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公开(公告)号:US20080058341A1
公开(公告)日:2008-03-06
申请号:US11752201
申请日:2007-05-22
申请人: Penglie Zhang , Andrew Pennell , John Wright , Wei Chen , Manmohan Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark Gleason , Yibin Zeng , Kevin Greenman
发明人: Penglie Zhang , Andrew Pennell , John Wright , Wei Chen , Manmohan Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark Gleason , Yibin Zeng , Kevin Greenman
IPC分类号: A61K31/497 , A61P43/00 , C07D401/00 , C07D487/00
CPC分类号: A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04
摘要: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
摘要翻译: 提供了作为CCR1受体的有效拮抗剂并具有体内抗炎活性的化合物。 化合物通常为芳基哌嗪衍生物,并且可用于药物组合物,用于治疗CCR1介导的疾病的方法,以及用于鉴定竞争性CCR1拮抗剂的测定中的对照。
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公开(公告)号:US20070112015A1
公开(公告)日:2007-05-17
申请号:US11590658
申请日:2006-10-30
申请人: Clarence Hurt , Andrew Pennell , John Wright , Manmohan Leleti , Qiang Wang , William Thomas , Yandong Li , Dean Dragoli
发明人: Clarence Hurt , Andrew Pennell , John Wright , Manmohan Leleti , Qiang Wang , William Thomas , Yandong Li , Dean Dragoli
IPC分类号: A61K31/519 , A61K31/4745 , A61K31/4741 , C07D491/02 , C07D487/02 , C07D471/02
CPC分类号: C07D217/22 , C07D217/26 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D417/04 , C07D471/04 , C07D491/04
摘要: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.
摘要翻译: 提供了作为C5a受体调节剂的化合物。 化合物是取代的二氢吡啶并且可用于药物组合物,用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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公开(公告)号:US20070037794A1
公开(公告)日:2007-02-15
申请号:US11486974
申请日:2006-07-14
申请人: Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
发明人: Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
IPC分类号: A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/444 , C07D417/14 , C07D413/14 , C07D403/14
CPC分类号: A61K31/444 , A61K31/437 , A61K31/4439 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要: Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译: 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明,这些化合物可用于治疗炎症,CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物,并且可用于药物组合物,用于治疗CCR2介导的疾病的方法,以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号:US20060173019A1
公开(公告)日:2006-08-03
申请号:US11332786
申请日:2006-01-13
申请人: Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Jeff Jin , Jimmie Moore , Yibin Zang , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
发明人: Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Jeff Jin , Jimmie Moore , Yibin Zang , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
IPC分类号: A61K31/496 , A61K31/4545 , C07D403/02 , C07D401/02
CPC分类号: C07C311/21 , C07D213/48 , C07D213/61 , C07D213/643 , C07D213/70 , C07D213/73 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/89 , C07D241/22 , C07D263/32 , C07D401/04 , C07D405/04 , C07D409/12 , C07D413/06 , C07D413/10 , C07D417/12 , C07D471/04
摘要: Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
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公开(公告)号:US20070021466A1
公开(公告)日:2007-01-25
申请号:US11486395
申请日:2006-07-13
申请人: Solomon Ungashe , John Wright , Andrew Pennell , Zheng Wei , Anita Melikian
发明人: Solomon Ungashe , John Wright , Andrew Pennell , Zheng Wei , Anita Melikian
IPC分类号: A61K31/444 , A61K31/44
CPC分类号: C07D213/50
摘要: Compounds are provided that act as potent antagonists of the CCR2 receptor. These compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译: 提供了作为CCR2受体的有效拮抗剂的化合物。 这些化合物可用于治疗炎症,CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物,并且可用于药物组合物,用于治疗CCR2介导的疾病的方法,以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号:US20060111351A1
公开(公告)日:2006-05-25
申请号:US11255163
申请日:2005-10-20
申请人: Solomon Ungashe , John Wright , Andrew Pennell , Zheng Wei , Anita Melikian
发明人: Solomon Ungashe , John Wright , Andrew Pennell , Zheng Wei , Anita Melikian
IPC分类号: A61K31/5377 , C07D413/02
CPC分类号: C07D213/50 , C07D213/26 , C07D213/52 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D405/12 , C07D413/12
摘要: Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
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公开(公告)号:US09762273B2
公开(公告)日:2017-09-12
申请号:US15285474
申请日:2016-10-04
IPC分类号: H04B1/10 , H04B17/345 , H04J13/00
CPC分类号: H04B1/1027 , H04B17/345 , H04J13/0029
摘要: Mechanisms for interferer detection can detect interferers by detecting elevated signal amplitudes in one or more of a plurality of bins (or bands) in a frequency range between a maximum frequency (fMAX) and a minimum frequency (fMIN). To perform rapid interferer detection, the mechanisms downconvert an input signal x(t) with a local oscillator (LO) to a complex baseband signal xI(t)+jxQ(t). xI(t) and xQ(t) are then multiplied by m unique pseudorandom noise (PN) sequences (e.g., Gold sequences) gm(t) to produce m branch signals for I and m branch signals for Q. The branch signals are then low pass filtered, converted from analog to digital form, and pairwise combined by a pairwise complex combiner. Finally, a support recovery function is used to identify interferers.
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公开(公告)号:US20170026066A1
公开(公告)日:2017-01-26
申请号:US15285474
申请日:2016-10-04
IPC分类号: H04B1/10 , H04J13/00 , H04B17/345
CPC分类号: H04B1/1027 , H04B17/345 , H04J13/0029
摘要: Mechanisms for interferer detection can detect interferers by detecting elevated signal amplitudes in one or more of a plurality of bins (or bands) in a frequency range between a maximum frequency (fMAX) and a minimum frequency (fMIN). To perform rapid interferer detection, the mechanisms downconvert an input signal x(t) with a local oscillator (LO) to a complex baseband signal xI(t)+jxQ(t). xI(t) and xQ(t) are then multiplied by m unique pseudorandom noise (PN) sequences (e.g., Gold sequences) gm(t) to produce m branch signals for I and m branch signals for Q. The branch signals are then low pass filtered, converted from analog to digital form, and pairwise combined by a pairwise complex combiner. Finally, a support recovery function is used to identify interferers.
摘要翻译: 用于干扰源检测的机制可以通过在最大频率(fMAX)和最小频率(f M IN)之间的频率范围内检测多个箱体(或频带)中的一个或多个中的升高的信号幅度来检测干扰源。 为了执行快速干扰源检测,这些机制将本地振荡器(LO)的输入信号x(t)下变频为复基带信号xI(t)+ jxQ(t)。 然后将xI(t)和xQ(t)乘以m个唯一伪随机噪声(PN)序列(例如,Gold序列)gm(t),以产生用于Q的I和m个分支信号的m个分支信号。然后分支信号 低通滤波,从模数转换成数字形式,并由成对复合组合器成对组合。 最后,支持恢复功能用于识别干扰源。
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公开(公告)号:US20120192469A1
公开(公告)日:2012-08-02
申请号:US13015791
申请日:2011-01-28
申请人: Michael Kagen , Randy Fox , Ted Fisher , John Wright , Ben Shelswell
发明人: Michael Kagen , Randy Fox , Ted Fisher , John Wright , Ben Shelswell
CPC分类号: G09F15/0018 , F16B7/0413 , G09F15/0037
摘要: A three-sided channel coupler for connecting the upper and lower portions of a U-shaped sign post, the coupler comprising two U-shaped elements, an outer three-sided, U-shaped element and an inner, three-sided U-shaped element, the three sides of each element comprising a transverse face and two lateral legs, the inner element being smaller than the outer element, a plurality of cross-braces attached to the two lateral legs of each element to hold the two elements together and a plurality of vertical ribs on the inner surface of the outer element and on the outer surface of the inner element.
摘要翻译: 用于连接U形标志杆的上部和下部的三面通道联接器,该联接器包括两个U形元件,一个外部三面U形元件和一个内部三面U形 每个元件的三个侧面包括横向面和两个横向腿部,内部元件小于外部元件,多个横向支架连接到每个元件的两个侧向支腿以将两个元件保持在一起,并且一个 在外部元件的内表面上和内部元件的外表面上的多个垂直肋条。
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公开(公告)号:US20100284577A1
公开(公告)日:2010-11-11
申请号:US12437561
申请日:2009-05-08
申请人: Gang Hua , John Wright , Amir Akbarzadeh
发明人: Gang Hua , John Wright , Amir Akbarzadeh
IPC分类号: G06K9/00
CPC分类号: G06K9/00281 , G06K9/38 , G06K9/4642 , G06K9/6215
摘要: Representing a face by jointly quantizing features and spatial location to perform implicit elastic matching between features. A plurality of the features are extracted from a face image and expanded with a corresponding spatial location in the face image. Each of the expanded features is quantized based on one or more randomized decision trees. A histogram of the quantized features is calculated to represent the face image. The histogram is compared to histograms of other face images to identify a match, or to calculate a distance metric representative of a difference between faces.
摘要翻译: 通过联合量化特征和空间位置来表征特征之间的隐式弹性匹配。 从面部图像中提取多个特征并且利用面部图像中的对应的空间位置进行扩展。 基于一个或多个随机化决策树来量化每个扩展特征。 计算量化特征的直方图以表示脸部图像。 将直方图与其他面部图像的直方图进行比较以识别匹配,或者计算表示面部之间的差异的距离度量。
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