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公开(公告)号：US5514376A
公开(公告)日：1996-05-07
申请号：US16486
申请日：1993-02-10
CPC分类号： C12N7/00 , A61K39/12 , A61K39/29 , A61K2039/5252 , A61K2039/5254 , A61K2039/575 , C12N2770/32434 , C12N2770/32451 , C12N2770/32464
摘要： Hepatitis A virus is attenuated in virulence by in vitro passage in susceptible cell cultures, without prior passage in a subhuman primate. This process results in a live, attenuated hepatitis A virus vaccine suitable for human disease prevention.
摘要翻译： 甲型肝炎病毒通过在易感细胞培养物中的体外传代而在毒力下减弱，而无需先前在非人灵长类动物中传代。 该过程导致适合人类疾病预防的活的，减毒的甲型肝炎病毒疫苗。
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公开(公告)号：US5021348A
公开(公告)日：1991-06-04
申请号：US609677
申请日：1984-05-14
CPC分类号： C12N7/00 , A61K39/12 , A61K39/29 , A61K2039/5254 , C12N2770/32434 , C12N2770/32464
摘要： Hepatitis A virus is attenuated by propagation in cell culture in vitro by direct inoculation of the cell cultures with a human clinical specimen containing the virus.
摘要翻译： 通过用含有病毒的人临床标本直接接种细胞培养物，甲型肝炎病毒在细胞培养物中的繁殖减弱。
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公开(公告)号：US5766603A
公开(公告)日：1998-06-16
申请号：US458196
申请日：1995-06-02
CPC分类号： C12N7/00 , A61K39/12 , A61K39/29 , A61K2039/5252 , A61K2039/5254 , A61K2039/575 , C12N2770/32434 , C12N2770/32451 , C12N2770/32464
摘要： Hepatitis A virus is attenuated in virulence by in vitro passage in susceptible cell cultures, without prior passage in a subhuman primate. This process results in a live, attenuated hepatitis A virus vaccine suitable for human disease prevention.
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公开(公告)号：US4164566A
公开(公告)日：1979-08-14
申请号：US934293
申请日：1978-08-17
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , C12N2770/32434 , C12N2770/32451
摘要： Hepatitis A virus is passaged at least once in a susceptible sub-human primate; the infected liver from such passage is used to inoculate an in vitro cell culture, the inoculated cell culture is incubated until hepatitis A antigen is detected in the cell sheet or culture fluid, and at least two serial in vitro passages in cell culture are carried out. The hepatitis A virus so modified can be used to prepare live, attenuated hepatitis A vaccine or an inactivated hepatitis A vaccine.
摘要翻译： {PG，1甲型肝炎病毒在易感亚人灵长类动物中传代至少一次; 将来自该传代的受感染的肝脏用于接种体外细胞培养物，孵育接种的细胞培养物直至在细胞片或培养液中检测到甲型肝炎抗原，并进行细胞培养中的至少两次连续体外传代 。 如此修饰的甲型肝炎病毒可用于制备活的，减毒的甲型肝炎疫苗或灭活的甲型肝炎疫苗。
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公开(公告)号：US4031203A
公开(公告)日：1977-06-21
申请号：US693668
申请日：1976-06-07
IPC分类号： A61K39/29 , G01N33/576 , A61K39/12
CPC分类号： A61K39/29 , A61K39/12 , G01N33/5768 , C12N2770/32434
摘要： Hepatitis A antigen obtained from the livers of non-human primates infected with hepatitis A (infectious hepatitis) virus has been found to be usable in fast, simple assays for hepatitis A antibody and thus usable in diagnosis of hepatitis A disease in humans, and for the preparation of hepatitis A vaccine.
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公开(公告)号：US4017601A
公开(公告)日：1977-04-12
申请号：US623184
申请日：1975-10-16
IPC分类号： G01N33/576 , A61K39/29 , C12Q1/70 , A61K39/12
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/5252 , A61K2039/575 , C12N2770/32434
摘要： Hepatitis A antigen obtained from the stools of patients infected with hepatitis A (infectious hepatitis) virus has been found to be usable in fast, simple assays for hepatitis A antibody and thus usable in diagnosis of hepatitis A disease, and for the preparation of hepatitis A vaccine.
摘要翻译： 已经发现从感染甲型肝炎（感染性肝炎）病毒的患者的粪便获得的甲型肝炎抗原可用于甲型肝炎抗体的快速，简单的测定中，因此可用于诊断甲型肝炎疾病和用于制备甲型肝炎 疫苗。
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公开(公告)号：US4029764A
公开(公告)日：1977-06-14
申请号：US530623
申请日：1974-12-09
IPC分类号： C12N7/00 , A61K39/29 , G01N33/576 , A61K39/12
CPC分类号： G01N33/5768
摘要： Hepatitis A antigen obtained from the livers of non-human primates infected with hepatitis A (infectious hepatitis) virus has been found to be usable in fast, simple assays for hepatitis A antibody and thus usable in diagnosis of hepatitis A disease in humans, and for the preparation of hepatitis A vaccine.
摘要翻译： 已经发现从感染甲型肝炎（感染性肝炎）病毒的非人灵长类动物的肝脏获得的甲型肝炎抗原可用于甲型肝炎抗体的快速，简单的测定中，因此可用于诊断人类中的甲型肝炎病毒 甲型肝炎疫苗的制备。
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公开(公告)号：US4004981A
公开(公告)日：1977-01-25
申请号：US573655
申请日：1975-05-01
摘要： Apparatus for physically removing cells in sterile manner from a disc stack on which the cells have been cultured comprises a substantially shaft-like member having at least one rod-like member mounted at substantially a right angle to the axis of the shaft.
摘要翻译： 用于以消毒方式物理去除细胞已经培养的盘堆叠的细胞的装置包括具有至少一个棒状部件的大致轴状部件，所述杆状部件以与轴的轴线大致成直角的角度安装。
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公开(公告)号：US4459286A
公开(公告)日：1984-07-10
申请号：US462594
申请日：1983-01-31
IPC分类号： A61K39/095 , A61K39/102 , A61K39/40 , C07G7/00
CPC分类号： A61K39/095 , A61K39/102 , A61K2039/6068 , A61K2039/627 , Y10S530/806 , Y10S530/807 , Y10S530/825
摘要： Haemophilus influenzae type B polysaccharide is coupled through a spacer to a serotype outer membrane protein from Neisseria meningitidis. This conjugate has enhanced antigenicity and immunogenicity relative to the unconjugated polysaccharide.
摘要翻译： 流感嗜血杆菌B型多糖通过间隔物与来自脑膜炎奈瑟球菌的血清型外膜蛋白偶联。 该缀合物相对于非共轭多糖具有增强的抗原性和免疫原性。
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公开(公告)号：US4022206A
公开(公告)日：1977-05-10
申请号：US600983
申请日：1975-08-01
摘要： Vaccine delivery system having a lyophilized vaccine in human dosage concentration loaded into presterilized single dosage syringe having a squeezable body portion and a separate package containing enough water for injection to reconstitute the single dose of lyophilized vaccine.
摘要翻译： 将具有人体剂量浓度的冻干疫苗的疫苗递送系统装载到具有可挤压主体部分的预杀灭的单剂量注射器中，以及包含足够的注射用水的单独包装以重构单剂量的冻干疫苗。
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