定分子的质荷比和至少另外的物理化学性质如洗脱时间或电荷状态的基础。 可以使用进一步的物理化学性质。 然后可以将实验确定的精确质量和物理化学性质与信息查找表进行比较。 可以生成查找表，也可以计算常规数据库中的数据的物理化学性质。 可以使用在两个不同样品中识别和优选鉴定相同分子的能力来确定特定生物分子是否在实验样品中相对于对照样品表达不同。

    Method of analyzing differential expression of proteins in proteomes by mass spectrometry
    5.
    发明授权
    Method of analyzing differential expression of proteins in proteomes by mass spectrometry 有权
    通过质谱分析蛋白质组蛋白差异表达的方法

    公开(公告)号：US08030089B2

    公开(公告)日：2011-10-04

    申请号：US10893415

    申请日：2004-07-16

    申请人： Scott Geromanos ,  Ashok R. Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    发明人： Scott Geromanos ,  Ashok R. Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    IPC分类号： G01N24/00

    CPC分类号： G01N33/6848 ,  C12Q1/6872 ,  G01N33/6842 ,  G01N33/6851 ,  H01J49/0031 ,  Y10T436/24

    摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognize and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.

    摘要翻译： 公开了鉴定生物来源分子的方法。 鉴定分子和准确确定分子的质荷比和至少另外的物理化学性质如洗脱时间或电荷状态的基础。 可以使用进一步的物理化学性质。 然后可以将实验确定的精确质量和物理化学性质与信息查找表进行比较。 可以生成查找表，也可以计算常规数据库中的数据的物理化学性质。 可以使用在两个不同样品中识别和优选鉴定相同分子的能力来确定特定生物分子是否在实验样品中相对于对照样品表达不同。

    Methods of diagnosing tumors using the G-protein coupled receptor (GPCR), RAI-3
    6.
    发明授权
    Methods of diagnosing tumors using the G-protein coupled receptor (GPCR), RAI-3 有权
    使用G蛋白偶联受体（GPCR），RAI-3诊断肿瘤的方法

    公开(公告)号：US07517652B2

    公开(公告)日：2009-04-14

    申请号：US11809905

    申请日：2007-05-31

    申请人： Gena S. Whitney ,  Gregory Opiteck ,  Leah Ann Garulacan ,  Chandra S. Ramanathan ,  Murray McKinnon ,  John N. Feder

    发明人： Gena S. Whitney ,  Gregory Opiteck ,  Leah Ann Garulacan ,  Chandra S. Ramanathan ,  Murray McKinnon ,  John N. Feder

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6886 ,  C07K14/705 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/5023 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/574 ,  G01N33/6884 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2800/122

    摘要： The present invention describes a G-protein coupled receptor (GPCR) family member newly identified as being modified, e.g., phosphorylated, and associated with tyrosine phosphorylated activation complexes, following exposure of cells to smoke from tobacco burning substances, namely, cigarette smoke. This GPCR protein is RAI-3, which was first found to be phosphorylated in cells treated with cigarette smoke and to be associated with other proteins activated in cigarette smoke treated cells by virtue of the present invention. Because cigarette smoke is considered to be a major causative factor of chronic obstructive pulmonary disease (COPD) and disorders and conditions related thereto, the RAI-3 protein is newly provided as a cellular drug target for screening, discovering, and identifying modulators for the treatment and/or prevention of COPD and its related disorders and conditions, such as emphysema and chronic bronchitis. In accordance with the present invention RAI-3 modulators, e.g., agonists and antagonists, can be used as therapeutics in the treatment of COPD and numerous other diseases and disorders that are associated with regulation of NF-κB and/or its associated or interacting signaling molecules. This invention further provides SNPs of RAI-3, e.g., for determining COPD association in individuals.

    摘要翻译： 本发明描述了在将烟草暴露于烟草燃烧物质（即香烟烟雾）之后，新鉴定为被修饰，例如磷酸化并与酪氨酸磷酸化活化复合物相关的G-蛋白偶联受体（GPCR）家族成员。 该GPCR蛋白是RAI-3，其首先被发现在用香烟烟雾处理的细胞中被磷酸化并且与通过本发明在香烟烟雾处理的细胞中活化的其它蛋白质相关联。 由于香烟烟雾被认为是慢性阻塞性肺疾病（COPD）的主要致病因素及与之相关的病症和病症，所以RAI-3蛋白质作为筛选，发现和鉴定调节剂治疗的细胞药物靶点被新提供 和/或预防COPD及其相关疾病和病症如肺气肿和慢性支气管炎。 根据本发明，RAI-3调节剂（例如激动剂和拮抗剂）可用作治疗COPD和许多与调节NF-κB和/或其相关或相互作用的信号相关的其它疾病和病症 分子。 本发明还提供RAI-3的SNP，例如用于确定个体中的COPD关联。

    Identification of biomarkers for liver toxicity
    7.
    发明授权
    Identification of biomarkers for liver toxicity 有权
    鉴定肝毒性的生物标志物

    公开(公告)号：US07452678B2

    公开(公告)日：2008-11-18

    申请号：US10873595

    申请日：2004-06-22

    申请人： Stephen K. Durham ,  Donna Dambach ,  Stanley Hefta ,  Frederic Moulin ,  Ji Gao ,  Gregory Opiteck ,  Stephen M. Storm ,  Leah Ann Garulacan ,  Jun-Hsiang Lin

    发明人： Stephen K. Durham ,  Donna Dambach ,  Stanley Hefta ,  Frederic Moulin ,  Ji Gao ,  Gregory Opiteck ,  Stephen M. Storm ,  Leah Ann Garulacan ,  Jun-Hsiang Lin

    IPC分类号： G01N33/53

    CPC分类号： G01N33/5014 ,  G01N33/576

    摘要： The present invention relates to biomarker polypeptides, polynucleotides, and antibodies that have utility in predicting in vitro and/or in vivo hepatotoxicity of various drugs, compounds, or other therapeutic agents (i.e., test substances). Also related are screens, kits, microarrays, and cell culture systems that employ the polypeptides, polynucleotides, and/or antibodies of the invention. The reagents and methods of the invention are useful for predicting hepatotoxic effects resulting from treatment with one or more test substances, and can be utilized before, after, or concurrently with pre-clinical, clinical, and/or post-clinical testing. In this way, the reagents and methods of the invention can be used to identify test substances or combinations of test substances that cause hepatic injury, including idiosyncratic hepatotoxicity, and thereby prevent medical complications (e.g., liver failure) resulting from such injury.

    摘要翻译： 本发明涉及可用于预测各种药物，化合物或其它治疗剂（即测试物质）的体外和/或体内肝毒性的生物标记多肽，多核苷酸和抗体。 还涉及使用本发明的多肽，多核苷酸和/或抗体的筛选，试剂盒，微阵列和细胞培养系统。 本发明的试剂和方法可用于预测用一种或多种测试物质治疗产生的肝毒性作用，并且可以在临床前，临床和/或临床后测试之前，之后或同时使用。 以这种方式，本发明的试剂和方法可以用于鉴定引起肝损伤（包括特异性肝毒性）的测试物质或测试物质的组合，从而防止由于这种损伤引起的医疗并发症（例如肝衰竭）。

    Method of mass spectrometry
    8.
    发明申请
    Method of mass spectrometry 审中-公开

    公开(公告)号：US20080286764A9

    公开(公告)日：2008-11-20

    申请号：US10892768

    申请日：2004-07-16

    申请人： Scott Geromanos ,  Ashok Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    发明人： Scott Geromanos ,  Ashok Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    IPC分类号： C12Q1/68 ,  G06F19/00 ,  G01N33/00

    CPC分类号： G01N33/6848 ,  C12Q1/6872 ,  G01N33/6842 ,  G01N33/6851 ,  H01J49/0031 ,  Y10T436/24

    摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.

    Method of mass spectrometer
    9.
    发明申请
    Method of mass spectrometer 审中-公开
    质谱仪方法

    公开(公告)号：US20080135744A1

    公开(公告)日：2008-06-12

    申请号：US10893212

    申请日：2004-07-16

    申请人： Scott Geromanos ,  Ashok R. Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    发明人： Scott Geromanos ,  Ashok R. Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    IPC分类号： B01D59/44

    CPC分类号： G01N33/6848 ,  C12Q1/6872 ,  G01N33/6842 ,  G01N33/6851 ,  H01J49/0031 ,  Y10T436/24

    摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.

    摘要翻译： 公开了鉴定生物来源分子的方法。 鉴定分子和准确确定分子的质荷比和至少另外的物理化学性质如洗脱时间或电荷状态的基础。 可以使用进一步的物理化学性质。 然后可以将实验确定的精确质量和物理化学性质与信息查找表进行比较。 可以生成查找表，也可以计算常规数据库中的数据的物理化学性质。 可以使用在两个不同样品中识别和优选鉴定相同分子的能力来确定特定生物分子是否在实验样品中相对于对照样品表达不同。

    Method of mass spectrometry
    10.
    发明申请
    Method of mass spectrometry 审中-公开
    质谱法

    公开(公告)号：US20070009898A1

    公开(公告)日：2007-01-11

    申请号：US10892768

    申请日：2004-07-16

    申请人： Scott Geromanos ,  Ashok Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    发明人： Scott Geromanos ,  Ashok Dongre ,  Gregory Opiteck ,  Jeffrey Silva

    IPC分类号： C12Q1/68 ,  G06F19/00 ,  G01N33/00

    CPC分类号： G01N33/6848 ,  C12Q1/6872 ,  G01N33/6842 ,  G01N33/6851 ,  H01J49/0031 ,  Y10T436/24

    摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.

    摘要翻译： 公开了鉴定生物来源分子的方法。 鉴定分子和准确确定分子的质荷比和至少另外的物理化学性质如洗脱时间或电荷状态的基础。 可以使用进一步的物理化学性质。 然后可以将实验确定的精确质量和物理化学性质与信息查找表进行比较。 可以生成查找表，也可以计算常规数据库中的数据的物理化学性质。 可以使用在两个不同样品中识别和优选鉴定相同分子的能力来确定特定生物分子是否在实验样品中相对于对照样品表达不同。