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    Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy
    3.
    发明授权
    Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy 失效
    碳酸氢盐溶液在两部分用于腹膜透析或连续肾替代治疗中的替代

    公开(公告)号：US06309673B1

    公开(公告)日：2001-10-30

    申请号：US09393743

    申请日：1999-09-10

    申请人： Annick Duponchelle ,  Dirk Faict ,  Patrick Balteau ,  Jean-Pierre Hartman ,  Leo Martis ,  Francesco Peluso

    发明人： Annick Duponchelle ,  Dirk Faict ,  Patrick Balteau ,  Jean-Pierre Hartman ,  Leo Martis ,  Francesco Peluso

    IPC分类号： A61K3300

    CPC分类号： A61M1/287 ,  A61K33/14 ,  A61M1/1654 ,  A61K33/10 ,  A61K2300/00

    摘要： The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.

    摘要翻译： 本发明提供用于稳定用于腹膜透析或血液滤过的基于碳酸氢根的溶液的装置和方法。 将本发明的基于碳酸氢盐的溶液配制并储存在至少两部分中 - 碱性碳酸氢盐浓缩物和酸性浓缩物。 将碱式碳酸氢盐浓缩物调节至约8.6至10.0的pH。 将酸性浓缩物调节至具有约1.0至3.0的稳定的酸性pH。 在混合时，虽然存在混合碳酸氢盐溶液的pH的一些变化，本发明人已经发现，通过适当选择浓缩物的参数，混合溶液的pH总是在可接受的生理范围内。

    CONTAINERS COMPRISING PEELABLE SEALS
    8.
    发明申请
    CONTAINERS COMPRISING PEELABLE SEALS 审中-公开
    包装有密封件的容器

    公开(公告)号：US20110038755A1

    公开(公告)日：2011-02-17

    申请号：US12539948

    申请日：2009-08-12

    申请人： Giampiero Pesci ,  Patrick R. Balteau ,  Jean-Pierre Hartman ,  Noel G. Smith ,  Fabio Giuseppe Casartelli

    发明人： Giampiero Pesci ,  Patrick R. Balteau ,  Jean-Pierre Hartman ,  Noel G. Smith ,  Fabio Giuseppe Casartelli

    IPC分类号： A61L2/04 ,  B65D25/04

    CPC分类号： B65D81/3266 ,  B65D31/14 ,  B65D31/145

    摘要： Multi-chambered containers having peelable seals and methods of sterilizing the same are provided. In an embodiment, the present disclosure provides a flexible fluid container comprising a first chamber and a second chamber. The second chamber is attached to a tube for providing fluid communication from the second chamber to the exterior of the container. The first chamber and the second chamber are separated by a first peelable seal having a channel so constructed and arranged to allow a controlled quantity of fluid to pass therethrough.

    摘要翻译： 提供具有可剥离密封件的多室容器及其灭菌方法。 在一个实施例中，本公开提供了一种包括第一室和第二室的柔性流体容器。 第二室附接到管，用于提供从第二室到容器的外部的流体连通。 第一腔室和第二腔室由第一可剥离密封件分开，第一可剥离密封件具有如此构造和布置以允许受控量的流体通过的通道。