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公开(公告)号：US07404813B2
公开(公告)日：2008-07-29
申请号：US10316779
申请日：2002-12-11
申请人： Paul T. Van Gompel , David F. Bishop , Monica S. Diaz , Jacqueline A. Gross , Cindy L. Price , Monica G. Varriale
发明人： Paul T. Van Gompel , David F. Bishop , Monica S. Diaz , Jacqueline A. Gross , Cindy L. Price , Monica G. Varriale
IPC分类号： A61F13/15
CPC分类号： A61F13/496 , A61F13/49012 , A61F13/505 , A61F13/64 , A61F2013/49063
摘要： An undergarment includes a body panel and an crotch member. The crotch member includes first and second terminal edges and laterally opposed side edges. The crotch member has a longitudinally extending length defined between the first and second terminal edges. The crotch member is connected to the body panel at an attachment location, which is longitudinally spaced along the length of the crotch member from the first terminal edge thereof. The crotch member includes an unattached end portion that extends between the attachment location and the first terminal edge and that is unattached to the body panel. Methods of using and manufacturing the undergarment are also provided.
摘要翻译： 内衣包括身体面板和裆部构件。 裆部构件包括第一和第二末端边缘和横向相对的侧边缘。 裆部构件具有限定在第一和第二端边缘之间的纵向延伸的长度。 裆部构件在与裆部构件的长度方向上从其第一端边缘纵向间隔开的附接位置处连接到身体面板。 裆部构件包括在附接位置和第一末端边缘之间延伸并且未附接到身体面板的未附接端部。 还提供了使用和制造内衣的方法。
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2.发明授权Cloning and expression of biologically active .alpha.-galactosidase A as a fusion protein 失效生物活性α-半乳糖苷酶A作为融合蛋白的克隆和表达
公开(公告)号：US5580757A
公开(公告)日：1996-12-03
申请号：US261577
申请日：1994-06-17
IPC分类号： C12N15/09 , A61K35/18 , A61K38/00 , C07K14/31 , C12N9/10 , C12N9/24 , C12N9/40 , C12N15/54 , C12N15/56 , C12R1/91 , C12P21/06 , C12N15/62
CPC分类号： C12N9/2465 , A61K35/18 , C07K14/31 , C12N9/1081 , C12Y302/01022 , C12Y302/01049 , A61K38/00 , C07K2319/00 , C07K2319/61 , C07K2319/705
摘要： The present invention involves the production of large quantities of human .alpha.-Gal A by cloning and expressing the .alpha.-Gal A coding sequence in eukaryotic host cell expression systems. The eukaryotic expression systems, and in particular the mammalian host cell expression system described herein provide for the appropriate cotranslational and posttranslational modifications required for proper processing, e.g., glycosylation, phosphorylation, etc. and sorting of the expression product so that an active enzyme is produced. In addition, the expression of fusion proteins which simplify purification is described.Using the methods described herein, the recombinant .alpha.-Gal A is secreted by the engineered host cells so that it is recovered from the culture medium in good yield. The .alpha.-Gal A produced in accordance with the invention may be used, but is not limited to, in the treatment in Fabry Disease; for the hydrolysis of .alpha.-galactosyl residues in glycoconjugates; and/or for the conversion of the blood group B antigen on erythrocytes to the blood group O antigen.
摘要翻译： 本发明涉及通过在真核宿主细胞表达系统中克隆并表达α-GalA编码序列来生产大量的人α-Gal。 真核表达系统，特别是本文所述的哺乳动物宿主细胞表达系统提供适当的共转译和翻译后修饰，以进行适当的加工（例如糖基化，磷酸化等）和排序表达产物，从而产生活性酶 。 此外，描述了简化纯化的融合蛋白的表达。 使用本文所述的方法，重组α-Gal被工程化的宿主细胞分泌，从而以良好的产率从培养基中回收。 可以使用根据本发明产生的α-Gal A，但不限于，在法布里病的治疗中; 用于糖缀合物中α-半乳糖苷残基的水解; 和/或用于将红细胞上的血型B抗原转化为血型O抗原。
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3.发明授权
公开(公告)号：US5356804A
公开(公告)日：1994-10-18
申请号：US602824
申请日：1990-10-24
CPC分类号： C12N9/2465 , A61K35/18 , A61K38/00
摘要： The present invention involves the production of large quantities of human .alpha.-Gal A by cloning and expressing the .alpha.-Gal A coding sequence in eukaryotic host cell expression systems. The eukaryotic expression systems, and in particular the mammalian host cell expression system described herein provide for the appropriate cotranslational and posttranslational modifications required for proper processing, e.g., glycosylation, phosphorylation, etc. and sorting of the expression product so that an glycosylation, phosphorylation, etc. and sorting of the expression product so that an active enzyme is produced. In addition, the expression of fusion proteins which simplify purification is described.Using the methods described herein, the recombinant .alpha.-Gal A is secreted by the engineered host cells so that it is recovered from the culture medium in good yield. The .alpha.-Gal A produced in accordance with the invention may be used in the treatment in Fabry Disease; for the hydrolysis of .alpha.-galactosyl residues in glycoconjugates; and/or for the conversion of the blood group B antigen on erythrocytes to the blood group O antigen.
摘要翻译： 本发明涉及通过在真核宿主细胞表达系统中克隆并表达α-GalA编码序列来生产大量的人α-Gal。 本文所述的真核表达系统，特别是哺乳动物宿主细胞表达系统提供适当的翻译和翻译后修饰，以进行适当的加工，例如糖基化，磷酸化等，并对表达产物进行分选，使得糖基化，磷酸化， 等等，并对表达产物进行分选以产生活性酶。 此外，描述了简化纯化的融合蛋白的表达。 使用本文所述的方法，重组α-Gal被工程化的宿主细胞分泌，从而以良好的产率从培养基中回收。 根据本发明产生的α-Gal可用于法布里病的治疗; 用于糖缀合物中α-半乳糖苷残基的水解; 和/或用于将红细胞上的血型B抗原转化为血型O抗原。
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4.发明授权Fibrous nonwoven web surge layer for personal care absorbent articles and the like 失效用于个人护理吸收制品的纤维非织造网浪涌层等
公开(公告)号：US5486166A
公开(公告)日：1996-01-23
申请号：US386244
申请日：1995-02-09
申请人： David F. Bishop , Clifford J. Ellis
发明人： David F. Bishop , Clifford J. Ellis
CPC分类号： A61F13/534 , A61F13/15203 , A61F2013/153 , A61F2013/15317 , A61F2013/15406 , A61F2013/15463 , A61F2013/1556 , A61F2013/53016 , A61F2013/530167 , A61F2013/53024 , A61F2013/53795 , A61F2013/8491 , Y10T428/249953 , Y10T442/638 , Y10T442/64 , Y10T442/641 , Y10T442/692
摘要： Disclosed herein is a lofty fibrous nonwoven web which is particularly well-suited for use as a surge layer in personal care absorbent articles including, but not limited to, diapers, training pants, incontinence garments, sanitary napkins, bandages and the like. The fibrous nonwoven web is made from a plurality of fibers heat bonded to one another to form a lofty nonwoven web having a basis weight of at least 20 grams per square meter, a void volume of between about 80 and about 117 centimeters per gram of web while under a pressure of 689 dynes per square centimeter, a permeability of about 8,000 to about 15,000 darcy, a porosity of about 98.6 percent to about 99.4 percent and a surface area per void of about 10 to about 25 square centimeters per cubic centimeter. The fibrous nonwoven web will have a saturation capacity of between about 55 and about 80 grams of 0.9 percent saline solution per gram of web and a compression resilience in both the wet and dry state of at least about 60 percent.
摘要翻译： 本文公开了一种高度纤维非织造纤维网，其特别适合用作个人护理吸收制品中的浪涌层，包括但不限于尿布，训练裤，失禁服，卫生巾，绷带等。 纤维非织造纤维网由多个彼此热粘合的纤维制成，以形成基重为至少20克/平方米的高度非织造纤维网，空隙体积为约80至约117厘米/克纤维网 而在689达因/平方厘米的压力下，约8,000至约15,000达里尔的渗透性，约98.6％至约99.4％的孔隙率和约10至约25平方厘米每立方厘米的每个空隙的表面积。 纤维非织造纤维网的饱和容量为每克纤维网约0.9至约80克的0.9％盐水溶液，至少约60％的湿和干态压缩弹性。
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5.发明授权Cloning and expression of biologically active .alpha.-n-acetylgalactosaminidase 失效生物活性α-N-乙酰半乳糖胺酶的克隆和表达
公开(公告)号：US5382524A
公开(公告)日：1995-01-17
申请号：US602608
申请日：1990-10-24
CPC分类号： C12Y302/01049 , C12N9/2465 , A61K38/00
摘要： The present invention involves the production of human .alpha.-GalNAc by cloning and expressing the .alpha.-GalNAc coding sequence in eukaryotic host cell expressions systems. The eukaryotic expression systems, and in particular the mammalian host cell expression systems described herein provide for the appropriate co-translational and post-translation modifications required or proper processing, e.g., glycosylation, phosphorylation, etc. and sorting of the expression product so that an active enzyme is produced.The .alpha.-GalNAc produced in accordance with the invention may be used in the treatment of Schindler disease or for the hydrolysis of .alpha.-N-acetylgalactosaminyl moieties in various glycoconjugates.
摘要翻译： 本发明涉及通过在真核宿主细胞表达系统中克隆和表达α-GalNAc编码序列来生产人α-GalNAc。 本文所述的真核表达系统，特别是哺乳动物宿主细胞表达系统提供了所需的适当的协同翻译和翻译后修饰或适当的加工，例如糖基化，磷酸化等，并且对表达产物进行排序，使得 生产活性酶。 根据本发明产生的α-GalNAc可用于治疗辛德勒病或用于各种糖缀合物中α-N-乙酰半乳糖胺基部分的水解。
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公开(公告)号：US08361046B2
公开(公告)日：2013-01-29
申请号：US12262348
申请日：2008-10-31
申请人： David F. Bishop , Russell J. Brumm , Patsy A. Krautkramer , Catherine Marguerite Hancock-Cooke , Russell E. Thorson , John T. Hahn
发明人： David F. Bishop , Russell J. Brumm , Patsy A. Krautkramer , Catherine Marguerite Hancock-Cooke , Russell E. Thorson , John T. Hahn
CPC分类号： A61F13/51484 , A61F13/49009 , A61F13/51464
摘要： Absorbent articles with carefully controlled stretch properties are provided. Of particular advantage, the carefully controlled stretch properties can prevent too much tension in the front leg area of the garment. The outer cover is constructed such that the front leg zone has a tension of less than about 1200 grams-force at about 160% to about 175% stretch in the lateral direction, and each of the front waist zone, the front crotch zone, the back crotch zone, the back leg zone, and the back waist zone of the outer cover has a tension of greater than about 1500 grams-force at about 160% to about 175% stretch in the lateral direction. Methods of making such an absorbent article are also provided.
摘要翻译： 提供具有精心控制的拉伸性能的吸收制品。 特别有利的是，仔细控制的拉伸性能可以防止衣服的前腿区域产生太大的张力。 外盖被构造成使得前腿区域在横向方向上具有小于约1200克力的张力，大约160％至大约175％的拉伸，并且前腰围区域，前裆区域， 后裆区域，后腿区域和外覆盖层的后腰区域在横向方向上具有约160％至约175％的拉伸强度大于约1500克力的张力。 还提供制造这种吸收制品的方法。
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公开(公告)号：US5401650A
公开(公告)日：1995-03-28
申请号：US983451
申请日：1992-11-30
IPC分类号： C12N15/09 , A61K35/18 , A61K38/00 , C07K14/31 , C12N9/10 , C12N9/24 , C12N9/40 , C12N15/54 , C12N15/56 , C12R1/91 , C12N15/00
CPC分类号： C12N9/2465 , A61K35/18 , C07K14/31 , C12N9/1081 , C12Y302/01022 , C12Y302/01049 , A61K38/00 , C07K2319/00 , C07K2319/61 , C07K2319/705
摘要： The present invention involves the production of large quantities of human .alpha.-Gal A by cloning and expressing the .alpha.-Gal A coding sequence in eukaryotic host cell expression systems. The eukaryotic expression systems, and in particular the mammalian host cell expression system described herein provide for the appropriate cotranslational and posttranslational modifications required for proper processing, e.g., glycosylation, phosphorylation, etc. and sorting of the expression product so that an active enzyme is produced. In addition, the expression of fusion proteins which simplify purification is described.Using the methods described herein, the recombinant .alpha.-Gal A is secreted by the engineered host cells so that it is recovered from the culture medium in good yield. The .alpha.-Gal A produced in accordance with the invention may be used, but is not limited to, in the treatment in Fabry Disease; for the hydrolysis of .alpha.-galactosyl residues in glycoconjugates; and/or for the conversion of the blood group B antigen on erythrocytes to the blood group O antigen.
摘要翻译： 本发明涉及通过在真核宿主细胞表达系统中克隆并表达α-GalA编码序列来生产大量的人α-Gal。 真核表达系统，特别是本文所述的哺乳动物宿主细胞表达系统提供适当的共转译和翻译后修饰，以进行适当的加工（例如糖基化，磷酸化等）和排序表达产物，从而产生活性酶 。 此外，描述了简化纯化的融合蛋白的表达。 使用本文所述的方法，重组α-Gal被工程化的宿主细胞分泌，从而以良好的产率从培养基中回收。 可以使用根据本发明产生的α-Gal A，但不限于，在法布里病的治疗中; 用于糖缀合物中α-半乳糖苷残基的水解; 和/或用于将红细胞上的血型B抗原转化为血型O抗原。
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公开(公告)号：US20100114048A1
公开(公告)日：2010-05-06
申请号：US12262348
申请日：2008-10-31
申请人： David F. Bishop , Russell J. Brumm , Patsy A. Krautkramer , Catherine Marguerite Hancock-Cooke , Russell E. Thorson , John T. Hahn
发明人： David F. Bishop , Russell J. Brumm , Patsy A. Krautkramer , Catherine Marguerite Hancock-Cooke , Russell E. Thorson , John T. Hahn
IPC分类号： A61F13/15
CPC分类号： A61F13/51484 , A61F13/49009 , A61F13/51464
摘要： Absorbent articles with carefully controlled stretch properties are provided. Of particular advantage, the carefully controlled stretch properties can prevent too much tension in the front leg area of the garment. The outer cover is constructed such that the front leg zone has a tension of less than about 1200 grams-force at about 160% to about 175% stretch in the lateral direction, and each of the front waist zone, the front crotch zone, the back crotch zone, the back leg zone, and the back waist zone of the outer cover has a tension of greater than about 1500 grams-force at about 160% to about 175% stretch in the lateral direction. Methods of making such an absorbent article are also provided.
摘要翻译： 提供具有精心控制的拉伸性能的吸收制品。 特别有利的是，仔细控制的拉伸性能可以防止衣服的前腿区域产生太大的张力。 外盖被构造成使得前腿区域在横向方向上具有小于约1200克力的张力，大约160％至大约175％的拉伸，并且前腰围区域，前裆区域， 后裆区域，后腿区域和外覆盖层的后腰区域在横向方向上具有约160％至约175％的拉伸强度大于约1500克力的张力。 还提供制造这种吸收制品的方法。
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9.发明授权Three-piece garment having an absorbent insert secured with variable adhesive regions 有权具有吸收性插入物的三件式衣服用可变的粘合剂区域固定公开(公告)号：US07250549B2
公开(公告)日：2007-07-31
申请号：US10748712
申请日：2003-12-30
申请人： Sandra A. Richlen , Paul Christoffel , Suzanne M. Schmoker , Paul Hasler , Sarah Freiburger , David F. Bishop , Melanie J. Milslagle
发明人： Sandra A. Richlen , Paul Christoffel , Suzanne M. Schmoker , Paul Hasler , Sarah Freiburger , David F. Bishop , Melanie J. Milslagle
IPC分类号： A61F13/15
CPC分类号： A61F13/496 , A61F13/15756 , A61F13/539 , Y10T428/277 , Y10T428/28
摘要： An absorbent garment includes a front body panel having a terminal waist edge and a terminal crotch edge and a rear body panel having a terminal waist edge and a terminal crotch edge. The terminal crotch edge of the rear body panel is longitudinally spaced from and forms a gap with the terminal crotch edge of the front body panel. An absorbent insert includes first and second longitudinally spaced end portions and opposite laterally spaced side edges. The absorbent insert bridges the gap between the front and rear body panels with the first and second end portions overlying and connected to the front and rear body panels respectively. At least one of the first and second end portions of the absorbent insert is connected respectively to a corresponding one of the front and rear body panels with at least first and second adhesive regions having first and second adhesive basis weights respectively. At least a portion of the second adhesive region is located adjacent the terminal crotch edge of at least one of the front and rear body panels. The second adhesive basis weight is greater than the first adhesive basis weight. In another aspect, the first adhesive region has a first peel strength and the first and second adhesive regions in combination have a second peel strength. In one embodiment, the second peel strength is greater than the first peel strength. In another aspect, a method of assembling the absorbent garment is provided.
摘要翻译： 吸收性服装包括具有终端腰边缘和终端裆边缘的前体面板和具有终端腰边缘和终端裆边缘的后体面板。 后体板的端子裆边缘与前身板的端子裆边缘纵向间隔开并形成间隙。 吸收性插入物包括第一和第二纵向间隔开的端部和相对的侧向间隔开的侧边缘。 吸收性插入物桥接前身板和后体板之间的间隙，第一和第二端部分别覆盖并连接到前和后主体板。 吸收性插入物的第一和第二端部中的至少一个分别与至少第一和第二粘合剂区域分别连接到前部和后部主体面板中的对应的一个，其具有分别具有第一和第二粘合剂基重。 第二粘合剂区域的至少一部分位于与前身板和后身板中的至少一个的终端裆边相邻。 第二粘合剂基重大于第一粘合剂基重。 另一方面，第一粘合剂区域具有第一剥离强度，并且组合的第一和第二粘合剂区域具有第二剥离强度。 在一个实施例中，第二剥离强度大于第一剥离强度。 另一方面，提供一种组装吸收性服装的方法。
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公开(公告)号：US06755808B2
公开(公告)日：2004-06-29
申请号：US10053251
申请日：2001-11-02
IPC分类号： A61F1315
CPC分类号： A61F13/496 , A61F13/49413 , A61F13/49466 , A61F13/5644 , A61F2013/49063
摘要： An absorbent garment includes a body panel and an absorbent composite having a longitudinally extending length and a laterally extending width and including a backsheet, a topsheet and a retention portion disposed between the backsheet and the topsheet. The absorbent composite is connected to the body panel and includes a side margin that is not attached to the body panel and that extends laterally outboard and terminates in a free edge. In one preferred embodiment, the free edge does not extend along the entirety of the length of the absorbent composite. Rather, the entire width of an end of the absorbent composite is secured to the body panel. Preferably, the width of the side margin along the portion of the absorbent composite overlapping the body panel is relatively constant.
摘要翻译： 吸收性服装包括身体面板和吸收性复合材料，其具有纵向延伸的长度和横向延伸的宽度，并且包括底片，顶片和设置在底片和顶片之间的保持部分。 吸收性复合材料连接到主体面板并且包括未附接到主体面板并且横向外侧延伸并终止于自由边缘的侧边缘。 在一个优选实施例中，自由边缘不沿吸收性复合材料的整个长度延伸。 相反，吸收性复合材料的端部的整个宽度固定到主体面板。 优选地，沿着吸收性复合物与身体面板重叠的部分的侧边缘的宽度相对恒定。
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