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公开(公告)号:US20050164344A1
公开(公告)日:2005-07-28
申请号:US11008889
申请日:2004-12-10
申请人: Paul Worley , Jian Tu , Bo Xiao , Daniel Leahy , Jutta Beneken , Anthony Lanahan , Paul Brakeman
发明人: Paul Worley , Jian Tu , Bo Xiao , Daniel Leahy , Jutta Beneken , Anthony Lanahan , Paul Brakeman
CPC分类号: C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00
摘要: A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.
摘要翻译: 提供了一种用于鉴定调节与荷马相关并由细胞表面或细胞内受体介导的细胞因子反应的化合物的方法。 还提供了一种鉴定调节与荷马相关的受体活化钙动员的化合物的方法。 提供了一种基于荷马蛋白结合结构域的晶体结构坐标来鉴定抑制荷马蛋白活性的化合物的方法。 还提供了一种鉴定影响细胞表面受体形成簇的化合物的方法。 还提供了编码荷马蛋白以及荷马蛋白和荷马相互作用蛋白的核酸。
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公开(公告)号:US07378498B2
公开(公告)日:2008-05-27
申请号:US11008889
申请日:2004-12-10
申请人: Paul F. Worley , Jian Cheng Tu , Bo Xiao , Daniel Leahy , Jutta Beneken , Anthony A. Lanahan , Paul R. Brakeman
发明人: Paul F. Worley , Jian Cheng Tu , Bo Xiao , Daniel Leahy , Jutta Beneken , Anthony A. Lanahan , Paul R. Brakeman
IPC分类号: C07K14/435 , C07H21/04
CPC分类号: C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00
摘要: A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.
摘要翻译: 提供了一种用于鉴定调节与荷马相关并由细胞表面或细胞内受体介导的细胞因子反应的化合物的方法。 还提供了一种鉴定调节与荷马相关的受体活化钙动员的化合物的方法。 提供了一种基于荷马蛋白结合结构域的晶体结构坐标来鉴定抑制荷马蛋白活性的化合物的方法。 还提供了一种鉴定影响细胞表面受体形成簇的化合物的方法。 还提供了编码荷马蛋白以及荷马蛋白和荷马相互作用蛋白的核酸。
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公开(公告)号:US06720175B1
公开(公告)日:2004-04-13
申请号:US09377285
申请日:1999-08-18
申请人: Paul F. Worley , Jian Cheng Tu , Bo Xiao , Daniel Leahy , Jutta Beneken , Anthony A. Lanahan , Paul R. Brakeman
发明人: Paul F. Worley , Jian Cheng Tu , Bo Xiao , Daniel Leahy , Jutta Beneken , Anthony A. Lanahan , Paul R. Brakeman
IPC分类号: C07H2104
CPC分类号: C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00
摘要: A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.
摘要翻译: 提供了一种用于鉴定调节与荷马相关并由细胞表面或细胞内受体介导的细胞应答的化合物的方法。 还提供了一种鉴定调节与荷马相关的受体活化钙动员的化合物的方法。 提供了一种基于荷马蛋白结合结构域的晶体结构坐标来鉴定抑制荷马蛋白活性的化合物的方法。 还提供了一种鉴定影响细胞表面受体形成簇的化合物的方法。 还提供了编码荷马蛋白以及荷马蛋白和荷马相互作用蛋白的核酸。
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公开(公告)号:US06864083B2
公开(公告)日:2005-03-08
申请号:US10192381
申请日:2002-07-09
申请人: Paul F. Worley , Jian Cheng Tu , Bo Xiao , Daniel Leahy , Jutta Beneken , Anthony A. Lanahan , Paul R. Brakeman
发明人: Paul F. Worley , Jian Cheng Tu , Bo Xiao , Daniel Leahy , Jutta Beneken , Anthony A. Lanahan , Paul R. Brakeman
CPC分类号: C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00
摘要: A method is provided for identifying a compound that modulates a cellualr response associate with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.
摘要翻译: 提供了一种鉴定调节与荷马相关并由细胞表面或细胞内受体介导的纤维素反应的化合物的方法。 还提供了一种鉴定调节与荷马相关的受体活化钙动员的化合物的方法。 提供了一种基于荷马蛋白结合结构域的晶体结构坐标来鉴定抑制荷马蛋白活性的化合物的方法。 还提供了一种鉴定影响细胞表面受体形成簇的化合物的方法。 还提供了编码荷马蛋白以及荷马蛋白和荷马相互作用蛋白的核酸。
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公开(公告)号:US20070107585A1
公开(公告)日:2007-05-17
申请号:US11531669
申请日:2006-09-13
申请人: Daniel Leahy , James Zielinski , Mark Barthold , Lucas Pope
发明人: Daniel Leahy , James Zielinski , Mark Barthold , Lucas Pope
IPC分类号: G10H7/00
CPC分类号: G06Q50/10 , A63F2300/8047
摘要: A music production system is presented that includes a music module to access computer software applications and produce music compositions. The system in a first mode records and corrects the pitch of a tune, typically a tune sung by a user at a microphone. The user may produce additional tracks with the software applications including instruments playing the recorded and corrected tune or to accompany the user while singing the tune. In a second mode, the system generates virtual characters such as band members, a producer and/or a manager to simulate the production and presentation of the recorded tune as a stage show as part of a recording industry. Virtual characters may assist in the use of user interface functions during music composition development and orchestration.
摘要翻译: 提出了一种音乐制作系统,其中包括一个音乐模块,用于访问计算机软件应用程序和制作音乐作品。 第一模式中的系统记录和校正乐曲的音调,通常是用户在麦克风处播放的曲调。 用户可以通过软件应用产生附加的轨道,包括演奏记录和校正的乐曲的乐器,或伴奏用户唱歌时。 在第二模式中,系统生成诸如乐队成员,制作人和/或管理者之类的虚拟角色,以便将作为记录行业的一部分的记录乐曲的制作和呈现作为舞台表演。 虚拟角色可能有助于在音乐构图开发和编排过程中使用用户界面功能。
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公开(公告)号:US07563975B2
公开(公告)日:2009-07-21
申请号:US11531669
申请日:2006-09-13
申请人: Daniel Leahy , James Zielinski , Mark Barthold , Lucas Pope
发明人: Daniel Leahy , James Zielinski , Mark Barthold , Lucas Pope
CPC分类号: G06Q50/10 , A63F2300/8047
摘要: A music production system is presented that includes a music module to access computer software applications and produce music compositions. The system in a first mode records and corrects the pitch of a tune, typically a tune sung by a user at a microphone. The user may produce additional tracks with the software applications including instruments playing the recorded and corrected tune or to accompany the user while singing the tune. In a second mode, the system generates virtual characters such as band members, a producer and/or a manager to simulate the production and presentation of the recorded tune as a stage show as part of a recording industry. Virtual characters may assist in the use of user interface functions during music composition development and orchestration.
摘要翻译: 提出了一种音乐制作系统,其中包括一个音乐模块,用于访问计算机软件应用程序和制作音乐作品。 第一模式中的系统记录和校正乐曲的音调,通常是用户在麦克风处播放的曲调。 用户可以通过软件应用产生附加的轨道,包括播放记录和校正的乐曲的乐器,或伴奏用户唱歌时。 在第二模式中,系统生成诸如乐队成员,制作人和/或管理者之类的虚拟角色,以便将作为记录行业的一部分的记录乐曲的制作和呈现作为舞台表演。 虚拟角色可能有助于在音乐构图开发和编排过程中使用用户界面功能。
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